Next Article in Journal
Design and Synthesis of Some Thiazolidin-4-ones Based on (7-Hydroxy-2-oxo-2H-chromen-4-yl) Acetic Acid
Previous Article in Journal
Identification and Quantification of Flavonoids and Phenolic Acids in Burr Parsley (Caucalis platycarpos L.), Using High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry
Open AccessArticle

Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity

1
Grupo de Química Orgánica de Productos Naturales-SIU, Universidad de Antioquia, P.O. Box 1226, Medellín, Colombia
2
Instituto de Química, Universidad de Antioquia, Universidad de Antioquia, P.O. Box 1226, Medellín, Colombia
3
PECET-SIU, Universidad de Antioquia, P.O. Box 1226, Medellín, Colombia
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(7), 2491-2500; https://doi.org/10.3390/molecules14072491
Received: 7 June 2009 / Accepted: 18 June 2009 / Published: 10 July 2009
Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index. View Full-Text
Keywords: metathesis; lactones; antiparasite; leishmania metathesis; lactones; antiparasite; leishmania
Show Figures

Graphical abstract

MDPI and ACS Style

Castaño, M.; Cardona, W.; Quiñones, W.; Robledo, S.; Echeverri, F. Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules 2009, 14, 2491-2500.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop