Molecules

6 pages, 95 KB

Open AccessCommunication

A New Neolignan Glycoside from the Leaves of Acer truncatum

by Lang-Ping Dong¹, Wei Ni¹, Jin-Yang Dong³, Jun-Zhu Li¹, Chang-Xiang Chen¹ and Hai-Yang Liu^1,*

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, Yunnan, P.R. China

² Graduate School of Chinese Academy of Sciences, Beijng 100039, P.R. China

³ Key Laboratory for Conservation and Utilization of Bioresources, Yunnan University, Kunming, Yunnan 650091, P. R. China

Molecules 2006, 11(12), 1009-1014; https://doi.org/10.3390/11121009 - 21 Dec 2006

Cited by 32 | Viewed by 11320

Abstract

A new neolignan glycoside, (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl- 8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1′-benzofuranpropanol 9′-O-β-D- glucopyranoside (1) was isolated from the leaves of Acer truncatum along with (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl-8-hydroxymethyl-7-(4-O-α-L-rhamno- pyranosyloxy-3-methoxyphenyl)-1′-benzofuranpropanol (2), schizandriside (3), lyoniresinol (4), berchemol (5), (-)-pinoresinol-4-O-β-D-glucopyranoside (6), hecogenin (7), chlorogenic acid (8) and neochlorogenic acid (9). Their structures were elucidated [...] Read more.

A new neolignan glycoside, (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl- 8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1′-benzofuranpropanol 9′-O-β-D- glucopyranoside (1) was isolated from the leaves of Acer truncatum along with (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl-8-hydroxymethyl-7-(4-O-α-L-rhamno- pyranosyloxy-3-methoxyphenyl)-1′-benzofuranpropanol (2), schizandriside (3), lyoniresinol (4), berchemol (5), (-)-pinoresinol-4-O-β-D-glucopyranoside (6), hecogenin (7), chlorogenic acid (8) and neochlorogenic acid (9). Their structures were elucidated on the basis of extensive spectroscopic data. The absolute configuration of compounds 1 was established by its CD spectrum. The antibacterial activities of compounds 1-7 were evaluated. Full article

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9 pages, 80 KB

Open AccessArticle

Synthesis and Spectral Investigations of Manganese(II), Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Complexes of New Polydentate Ligands Containing a 1,8-Naphthyridine Moiety

by Sreedasyam Jagannatha Swamy^*, Erra Ram Reddy, Devunuri Naga Raju and Sunkari Jyothi

Department of Chemistry, Kakatiya University, Warangal – 506 009, India

Molecules 2006, 11(12), 1000-1008; https://doi.org/10.3390/11121000 - 21 Dec 2006

Cited by 20 | Viewed by 9422

Abstract

2-(o-Hydroxyphenyl)-1,8-naphthyridine (HN), 2-(4-hydroxy-6-methylpyran-2-one-3-yl)-1,8-naphthyridine (HMPN) and 2-(benzimidazol-2-yl)-1,8-naphthyridine(BN) react with acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) to yield metal ioncomplexes of definite composition. These compounds were characterized by elementalanalyses, molar conductivity, magnetic susceptibility measurements, thermal studies, IR,UV-visible, NMR and mass spectral investigations. The [...] Read more.

2-(o-Hydroxyphenyl)-1,8-naphthyridine (HN), 2-(4-hydroxy-6-methylpyran-2-one-3-yl)-1,8-naphthyridine (HMPN) and 2-(benzimidazol-2-yl)-1,8-naphthyridine(BN) react with acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) to yield metal ioncomplexes of definite composition. These compounds were characterized by elementalanalyses, molar conductivity, magnetic susceptibility measurements, thermal studies, IR,UV-visible, NMR and mass spectral investigations. The complexes are found to have theformulae [M(HN)₂(H₂O)₂], [M(HMPN)₂(H₂O)₂] and [M(BN)₂(OAc)₂], respectively. Full article

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12 pages, 93 KB

Open AccessArticle

Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

by Li Zhang¹, Beiying Qiu², Xin Li¹, Xin Wang¹, Jingya Li², Yongliang Zhang¹, Jian Liu¹, Jia Li² and Jingkang Shen^1,*

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P.R. China

² The National Center for Drug Screening, 189 Guoshoujing Road, Shanghai 201203, P.R. China

Molecules 2006, 11(12), 988-999; https://doi.org/10.3390/11120988 - 21 Dec 2006

Cited by 15 | Viewed by 11761

Abstract

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay. Full article

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10 pages, 81 KB

Open AccessArticle

CuCl₂-catalyzed One-pot Formation of Tetrahydroquinolines from N-Methyl-N-alkylanilines and Vinyl Ethers in the Presence of t-Butylhydroperoxide

by Xianghua Yang, Chanjuan Xi^* and Yanfeng Jiang

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education),Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China

Molecules 2006, 11(12), 978-987; https://doi.org/10.3390/11120978 - 20 Dec 2006

Cited by 12 | Viewed by 9801

Abstract

Tetrahydroquinoline skeletons can be formed by a CuCl₂-catalyzed one-potreaction of N-methyl-N-alkylanilines and vinyl ethers in the presence of t-butyl-hydroperoxide. Full article

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10 pages, 61 KB

Open AccessCommunication

Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

by Mario Sechi^1,*

, Fabio Casu¹, Ilaria Campesi¹, Stefano Fiori² and Alberto Mariani²

¹ Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy

² Dipartimento di Chimica, Università di Sassari and local INSTM Research Unit, Via Vienna 2, 07100 Sassari, Italy

Molecules 2006, 11(12), 968-977; https://doi.org/10.3390/11120968 - 18 Dec 2006

Cited by 8 | Viewed by 9480

Abstract

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds. Full article

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9 pages, 74 KB

Open AccessArticle

Synthesis of (R)-2-(Benzyloxy)-tetrahydro-5,5-dimethylfuran by a New Oxidative Rearrangement

by D. Díez^*

, M. G. Nuñez, R. F. Moro, N. M. Garrido, I. S. Marcos, P. Basabe and J. G. Urones

Departamento de Química Orgánica,Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain

Molecules 2006, 11(12), 959-967; https://doi.org/10.3390/11120959 - 18 Dec 2006

Cited by 2 | Viewed by 9181

Abstract

The rearrangement under oxidative conditions of 3-(benzyloxy)-tetrahydro- 2,6,6-trimethyl-2H-pyran-2-carbaldehydes to afford a chiral protected tetrahydrofuran lactol is described. Full article

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6 pages, 48 KB

Open AccessCommunication

Synthesis and Characterization of Dimethacrylate Monomer with High Molecular Weight for Root Canal Filling Materials

by Fang Liu^1,*, Jing-wie He¹, Zheng-mei Lin², Jun-qi Ling² and De-min Jia¹

¹ College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China

² Guanghua College of Stomatology, Institute of Stomatology, Sun Yat-sen University, Guangzhou 510060, China

Molecules 2006, 11(12), 953-958; https://doi.org/10.3390/11120953 - 7 Dec 2006

Cited by 12 | Viewed by 11507

Abstract

A new dimethacrylate monomer 9,9'-bis[4-(2'-hydroxy-3'-methacryloyloxy-propoxy)phenyl] fluorene (3) with a molecular weight of 634 was synthesized in 51.4%yield by addition of a glycidyl ether group to 9,9'-bis(4-hydroxyphenyl) fluorene (1) bythe reaction of compound 1 with epichlorohydrin, and then introducing the methacrylatemoiety by the reaction [...] Read more.

A new dimethacrylate monomer 9,9'-bis[4-(2'-hydroxy-3'-methacryloyloxy-propoxy)phenyl] fluorene (3) with a molecular weight of 634 was synthesized in 51.4%yield by addition of a glycidyl ether group to 9,9'-bis(4-hydroxyphenyl) fluorene (1) bythe reaction of compound 1 with epichlorohydrin, and then introducing the methacrylatemoiety by the reaction of the epoxy group with methacrylic acid. The structure ofmonomer 3 was confirmed by FT-IR, ¹H-NMR, mass spectra and elemental analysis. Full article

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13 pages, 391 KB

Open AccessArticle

Microwave Assisted Synthesis of Molybdenum and Tungsten Tetracarbonyl Complexes with a Pyrazolylpyridine Ligand. Crystal structure of cis-[Mo(CO)₄{ethyl[3-(2-pyridyl)-1-pyrazolyl]acetate}]

by Ana C. Coelho¹, Filipe A. Almeida Paz¹, Jacek Klinowski², Martyn Pillinger¹ and Isabel S. Gonçalves^1,*

¹ Department of Chemistry, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal

² Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK

Molecules 2006, 11(12), 940-952; https://doi.org/10.3390/molecules11120940 - 6 Dec 2006

Cited by 16 | Viewed by 12219

Abstract

We report the one-step syntheses in good yields of the complexes cis-[M(CO)₄(pzpy)] {M = Mo, W; pzpy = ethyl[3-(2-pyridyl)-1-pyrazolyl]acetate} directlyfrom the corresponding M(CO)₆ starting materials by using microwave-assisted heatingand reaction times of either 30 s (M = Mo) or 15 [...] Read more.

We report the one-step syntheses in good yields of the complexes cis-[M(CO)₄(pzpy)] {M = Mo, W; pzpy = ethyl[3-(2-pyridyl)-1-pyrazolyl]acetate} directlyfrom the corresponding M(CO)₆ starting materials by using microwave-assisted heatingand reaction times of either 30 s (M = Mo) or 15 min (M = W). The structure of themolybdenum tetracarbonyl complex was determined by single crystal X-ray diffraction.The compound is monomeric and the molybdenum atom has a highly distorted octahedralgeometry. The close packing of the individual cis-[Mo(CO)4(pzpy)] species is essentiallydriven by the need to fill the space effectively, closely mediated by weak C–H···O andπ···π interactions. Full article

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Molecules, Volume 11, Issue 12 (December 2006) – 8 articles , Pages 940-1014

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