Next Article in Journal
Improving Neural Machine Translation by Filtering Synthetic Parallel Data
Next Article in Special Issue
Chemical Reaction Networks Possess Intrinsic, Temperature-Dependent Functionality
Previous Article in Journal
On the Statistical Mechanics of Life: Schrödinger Revisited
Previous Article in Special Issue
Fitness Gain of Individually Sensed Information by Cells
Open AccessArticle

Dissipation in Non-Steady State Regulatory Circuits

Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, 02-097 Warszawa, Poland
Laboratoire de Physique de l’École Normale Supérieure (PSL University), CNRS, Sorbonne Université, and Université de Paris, 75005 Paris, France
Capital Fund Management, 23 rue de l’Université, 75007 Paris, France
Author to whom correspondence should be addressed.
Entropy 2019, 21(12), 1212;
Received: 8 November 2019 / Revised: 4 December 2019 / Accepted: 5 December 2019 / Published: 10 December 2019
(This article belongs to the Special Issue Information Flow and Entropy Production in Biomolecular Networks)
In order to respond to environmental signals, cells often use small molecular circuits to transmit information about their surroundings. Recently, motivated by specific examples in signaling and gene regulation, a body of work has focused on the properties of circuits that function out of equilibrium and dissipate energy. We briefly review the probabilistic measures of information and dissipation and use simple models to discuss and illustrate trade-offs between information and dissipation in biological circuits. We find that circuits with non-steady state initial conditions can transmit more information at small readout delays than steady state circuits. The dissipative cost of this additional information proves marginal compared to the steady state dissipation. Feedback does not significantly increase the transmitted information for out of steady state circuits but does decrease dissipative costs. Lastly, we discuss the case of bursty gene regulatory circuits that, even in the fast switching limit, function out of equilibrium. View Full-Text
Keywords: biomolecular circuits; regulation; dissipation; stochastic systems biomolecular circuits; regulation; dissipation; stochastic systems
Show Figures

Figure 1

MDPI and ACS Style

Szymańska-Rożek, P.; Villamaina, D.; Miȩkisz, J.; Walczak, A.M. Dissipation in Non-Steady State Regulatory Circuits. Entropy 2019, 21, 1212.

AMA Style

Szymańska-Rożek P, Villamaina D, Miȩkisz J, Walczak AM. Dissipation in Non-Steady State Regulatory Circuits. Entropy. 2019; 21(12):1212.

Chicago/Turabian Style

Szymańska-Rożek, Paulina; Villamaina, Dario; Miȩkisz, Jacek; Walczak, Aleksandra M. 2019. "Dissipation in Non-Steady State Regulatory Circuits" Entropy 21, no. 12: 1212.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop