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Open AccessArticle

Dissipation in Non-Steady State Regulatory Circuits

1
Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, 02-097 Warszawa, Poland
2
Laboratoire de Physique de l’École Normale Supérieure (PSL University), CNRS, Sorbonne Université, and Université de Paris, 75005 Paris, France
3
Capital Fund Management, 23 rue de l’Université, 75007 Paris, France
*
Author to whom correspondence should be addressed.
Entropy 2019, 21(12), 1212; https://doi.org/10.3390/e21121212
Received: 8 November 2019 / Revised: 4 December 2019 / Accepted: 5 December 2019 / Published: 10 December 2019
(This article belongs to the Special Issue Information Flow and Entropy Production in Biomolecular Networks)
In order to respond to environmental signals, cells often use small molecular circuits to transmit information about their surroundings. Recently, motivated by specific examples in signaling and gene regulation, a body of work has focused on the properties of circuits that function out of equilibrium and dissipate energy. We briefly review the probabilistic measures of information and dissipation and use simple models to discuss and illustrate trade-offs between information and dissipation in biological circuits. We find that circuits with non-steady state initial conditions can transmit more information at small readout delays than steady state circuits. The dissipative cost of this additional information proves marginal compared to the steady state dissipation. Feedback does not significantly increase the transmitted information for out of steady state circuits but does decrease dissipative costs. Lastly, we discuss the case of bursty gene regulatory circuits that, even in the fast switching limit, function out of equilibrium. View Full-Text
Keywords: biomolecular circuits; regulation; dissipation; stochastic systems biomolecular circuits; regulation; dissipation; stochastic systems
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Szymańska-Rożek, P.; Villamaina, D.; Miȩkisz, J.; Walczak, A.M. Dissipation in Non-Steady State Regulatory Circuits. Entropy 2019, 21, 1212.

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