Special Issue "Alkaloids: Novel Therapeutic Perspectives"

Quicklinks

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 October 2014

Special Issue Editors

Guest Editor
Prof. Dr. Patricia Valentao
Pharmacognosy Laboratory, Pharmacy Faculty, University of Oporto, R. Aníbal Cunha, 164, 4050 054 Porto
E-Mail: valentao@ff.up.pt

Guest Editor
Prof. Dr. Mariana Sottomayor
Department of Botany, Faculty of Sciences and Institute for Molecular and Cell Biology (IBMC) , University of Porto Rua do Campo Alegre, 823 4150-180 Porto
E-Mail: msottoma@ibmc.up.pt

Special Issue Information

Dear Colleagues,

Finding novel bioactive compounds of natural origin has been a major concern for pharmaceuticals research. Among those natural products, alkaloids area among the oldest drugs in medicine and are promising, novel drug candidates.  Alkaloids are characterized by the presence of a basic nitrogen (usually in a heterocycle); they exhibit highly complex structures that are believed to function as herbivorism deterrents in plants. Hence, they show strong physiological activities in animals, which may translate into important therapeutic actions in humans, under adequate dosages. In recent years, the number of new alkaloids isolated, identified, and studied for their medicinal potential has increased. These alkaloids largely originate from unexpected organisms, such as marine sponges, algae, etc. Moreover, the characterization of many novel therapy targets urges the reappraisal of old alkaloids. This Special Issue is devoted to the recent knowledge concerning the potential of alkaloids as therapeutic options for human diseases, their targets, and mechanisms of action.

Prof. Dr. Patricia Valentao
Prof. Dr. Mariana Sottomayor
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Keywords

  • Pyridine group: piperine, coniine, trigonelline, arecaidine, guvacine, pilocarpine, cytisine, nicotine, sparteine, pelletierine.
  • Pyrrolidine group: hygrine, cuscohygrine, nicotine.
  • Tropane group: atropine, cocaine, ecgonine, scopolamine, catuabine.
  • Quinoline group: quinine, quinidine, dihydroquinine, dihydroquinidine, strychnine, brucine, veratrine, cevadine.
  • Isoquinoline group: the opium alkaloids (morphine, codeine, thebaine, isopapa-dimethoxy-aniline, papaverine, narcotine, sanguinarine, narceine, hydrastine, berberine).
  • Phenethylamine group: mescaline, ephedrine, dopamine, amphetamine
  • Indole group: tryptamines (DMT, N-methyltryptamine, psilocybin, serotonin), ergolines: the ergot alkaloids (ergine, ergotamine, lysergic acid, etc.), beta-carbolines (harmine, harmaline, yohimbine, reserpine, emetine), rauwolfia alkaloids (reserpine).
  • Purine group: xanthines (caffeine, theobromine, theophylline).
  • Terpenoid group: aconite alkaloids (aconitine).
  • Steroids: solanine, samandaris, i.e., quaternary ammonium compounds (muscarine, choline, neurine).
  • organic chemistry, natural product chemistry, medicinal chemistry, analytical chemistry, etc.

Published Papers (34 papers)

Download All Papers
Sort by:
Display options:
Select articles Export citation of selected articles as:
Select/unselect all
Displaying article 1-34
p. 14699-14709
by , , , , , , , , , ,  and
Molecules 2014, 19(9), 14699-14709; doi:10.3390/molecules190914699
Received: 15 August 2014; in revised form: 7 September 2014 / Accepted: 9 September 2014 / Published: 16 September 2014
Show/Hide Abstract | PDF Full-text (852 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
abstract graphic
p. 13042-13060
by , , , , ,  and
Molecules 2014, 19(9), 13042-13060; doi:10.3390/molecules190913042
Received: 14 May 2014; Accepted: 20 August 2014 / Published: 25 August 2014
Show/Hide Abstract | PDF Full-text (836 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 12619-12629
by , , ,  and
Molecules 2014, 19(8), 12619-12629; doi:10.3390/molecules190812619
Received: 1 August 2014; in revised form: 9 August 2014 / Accepted: 11 August 2014 / Published: 19 August 2014
Show/Hide Abstract | PDF Full-text (985 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 12328-12335
by  and
Molecules 2014, 19(8), 12328-12335; doi:10.3390/molecules190812328
Received: 25 July 2014; in revised form: 11 August 2014 / Accepted: 11 August 2014 / Published: 15 August 2014
Show/Hide Abstract | PDF Full-text (657 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
abstract graphic
p. 12349-12367
by , ,  and
Molecules 2014, 19(8), 12349-12367; doi:10.3390/molecules190812349
Received: 27 June 2014; in revised form: 6 August 2014 / Accepted: 11 August 2014 / Published: 15 August 2014
Show/Hide Abstract | PDF Full-text (1094 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 11896-11914
by , , , , , ,  and
Molecules 2014, 19(8), 11896-11914; doi:10.3390/molecules190811896
Received: 25 June 2014; in revised form: 2 August 2014 / Accepted: 5 August 2014 / Published: 11 August 2014
Show/Hide Abstract | PDF Full-text (2158 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 9999-10010
by , , ,  and
Molecules 2014, 19(7), 9999-10010; doi:10.3390/molecules19079999
Received: 23 May 2014; in revised form: 18 June 2014 / Accepted: 27 June 2014 / Published: 10 July 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (379 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 8762-8772
by , , , , , ,  and
Molecules 2014, 19(7), 8762-8772; doi:10.3390/molecules19078762
Received: 21 May 2014; in revised form: 17 June 2014 / Accepted: 19 June 2014 / Published: 25 June 2014
Show/Hide Abstract | PDF Full-text (334 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 8257-8263
by , , ,  and
Molecules 2013, 18(7), 8257-8263; doi:10.3390/molecules18078257
Received: 13 May 2013; in revised form: 28 June 2013 / Accepted: 3 July 2013 / Published: 12 July 2013
Show/Hide Abstract | PDF Full-text (193 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 191-206
by  and
Molecules 2012, 17(1), 191-206; doi:10.3390/molecules17010191
Received: 9 November 2011; in revised form: 7 December 2011 / Accepted: 24 December 2011 / Published: 27 December 2011
Show/Hide Abstract | Cited by 22 | PDF Full-text (259 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
abstract graphic
p. 9665-9696
by ,  and
Molecules 2011, 16(11), 9665-9696; doi:10.3390/molecules16119665
Received: 24 October 2011; Accepted: 9 November 2011 / Published: 23 November 2011
Show/Hide Abstract | Cited by 15 | PDF Full-text (301 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 9520-9533
by , , , , , , , ,  and
Molecules 2011, 16(11), 9520-9533; doi:10.3390/molecules16119520
Received: 17 October 2011; in revised form: 27 October 2011 / Accepted: 7 November 2011 / Published: 15 November 2011
Show/Hide Abstract | Cited by 6 | PDF Full-text (250 KB) | Supplementary Files
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
abstract graphic
p. 9153-9160
by ,  and
Molecules 2011, 16(11), 9153-9160; doi:10.3390/molecules16119153
Received: 8 October 2011; in revised form: 21 October 2011 / Accepted: 27 October 2011 / Published: 2 November 2011
Show/Hide Abstract | PDF Full-text (193 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 8515-8534
by , , , ,  and
Molecules 2011, 16(10), 8515-8534; doi:10.3390/molecules16108515
Received: 22 July 2011; in revised form: 7 September 2011 / Accepted: 26 September 2011 / Published: 11 October 2011
Show/Hide Abstract | Cited by 14 | PDF Full-text (413 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 8020-8032
by ,  and
Molecules 2011, 16(9), 8020-8032; doi:10.3390/molecules16098020
Received: 25 August 2011; in revised form: 15 September 2011 / Accepted: 15 September 2011 / Published: 16 September 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (368 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 7480-7487
by , ,  and
Molecules 2011, 16(9), 7480-7487; doi:10.3390/molecules16097480
Received: 28 June 2011; in revised form: 16 August 2011 / Accepted: 31 August 2011 / Published: 2 September 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (544 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
abstract graphic
p. 7344-7356
by , , , ,  and
Molecules 2011, 16(9), 7344-7356; doi:10.3390/molecules16097344
Received: 4 July 2011; in revised form: 8 August 2011 / Accepted: 19 August 2011 / Published: 29 August 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (492 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 7199-7209
by , , ,  and
Molecules 2011, 16(9), 7199-7209; doi:10.3390/molecules16097199
Received: 12 July 2011; in revised form: 16 August 2011 / Accepted: 17 August 2011 / Published: 25 August 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (554 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
abstract graphic
p. 7155-7170
by , , , ,  and
Molecules 2011, 16(8), 7155-7170; doi:10.3390/molecules16087155
Received: 18 May 2011; in revised form: 6 July 2011 / Accepted: 3 August 2011 / Published: 23 August 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (2020 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 7125-7131
by , , , , , , , ,  and
Molecules 2011, 16(8), 7125-7131; doi:10.3390/molecules16087125
Received: 27 June 2011; in revised form: 26 July 2011 / Accepted: 4 August 2011 / Published: 22 August 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (432 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 7097-7104
by , , , ,  and
Molecules 2011, 16(8), 7097-7104; doi:10.3390/molecules16087097
Received: 9 June 2011; in revised form: 20 July 2011 / Accepted: 26 July 2011 / Published: 18 August 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (438 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 6541-6548
by , ,  and
Molecules 2011, 16(8), 6541-6548; doi:10.3390/molecules16086541
Received: 20 June 2011; in revised form: 15 July 2011 / Accepted: 20 July 2011 / Published: 4 August 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (374 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 5268-5282
by , , , ,  and
Molecules 2011, 16(6), 5268-5282; doi:10.3390/molecules16065268
Received: 23 May 2011; Accepted: 22 June 2011 / Published: 23 June 2011
Show/Hide Abstract | Cited by 7 | PDF Full-text (653 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 3345-3350
by , , ,  and
Molecules 2011, 16(4), 3345-3350; doi:10.3390/molecules16043345
Received: 22 February 2011; in revised form: 26 March 2011 / Accepted: 30 March 2011 / Published: 19 April 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (140 KB) | Supplementary Files
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 3198-3223
by , , , , , , , , ,  and
Molecules 2008, 13(12), 3198-3223; doi:10.3390/molecules13123198
Received: 30 July 2008; in revised form: 7 November 2008 / Accepted: 2 December 2008 / Published: 17 December 2008
Show/Hide Abstract | Cited by 34 | PDF Full-text (183 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 2462-2473
by  and
Molecules 2008, 13(10), 2462-2473; doi:10.3390/molecules13102462
Received: 30 June 2008; in revised form: 5 September 2008 / Accepted: 30 September 2008 / Published: 3 October 2008
Show/Hide Abstract | Cited by 16 | PDF Full-text (203 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 1875-1896
by
Molecules 2008, 13(8), 1875-1896; doi:10.3390/molecules13081875
Received: 5 August 2008; in revised form: 24 August 2008 / Accepted: 26 August 2008 / Published: 27 August 2008
Show/Hide Abstract | Cited by 11 | PDF Full-text (410 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 1722-1742
by , ,  and
Molecules 2008, 13(8), 1722-1742; doi:10.3390/molecules13081722
Received: 3 June 2008; in revised form: 12 August 2008 / Accepted: 14 August 2008 / Published: 18 August 2008
Show/Hide Abstract | Cited by 14 | PDF Full-text (1422 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 1584-1598
by , , ,  and
Molecules 2008, 13(8), 1584-1598; doi:10.3390/molecules1301584
Received: 6 May 2008; in revised form: 24 June 2008 / Accepted: 23 July 2008 / Published: 6 August 2008
Show/Hide Abstract | Cited by 1 | PDF Full-text (221 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 1518-1529
by , , ,  and
Molecules 2008, 13(7), 1518-1529; doi:10.3390/molecules13071518
Received: 28 May 2008; in revised form: 22 June 2008 / Accepted: 18 July 2008 / Published: 30 July 2008
Show/Hide Abstract | Cited by 6 | PDF Full-text (323 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 1465-1471
by , ,  and
Molecules 2008, 13(7), 1465-1471; doi:10.3390/molecules13071465
Received: 25 June 2008; Accepted: 16 July 2008 / Published: 17 July 2008
Show/Hide Abstract | Cited by 3 | PDF Full-text (205 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 475-487
by , , , ,  and
Molecules 2008, 13(2), 475-487; doi:10.3390/molecules13020475
Received: 30 January 2008; in revised form: 22 February 2008 / Accepted: 25 February 2008 / Published: 27 February 2008
Show/Hide Abstract | Cited by 3 | PDF Full-text (141 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 272-300
by , , , , ,  and
Molecules 2008, 13(2), 272-300; doi:10.3390/molecules13020272
Received: 1 January 2008; in revised form: 1 February 2008 / Accepted: 2 February 2008 / Published: 6 February 2008
Show/Hide Abstract | Cited by 34 | PDF Full-text (258 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
p. 3-10
by
Molecules 2008, 13(1), 3-10; doi:10.3390/molecules13010003
Received: 4 December 2007; Accepted: 30 December 2007 / Published: 9 January 2008
Show/Hide Abstract | Cited by 2 | PDF Full-text (83 KB)
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Select/unselect all
Displaying article 1-34
Select articles Export citation of selected articles as:

Last update: 23 May 2014

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert