Special Issue "Alkaloids: Novel Therapeutic Perspectives"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 October 2014

Special Issue Editors

Guest Editor
Prof. Dr. Patricia Valentao
Pharmacognosy Laboratory, Pharmacy Faculty, University of Oporto, R. Aníbal Cunha, 164, 4050 054 Porto
E-Mail: valentao@ff.up.pt

Guest Editor
Prof. Dr. Mariana Sottomayor
Department of Botany, Faculty of Sciences and Institute for Molecular and Cell Biology (IBMC) , University of Porto Rua do Campo Alegre, 823 4150-180 Porto
E-Mail: msottoma@ibmc.up.pt

Special Issue Information

Dear Colleagues,

Finding novel bioactive compounds of natural origin has been a major concern for pharmaceuticals research. Among those natural products, alkaloids area among the oldest drugs in medicine and are promising, novel drug candidates.  Alkaloids are characterized by the presence of a basic nitrogen (usually in a heterocycle); they exhibit highly complex structures that are believed to function as herbivorism deterrents in plants. Hence, they show strong physiological activities in animals, which may translate into important therapeutic actions in humans, under adequate dosages. In recent years, the number of new alkaloids isolated, identified, and studied for their medicinal potential has increased. These alkaloids largely originate from unexpected organisms, such as marine sponges, algae, etc. Moreover, the characterization of many novel therapy targets urges the reappraisal of old alkaloids. This Special Issue is devoted to the recent knowledge concerning the potential of alkaloids as therapeutic options for human diseases, their targets, and mechanisms of action.

Prof. Dr. Patricia Valentao
Prof. Dr. Mariana Sottomayor
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Keywords

  • Pyridine group: piperine, coniine, trigonelline, arecaidine, guvacine, pilocarpine, cytisine, nicotine, sparteine, pelletierine.
  • Pyrrolidine group: hygrine, cuscohygrine, nicotine.
  • Tropane group: atropine, cocaine, ecgonine, scopolamine, catuabine.
  • Quinoline group: quinine, quinidine, dihydroquinine, dihydroquinidine, strychnine, brucine, veratrine, cevadine.
  • Isoquinoline group: the opium alkaloids (morphine, codeine, thebaine, isopapa-dimethoxy-aniline, papaverine, narcotine, sanguinarine, narceine, hydrastine, berberine).
  • Phenethylamine group: mescaline, ephedrine, dopamine, amphetamine
  • Indole group: tryptamines (DMT, N-methyltryptamine, psilocybin, serotonin), ergolines: the ergot alkaloids (ergine, ergotamine, lysergic acid, etc.), beta-carbolines (harmine, harmaline, yohimbine, reserpine, emetine), rauwolfia alkaloids (reserpine).
  • Purine group: xanthines (caffeine, theobromine, theophylline).
  • Terpenoid group: aconite alkaloids (aconitine).
  • Steroids: solanine, samandaris, i.e., quaternary ammonium compounds (muscarine, choline, neurine).
  • organic chemistry, natural product chemistry, medicinal chemistry, analytical chemistry, etc.

Published Papers (28 papers)

Molecules 2014, 19(7), 9999-10010; doi:10.3390/molecules19079999
Received: 23 May 2014; in revised form: 18 June 2014 / Accepted: 27 June 2014 / Published: 10 July 2014
Show/Hide Abstract | PDF Full-text (379 KB) | Supplementary Files
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Molecules 2014, 19(7), 8762-8772; doi:10.3390/molecules19078762
Received: 21 May 2014; in revised form: 17 June 2014 / Accepted: 19 June 2014 / Published: 25 June 2014
Show/Hide Abstract | PDF Full-text (334 KB)

Molecules 2013, 18(7), 8257-8263; doi:10.3390/molecules18078257
Received: 13 May 2013; in revised form: 28 June 2013 / Accepted: 3 July 2013 / Published: 12 July 2013
Show/Hide Abstract | PDF Full-text (193 KB)

Molecules 2012, 17(1), 191-206; doi:10.3390/molecules17010191
Received: 9 November 2011; in revised form: 7 December 2011 / Accepted: 24 December 2011 / Published: 27 December 2011
Show/Hide Abstract | Cited by 21 | PDF Full-text (259 KB)
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Molecules 2011, 16(11), 9665-9696; doi:10.3390/molecules16119665
Received: 24 October 2011; Accepted: 9 November 2011 / Published: 23 November 2011
Show/Hide Abstract | Cited by 14 | PDF Full-text (301 KB)

Molecules 2011, 16(11), 9520-9533; doi:10.3390/molecules16119520
Received: 17 October 2011; in revised form: 27 October 2011 / Accepted: 7 November 2011 / Published: 15 November 2011
Show/Hide Abstract | Cited by 6 | PDF Full-text (250 KB) | Supplementary Files
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Molecules 2011, 16(11), 9153-9160; doi:10.3390/molecules16119153
Received: 8 October 2011; in revised form: 21 October 2011 / Accepted: 27 October 2011 / Published: 2 November 2011
Show/Hide Abstract | PDF Full-text (193 KB)

Molecules 2011, 16(10), 8515-8534; doi:10.3390/molecules16108515
Received: 22 July 2011; in revised form: 7 September 2011 / Accepted: 26 September 2011 / Published: 11 October 2011
Show/Hide Abstract | Cited by 12 | PDF Full-text (413 KB)

Molecules 2011, 16(9), 8020-8032; doi:10.3390/molecules16098020
Received: 25 August 2011; in revised form: 15 September 2011 / Accepted: 15 September 2011 / Published: 16 September 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (368 KB)

Molecules 2011, 16(9), 7480-7487; doi:10.3390/molecules16097480
Received: 28 June 2011; in revised form: 16 August 2011 / Accepted: 31 August 2011 / Published: 2 September 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (544 KB)
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Molecules 2011, 16(9), 7344-7356; doi:10.3390/molecules16097344
Received: 4 July 2011; in revised form: 8 August 2011 / Accepted: 19 August 2011 / Published: 29 August 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (492 KB)

Molecules 2011, 16(9), 7199-7209; doi:10.3390/molecules16097199
Received: 12 July 2011; in revised form: 16 August 2011 / Accepted: 17 August 2011 / Published: 25 August 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (554 KB)
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Molecules 2011, 16(8), 7155-7170; doi:10.3390/molecules16087155
Received: 18 May 2011; in revised form: 6 July 2011 / Accepted: 3 August 2011 / Published: 23 August 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (2020 KB)

Molecules 2011, 16(8), 7125-7131; doi:10.3390/molecules16087125
Received: 27 June 2011; in revised form: 26 July 2011 / Accepted: 4 August 2011 / Published: 22 August 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (432 KB)

Molecules 2011, 16(8), 7097-7104; doi:10.3390/molecules16087097
Received: 9 June 2011; in revised form: 20 July 2011 / Accepted: 26 July 2011 / Published: 18 August 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (438 KB)

Molecules 2011, 16(8), 6541-6548; doi:10.3390/molecules16086541
Received: 20 June 2011; in revised form: 15 July 2011 / Accepted: 20 July 2011 / Published: 4 August 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (374 KB)

Molecules 2011, 16(6), 5268-5282; doi:10.3390/molecules16065268
Received: 23 May 2011; Accepted: 22 June 2011 / Published: 23 June 2011
Show/Hide Abstract | Cited by 7 | PDF Full-text (653 KB)

Molecules 2011, 16(4), 3345-3350; doi:10.3390/molecules16043345
Received: 22 February 2011; in revised form: 26 March 2011 / Accepted: 30 March 2011 / Published: 19 April 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (140 KB) | Supplementary Files

Molecules 2008, 13(12), 3198-3223; doi:10.3390/molecules13123198
Received: 30 July 2008; in revised form: 7 November 2008 / Accepted: 2 December 2008 / Published: 17 December 2008
Show/Hide Abstract | Cited by 32 | PDF Full-text (183 KB)

Molecules 2008, 13(10), 2462-2473; doi:10.3390/molecules13102462
Received: 30 June 2008; in revised form: 5 September 2008 / Accepted: 30 September 2008 / Published: 3 October 2008
Show/Hide Abstract | Cited by 16 | PDF Full-text (203 KB)

Molecules 2008, 13(8), 1875-1896; doi:10.3390/molecules13081875
Received: 5 August 2008; in revised form: 24 August 2008 / Accepted: 26 August 2008 / Published: 27 August 2008
Show/Hide Abstract | Cited by 11 | PDF Full-text (410 KB)

Molecules 2008, 13(8), 1722-1742; doi:10.3390/molecules13081722
Received: 3 June 2008; in revised form: 12 August 2008 / Accepted: 14 August 2008 / Published: 18 August 2008
Show/Hide Abstract | Cited by 13 | PDF Full-text (1422 KB)

Molecules 2008, 13(8), 1584-1598; doi:10.3390/molecules1301584
Received: 6 May 2008; in revised form: 24 June 2008 / Accepted: 23 July 2008 / Published: 6 August 2008
Show/Hide Abstract | Cited by 1 | PDF Full-text (221 KB)

Molecules 2008, 13(7), 1518-1529; doi:10.3390/molecules13071518
Received: 28 May 2008; in revised form: 22 June 2008 / Accepted: 18 July 2008 / Published: 30 July 2008
Show/Hide Abstract | Cited by 6 | PDF Full-text (323 KB)

Molecules 2008, 13(7), 1465-1471; doi:10.3390/molecules13071465
Received: 25 June 2008; Accepted: 16 July 2008 / Published: 17 July 2008
Show/Hide Abstract | Cited by 3 | PDF Full-text (205 KB)

Molecules 2008, 13(2), 475-487; doi:10.3390/molecules13020475
Received: 30 January 2008; in revised form: 22 February 2008 / Accepted: 25 February 2008 / Published: 27 February 2008
Show/Hide Abstract | Cited by 3 | PDF Full-text (141 KB)

Molecules 2008, 13(2), 272-300; doi:10.3390/molecules13020272
Received: 1 January 2008; in revised form: 1 February 2008 / Accepted: 2 February 2008 / Published: 6 February 2008
Show/Hide Abstract | Cited by 34 | PDF Full-text (258 KB)

Molecules 2008, 13(1), 3-10; doi:10.3390/molecules13010003
Received: 4 December 2007; Accepted: 30 December 2007 / Published: 9 January 2008
Show/Hide Abstract | Cited by 2 | PDF Full-text (83 KB)

Last update: 23 May 2014

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