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Molecules 2008, 13(8), 1722-1742; doi:10.3390/molecules13081722
Review

Application of Metabolic Engineering to the Production of Scopolamine

1,* , 2
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1
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3
Received: 3 June 2008 / Revised: 12 August 2008 / Accepted: 14 August 2008 / Published: 18 August 2008
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Abstract

Scopolamine is an alkaloid widely used in medicine for its anticholinergic activity. The aim of this review is to show that metabolic engineering techniques constitute a suitable tool to improve the production of tropane alkaloids, focusing in particular on scopolamine. We present an overview of results obtained by various research groups, including our own, who have studied the overexpression of genes involved in the biosynthesis of scopolamine in different plant species that produce tropane alkaloids. Experiments carried out to improve production in hairy root cultures will also be described, as well as those attempting to biotransform hyoscyamine into scopolamine in roots and transgenic tobacco cells.
Keywords: Scopolamine; hyoscyamine; hairy roots; putrescine N-methyltransferase; hyoscyamine-6-β-hydroxylase. Scopolamine; hyoscyamine; hairy roots; putrescine N-methyltransferase; hyoscyamine-6-β-hydroxylase.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Palazón, J.; Navarro-Ocaña, A.; Hernandez-Vazquez, L.; Mirjalili, M.H. Application of Metabolic Engineering to the Production of Scopolamine. Molecules 2008, 13, 1722-1742.

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