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Special Issue "Natural Anti-Inflammatory Agents 2018"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 September 2018

Special Issue Editors

Guest Editor
Prof. Dr. Paula B. Andrade

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal
Website | E-Mail
Fax: +351-226093390
Interests: metabolite profiling of natural matrices; natural agents for inflammation; neurodegenerative disorders
Guest Editor
Prof. Dr. Patrícia Valentão

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal
Website | E-Mail
Fax: +351-226093390
Interests: metabolite profiling of natural matrices; evaluation of bioactive agents from natural sources

Special Issue Information

Dear Colleagues,

Inflammation is the organism’s natural response to stimuli that are perceived as harmful, from germs, toxins, and environmental pollutants, to injury and stress, among others. This complex process involves immune, vascular and cellular biochemical reactions. At a damaged site, the process starts with the migration of immune cells from blood vessels and the release of mediators, followed by the recruitment of inflammatory cells and the release of various oxidative agents and pro-inflammatory cytokines, with arachidonic acid playing a pivotal role. Normal inflammation is self-limiting, but aberrant resolution and prolonged inflammation lead to chronic disorders, as excessive oxidants and inflammatory mediators have deleterious effects, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs, finally leading to systemic disorders. The search for new anti-inflammatory drugs has been a current preoccupation, due to the need for effective drugs, with less adverse reactions than those used nowadays. Concerning this issue, there has been increasing awareness of the potential interest in natural products. This Special Issue is devoted to the exploitation of natural matrices as sources of new anti-inflammatory molecules and their mechanism of action.

Prof. Dr. Paula Andrade
Prof. Dr. Patrícia Valentão
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-inflammatory
  • arachidonic acid
  • cytokines
  • eicosanoids
  • gene expression
  • inflammatory cells
  • inflammatory enzymes
  • natural products
  • transcription factors

Published Papers (5 papers)

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Editorial

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Open AccessEditorial Insights into Natural Products in Inflammation
Int. J. Mol. Sci. 2018, 19(3), 644; https://doi.org/10.3390/ijms19030644
Received: 2 February 2018 / Revised: 20 February 2018 / Accepted: 23 February 2018 / Published: 25 February 2018
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(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)

Research

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Open AccessArticle Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway
Int. J. Mol. Sci. 2018, 19(7), 2037; https://doi.org/10.3390/ijms19072037
Received: 10 June 2018 / Revised: 9 July 2018 / Accepted: 9 July 2018 / Published: 13 July 2018
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Abstract
Farrerol, a type of 2, 3-dihydro-flavonoid, is obtained from Rhododendron. Previous studies have shown that Farrerol performs multiple biological activities, such as anti-inflammatory, antibacterial, and antioxidant activity. In this study, we aim to investigate the effect of Farrerol on colonic inflammation and explore
[...] Read more.
Farrerol, a type of 2, 3-dihydro-flavonoid, is obtained from Rhododendron. Previous studies have shown that Farrerol performs multiple biological activities, such as anti-inflammatory, antibacterial, and antioxidant activity. In this study, we aim to investigate the effect of Farrerol on colonic inflammation and explore its potential mechanisms. We found that the effect of Farrerol was evaluated via the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model in mice and found that Farrerol has a protective effect on TNBS-induced colitis. Farrerol administration significantly improved the weight change, clinical scores, colon length, and intestinal epithelium barrier damage and markedly decreased the inflammatory cytokines production in TNBS-induced mice. The protective effect of Farrerol was also observed in LPS-induced RAW264.7 cells. We found that Farrerol observably reduced the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation. In conclusion, the study found that Farrerol has a beneficial effect on TNBS-induced colitis and might be a natural therapeutic agent for IBD treatment. Full article
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)
Figures

Graphical abstract

Open AccessArticle Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT/NF-κB p65, ERK1/2 and P38 Signaling Pathway
Int. J. Mol. Sci. 2018, 19(6), 1770; https://doi.org/10.3390/ijms19061770
Received: 14 May 2018 / Revised: 7 June 2018 / Accepted: 9 June 2018 / Published: 14 June 2018
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Abstract
Farrerol has been proved to have an anti-inflammatory effect. However, the effects of farrerol on mastitis have not been investigated. This study was aimed to investigate the effect and mechanism of farrerol in lipopolysaccharide (LPS)-induced mouse mastitis and LPS-induced inflammatory response of mouse
[...] Read more.
Farrerol has been proved to have an anti-inflammatory effect. However, the effects of farrerol on mastitis have not been investigated. This study was aimed to investigate the effect and mechanism of farrerol in lipopolysaccharide (LPS)-induced mouse mastitis and LPS-induced inflammatory response of mouse mammary epithelial cells (mMECs). In vivo, LPS were injected to the tetrad pair of nipples for establishing mouse mastitis, and then tested the effect of farrerol on histopathological changes, inflammatory response and activation degree of protein kinase B (AKT), nuclear factor-kappa B p65 (NF-κB p65), p38, extracellular regulated protein kinase (ERK1/2). In vitro, the mMECs were incubated by farrerol for 1 h following by stimulating with LPS, and then the inflammatory response and the related signaling pathways were detected. The in vivo results found that farrerol could improve pathological injury of mammary gland, attenuate the activity of myeloperoxidase (MPO), inhibit the production of pro-inflammatory mediators and the phosphorylation of AKT, NF-κB p65, p38 and ERK1/2. The in vitro results also found farrerol inhibited inflammatory response and the related signaling pathways. Collectively, this study revealed that farrerol inhibits the further development of LPS-induced mastitis by inhibiting inflammatory response via down regulating phosphorylation of AKT, NF-κB p65, p38, and ERK1/2. These findings suggest that farrerol may be used as an anti-inflammatory drug for mastitis. Full article
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)
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Open AccessArticle Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response
Int. J. Mol. Sci. 2018, 19(3), 800; https://doi.org/10.3390/ijms19030800
Received: 11 February 2018 / Revised: 1 March 2018 / Accepted: 9 March 2018 / Published: 10 March 2018
Cited by 1 | PDF Full-text (2170 KB) | HTML Full-text | XML Full-text
Abstract
Astragalus membranaceus, dried root extract, also known as Astragali radix, is used in traditional Chinese medicine as a tonic remedy. Moreover, it has been reported that Astragalus membranaceus could attenuate intestinal inflammation; however, the underlying mechanism for its anti-inflammatory activity in
[...] Read more.
Astragalus membranaceus, dried root extract, also known as Astragali radix, is used in traditional Chinese medicine as a tonic remedy. Moreover, it has been reported that Astragalus membranaceus could attenuate intestinal inflammation; however, the underlying mechanism for its anti-inflammatory activity in intestinal epithelial cells (IECs) remains unclear. In this study, we evaluated Astragalus membranaceus extract (5–100 µg/mL) in a model of inflammation and oxidative stress for IECs. We showed that Astragalus membranaceus extract reduced the inflammatory response induced by lipopolysaccharide from E. coli (LPS) plus interferon-γ (IFN), decreasing tumor necrosis factor-α (TNF-α) release, cycloxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, nitrotyrosine formation, nuclear factor-κB (NF-κB) activation, and reactive oxygen species (ROS) release in the non-tumorigenic intestinal epithelial cell line (IEC-6). The antioxidant potential of Astragalus membranaceus extract was also evaluated in a model of hydrogen peroxide (H2O2)-induced oxidative stress in IEC-6, indicating that this extract reduced ROS release and increased nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation and the expression of antioxidant cytoprotective factors in these cells. The results contributed to clarify the mechanisms involved in Astragalus membranaceus extract-reduced inflammation and highlighted the potential use of this extract as an anti-inflammatory and antioxidant remedy for intestinal diseases. Full article
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)
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Graphical abstract

Review

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Open AccessReview Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
Int. J. Mol. Sci. 2018, 19(6), 1812; https://doi.org/10.3390/ijms19061812
Received: 15 May 2018 / Revised: 10 June 2018 / Accepted: 12 June 2018 / Published: 20 June 2018
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Abstract
Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused
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Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility. Full article
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)
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Graphical abstract

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