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Special Issue "Natural Anti-Inflammatory Agents 2018"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 April 2018

Special Issue Editors

Guest Editor
Prof. Dr. Paula B. Andrade

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal
Website | E-Mail
Fax: +351-226093390
Interests: metabolite profiling of natural matrices; natural agents for inflammation; neurodegenerative disorders
Guest Editor
Prof. Dr. Patrícia Valentão

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal
Website | E-Mail
Fax: +351-226093390
Interests: metabolite profiling of natural matrices; evaluation of bioactive agents from natural sources

Special Issue Information

Dear Colleagues,

Inflammation is the organism’s natural response to stimuli that are perceived as harmful, from germs, toxins, and environmental pollutants, to injury and stress, among others. This complex process involves immune, vascular and cellular biochemical reactions. At a damaged site, the process starts with the migration of immune cells from blood vessels and the release of mediators, followed by the recruitment of inflammatory cells and the release of various oxidative agents and pro-inflammatory cytokines, with arachidonic acid playing a pivotal role. Normal inflammation is self-limiting, but aberrant resolution and prolonged inflammation lead to chronic disorders, as excessive oxidants and inflammatory mediators have deleterious effects, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs, finally leading to systemic disorders. The search for new anti-inflammatory drugs has been a current preoccupation, due to the need for effective drugs, with less adverse reactions than those used nowadays. Concerning this issue, there has been increasing awareness of the potential interest in natural products. This Special Issue is devoted to the exploitation of natural matrices as sources of new anti-inflammatory molecules and their mechanism of action.

Prof. Dr. Paula Andrade
Prof. Dr. Patrícia Valentão
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-inflammatory
  • arachidonic acid
  • cytokines
  • eicosanoids
  • gene expression
  • inflammatory cells
  • inflammatory enzymes
  • natural products
  • transcription factors

Published Papers (2 papers)

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Editorial

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Open AccessEditorial Insights into Natural Products in Inflammation
Int. J. Mol. Sci. 2018, 19(3), 644; doi:10.3390/ijms19030644
Received: 2 February 2018 / Revised: 20 February 2018 / Accepted: 23 February 2018 / Published: 25 February 2018
PDF Full-text (207 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)

Research

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Open AccessArticle Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response
Int. J. Mol. Sci. 2018, 19(3), 800; doi:10.3390/ijms19030800
Received: 11 February 2018 / Revised: 1 March 2018 / Accepted: 9 March 2018 / Published: 10 March 2018
PDF Full-text (2170 KB) | HTML Full-text | XML Full-text
Abstract
Astragalus membranaceus, dried root extract, also known as Astragali radix, is used in traditional Chinese medicine as a tonic remedy. Moreover, it has been reported that Astragalus membranaceus could attenuate intestinal inflammation; however, the underlying mechanism for its anti-inflammatory activity in
[...] Read more.
Astragalus membranaceus, dried root extract, also known as Astragali radix, is used in traditional Chinese medicine as a tonic remedy. Moreover, it has been reported that Astragalus membranaceus could attenuate intestinal inflammation; however, the underlying mechanism for its anti-inflammatory activity in intestinal epithelial cells (IECs) remains unclear. In this study, we evaluated Astragalus membranaceus extract (5–100 µg/mL) in a model of inflammation and oxidative stress for IECs. We showed that Astragalus membranaceus extract reduced the inflammatory response induced by lipopolysaccharide from E. coli (LPS) plus interferon-γ (IFN), decreasing tumor necrosis factor-α (TNF-α) release, cycloxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, nitrotyrosine formation, nuclear factor-κB (NF-κB) activation, and reactive oxygen species (ROS) release in the non-tumorigenic intestinal epithelial cell line (IEC-6). The antioxidant potential of Astragalus membranaceus extract was also evaluated in a model of hydrogen peroxide (H2O2)-induced oxidative stress in IEC-6, indicating that this extract reduced ROS release and increased nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation and the expression of antioxidant cytoprotective factors in these cells. The results contributed to clarify the mechanisms involved in Astragalus membranaceus extract-reduced inflammation and highlighted the potential use of this extract as an anti-inflammatory and antioxidant remedy for intestinal diseases. Full article
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)
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