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Special Issue "Biological Potential of Marine and Terrestrial Species"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 December 2018

Special Issue Editors

Guest Editor
Prof. Dr. Paula B. Andrade

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal
Website | E-Mail
Fax: +351-226093390
Interests: metabolite profiling of natural matrices; natural agents for inflammation; neurodegenerative disorders
Guest Editor
Prof. Dr. Patrícia Valentão

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal
Website | E-Mail
Fax: +351-226093390
Interests: metabolite profiling of natural matrices; evaluation of bioactive agents from natural sources

Special Issue Information

Dear Colleagues,

The search for novel bioactive compounds in natural sources has been increasingly receiving a great amount of attention, driven by the need of finding alternatives with higher efficacy, and less undesirable effects than those currently used in therapeutics. Despite the historical value of terrestrial species, plants, in particular, being the most prolific source of bioactive molecules, sea contains a genetic diversity that is superior to land, comprising living organisms that could be responsible for the production of unknown compounds that might give a significant contribution to drug discovery.

This Special Issue will focus several aspects related to the bioactivity of both plant and animal species, covering from well characterized extracts to isolated compounds, primary and secondary metabolism, bioavailability and toxicological features, by exploring the relevant current scientific research to provide a general perspective of this broad area.

Prof. Dr. Paula B. Andrade
Prof. Dr. Patrícia Valentão
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural products
  • Plants
  • Macroinvertebrates
  • Seaweeds
  • Bioactivity
  • Drug discovery

Published Papers (1 paper)

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Research

Open AccessArticle Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage
Molecules 2018, 23(4), 849; https://doi.org/10.3390/molecules23040849
Received: 7 February 2018 / Revised: 5 April 2018 / Accepted: 6 April 2018 / Published: 8 April 2018
PDF Full-text (15390 KB) | HTML Full-text | XML Full-text
Abstract
The natural compound sinularin, isolated from marine soft corals, is antiproliferative against several cancers, but its possible selective killing effect has rarely been investigated. This study investigates the selective killing potential and mechanisms of sinularin-treated breast cancer cells. In 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H- tetrazolium, inner salt
[...] Read more.
The natural compound sinularin, isolated from marine soft corals, is antiproliferative against several cancers, but its possible selective killing effect has rarely been investigated. This study investigates the selective killing potential and mechanisms of sinularin-treated breast cancer cells. In 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H- tetrazolium, inner salt (MTS) assay, sinularin dose-responsively decreased the cell viability of two breast cancer (SKBR3 and MDA-MB-231) cells, but showed less effect on breast normal (M10) cells after a 24 h treatment. According to 7-aminoactinomycin D (7AAD) flow cytometry, sinularin dose-responsively induced the G2/M cycle arrest of SKBR3 cells. Sinularin dose-responsively induced apoptosis on SKBR3 cells in terms of a flow cytometry-based annexin V/7AAD assay and pancaspase activity, as well as Western blotting for cleaved forms of poly(ADP-ribose) polymerase (PARP), caspases 3, 8, and 9. These caspases and PARP activations were suppressed by N-acetylcysteine (NAC) pretreatment. Moreover, sinularin dose-responsively induced oxidative stress and DNA damage according to flow cytometry analyses of reactive oxygen species (ROS), mitochondrial membrane potential (MitoMP), mitochondrial superoxide, and 8-oxo-2′-deoxyguanosine (8-oxodG)). In conclusion, sinularin induces selective killing, G2/M arrest, apoptosis, and oxidative DNA damage of breast cancer cells. Full article
(This article belongs to the Special Issue Biological Potential of Marine and Terrestrial Species)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Anti-bacterial adhesion activity of tropical microalgae extracts.
Article type: article
Author: Fabienne Fay

Title: Drug Discovery and Medicinal Properties of Caribbean Plants
Article type: Article
Author: Claudia Ospina-Millan

Title: Anti-arthritis effect through anti-inflammatory effect of Sargassum muticum extract in Collagen Induced Arthritis (CIA) mice
Article type: Original research article
Authors: Ph.D H.L Jeon, Ph.D Y.J.Yoon, and Prof. Se Chan Kang
Affiliations: Department of Oriental Medicine Biotechnology, KyungHee University
Abstract: Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage, functional loss. It is characterized by synovial inflammation that leads to progressive cartilage destruction. These inflammation cause redness and edema in the joints. For this reason, research is continuing on functional foods that reduce the inflammatory response. We focused on anti-inflammatory effects of Sargassum muticum, and confirmed the effect of extract on collagen-induced arthritis DBA/1J mice model. The extract was given at concentrations of 50, 100 and 200 mg/kg, and the arthritis score and edema volume were significantly different from the vehicle group. The level of IL-6, TNF-α and IFN-γ was determined in serum and splenocytes. The expression of these cytokines in the serum was remarkably decreased from 100 mg/kg, and it was confirmed that it was noticeably decreased at 200 mg/kg in splenocytes. Also, Immunohistochemical analysis of IL-6 and TNF-α in the joints revealed that the inflammatory response was noticeably low when treated with Sargassum muticum extract. This study provides results for Sargassum muticum extract, which can contribute to the alleviation of edema and symptoms by reducing the expression of inflammatory cytokines, and suggesting that it may be a useful substance to help in relief of symptoms.

 

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