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Molecules 2011, 16(11), 9153-9160; doi:10.3390/molecules16119153

Polar Compounds Isolated from the Leaves of Albertisia delagoensis (Menispermaceae)

1, 2,*  and 3
1 School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK 2 Department of Botany, University of Zululand, P/Bag X1001, Kwa-Dlangezwa 3880, South Africa 3 Department of Surgery and Cancer, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
* Author to whom correspondence should be addressed.
Received: 8 October 2011 / Revised: 21 October 2011 / Accepted: 27 October 2011 / Published: 2 November 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Aqueous infusions of the leaves of the shrub Albertisia delagoensis (Menispermaceae) are used in South Africa in traditional Zulu medicine to alleviate a variety of symptoms, including fever, and intestinal problems. We report the analysis of such an aqueous extract using the HPLC-NMR technique. A number of polar compounds were identified, including proto-quercitol, nicotinic acid, allantoic acid, 3,4-dihydroxy-benzoic acid, phthalic acid and the aporphine alkaloid derivative roemrefidine. Allantoic acid and roemrefidine have been fully characterised by 1H- and 13C-NMR and mass spectrometry. Earlier reports of antiplasmodial activity of roemrefidine and of A. delagoensis extracts are correlated with this study and with the antipyretic properties of neutral aqueous extracts.
Keywords: Albertisia delagoensis; traditional medicine; roemrefidine; allantoic acid; HPLC-NMR Albertisia delagoensis; traditional medicine; roemrefidine; allantoic acid; HPLC-NMR
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hawkes, G.E.; Wet, H.; Li, J. Polar Compounds Isolated from the Leaves of Albertisia delagoensis (Menispermaceae). Molecules 2011, 16, 9153-9160.

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