Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine
AbstractIn previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermal models of nociception. In this study, we evaluated the possible mechanism of action of this alkaloid in mice, using the writhing test. The antinociceptive effect of caulerpine was not affected by intraperitoneal (i.p.) pretreatment of mice with naloxone, flumazenil, l-arginine or atropine, thus discounting the involvement of the opioid, GABAergic, l-arginine-nitric oxide and (muscarinic) cholinergic pathways, respectively. In contrast, i.p. pretreatment with yohimbine, an α2-adrenoceptor antagonist, or tropisetron, a 5-HT3 antagonist, significantly blocked caulerpine-induced antinociception. These results suggest that caulerpine exerts its antinociceptive effect in the writhing test via pathways involving α2-adrenoceptors and 5-HT3 receptors. In summary, this alkaloid could be of interest in the development of new dual-action analgesic drugs. View Full-Text
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Cavalcante-Silva, L.H.A.; Falcão, M.A.P.; Vieira, A.C.S.; Viana, M.D.M.; de Araújo-Júnior, J.X.; Sousa, J.C.F.; Silva, T.M.S.; Barbosa-Filho, J.M.; Noël, F.; de Miranda, G.E.C.; Santos, B.V.O.; Alexandre-Moreira, M.S. Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine. Molecules 2014, 19, 14699-14709.
Cavalcante-Silva LHA, Falcão MAP, Vieira ACS, Viana MDM, de Araújo-Júnior JX, Sousa JCF, Silva TMS, Barbosa-Filho JM, Noël F, de Miranda GEC, Santos BVO, Alexandre-Moreira MS. Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine. Molecules. 2014; 19(9):14699-14709.Chicago/Turabian Style
Cavalcante-Silva, Luiz H.A.; Falcão, Maria A.P.; Vieira, Ana C.S.; Viana, Max D.M.; de Araújo-Júnior, João X.; Sousa, Jéssica C.F.; Silva, Tania M.S.; Barbosa-Filho, José M.; Noël, François; de Miranda, George E.C.; Santos, Bárbara V.O.; Alexandre-Moreira, Magna S. 2014. "Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine." Molecules 19, no. 9: 14699-14709.