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Molecules 2014, 19(9), 14699-14709; doi:10.3390/molecules190914699

Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine

1
Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, Brazil
2
Laboratory of Medicinal Chemistry, Posgraduate Program in Pharmaceutical Sciences, Federal University of Alagoas, Maceió 57020-720, Brazil
3
Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, Brazil
4
Molecular Sciences Department, Federal Rural University of Pernambuco, Recife 52171-900, Brazil
5
Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil
6
Laboratory of Biochemical and Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-912, Brazil
7
Laboratory of Marine Algae, Department of Systematics and Ecology, Federal University of Paraíba, João Pessoa 58051-900, Brazil
*
Authors to whom correspondence should be addressed.
Received: 15 August 2014 / Revised: 7 September 2014 / Accepted: 9 September 2014 / Published: 16 September 2014
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Abstract

In previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermal models of nociception. In this study, we evaluated the possible mechanism of action of this alkaloid in mice, using the writhing test. The antinociceptive effect of caulerpine was not affected by intraperitoneal (i.p.) pretreatment of mice with naloxone, flumazenil, l-arginine or atropine, thus discounting the involvement of the opioid, GABAergic, l-arginine-nitric oxide and (muscarinic) cholinergic pathways, respectively. In contrast, i.p. pretreatment with yohimbine, an α2-adrenoceptor antagonist, or tropisetron, a 5-HT3 antagonist, significantly blocked caulerpine-induced antinociception. These results suggest that caulerpine exerts its antinociceptive effect in the writhing test via pathways involving α2-adrenoceptors and 5-HT3 receptors. In summary, this alkaloid could be of interest in the development of new dual-action analgesic drugs. View Full-Text
Keywords: caulerpine; antinociception; adrenergic pathway; serotonergic pathway caulerpine; antinociception; adrenergic pathway; serotonergic pathway
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MDPI and ACS Style

Cavalcante-Silva, L.H.A.; Falcão, M.A.P.; Vieira, A.C.S.; Viana, M.D.M.; de Araújo-Júnior, J.X.; Sousa, J.C.F.; Silva, T.M.S.; Barbosa-Filho, J.M.; Noël, F.; de Miranda, G.E.C.; Santos, B.V.O.; Alexandre-Moreira, M.S. Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine. Molecules 2014, 19, 14699-14709.

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