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Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba - UFPB, Cx. Postal 5009, 58051-970, João Pessoa, PB, Brazil
Laboratório de Produtos Naturais, Universidade Estadual de Campinas - UNICAMP, Cx. Postal 6109, 13083-970, Campinas, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 30 July 2008; in revised form: 7 November 2008 / Accepted: 2 December 2008 / Published: 17 December 2008
(This article belongs to the Special Issue Alkaloids
Abstract: Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals.
Keywords: Alkaloids; Antiulcer activity; Peptic ulcer; Review
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De Sousa Falcão, H.; Leite, J.A.; Barbosa-Filho, J.M.; De Athayde-Filho, P.F.; De Oliveira Chaves, M.C.; Moura, M.D.; Ferreira, A.L.; De Almeida, A.B.A.; Souza-Brito, A.R.M.; De Fátima Formiga Melo Diniz, M.; Batista, L.M. Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review. Molecules 2008, 13, 3198-3223.
De Sousa Falcão H, Leite JA, Barbosa-Filho JM, De Athayde-Filho PF, De Oliveira Chaves MC, Moura MD, Ferreira AL, De Almeida ABA, Souza-Brito ARM, De Fátima Formiga Melo Diniz M, Batista LM. Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review. Molecules. 2008; 13(12):3198-3223.
De Sousa Falcão, Heloina; Leite, Jacqueline A.; Barbosa-Filho, José M.; De Athayde-Filho, Petrônio F.; De Oliveira Chaves, Maria C.; Moura, Marcelo D.; Ferreira, Anderson L.; De Almeida, Ana B.A.; Souza-Brito, Alba R.M.; De Fátima Formiga Melo Diniz, Margareth; Batista, Leônia M. 2008. "Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review." Molecules 13, no. 12: 3198-3223.