Molecules 2008, 13(12), 3198-3223; doi:10.3390/molecules13123198

Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review

1email, 1email, 1email, 1email, 1email, 1email, 2email, 2email, 2email, 1email and 1,* email
Received: 30 July 2008; in revised form: 7 November 2008 / Accepted: 2 December 2008 / Published: 17 December 2008
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals.
Keywords: Alkaloids; Antiulcer activity; Peptic ulcer; Review
PDF Full-text Download PDF Full-Text [183 KB, uploaded 18 June 2014 19:28 CEST]

Export to BibTeX |

MDPI and ACS Style

De Sousa Falcão, H.; Leite, J.A.; Barbosa-Filho, J.M.; De Athayde-Filho, P.F.; De Oliveira Chaves, M.C.; Moura, M.D.; Ferreira, A.L.; De Almeida, A.B.A.; Souza-Brito, A.R.M.; De Fátima Formiga Melo Diniz, M.; Batista, L.M. Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review. Molecules 2008, 13, 3198-3223.

AMA Style

De Sousa Falcão H, Leite JA, Barbosa-Filho JM, De Athayde-Filho PF, De Oliveira Chaves MC, Moura MD, Ferreira AL, De Almeida ABA, Souza-Brito ARM, De Fátima Formiga Melo Diniz M, Batista LM. Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review. Molecules. 2008; 13(12):3198-3223.

Chicago/Turabian Style

De Sousa Falcão, Heloina; Leite, Jacqueline A.; Barbosa-Filho, José M.; De Athayde-Filho, Petrônio F.; De Oliveira Chaves, Maria C.; Moura, Marcelo D.; Ferreira, Anderson L.; De Almeida, Ana B.A.; Souza-Brito, Alba R.M.; De Fátima Formiga Melo Diniz, Margareth; Batista, Leônia M. 2008. "Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review." Molecules 13, no. 12: 3198-3223.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert