Molecules 2014, 19(8), 12328-12335; doi:10.3390/molecules190812328

PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

1,†email and 2,†,* email
Received: 25 July 2014; in revised form: 11 August 2014 / Accepted: 11 August 2014 / Published: 15 August 2014
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment.
Keywords: PM00104; Zalypsis; alkaloid; chemotherapy; cancer therapy
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MDPI and ACS Style

Petek, B.J.; Jones, R.L. PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Molecules 2014, 19, 12328-12335.

AMA Style

Petek BJ, Jones RL. PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Molecules. 2014; 19(8):12328-12335.

Chicago/Turabian Style

Petek, Bradley J.; Jones, Robin L. 2014. "PM00104 (Zalypsis®): A Marine Derived Alkylating Agent." Molecules 19, no. 8: 12328-12335.

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