Next Article in Journal
Molecular Modeling to Study Dendrimers for Biomedical Applications
Next Article in Special Issue
Toxicity of Evodiae fructus on Rat Liver Mitochondria: The Role of Oxidative Stress and Mitochondrial Permeability Transition
Previous Article in Journal
Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts
Previous Article in Special Issue
Antioxidant and Anticancer Aporphine Alkaloids from the Leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena
Article Menu

Export Article

Open AccessReview
Molecules 2014, 19(12), 20391-20423; doi:10.3390/molecules191220391

Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy
*
Author to whom correspondence should be addressed.
Received: 14 October 2014 / Revised: 7 November 2014 / Accepted: 27 November 2014 / Published: 5 December 2014
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)

Abstract

The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery. View Full-Text
Keywords: alkaloids; marine invertebrates; anticancer; natural products; drug discovery alkaloids; marine invertebrates; anticancer; natural products; drug discovery
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Imperatore, C.; Aiello, A.; D'Aniello, F.; Senese, M.; Menna, M. Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development. Molecules 2014, 19, 20391-20423.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top