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Molecules 2008, 13(8), 1875-1896; doi:10.3390/molecules13081875
Review

Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine

Received: 5 August 2008; in revised form: 24 August 2008 / Accepted: 26 August 2008 / Published: 27 August 2008
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Abstract: Strictosidine, the precursor of more than 2,500 indole alkaloids, was isolated from four species of three plant families. By searching the Dictionary of Natural Products on DVD it was found that about 150 indole alkaloids were obtained from the same species (coalkaloids), which is a direct proof of their common origin. On the base of their threedimensional structure, taxonomic properties and standard reaction mechanisms an extended network was established which involved the four fundamental skeletons, the three types of carbon framework in the secologanin subunit and all major groups of indole alkaloids derived from secologanin and tryptamine (except a few minor groups, in which only less then 10 alkaloids were known). The system was extended to the heterodimer indole alkaloids and the quinoindole alkaloids as well.
Keywords: Secologanin; coalkaloid; dimer alkaloid; reaction mechanism; computer searching; chemotaxonomy Secologanin; coalkaloid; dimer alkaloid; reaction mechanism; computer searching; chemotaxonomy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Szabó, L.F. Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine. Molecules 2008, 13, 1875-1896.

AMA Style

Szabó LF. Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine. Molecules. 2008; 13(8):1875-1896.

Chicago/Turabian Style

Szabó, László F. 2008. "Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine." Molecules 13, no. 8: 1875-1896.


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