Next Article in Journal
Two-Step Separation of Nostotrebin 6 from Cultivated Soil Cyanobacterium (Nostoc sp.) by High Performance Countercurrent Chromatography
Next Article in Special Issue
Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides and Their Acetylcholinesterase Inhibitory Activity
Previous Article in Journal
Preparative Separation of Alkaloids from Picrasma quassioides (D. Don) Benn. by Conventional and pH-Zone-Refining Countercurrent Chromatography
Previous Article in Special Issue
The Pharmacological Activities of (−)-Anonaine
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(7), 8762-8772; doi:10.3390/molecules19078762

Cytotoxic Aporphine Alkaloids from Leaves and Twigs of Pseuduvaria trimera (Craib)

Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand
Science and Technology Research Institute, Chiang Mai University, Chiang Mai 53000, Thailand
The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10220, Thailand
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand
Author to whom correspondence should be addressed.
Received: 21 May 2014 / Revised: 17 June 2014 / Accepted: 19 June 2014 / Published: 25 June 2014
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
View Full-Text   |   Download PDF [334 KB, uploaded 25 June 2014]   |  


From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5-trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3-trimethoxy-4,5-dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and 2 exhibited cytotoxic activity with IC50 values of 26.36 ± 5.18 μM and 12.88 ± 2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75 ± 4.45 and 67.06 ± 3.5 μM, respectively, for human breast cancer MDA-MB231 cells. Both compounds displayed anti-cancer activity but less than that of doxorubicin; a conventional chemotherapeutic drug, the IC50 levels of which were 2.21 ± 1.72 and 1.83 ± 0.09 μM for HepG2 and MDA-MB231 cells, respectively. View Full-Text
Keywords: aporphine alkaloid; cytotoxicity; anti-cancer; Pseuduvaria trimera; Annonaceae aporphine alkaloid; cytotoxicity; anti-cancer; Pseuduvaria trimera; Annonaceae

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sesang, W.; Punyanitya, S.; Pitchuanchom, S.; Udomputtimekakul, P.; Nuntasaen, N.; Banjerdpongchai, R.; Wudtiwai, B.; Pompimon, W. Cytotoxic Aporphine Alkaloids from Leaves and Twigs of Pseuduvaria trimera (Craib). Molecules 2014, 19, 8762-8772.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top