Cytotoxic Aporphine Alkaloids from Leaves and Twigs of Pseuduvaria trimera (Craib)
AbstractFrom ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5-trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3-trimethoxy-4,5-dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and 2 exhibited cytotoxic activity with IC50 values of 26.36 ± 5.18 μM and 12.88 ± 2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75 ± 4.45 and 67.06 ± 3.5 μM, respectively, for human breast cancer MDA-MB231 cells. Both compounds displayed anti-cancer activity but less than that of doxorubicin; a conventional chemotherapeutic drug, the IC50 levels of which were 2.21 ± 1.72 and 1.83 ± 0.09 μM for HepG2 and MDA-MB231 cells, respectively. View Full-Text
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Sesang, W.; Punyanitya, S.; Pitchuanchom, S.; Udomputtimekakul, P.; Nuntasaen, N.; Banjerdpongchai, R.; Wudtiwai, B.; Pompimon, W. Cytotoxic Aporphine Alkaloids from Leaves and Twigs of Pseuduvaria trimera (Craib). Molecules 2014, 19, 8762-8772.
Sesang W, Punyanitya S, Pitchuanchom S, Udomputtimekakul P, Nuntasaen N, Banjerdpongchai R, Wudtiwai B, Pompimon W. Cytotoxic Aporphine Alkaloids from Leaves and Twigs of Pseuduvaria trimera (Craib). Molecules. 2014; 19(7):8762-8772.Chicago/Turabian Style
Sesang, Wuttikrai; Punyanitya, Sittiporn; Pitchuanchom, Siripit; Udomputtimekakul, Phansuang; Nuntasaen, Narong; Banjerdpongchai, Ratana; Wudtiwai, Benjawan; Pompimon, Wilart. 2014. "Cytotoxic Aporphine Alkaloids from Leaves and Twigs of Pseuduvaria trimera (Craib)." Molecules 19, no. 7: 8762-8772.