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Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010
Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa-PB, Brazil
Department of Chemistry, Federal University of Paraíba, 58059-900, João Pessoa-PB, Brazil
* Author to whom correspondence should be addressed.
Received: 22 July 2011; in revised form: 7 September 2011 / Accepted: 26 September 2011 / Published: 11 October 2011
(This article belongs to the Special Issue Alkaloids
Abstract: Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.
Keywords: alkaloids; anti-inflammatory activity; inflammation; experimental models; review
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MDPI and ACS Style
Souto, A.L.; Tavares, J.F.; da Silva, M.S.; Diniz, M.F.F.M.; de Athayde-Filho, P.F.; Barbosa Filho, J.M. Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010. Molecules 2011, 16, 8515-8534.
Souto AL, Tavares JF, da Silva MS, Diniz MFFM, de Athayde-Filho PF, Barbosa Filho JM. Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010. Molecules. 2011; 16(10):8515-8534.
Souto, Augusto Lopes; Tavares, Josean Fechine; da Silva, Marcelo Sobral; Diniz, Margareth de Fátima Formiga Melo; de Athayde-Filho, Petrônio Filgueiras; Barbosa Filho, José Maria. 2011. "Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010." Molecules 16, no. 10: 8515-8534.