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Molecules 2011, 16(9), 8020-8032; doi:10.3390/molecules16098020

The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke

1 Department of Surgery, Far Eastern Memorial Hospital, Pan-Chiao, New Taipei 220, Taiwan 2 Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li, Taoyuan 320, Taiwan 3 Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 August 2011 / Revised: 15 September 2011 / Accepted: 15 September 2011 / Published: 16 September 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Stroke is one of the leading causes of mortality, with a high incidence of severe morbidity in survivors. The treatment to minimize tissue injury after stroke is still unsatisfactory and it is mandatory to develop effective treatment strategies for stroke. The pathophysiology of ischemic stroke is complex and involves many processes including energy failure, loss of ion homeostasis, increased intracellular calcium level, platelet aggregation, production of reactive oxygen species, disruption of blood brain barrier, and inflammation and leukocyte infiltration, etc. Tetrandrine, a bisbenzylisoquinoline alkaloid, has many pharmacologic effects including anti-inflammatory and cytoprotective effects. In addition, tetrandrine has been found to protect the liver, heart, small bowel and brain from ischemia/reperfusion injury. It is a calcium channel blocker, and can inhibit lipid peroxidation, reduce generation of reactive oxygen species, suppress the production of cytokines and inflammatory mediators, inhibit neutrophil recruitment and platelet aggregation, which are all devastating factors during ischemia/reperfusion injury of the brain. Because tetrandrine can counteract these important pathophysiological processes of ischemic stroke, it has the potential to be a protective agent for ischemic stroke.
Keywords: ischemic stroke; tetrandrine; alkaloid ischemic stroke; tetrandrine; alkaloid
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.; Tsai, Y.-H.; Tseng, S.-H. The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke. Molecules 2011, 16, 8020-8032.

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