Next Article in Journal
Synthesis and NMR-Study of the 2,3,4,5-Tetraethylsilole Dianion [SiC4Et4]2−•2[Li]+
Next Article in Special Issue
Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010
Previous Article in Journal
Exploiting the Nucleotide Substrate Specificity of Repair DNA Polymerases To Develop Novel Anticancer Agents
Previous Article in Special Issue
Application of Preparative High-Speed Counter-Current Chromatography for the Separation of Two Alkaloids from the Roots of Tabernaemontana catharinensis (Apocynaceae)
Molecules 2011, 16(9), 8020-8032; doi:10.3390/molecules16098020
Review

The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke

1,2
, 1,2
 and 3,*
Received: 25 August 2011; in revised form: 15 September 2011 / Accepted: 15 September 2011 / Published: 16 September 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Download PDF [368 KB, uploaded 18 June 2014]
Abstract: Stroke is one of the leading causes of mortality, with a high incidence of severe morbidity in survivors. The treatment to minimize tissue injury after stroke is still unsatisfactory and it is mandatory to develop effective treatment strategies for stroke. The pathophysiology of ischemic stroke is complex and involves many processes including energy failure, loss of ion homeostasis, increased intracellular calcium level, platelet aggregation, production of reactive oxygen species, disruption of blood brain barrier, and inflammation and leukocyte infiltration, etc. Tetrandrine, a bisbenzylisoquinoline alkaloid, has many pharmacologic effects including anti-inflammatory and cytoprotective effects. In addition, tetrandrine has been found to protect the liver, heart, small bowel and brain from ischemia/reperfusion injury. It is a calcium channel blocker, and can inhibit lipid peroxidation, reduce generation of reactive oxygen species, suppress the production of cytokines and inflammatory mediators, inhibit neutrophil recruitment and platelet aggregation, which are all devastating factors during ischemia/reperfusion injury of the brain. Because tetrandrine can counteract these important pathophysiological processes of ischemic stroke, it has the potential to be a protective agent for ischemic stroke.
Keywords: ischemic stroke; tetrandrine; alkaloid ischemic stroke; tetrandrine; alkaloid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Chen, Y.; Tsai, Y.-H.; Tseng, S.-H. The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke. Molecules 2011, 16, 8020-8032.

AMA Style

Chen Y, Tsai Y-H, Tseng S-H. The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke. Molecules. 2011; 16(9):8020-8032.

Chicago/Turabian Style

Chen, Yun; Tsai, Ya-Hui; Tseng, Sheng-Hong. 2011. "The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke." Molecules 16, no. 9: 8020-8032.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert