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Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity
Natural Health Products Directorate, Health Products and Food Branch, Health Canada, 2936 Baseline Road, Ottawa, Ontario, K1A 0K9, Canada
* Author to whom correspondence should be addressed.
Received: 9 November 2011; in revised form: 7 December 2011 / Accepted: 24 December 2011 / Published: 27 December 2011
(This article belongs to the Special Issue Alkaloids
Abstract: The chromone and flavonoid alkaloids represent an unusual group of structurally diverse secondary metabolites, derived from the convergence of multiple biosynthetic pathways that are widely distributed through the plant and animal kingdoms. Many of them have been discovered through bioassay-guided chemical investigations of traditional medicines, suggesting potential therapeutic significance. Their unique structures and varied pharmacological activities may provide important new leads for the discovery of drugs with novel mechanisms of action. Potential therapeutic indications are as diverse as cancer and viral infections, inflammation and immunomodulation, neurological and psychiatric conditions, and diabetes.
Keywords: flavonoids; alkaloids; flavonoid alkaloids; chromone alkaloids; natural occurrence
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MDPI and ACS Style
Khadem, S.; Marles, R.J. Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity. Molecules 2012, 17, 191-206.
Khadem S, Marles RJ. Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity. Molecules. 2012; 17(1):191-206.
Khadem, Shahriar; Marles, Robin J. 2012. "Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity." Molecules 17, no. 1: 191-206.