Next Article in Journal
Molecular Properties of Water-Unextractable Proteoglycans from Hypsizygus marmoreus and Their in Vitro Immunomodulatory Activities
Next Article in Special Issue
The Pharmacological Activities of (−)-Anonaine
Previous Article in Journal
Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition
Previous Article in Special Issue
A Journey Under the Sea: The Quest for Marine Anti-Cancer Alkaloids
Molecules 2012, 17(1), 191-206; doi:10.3390/molecules17010191

Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity

*  and
Natural Health Products Directorate, Health Products and Food Branch, Health Canada, 2936 Baseline Road, Ottawa, Ontario, K1A 0K9, Canada
* Author to whom correspondence should be addressed.
Received: 9 November 2011 / Revised: 7 December 2011 / Accepted: 24 December 2011 / Published: 27 December 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Download PDF [259 KB, uploaded 18 June 2014]   |  


The chromone and flavonoid alkaloids represent an unusual group of structurally diverse secondary metabolites, derived from the convergence of multiple biosynthetic pathways that are widely distributed through the plant and animal kingdoms. Many of them have been discovered through bioassay-guided chemical investigations of traditional medicines, suggesting potential therapeutic significance. Their unique structures and varied pharmacological activities may provide important new leads for the discovery of drugs with novel mechanisms of action. Potential therapeutic indications are as diverse as cancer and viral infections, inflammation and immunomodulation, neurological and psychiatric conditions, and diabetes.
Keywords: flavonoids; alkaloids; flavonoid alkaloids; chromone alkaloids; natural occurrence flavonoids; alkaloids; flavonoid alkaloids; chromone alkaloids; natural occurrence
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Khadem, S.; Marles, R.J. Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity. Molecules 2012, 17, 191-206.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert