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Molecules 2011, 16(8), 7125-7131; doi:10.3390/molecules16087125
Communication

Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

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Received: 27 June 2011 / Revised: 26 July 2011 / Accepted: 4 August 2011 / Published: 22 August 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Abstract

Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively.
Keywords: Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lúcio, A.S.S.C.; Da Silva Almeida, J.R.G.; Barbosa-Filho, J.M.; Pita, J.C.L.R.; Branco, M.V.S.C.; De Fátima Formiga Melo Diniz, M.; De Fátima Agra, M.; Da-Cunha, E.V.; Da Silva, M.S.; Tavares, J.F. Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules 2011, 16, 7125-7131.

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