Next Article in Journal
Anti-Inflammatory Effect of Myristicin on RAW 264.7 Macrophages Stimulated with Polyinosinic-Polycytidylic Acid
Next Article in Special Issue
The Growth Suppressing Effects of Girinimbine on Hepg2 Involve Induction of Apoptosis and Cell Cycle Arrest
Previous Article in Journal
Essential Oil Composition of the Different Parts and In Vitro Shoot Culture of Eryngium planum L.
Previous Article in Special Issue
Alkaloids from Hippeastrum papilio
Molecules 2011, 16(8), 7125-7131; doi:10.3390/molecules16087125

Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

1 Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa, PB, Brazil 2 Academic Collegiate of Pharmaceutical Sciences, Federal University of Sao Francisco Valley, P.O. Box 252, 56306-410, Petrolina, PE, Brazil 3 State University of Paraíba, Department of Pharmacy, 58100-000, Campina Grande, PB, Brazil
* Author to whom correspondence should be addressed.
Received: 27 June 2011 / Revised: 26 July 2011 / Accepted: 4 August 2011 / Published: 22 August 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Download PDF [432 KB, uploaded 18 June 2014]


Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively.
Keywords: Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Lúcio, A.S.S.C.; Da Silva Almeida, J.R.G.; Barbosa-Filho, J.M.; Pita, J.C.L.R.; Branco, M.V.S.C.; De Fátima Formiga Melo Diniz, M.; De Fátima Agra, M.; Da-Cunha, E.V.; Da Silva, M.S.; Tavares, J.F. Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules 2011, 16, 7125-7131.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert