Molecules 2011, 16(8), 7125-7131; doi:10.3390/molecules16087125
Communication

Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

Received: 27 June 2011; in revised form: 26 July 2011 / Accepted: 4 August 2011 / Published: 22 August 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively.
Keywords: Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity
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MDPI and ACS Style

Lúcio, A.S.S.C.; Da Silva Almeida, J.R.G.; Barbosa-Filho, J.M.; Pita, J.C.L.R.; Branco, M.V.S.C.; De Fátima Formiga Melo Diniz, M.; De Fátima Agra, M.; Da-Cunha, E.V.; Da Silva, M.S.; Tavares, J.F. Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules 2011, 16, 7125-7131.

AMA Style

Lúcio ASSC, Da Silva Almeida JRG, Barbosa-Filho JM, Pita JCLR, Branco MVSC, De Fátima Formiga Melo Diniz M, De Fátima Agra M, Da-Cunha EV, Da Silva MS, Tavares JF. Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules. 2011; 16(8):7125-7131.

Chicago/Turabian Style

Lúcio, Ana Silvia Suassuna Carneiro; Da Silva Almeida, Jackson Roberto Guedes; Barbosa-Filho, José Maria; Pita, João Carlos Lima Rodrigues; Branco, Marianna Vieira Sobral Castello; De Fátima Formiga Melo Diniz, Margareth; De Fátima Agra, Maria; Da-Cunha, Emidio V.L.; Da Silva, Marcelo Sobral; Tavares, Josean Fechine. 2011. "Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)." Molecules 16, no. 8: 7125-7131.

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