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Molecules 2011, 16(8), 7125-7131; doi:10.3390/molecules16087125

Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

1
Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa, PB, Brazil
2
Academic Collegiate of Pharmaceutical Sciences, Federal University of Sao Francisco Valley, P.O. Box 252, 56306-410, Petrolina, PE, Brazil
3
State University of Paraíba, Department of Pharmacy, 58100-000, Campina Grande, PB, Brazil
*
Author to whom correspondence should be addressed.
Received: 27 June 2011 / Revised: 26 July 2011 / Accepted: 4 August 2011 / Published: 22 August 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Abstract

Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively.
Keywords: Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lúcio, A.S.S.C.; Da Silva Almeida, J.R.G.; Barbosa-Filho, J.M.; Pita, J.C.L.R.; Branco, M.V.S.C.; De Fátima Formiga Melo Diniz, M.; De Fátima Agra, M.; Da-Cunha, E.V.; Da Silva, M.S.; Tavares, J.F. Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules 2011, 16, 7125-7131.

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