Molecules 2011, 16(8), 7125-7131; doi:10.3390/molecules16087125
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Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

1 Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa, PB, Brazil 2 Academic Collegiate of Pharmaceutical Sciences, Federal University of Sao Francisco Valley, P.O. Box 252, 56306-410, Petrolina, PE, Brazil 3 State University of Paraíba, Department of Pharmacy, 58100-000, Campina Grande, PB, Brazil
* Author to whom correspondence should be addressed.
Received: 27 June 2011; in revised form: 26 July 2011 / Accepted: 4 August 2011 / Published: 22 August 2011
(This article belongs to the Special Issue Alkaloids)
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Abstract: Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively.
Keywords: Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity

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MDPI and ACS Style

Lúcio, A.S.S.C.; Da Silva Almeida, J.R.G.; Barbosa-Filho, J.M.; Pita, J.C.L.R.; Branco, M.V.S.C.; De Fátima Formiga Melo Diniz, M.; De Fátima Agra, M.; Da-Cunha, E.V.; Da Silva, M.S.; Tavares, J.F. Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules 2011, 16, 7125-7131.

AMA Style

Lúcio ASSC, Da Silva Almeida JRG, Barbosa-Filho JM, Pita JCLR, Branco MVSC, De Fátima Formiga Melo Diniz M, De Fátima Agra M, Da-Cunha EV, Da Silva MS, Tavares JF. Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules. 2011; 16(8):7125-7131.

Chicago/Turabian Style

Lúcio, Ana Silvia Suassuna Carneiro; Da Silva Almeida, Jackson Roberto Guedes; Barbosa-Filho, José Maria; Pita, João Carlos Lima Rodrigues; Branco, Marianna Vieira Sobral Castello; De Fátima Formiga Melo Diniz, Margareth; De Fátima Agra, Maria; Da-Cunha, Emidio V.L.; Da Silva, Marcelo Sobral; Tavares, Josean Fechine. 2011. "Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)." Molecules 16, no. 8: 7125-7131.

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