Thrombosis: From Basic Mechanisms to Saving Lives

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biomedicines biomedicines	4.757	3.0	2013	17.4 Days	2200 CHF
Diagnostics diagnostics	3.992	2.4	2011	17.7 Days	2000 CHF
International Journal of Molecular Sciences ijms	6.208	6.9	2000	15.9 Days	2500 CHF
International Journal of Translational Medicine ijtm	-	-	2021	18.8 Days	1000 CHF
Reports reports	-	-	2018	19.5 Days	1400 CHF

Open AccessReview

Platelet–Neutrophil Crosstalk in Thrombosis

by

Laura J. Mereweather

,

Adela Constantinescu-Bercu

,

James T. B. Crawley

and

Isabelle I. Salles-Crawley

Int. J. Mol. Sci. 2023, 24(2), 1266; https://doi.org/10.3390/ijms24021266 - 09 Jan 2023

Viewed by 894

Abstract

Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while neutrophils are the guardians of our immune defences against invading pathogens. The interplay between platelets and innate immunity, and subsequent triggering of the activation of coagulation is part of [...] Read more.

Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while neutrophils are the guardians of our immune defences against invading pathogens. The interplay between platelets and innate immunity, and subsequent triggering of the activation of coagulation is part of the host system to prevent systemic spread of pathogen in the blood stream. Aberrant immunothrombosis and excessive inflammation can however, contribute to the thrombotic burden observed in many cardiovascular diseases. In this review, we highlight how platelets and neutrophils interact with each other and how their crosstalk is central to both arterial and venous thrombosis and in COVID-19. While targeting platelets and coagulation enables efficient antithrombotic treatments, they are often accompanied with a bleeding risk. We also discuss how novel approaches to reduce platelet-mediated recruitment of neutrophils could represent promising therapies to treat thrombosis without affecting haemostasis. Full article

(This article belongs to the Topic Thrombosis: From Basic Mechanisms to Saving Lives)

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Open AccessArticle

Venous Thromboembolism in Cancer Patients Undergoing Chemotherapy: A Systematic Review and Meta-Analysis

by

Ming-Yee Sun

and

Sonu M. M. Bhaskar

Diagnostics 2022, 12(12), 2954; https://doi.org/10.3390/diagnostics12122954 - 25 Nov 2022

Cited by 1 | Viewed by 533

Abstract

Objective: Venous thromboembolism (VTE) is a life-threatening complication that may exacerbate cancer prognosis. Whilst some studies indicate an increased risk of VTE in cancer patients undergoing chemotherapy, the prevalence estimates on the pooled prevalence of VTE in cancer patients undergoing chemotherapy are [...] Read more.

Objective: Venous thromboembolism (VTE) is a life-threatening complication that may exacerbate cancer prognosis. Whilst some studies indicate an increased risk of VTE in cancer patients undergoing chemotherapy, the prevalence estimates on the pooled prevalence of VTE in cancer patients undergoing chemotherapy are not known. This study aims to calculate the pooled prevalence of VTE in chemotherapy-treated cancer patients. Methods: Studies on VTE occurrence in cancer patients undergoing chemotherapy were retrieved after database search. The terms used included “cancer”, “chemotherapy”, and “venous thromboembolism”. A random-effects meta-analysis was conducted to obtain a pooled estimate of VTE prevalence in cancer patients undergoing chemotherapy. Results: A total of 102 eligible studies involving 30,671 patients (1773 with VTE, 28,898 without) were included in the meta-analysis. The pooled estimate of VTE prevalence was found to be 6%, ranging from 6% to 7% (ES 6%; 95% CI 6–7%; z = 18.53; p < 0.001). Conclusions: The estimated pooled prevalence rate of VTEs was 6% in cancer patients undergoing CRT, which was higher than the overall crude prevalence rate (5.78%). Comprehensive cancer care should consider stratified VTE risk assessment based on cancer phenotype, given that certain phenotypes of cancer such as bladder, gastric and ovarian posing particularly high risks of VTE. Full article

(This article belongs to the Topic Thrombosis: From Basic Mechanisms to Saving Lives)

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Open AccessCase Report

Arterial Thrombotic Complications in COVID-19: A Case of Renal Infarction

by

,

,

and

Biomedicines 2022, 10(10), 2354; https://doi.org/10.3390/biomedicines10102354 - 21 Sep 2022

Viewed by 700

Abstract

COVID-19 infection has been associated with thrombotic complications, especially venous thromboembolism. Although arterial thrombotic complications are rarely seen in these patients, we report the case of a 43-year-old patient who developed thrombosis of the main branch of the left renal artery, causing partial [...] Read more.

COVID-19 infection has been associated with thrombotic complications, especially venous thromboembolism. Although arterial thrombotic complications are rarely seen in these patients, we report the case of a 43-year-old patient who developed thrombosis of the main branch of the left renal artery, causing partial infarction of the left kidney associated with severe pain. He had no risk factors for thrombosis except for COVID-19 infection. We excluded any possible condition usually associated with renal artery thrombosis/embolism (i.e., cardiovascular, oncological, hematological, or rheumatic). The thrombosis resolved after a combination of anticoagulant and anti-platelet therapy. This case highlights the importance of the risk of recurrence of thrombosis in patients with a recent history of COVID-19, even after hospital discharge, improvement of the initial thrombotic event, and clearance of SARS-CoV-2 infection. Full article

(This article belongs to the Topic Thrombosis: From Basic Mechanisms to Saving Lives)

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Open AccessArticle

Neutrophils Mediate Pulmonary Artery Thrombosis In Situ

by

,

,

,

,

Eleonora A. Starikova

,

,

,

,

,

,

,

,

and

Int. J. Mol. Sci. 2022, 23(10), 5829; https://doi.org/10.3390/ijms23105829 - 23 May 2022

Cited by 3 | Viewed by 1596

Abstract

Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs). However, growing evidence suggests that occlusion of [...] Read more.

Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs). However, growing evidence suggests that occlusion of the vessels in the lungs can develop without preceding deep vein thrombosis (DVT). In this work, we used an inferior vena cava (IVC) complete ligation model of DVT in Wistar rats to explore the possibility and mechanisms of PA thrombosis under the conditions where all routes of thrombotic mass migration from peripheral veins are blocked. We demonstrate that rats both with normal and reduced neutrophil counts developed thrombi in the IVC, although, neutropenia caused a substantial decrease in thrombus size and a shift from fresh fibrin toward mature fibrin and connective tissue inside the thrombus. Massive fibrin deposition was found in the PA branches in the majority of DVT rats with normal neutrophil counts, but in none of the neutropenic animals. Neutrophil ablation also abolished macroscopic signs of lung damage. Altogether, the results demonstrate that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the DVT setting. Full article

(This article belongs to the Topic Thrombosis: From Basic Mechanisms to Saving Lives)

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