Advances in Biomaterials—2nd Edition

Topic Information

Dear Colleagues,

Biomaterials are materials that are put into the body for medical purposes, such as artificial joints, dentures, artificial blood vessels, artificial skin, and artificial organs. Research on biomaterials is conducted in the field of biomedical engineering. Research is conducted on materials, such as polymers and fiber materials, that can perform their intended functions when placed inside the body, such as materials that can be used for joints and blood vessels. Research is conducted in fields that focus on the functions of materials, such as structural/functional materials, mechanical materials/strength of materials, and composite materials/surface interface engineering. As a part of this topic, we would like to introduce biomaterials that are expected to be useful in future medical treatment.

Dr. Satoshi Komasa
Dr. Yoshiro Tahara
Prof. Dr. Tohru Sekino
Dr. Hideaki Sato
Prof. Dr. Yoshiya Hashimoto
Dr. Tetsuya Adachi
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Applied Sciences applsci	2.5	5.5	2011	16 Days	CHF 2400	Submit
Dentistry Journal dentistry	3.1	4.1	2013	25.4 Days	CHF 2000	Submit
Polymers polymers	4.9	9.7	2009	14.4 Days	CHF 2700	Submit
Applied Biosciences applbiosci	-	2.9	2022	22.8 Days	CHF 1200	Submit
Bioengineering bioengineering	3.7	5.3	2014	17 Days	CHF 2700	Submit
Materials materials	3.2	6.4	2008	15.5 Days	CHF 2600	Submit

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Published Papers (4 papers)

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17 pages, 6601 KB  

Open AccessArticle

Functional Surface Modification of Magnesium Implant by Drug-Loaded Biodegradable Polymer Coating

by Jung-Eun Park, Yong-Seok Jang, Seung-O Ko and Min-Ho Lee

Appl. Sci. 2026, 16(3), 1542; https://doi.org/10.3390/app16031542 - 3 Feb 2026

Viewed by 287

Abstract

Magnesium has attracted attention as an orthopedic implant material due to its excellent biocompatibility and biodegradability; however, rapid corrosion in physiological environments remains a major limitation. In this study, a polydopamine (PDA) intermediate layer and alginate/chitosan multilayer coating were formed on pure magnesium [...] Read more.

Magnesium has attracted attention as an orthopedic implant material due to its excellent biocompatibility and biodegradability; however, rapid corrosion in physiological environments remains a major limitation. In this study, a polydopamine (PDA) intermediate layer and alginate/chitosan multilayer coating were formed on pure magnesium surfaces, with dexamethasone incorporation to simultaneously improve corrosion resistance and bioactivity. SEM observation revealed that uniform coating layers were formed on alginate/chitosan multilayer coated specimens, and the chemical structure of the coating layers was confirmed through FT-IR and XRD analyses. Electrochemical analysis revealed that the PDA/alginate/chitosan coating group exhibited higher corrosion potential (Ecorr: −0.7514 ± 0.022 V vs. −1.706 ± 0.001 V) and lower corrosion current density (icorr: 2.275 ± 0.15 × 10⁻⁷ A/cm² vs. 1.528 ± 0.47 × 10⁻⁴ A/cm²) compared to pure magnesium, with the highest impedance indicating superior corrosion resistance. In tape peel testing, the polydopamine-coated group demonstrated superior adhesion compared to the non-coated group, and sustained release of dexamethasone was confirmed. MC3T3-E1 cell culture results confirmed cell proliferation in all specimens, with the PDA/alginate/chitosan group exhibiting the highest ALP activity compared to other surface-treated groups. Based on these results, the PDA/alginate/chitosan multilayer coating was confirmed to be an effective surface modification method for corrosion control and promotion of osteoblast differentiation on magnesium. Full article

(This article belongs to the Topic Advances in Biomaterials—2nd Edition)

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31 pages, 6017 KB  

Open AccessReview

Progress in the Expression, Purification, and Characterization of Recombinant Collagen

by Youlin Deng, Jiyao Kang, Xiaoqun Duan, Yingjun Kong, Weiquan Xie, Dongjie Lei, Tingchun Wang and Guifeng Zhang

Bioengineering 2026, 13(2), 159; https://doi.org/10.3390/bioengineering13020159 - 28 Jan 2026

Viewed by 470

Abstract

Synthesized by expressing natural collagen sequences in specific hosts, recombinant collagen exhibits multiple advantages, encompassing a higher content of bioactive domains, enhanced antioxidant activity, the absence of viral pathogens, favorable hydrophilicity, reproducible production, and low immunogenicity. Consequently, it has found extensive use in [...] Read more.

Synthesized by expressing natural collagen sequences in specific hosts, recombinant collagen exhibits multiple advantages, encompassing a higher content of bioactive domains, enhanced antioxidant activity, the absence of viral pathogens, favorable hydrophilicity, reproducible production, and low immunogenicity. Consequently, it has found extensive use in applications ranging from biomaterials and pharmaceuticals to skincare. This review systematically explores various expression systems for recombinant collagen, including those utilizing Escherichia coli, Pichia pastoris, plants, insect baculovirus, and mammalian cells. It provides a detailed comparison of their differences and commonalities in terms of production efficiency, post-translational modification capability, and cost-effectiveness. Key separation and purification techniques for recombinant collage-notably precipitation, affinity chromatography, ion-exchange chromatography, and gel filtration chromatography are further introduced, with an in-depth analysis of the applicable scenarios and purification outcomes for each method. Finally, the review comprehensively summarizes the characterization methods for both the physicochemical properties and biological functions of recombinant collagen. For physicochemical properties, techniques covered include scanning electron microscopy, micro-differential thermal analysis, circular dichroism spectroscopy, SDS-PAGE, mass spectrometry, and Fourier-transform infrared spectroscopy. For biological functions, the focus is on its roles and the corresponding assessment methods in processes such as cell proliferation, migration, adhesion, and wound healing. Building upon this comprehensive overview, current challenges facing recombinant collagen are identified, and future directions are proposed, emphasizing the need to reduce R&D costs, refine testing methods for cosmetic products, and improve safety evaluation protocols to advance the field. Full article

(This article belongs to the Topic Advances in Biomaterials—2nd Edition)

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31 pages, 4258 KB  

Open AccessReview

From Industry to Dentistry: A Comprehensive Review of Zeolite as a Next-Generation Multifunctional Filler for Enhanced Mechanical Reinforcement and Antimicrobial Efficacy

by Sohaib Fadhil Mohammed, Mohd Firdaus Yhaya, Abdul Fattah Nongman, Matheel Al-Rawas, Marwan N. Arbilei and Tahir Yusuf Noorani

Dent. J. 2025, 13(11), 540; https://doi.org/10.3390/dj13110540 - 14 Nov 2025

Viewed by 1344

Abstract

Zeolites are becoming potentially important multifunctional fillers in dentistry, providing a distinctive blend of mechanical reinforcement, remineralization, and antimicrobial properties. Their crystalline aluminosilicate frameworks offer ion-exchange capacity, the controlled release of therapeutic ions (Ag⁺, Zn²⁺, Ca²⁺, Sr [...] Read more.

Zeolites are becoming potentially important multifunctional fillers in dentistry, providing a distinctive blend of mechanical reinforcement, remineralization, and antimicrobial properties. Their crystalline aluminosilicate frameworks offer ion-exchange capacity, the controlled release of therapeutic ions (Ag⁺, Zn²⁺, Ca²⁺, Sr²⁺, Cu²⁺), and compatibility with various dental composites. Sustainable and cost-effective zeolite production has become possible due to recent developments in synthetic strategies. These include the valorization of industrial and agricultural residues that are abundant in Si and Al. The incorporation of zeolites into dental adhesives, restorative composites, glass ionomer cements, root canal sealers, prosthetic materials, and implant coatings has been shown to improve mechanical stability and remineralization potential, and enhance antibacterial protection. The unique advantage of zeolites in integrating multifunctionality within a single system is emphasized when compared with other fillers, such as hydroxyapatite nanoparticles and bioactive glass. Nevertheless, obstacles persist with respect to clinical validation, regulatory pathways, and long-term biocompatibility. This review critically assesses the structure–function relationships, synthesis strategies, and dental applications of zeolites, while also delineating future perspectives for their translation into clinically approved, sustainable dental biomaterials. Full article

(This article belongs to the Topic Advances in Biomaterials—2nd Edition)

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22 pages, 4600 KB  

Open AccessReview

Progress in Self-Repair Technology for Concrete Cracks via Biomineralization

by Meirong Zong, Wenhao Wang, Haozhe Ma, Nshuti Cedrick, Yuting Sun, Xiancui Yan, Hui Liu, Pinghua Zhu and Minqi Hua

Materials 2025, 18(21), 5004; https://doi.org/10.3390/ma18215004 - 1 Nov 2025

Cited by 2 | Viewed by 1709

Abstract

Biomineralized self-healing concrete is a type of concrete that, during its service life, induces the generation of calcium carbonate through the participation of microorganisms or active enzymes, thereby achieving self-repair of cracks at different times. Self-healing concrete based on biomineralization can achieve sustainable [...] Read more.

Biomineralized self-healing concrete is a type of concrete that, during its service life, induces the generation of calcium carbonate through the participation of microorganisms or active enzymes, thereby achieving self-repair of cracks at different times. Self-healing concrete based on biomineralization can achieve sustainable crack repair and could enhance the strength and extend the service life of buildings. This article comprehensively analyzes the latest progress in bio-self-healing concrete, including microbial-based self-healing, enzyme-induced calcium carbonate precipitation (EICP), microcapsule-loaded microbial in situ remediation, and bio-inorganic mineral synergist self-healing technology. The maximum repairable width of the crack is 2.0 mm, and concrete strength can be increased by 135%. These methods offer new insights and strategies for the repair of concrete cracks, providing fundamental knowledge for the later application of intelligent engineering of bio-self-healing concrete and the analysis of micro-interface mechanisms. At the same time, they clarify the practical possibility of microbial technology in building materials science and engineering and offer key theoretical support for the long-term development of China’s construction industry. Full article

(This article belongs to the Topic Advances in Biomaterials—2nd Edition)

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