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Integrative Genomics and Multi-Omics Approaches for Sustainable Animal Production
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College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730000, China
College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730000, China
Institute of Animal Science, Xinjiang Academy of Animal Sciences, Urumqi 830000, China
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Integrative Genomics and Multi-Omics Approaches for Sustainable Animal Production

Abstract submission deadline
31 May 2027
Manuscript submission deadline
31 July 2027
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725

Topic Information

Dear Colleagues,

The global livestock industry faces pressing challenges, including the growing demand for high-quality animal products, the need to ensure animal health and welfare, and the imperative to reduce greenhouse gas emissions and resource utilization for sustainable agricultural development. The Topic, “Integrative Genomics and Multi-Omics Approaches for Sustainable Animal Production”, aims to showcase cutting-edge research that elucidates the molecular architecture underlying economically important traits in production animals. By integrating genomics, transcriptomics, epigenomics, chromatin accessibility profiling, proteomics, metabolomics, and microbiome analyses, recent advances now enable systematic investigation of complex biological networks regulating growth, reproduction, disease resistance, feed efficiency, and environmental adaptation.

This Topic welcomes original research articles, reviews, and short communications that uncover regulatory mechanisms of key economic traits, such as intramuscular fat deposition, feed conversion efficiency, and disease resistance in pigs, ruminants, poultry and other economically important animal species. By bridging fundamental biological insights with applied breeding strategies, it aims to provide innovative solutions for environmentally sustainable, low-input, and high-efficiency animal production systems in the context of modern sustainable agriculture.

Prof. Dr. Weimin Wang
Dr. Deyin Zhang
Prof. Dr. Weiwei Wu
Topic Editors

Keywords

  • multi-omics
  • economic trait
  • functional genomics
  • molecular breeding
  • environmental adaptation

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Agriculture
agriculture 		4.5 7.8 2011 17.4 Days CHF 2600 Submit
Animals
animals 		3.2 5.5 2011 15.7 Days CHF 2400 Submit
Biology
biology 		4.3 7.3 2012 14.2 Days CHF 2700 Submit
Genes
genes 		3.1 5.9 2010 13.3 Days CHF 2600 Submit
Journal of Genome Biotechnology and Genetics
jgbg 		- - 2026 15.0 days * CHF 1000 Submit

* Median value for all MDPI journals in the first half of 2026.


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Published Papers (1 paper)

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Article
A Study on the Mechanism of N-Carbamylglutamate’s (NCG) Effects on the Liver Transcriptome and Metabolism of Cold-Stressed Mongolian Ewes and Fetuses
by Kang Li, Yu Zhi, Lulu Shi, Jing Tian, Yunhua Li, Juan Du, Meimei Zhang, Hao Zhang, Zhong Dong, Ruijun Wang, Weiyong Guo and Tianlong Guo
Animals 2026, 16(18), 2932; https://doi.org/10.3390/ani16182932 - 18 Sep 2026
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Abstract
Chronic cold stress disrupts hepatic metabolism and fetal development of Mongolian sheep in northern pastoral zones, while systematic nutritional mitigation strategies remain poorly characterized. N-carbamylglutamate (NCG) promotes endogenous arginine synthesis; however, its hepatic regulatory roles against cold stress in pregnant ewes and fetuses [...] Read more.
Chronic cold stress disrupts hepatic metabolism and fetal development of Mongolian sheep in northern pastoral zones, while systematic nutritional mitigation strategies remain poorly characterized. N-carbamylglutamate (NCG) promotes endogenous arginine synthesis; however, its hepatic regulatory roles against cold stress in pregnant ewes and fetuses remain unclear. This study explored the potential protective effects of NCG via integrated hepatic transcriptome and metabolome analysis. Twenty-four late-gestation ewes were assigned to warm control, cold stress, and cold stress + NCG supplementation groups. Hepatic mRNA, lncRNA, circRNA, and miRNA sequencing, untargeted LC-MS metabolomics, multi-omics conjoint analysis, and qRT-PCR verification were performed using ewe and fetal liver tissues. The results indicated that cold stress potentially was associated with mTOR, PI3K/AKT, amino acid, and energy metabolic pathways, inducing extensive transcriptomic and metabolic alterations. NCG supplementation might reverse cold-induced transcriptional and metabolic disorders and restore glutathione and cysteine–methionine metabolism. qRT-PCR validated the differential expression of core hub genes AK4, AHCY, and RRM2, linking transcriptomic and metabolic reprogramming. Divergent hepatic molecular responses to NCG were observed between ewes and fetuses. Multi-omics correlation analysis suggested that maternal NCG may modulate hepatic energy and amino acid metabolism through mTOR and redox-related pathways under cold stress and potentially exert transgenerational hepatic effects on fetuses. These findings provide preliminary omics-based mechanistic hypotheses and a theoretical basis for nutritional intervention against cold stress in sheep production. Full article
(This article belongs to the Topic Integrative Genomics and Multi-Omics Approaches for Sustainable Animal Production)
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