Topic Editors

Institute of New Drug Development, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan
School of Pharmacy, Macau University of Science and Technology, Macau 999078, China
Neher's Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Macao, China

Advances in Controlled Release and Targeting of Drugs

Abstract submission deadline
20 January 2025
Manuscript submission deadline
20 March 2025
Viewed by
741

Topic Information

Dear Colleagues,

Drug delivery focuses on the approaches to improve pharmaceutical practices by enhancing drug molecule fractions that reach the target cells and receptors. The importance of this topic lies in the necessity of reducing the drug side effects and drug dosage. Drug delivery compounds consist of molecules (polymers, macromolecules, small molecules) capable of coordinating, transporting, and releasing drugs selectively to their targets. The coordination must be reversible to allow the subsequent release. The targeting can be active (through functional groups that interact with the targets) or passive (the delivery drug exploits the physical characteristics of the physical environment sorrounding the targets). Commercial systems include liposome compounds, cyclodextrins, and prodrug compounds. Recent research is trying to develop more sophisticated strategies by exploiting the progress in organic synthesis, supramolecular chemistry, and molecular machines. This topic collection covers all manuscripts about drug delivery systems.

Dr. Carmine Coluccini
Dr. Paolo Coghi
Dr. Xingxing Fan
Topic Editors

Keywords

  • drug delivery
  • drug release
  • drug targeting
  • prodrug
  • drug coordination

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Macromol
macromol
- 5.2 2021 20.4 Days CHF 1000 Submit
Molecules
molecules
4.2 7.4 1996 15.1 Days CHF 2700 Submit
Nanomaterials
nanomaterials
4.4 8.5 2010 13.8 Days CHF 2900 Submit
Pharmaceutics
pharmaceutics
4.9 7.9 2009 14.9 Days CHF 2900 Submit
Polymers
polymers
4.7 8.0 2009 14.5 Days CHF 2700 Submit

Preprints.org is a multidiscipline platform providing preprint service that is dedicated to sharing your research from the start and empowering your research journey.

MDPI Topics is cooperating with Preprints.org and has built a direct connection between MDPI journals and Preprints.org. Authors are encouraged to enjoy the benefits by posting a preprint at Preprints.org prior to publication:

  1. Immediately share your ideas ahead of publication and establish your research priority;
  2. Protect your idea from being stolen with this time-stamped preprint article;
  3. Enhance the exposure and impact of your research;
  4. Receive feedback from your peers in advance;
  5. Have it indexed in Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Published Papers (1 paper)

Order results
Result details
Journals
Select all
Export citation of selected articles as:
15 pages, 3171 KiB  
Article
Encapsulation of Gemcitabine on Porphyrin Aluminum Metal-Organic Framework by Mechano-Chemistry, Delayed Drug Release and Cytotoxicity to Pancreatic Cancer PANC-1 Cells
by Sheriff Umar and Alexander Samokhvalov
Molecules 2024, 29(13), 3189; https://doi.org/10.3390/molecules29133189 - 4 Jul 2024
Viewed by 421
Abstract
Gemcitabine is a widely used antimetabolite drug of pyrimidine structure, which can exist as a free-base molecular form (Gem). The encapsulated forms of medicinal drugs are of interest for delayed and local drug release. We utilized, for the first time, a novel approach [...] Read more.
Gemcitabine is a widely used antimetabolite drug of pyrimidine structure, which can exist as a free-base molecular form (Gem). The encapsulated forms of medicinal drugs are of interest for delayed and local drug release. We utilized, for the first time, a novel approach of mechano-chemistry by liquid-assisted grinding (LAG) to encapsulate Gem on a “matrix” of porphyrin aluminum metal-organic framework Al-MOF-TCPPH2 (compound 2). The chemical bonding of Gem to compound 2 was studied by ATR-FTIR spectroscopy and powder XRD. The interaction involves the C=O group of Gem molecules, which indicates the formation of the encapsulation complex in the obtained composite. Further, the delayed release of Gem from the composite was studied to phosphate buffered saline (PBS) at 37 °C using an automated drug dissolution apparatus equipped with an autosampler. The concentration of the released drug was determined by HPLC-UV analysis. The composite shows delayed release of Gem due to the bonded form and constant concentration thereafter, while pure Gem shows quick dissolution in less than 45 min. Delayed release of Gem drug from the composite follows the kinetic pseudo-first-order rate law. Further, for the first time, the mechanism of delayed release of Gem was assessed by the variable stirring speed of drug release media, and kinetic rate constant k was found to decrease when stirring speed is decreased (diffusion control). Finally, the prolonged time scale of toxicity of Gem to pancreatic cancer PANC-1 cells was studied by continuous measurements of proliferation (growth) for 6 days, using the xCELLigence real-time cell analyzer (RTCA), for the composite vs. pure drug, and their differences indicate delayed drug release. Aluminum metal-organic frameworks are new and promising materials for the encapsulation of gemcitabine and related small-molecule antimetabolites for controlled delayed drug release and potential use in drug-eluting implants. Full article
(This article belongs to the Topic Advances in Controlled Release and Targeting of Drugs)
Show Figures

Graphical abstract

Back to TopTop