Topic Editors

1. Department of Natural Sciences, Southeastern University, 1000 Longfellow Blvd., Lakeland, FL 33801, USA
2. Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA
School of Chemistry, University of Lincoln, Lincoln LN6 7DL, UK

Advances in Molecular Symmetry and Chirality Research

Abstract submission deadline
31 December 2025
Manuscript submission deadline
31 March 2026
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3071

Topic Information

Dear Colleagues,

In nature, chirality is widely found in fields such as chemistry, biology, and physics. In the field of chemistry, chirality research focuses on the chiral properties of molecules. Many organic molecules are chiral, which means that they exist in two mirror structures, namely, left-handed and right-handed. These mirror structures are called enantiomers, and they cannot be superimposed on each other by rotation or translation. Since the mirror structures of chiral molecules may have different properties in biological activity and chemical reactions, chirality research has important application value in fields such as drug development, food science, and environmental science. Molecular symmetry is a fundamental concept in chemistry, as it can be used to predict or explain many of a molecule's chemical properties, such as whether or not it has a dipole moment, as well as its allowed spectroscopic transitions. This involves classifying the states of the molecule using the irreducible representations from the character table of the symmetry group of the molecule. Symmetry is useful in the study of molecular orbitals, with applications in the Hückel method, the ligand field theory, and the Woodward–Hoffmann rules.

Prof. Dr. Ralph N. Salvatore
Dr. Guzman Gil-Ramirez
Topic Editors

Keywords

  • molecular symmetry
  • molecular chirality
  • drug development
  • food science
  • environmental science

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Atoms
atoms
1.7 2.7 2013 19.1 Days CHF 1500 Submit
Crystals
crystals
2.4 4.2 2011 11.1 Days CHF 2100 Submit
Molecules
molecules
4.2 7.4 1996 15.1 Days CHF 2700 Submit
Organics
organics
1.4 2.5 2020 22.4 Days CHF 1000 Submit
Symmetry
symmetry
2.2 5.4 2009 17.3 Days CHF 2400 Submit
Inorganics
inorganics
3.1 2.8 2013 15.8 Days CHF 2200 Submit

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Published Papers (3 papers)

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11 pages, 3987 KiB  
Article
Induced Chirality in CuO Nanostructures Using Amino Acid-Mediated Chemical Bath Deposition
by Lama Jabreen and Yitzhak Mastai
Crystals 2025, 15(3), 236; https://doi.org/10.3390/cryst15030236 - 28 Feb 2025
Viewed by 411
Abstract
This study explored the controlled formation of chiral copper(II) oxide (CuO) crystals using chiral amino acids as chirality-inducing agents. Utilizing chemical bath deposition (CBD) as the fabrication method, we achieved simple, reproducible synthesis suitable for industrial-scale applications. Our characterization of the induced chirality [...] Read more.
This study explored the controlled formation of chiral copper(II) oxide (CuO) crystals using chiral amino acids as chirality-inducing agents. Utilizing chemical bath deposition (CBD) as the fabrication method, we achieved simple, reproducible synthesis suitable for industrial-scale applications. Our characterization of the induced chirality through high-performance liquid chromatography (HPLC), circular dichroism (CD), and isothermal titration calorimetry (ITC) revealed distinctive chiral features. These findings not only advance our understanding of chirality control in inorganic nanostructures but also establish CBD as a viable technique for the large-scale production of chiral materials. Full article
(This article belongs to the Topic Advances in Molecular Symmetry and Chirality Research)
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20 pages, 3949 KiB  
Review
Precise Synthesis of High-Strength Chiral Au Nanomaterials: From Chiral Au Nanoclusters to Chiral Au Nanoparticles
by Haijuan Luo, Chuanhua Shi, Zhixun Zhang, Yan Nong, Juefei Dai, Chengcheng Feng, Wenjie Li, Xianyong Yu, Xueji Zhang and Huayan Yang
Inorganics 2025, 13(3), 72; https://doi.org/10.3390/inorganics13030072 - 27 Feb 2025
Viewed by 806
Abstract
Chiral gold nanomaterials have promising applications in biomedicine, catalysis, optics and other fields. However, the complexity of their chiral sources has led to many challenges in terms of the functional design and controlled synthesis. In this paper, we systematically review the development history [...] Read more.
Chiral gold nanomaterials have promising applications in biomedicine, catalysis, optics and other fields. However, the complexity of their chiral sources has led to many challenges in terms of the functional design and controlled synthesis. In this paper, we systematically review the development history of chiral Au nanomaterials; deeply analyze the synthesis strategy, chiral construction mechanism, and performance optimization pathway; and discuss the formation mechanism in light of the progress of cutting-edge research to look into the future direction of development. The aim is to provide theoretical and methodological support for the controllable synthesis of chiral gold nanomaterials. Full article
(This article belongs to the Topic Advances in Molecular Symmetry and Chirality Research)
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11 pages, 3122 KiB  
Article
A Computational DFT Study of the Stereoinversion of Succinimide Residues Formed in Proteins and Peptides Catalyzed by a Hydrogen Phosphate Ion: An Unsymmetrical SE1 Mechanism
by Ohgi Takahashi
Symmetry 2024, 16(10), 1369; https://doi.org/10.3390/sym16101369 - 15 Oct 2024
Viewed by 895
Abstract
Succinimide residues formed spontaneously from aspartic acid (Asp) and asparagine (Asn) residues in proteins and peptides are stereochemically unstable, undergoing partial l-to-d stereoinversion, and this is responsible for the d-Asp and d-β-Asp residues found in long-lived proteins. These stereoinverted [...] Read more.
Succinimide residues formed spontaneously from aspartic acid (Asp) and asparagine (Asn) residues in proteins and peptides are stereochemically unstable, undergoing partial l-to-d stereoinversion, and this is responsible for the d-Asp and d-β-Asp residues found in long-lived proteins. These stereoinverted abnormal amino acid residues are believed to be related to aging and some age-related diseases such as cataracts. Although the succinimide stereoinversion is nonenzymatic, a catalyst is required for it to occur at physiological temperature. In this study, it was found by density functional theory (DFT) calculations that a hydrogen phosphate ion (HPO42−) can effectively catalyze the stereoinversion of the succinimide intermediate. The HPO42− ion abstracts a proton from the asymmetric carbon atom of the succinimide residue to form an enolate intermediate. Then, while the resultant dihydrogen phosphate ion (H2PO4) remains bound to the enolate ion, a water molecule donates a proton to the enolate intermediate on the opposite side from the phosphate (which is the rate-determining step) to produce the inverted carbon atom. The calculated activation barrier (ca. 90 kJ mol−1) is consistent with a slow in vivo reaction. The present found mechanism can be termed the “unsymmetrical SE1” or “pseudo-SE2” mechanism. Full article
(This article belongs to the Topic Advances in Molecular Symmetry and Chirality Research)
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