Infection and Treatment of Antibiotic-Resistant ESKAPE Pathogens
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".
Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 434
Special Issue Editors
Interests: antibiotic resistance; alternative therapeutics; host-microbe interaction
Special Issue Information
Dear Colleagues,
The global challenge posed by bacterial infections, often accompanied by intricate antibiotic resistance patterns, significantly impacts human health. Antibiotics, while effective, wield a double-edged sword: they eliminate germs but simultaneously exert selective pressure on bacteria to evolve resistance.
Bacterial infections caused by multi-resistant pathogens (ESKAPE), including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp., have emerged as a major global health crisis during the past few decades.
Furthermore, antibiotic use disrupts the gut microbiota, fostering a reservoir of antimicrobial resistance genes and organisms, along with complications like antibiotic-associated diarrhea and superinfections. In contrast, pathogen-specific alternatives offer distinct advantages over antibiotics. Firstly, they allow bacterial growth within the host without imposing selection pressure or resistance. Secondly, these alternatives specifically target particular bacteria, leaving the host’s regular flora unaffected.
This Special Issue aims to compile novel research on alternative therapies combating bacterial infections. We seek studies on novel antimicrobials and innovative antibiotic alternatives, either used independently or in conjunction with traditional antibiotics. The precise characterizations of antimicrobial agents effective against multidrug-resistant infections are of particular interest. Additionally, we invite contributions in the form of review articles or concise reflections on these critical topics.
We eagerly await your submissions.
Dr. Peng Gao
Dr. Jie Shen
Guest Editors
Manuscript Submission Information
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Keywords
- antibiotics
- alternatives
- anti-virulence
- antibiotic adjuvant
- pathogen-specific agent
- vaccine
- bacteriophage
- microbiome modulator
- anti-biofilm
- lysin
- materials
- nanoparticles
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