Search Results (56)

Implantable medical devices present several technological challenges, one of the most critical being how to provide power supply and communication capabilities to a device hermetically sealed within the body. Using a battery as a power source represents a potential harm for the individual’s health because of possible toxic chemical release or overheating, and it requires periodic surgery for replacement. This paper proposes a batteryless implantable device powered by an inductive link and equipped with bidirectional wireless communication channels. The device, designed in a 180 nm CMOS process, is based on two different pairs of mutually coupled inductors that provide, respectively, power and a low-bitrate bidirectional communication link and a separate, high-bitrate, one-directional upstream connection. The main link is based on a 13.56 MHz carrier and allows power transmission and a half-duplex two-way communication at 106 kbps (downlink) and 30 kbps (uplink). The secondary link is based on a 27 MHz carrier, which provides one-way communication at 2.25 Mbps only in uplink. The low-bitrate links are needed to send commands and monitor the implanted system, while the high-bitrate link is required to receive a continuous stream of information from the implanted sensing devices. The microchip acts as a hub for power and data wireless transmission capable of managing up to four different neural recording and stimulation front ends, making the device employable in a complex, distributed, bidirectional neural prosthetic system. Full article

Wireless microsystems for neural signal recording have emerged as a solution to overcome the limitations of tethered systems, which restrict the mobility of subjects and introduce noise interference. However, existing microsystems often face data throughput, signal processing, and long-distance wireless transmission challenges. This study presents a high-performance wireless microsystem capable of 32-channel, 30 kHz real-time recording, featuring Field Programmable Gate Array (FPGA)-based signal processing to reduce transmission load. The microsystem is integrated with platinum nanoparticles/poly (3,4-ethylenedioxythiophene) polystyrene sulfonate-enhanced microelectrode arrays for improved signal quality. A custom NeuroWireless platform was developed for seamless data reception and storage. Experimental validation in rats demonstrated the microsystem’s ability to detect spikes and local field potentials from the hippocampal CA1 and CA2 subregions. Comparative analysis of the neural signals revealed distinct activity patterns between these subregions. The wireless microsystem achieves high accuracy and throughput over distances up to 30 m, demonstrating its resilience and potential for neuroscience research. This work provides a compact, adaptable solution for multi-channel neural signal detection and offers a foundation for future applications in brain–computer interfaces. Full article

The performance of the services provided by Global Navigation Satellite Systems (GNSSs) can be seriously degraded by the presence of wireless interferences, and Machine Learning (ML) has been applied to address this problem using the digital artifacts generated by the GNSS receiver. While such an application is not novel in the literature, the analysis of the impact of the bit-depth at which the GNSS signal is recorded has not received significant attention. The type and power level of the wireless interference are also important factors to investigate in this context. This paper addresses this gap by performing an extensive analysis of the impact of these factors on a data set of GNSS signals subject to three different types of wireless interferences with ML and DL algorithms. The analysis is a combination of a pre-processing phase where the Carrier-to-Noise Ratio (CNR) values of different satellites are evaluated, the extraction of relevant features for ML, and the application of a Convolutional Neural Network (CNN) with a multi-head attention layer. The results show that the proposed approach is able to detect the presence of interference with great accuracy (e.g., 99%) but the type of interference and bit-depth can decrease the performance. Full article

In biomedical research, telemetry is used to take automated physiological measurements wirelessly from animals, as it reduces their stress and allows recordings for large data collection over long periods. The ability to transmit high-throughput data from an in-body device (e.g., implantable systems, endoscopic capsules) to external devices can also be achieved by radiofrequency (RF), a standard wireless communication procedure. However, wireless in-body RF devices do not exceed a transmission speed of 2 Mbit/s, as signal absorption increases dramatically with tissue thickness and at higher frequencies. This paper presents the design of an optical wireless communication system (OWCS) for neural probes with an optical transmitter, sending out physiological data through an optical signal that is detected by an optical receiver. The optical receiver position is controlled by a tracking system of the small animal position, based on a cage with a piezoelectric floor. To validate the concept, an OWCS based on a wavelength of 850 nm for a data transfer of 5 Mbit/s, with an optical power of 55 mW, was demonstrated for a tissue thickness of approximately 10 mm, measured in an optical tissue phantom. Full article

Wireless neural signal transmission is essential for both neuroscience research and neural disorder therapies. However, conventional wireless systems are often constrained by low sampling rates, limited channel counts, and their support of only a single transmission mode. Here, we developed a wireless bi-directional brain–computer interface system featuring dual transmission modes. This system supports both low-power Bluetooth transmission and high-sampling-rate Wi-Fi transmission, providing flexibility for various application scenarios. The Bluetooth mode, with a maximum sampling rate of 14.4 kS/s, is well suited for detecting low-frequency signals, as demonstrated by both in vitro recordings of signals from 10 to 50 Hz and in vivo recordings of 16-channel local field potentials in mice. More importantly, the Wi-Fi mode, offering a maximum sampling rate of 56.8 kS/s, is optimized for recording high-frequency signals. This capability was validated through in vitro recordings of signals from 500 to 2000 Hz and in vivo recordings of single-neuron spike firings with amplitudes reaching hundreds of microvolts and high signal-to-noise ratios. Additionally, the system incorporates a wireless stimulation function capable of delivering current pulses up to 2.55 mA, with adjustable pulse width and polarity. Overall, this dual-mode system provides an efficient and flexible solution for both neural recording and stimulation applications. Full article

One aspect of reproducibility in preclinical research that is frequently overlooked is the physical condition in which physiological, pharmacological, or behavioural recordings are conducted. In this study, the physical conditions of mice were altered through the attachments of wireless electrophysiological recording devices (Neural Activity Tracker-1, NAT-1). NAT-1 devices are miniaturised multichannel devices with onboard memory for direct high-resolution recording of brain activity for >48 h. Such devices may limit the mobility of animals and affect their behavioural performance due to the added weight (total weight of approximately 3.4 g). The mice were additionally treated with saline (control), N-methyl-D-aspartate (NMDA) receptor antagonist MK801 (0.85 mg/kg), or the muscarinic acetylcholine receptor blocker scopolamine (0.65 mg/kg) to allow exploration of the effect of NAT-1 attachments in pharmacologically treated mice. We found only minimal differences in behavioural outcomes with NAT-1 attachments in standard parameters of locomotor activity widely reported for the open field test between the drug treatments. Hypoactivity was globally observed as a consistent outcome in the MK801-treated mice and hyperactivity in scopolamine groups regardless of NAT-1 attachments. These data collectively confirm the reproducibility for combined behavioural, pharmacological, and physiological endpoints even in the presence of lightweight wireless data loggers. The NAT-1 therefore constitutes a pertinent tool for investigating brain activity in, e.g., drug discovery and models of neuropsychiatric and/or neurodegenerative diseases with minimal effects on pharmacological and behavioural outcomes. Full article

The brain–computer interface (BCI) is one of the most powerful tools in neuroscience and generally includes a recording system, a processor system, and a stimulation system. Optogenetics has the advantages of bidirectional regulation, high spatiotemporal resolution, and cell-specific regulation, which expands the application scenarios of BCIs. In recent years, optogenetic BCIs have become widely used in the lab with the development of materials and software. The systems were designed to be more integrated, lightweight, biocompatible, and power efficient, as were the wireless transmission and chip-level embedded BCIs. The software is also constantly improving, with better real-time performance and accuracy and lower power consumption. On the other hand, as a cutting-edge technology spanning multidisciplinary fields including molecular biology, neuroscience, material engineering, and information processing, optogenetic BCIs have great application potential in neural decoding, enhancing brain function, and treating neural diseases. Here, we review the development and application of optogenetic BCIs. In the future, combined with other functional imaging techniques such as near-infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI), optogenetic BCIs can modulate the function of specific circuits, facilitate neurological rehabilitation, assist perception, establish a brain-to-brain interface, and be applied in wider application scenarios. Full article

In large indoor environments, accurate positioning and tracking of people and autonomous equipment have become essential requirements. The application of increasingly automated moving transportation units in large indoor spaces demands a precise knowledge of their positions, for both efficiency and safety reasons. Moreover, satellite-based Global Positioning System (GPS) signals are likely to be unusable in deep indoor spaces, and technologies like WiFi and Bluetooth are susceptible to signal noise and fading effects. For these reasons, a hybrid approach that employs at least two different signal typologies proved to be more effective, resilient, robust, and accurate in determining localization in indoor environments. This paper proposes an improved hybrid technique that implements fingerprinting-based indoor positioning using Received Signal Strength (RSS) information from available Wireless Local Area Network (WLAN) access points and Wireless Sensor Network (WSN) technology. Six signals were recorded on a regular grid of anchor points covering the research surface. For optimization purposes, appropriate raw signal weighing was applied in accordance with previous research on the same data. The novel approach in this work consisted of performing a virtual tessellation of the considered indoor surface with a regular set of tiles encompassing the whole area. The optimization process was focused on varying the size of the tiles as well as their relative position concerning the signal acquisition grid, with the goal of minimizing the average distance error based on tile identification accuracy. The optimization process was conducted using a standard Quantum Particle Swarm Optimization (QPSO), while the position error estimate for each tile configuration was performed using a 3-layer Multilayer Perceptron (MLP) neural network. These experimental results showed a 16% reduction in the positioning error when a suitable tile configuration was calculated in the optimization process. Our final achieved value of 0.611 m of location incertitude shows a sensible improvement compared to our previous results. Full article

Research of novel biosignal modalities with application to remote patient monitoring is a subject of state-of-the-art developments. This study is focused on sonified ECG modality, which can be transmitted as an acoustic wave and received by GSM (Global System for Mobile Communications) microphones. Thus, the wireless connection between the patient module and the cloud server can be provided over an audio channel, such as a standard telephone call or audio message. Patients, especially the elderly or visually impaired, can benefit from ECG sonification because the wireless interface is readily available, facilitating the communication and transmission of secure ECG data from the patient monitoring device to the remote server. The aim of this study is to develop an AI-driven algorithm for 12-lead ECG sonification to support diagnostic reliability in the signal processing chain of the audio ECG stream. Our methods present the design of two algorithms: (1) a transformer (ECG-to-Audio) based on the frequency modulation (FM) of eight independent ECG leads in the very low frequency band (300–2700 Hz); and (2) a transformer (Audio-to-ECG) based on a four-layer 1D convolutional neural network (CNN) to decode the audio ECG stream (10 s @ 11 kHz) to the original eight-lead ECG (10 s @ 250 Hz). The CNN model is trained in unsupervised regression mode, searching for the minimum error between the transformed and original ECG signals. The results are reported using the PTB-XL 12-lead ECG database (21,837 recordings), split 50:50 for training and test. The quality of FM-modulated ECG audio is monitored by short-time Fourier transform, and examples are illustrated in this paper and supplementary audio files. The errors of the reconstructed ECG are estimated by a popular ECG diagnostic toolbox. They are substantially low in all ECG leads: amplitude error (quartile range RMSE = 3–7 μV, PRD = 2–5.2%), QRS detector (Se, PPV > 99.7%), P-QRS-T fiducial points’ time deviation (<2 ms). Low errors generalized across diverse patients and arrhythmias are a testament to the efficacy of the developments. They support 12-lead ECG sonification as a wireless interface to provide reliable data for diagnostic measurements by automated tools or medical experts. Full article

Implantable microelectrodes arrays are used to record electrical signals from surrounding neurons and have led to incredible improvements in modern neuroscience research. Digital signals resulting from conditioning and the analog-to-digital conversion of neural spikes captured by microelectrodes arrays have to be elaborated in a dedicated DSP core devoted to a real-time spike-sorting process for the classification phase based on the source neurons from which they were emitted. On-chip spike-sorting is also essential to achieve enough data reduction to allow for wireless transmission within the power constraints imposed on implantable devices. The design of such integrated circuits must meet stringent constraints related to ultra-low power density and the minimum silicon area, as well as several application requirements. The aim of this work is to present real-time hardware architecture able to perform all the spike-sorting tasks on chip while satisfying the aforementioned stringent requirements related to this type of application. The proposed solution has been coded in VHDL language and simulated in the Cadence Xcelium tool to verify the functional behavior of the digital processing chain. Then, a synthesis and place and route flow has been carried out to implement the proposed architecture in both a 130 nm and a FD-SOI 28 nm CMOS process, with a 200 MHz clock frequency target. Post-layout simulations in the Cadence Xcelium tool confirmed the proper operation up to a 200 MHz clock frequency. The area occupation and power consumption of the proposed detection and clustering module are 0.2659 mm²/ch, 7.16 μW/ch, 0.0168 mm²/ch, and 0.47 μW/ch for the 130 nm and 28 nm implementation, respectively. Full article

Current trends in neurobiological research focus on analyzing complex interactions within brain structures. To conduct relevant experiments, it is often essential to employ animals with unhampered mobility and utilize electrophysiological equipment capable of wirelessly transmitting data. In prior research, we introduced an open-source wireless electrophysiology system to surmount these challenges. Nonetheless, this prototype exhibited several limitations, such as a hefty weight for the wireless module, redundant system components, a diminished sampling rate, and limited battery longevity. In this study, we unveil an enhanced version of the open-source wireless electrophysiology system, tailored for in vivo monitoring of neural activity in rodent brains. This new system has been successfully tested in real-time recordings of in vivo neural activity. Consequently, our development offers researchers a cost-effective and proficient tool for studying complex brain functions. Full article

In recent years, human activity monitoring and recognition have gained importance in providing valuable information to improve the quality of life. A lack of activity can cause health problems including falling, depression, and decreased mobility. Continuous activity monitoring can be useful to prevent progressive health problems. With this purpose, this study presents a wireless smart insole with four force-sensitive resistors (FSRs) that monitor foot contact states during activities for both indoor and outdoor use. The designed insole is a compact solution and provides walking comfort with a slim and flexible structure. Moreover, the inertial measurement unit (IMU) sensors designed in our previous study were used to collect 3-axis accelerometer and 3-axis gyroscope outputs. Smart insoles were located in the shoe sole for both right and left feet, and two IMU sensors were attached to the thigh area of each leg. The sensor outputs were collected and recorded from forty healthy volunteers for eight different gait-based activities including walking uphill and descending stairs. The obtained datasets were separated into three categories; foot contact states, the combination of acceleration and gyroscope outputs, and a set of all sensor outputs. The dataset for each category was separately fed into deep learning algorithms, namely, convolutional long–short-term memory neural networks. The performance of each neural network for each category type was examined. The results show that the neural network using only foot contact states presents 90.1% accuracy and provides better performance than the combination of acceleration and gyroscope datasets for activity recognition. Moreover, the neural network presents the best results with 93.4% accuracy using a combination of all the data compared with the other two categories. Full article

Smart home monitoring systems via internet of things (IoT) are required for taking care of elders at home. They provide the flexibility of monitoring elders remotely for their families and caregivers. Activities of daily living are an efficient way to effectively monitor elderly people at home and patients at caregiving facilities. The monitoring of such actions depends largely on IoT-based devices, either wireless or installed at different places. This paper proposes an effective and robust layered architecture using multisensory devices to recognize the activities of daily living from anywhere. Multimodality refers to the sensory devices of multiple types working together to achieve the objective of remote monitoring. Therefore, the proposed multimodal-based approach includes IoT devices, such as wearable inertial sensors and videos recorded during daily routines, fused together. The data from these multi-sensors have to be processed through a pre-processing layer through different stages, such as data filtration, segmentation, landmark detection, and 2D stick model. In next layer called the features processing, we have extracted, fused, and optimized different features from multimodal sensors. The final layer, called classification, has been utilized to recognize the activities of daily living via a deep learning technique known as convolutional neural network. It is observed from the proposed IoT-based multimodal layered system’s results that an acceptable mean accuracy rate of 84.14% has been achieved. Full article

Wireless passive neural recording systems integrate sensory electrophysiological interfaces with a backscattering-based telemetry system. Despite the circuit simplicity and miniaturization with this topology, the high electrode–tissue impedance creates a major barrier to achieving high signal sensitivity and low telemetry power. In this paper, buffered impedance is utilized to address this limitation. The resulting passive telemetry-based wireless neural recording is implemented with thin flexible packages. Thus, the paper reports neural recording implants and integrator systems with three improved features: (1) passive high impedance matching with a simple buffer circuit, (2) a bypass capacitor to route the high frequency and improve mixer performance, and (3) system packaging with an integrated, flexible, biocompatible patch to capture the neural signal. The patch consists of a U-slot dual-band patch antenna that receives the transmitted power from the interrogator and backscatters the modulated carrier power at a different frequency. When the incoming power was 5–10 dBm, the neurosensor could communicate with the interrogator at a maximum distance of 5 cm. A biosignal as low as 80 µV peak was detected at the receiver. Full article

Objective: We designed and validated a wireless, low-cost, easy-to-use, mobile, dry-electrode headset for scalp electroencephalography (EEG) recordings for closed-loop brain–computer (BCI) interface and internet-of-things (IoT) applications. Approach: The EEG-based BCI headset was designed from commercial off-the-shelf (COTS) components using a multi-pronged approach that balanced interoperability, cost, portability, usability, form factor, reliability, and closed-loop operation. Main Results: The adjustable headset was designed to accommodate 90% of the population. A patent-pending self-positioning dry electrode bracket allowed for vertical self-positioning while parting the user’s hair to ensure contact of the electrode with the scalp. In the current prototype, five EEG electrodes were incorporated in the electrode bracket spanning the sensorimotor cortices bilaterally, and three skin sensors were included to measure eye movement and blinks. An inertial measurement unit (IMU) provides monitoring of head movements. The EEG amplifier operates with 24-bit resolution up to 500 Hz sampling frequency and can communicate with other devices using 802.11 b/g/n WiFi. It has high signal–to–noise ratio (SNR) and common–mode rejection ratio (CMRR) (121 dB and 110 dB, respectively) and low input noise. In closed-loop BCI mode, the system can operate at 40 Hz, including real-time adaptive noise cancellation and 512 MB of processor memory. It supports LabVIEW as a backend coding language and JavaScript (JS), Cascading Style Sheets (CSS), and HyperText Markup Language (HTML) as front-end coding languages and includes training and optimization of support vector machine (SVM) neural classifiers. Extensive bench testing supports the technical specifications and human-subject pilot testing of a closed-loop BCI application to support upper-limb rehabilitation and provides proof-of-concept validation for the device’s use at both the clinic and at home. Significance: The usability, interoperability, portability, reliability, and programmability of the proposed wireless closed-loop BCI system provides a low-cost solution for BCI and neurorehabilitation research and IoT applications. Full article