Search Results (1,073)

While research on high-incidence tumors such as breast, prostate, and lung cancer has led to significant increases in patient survival in recent years, this has not been the case for low-incidence tumors such as high-grade gliomas, the most common and lethal brain tumors, for which the last significant therapeutic advance dates back to 2005. The high infiltration capacity of these tumors into normal brain tissue essential for both vegetative and relational life, the tumor microenvironment, with poor immunological activity, the multiple resistance mechanisms, and the unattractiveness of research investments due to the limited number of patients have made, and continue to make, the path to achieving significant improvements in the survival of patients with high-grade gliomas long and arduous. The objective of this article is to update the slow but continuous radiotherapeutic progress for adult and pediatric high-grade gliomas to the second half of 2023. We analyzed the progress of preclinical and clinical research on both adult and pediatric high-grade gliomas, with a particular focus on improvements in radiotherapy. Interactions between non-radiant new therapies and radiotherapy were also covered. A literature search was conducted in PubMed using the terms (“glioma* and radio*”) and the time limit of 1 July 2023 to 31 December 2023. The inclusion and exclusion criteria for the review were relevance to advances in radiotherapy for high-grade gliomas in adults and children. Treating patients with advanced disease progression only, using “historical” data as controls, as well as repurposing drugs developed for purposes completely different from their intended use, were the major (but not the only) methods to assess risk of bias in the included studies. The effect measures used in the synthesis or presentation of the results were tabulated and/or displayed in figures. A total of 100 relevant references were reviewed. Advances in preclinical studies and in clinical radiotherapy treatment planning, innovative fractionation, use of radioisotopes/radiopharmaceuticals, radiosensitization procedures, and radiation-induced damage were focused on. While this analysis may be limited by the relatively short publication period, high-grade glioma research remains impacted, especially at the clinical level, by potential issues with trial design, such as treating patients with advanced disease progression, using “historical” data as controls, and repurposing drugs developed for completely different purposes than intended. Addressing these aspects of high-grade glioma research could improve its efficacy, which often remains low despite the associated costs. Full article

Extensive coal mining activities can exert substantial negative impacts on surface ecosystems. Vegetation indices are widely recognized as effective indicators of land ecological conditions and provide valuable insights into long-term ecological changes in mining areas. In this study, the Zhaogu mining area of the Jiaozuo Coalfield was selected as the study site. Using the Google Earth Engine (GEE) platform, the Kernel Normalized Difference Vegetation Index (kNDVI) was constructed to generate a vegetation dataset covering the period from 2010 to 2024. The temporal dynamics and future trends of vegetation coverage were analyzed using Theil–Sen median trend analysis, the Mann–Kendall test, the Hurst index, and residual analysis. Furthermore, the relative contributions of climatic factors and human activities to vegetation changes were quantitatively assessed. The results indicate that: (1) vegetation coverage in the Zhaogu mining area exhibits an overall improving trend, affecting approximately 77.1% of the study area, while slight degradation is mainly concentrated in the southeastern region, accounting for about 15.2%; (2) vegetation dynamics are predominantly characterized by low and relatively low fluctuations, covering approximately 78.5% of the region, whereas areas with high fluctuations are limited and mainly distributed in zones with intensive mining activities; although the current vegetation trend is generally increasing, future projections suggest a potential decline in approximately 55.8% of the area; and (3) vegetation changes in the Zhaogu mining area are jointly influenced by climatic factors and human activities, with climatic factors promoting vegetation growth in approximately 70.6% of the study area, while human activities exert inhibitory effects in about 24.2%, particularly in regions affected by mining operations and urban expansion. Full article

Populus euphratica is a key constructive species in desert ecosystems and plays a vital role in maintaining their stability. However, effective automated methods for accurately delineating its distribution outlines are currently lacking. This study used the mainstream area of the Tarim River as a case study and proposed a technical solution for identifying the distribution outline of Populus euphratica using multi-source thematic classification data. First, cropland thematic data were used to optimize the accuracy of the Populus euphratica classification raster data. Discrete points were removed based on density to reduce their impact on boundary identification. Then, a hierarchical identification scheme was constructed using the alpha-shape algorithm to identify the boundaries of high- and low-density Populus euphratica distribution areas separately. Finally, the outlines of the Populus euphratica distribution polygons were smoothed, and the final distribution outline data were obtained after spatial merging. The results showed the following: (1) Applying a closing operation to the cropland thematic classification data to obtain the distribution range of shelterbelts effectively eliminated misclassified pixels. Using the kd-tree algorithm to remove sparse discrete points based on density, with a removal ratio of 5%, helped suppress the interference of outlier point sets on the Populus euphratica outline identification. (2) Constructing a hierarchical identification scheme based on differences in Populus euphratica density is critical for accurately delineating its distribution contours. Using the alpha-shape algorithm with parameters set to α = 0.02 and α = 0.006, the reconstructed geometries effectively covered both densely and sparsely distributed Populus euphratica areas. (3) In the morphological processing stage, a combination of three methods—Gaussian filtering, equidistant expansion, and gap filling—effectively ensured the accuracy of the Populus euphratica outline. Among the various smoothing algorithms, Gaussian filtering yielded the best results. The equidistant expansion method reduced the impact of elongated cavities, thereby contributing to boundary accuracy. This study enhances the automation of Populus euphratica vector data mapping and holds significant value for the scientific management and research of desert vegetation. Full article

SoilMERGE (SMERGE) is a 0.125-degree root zone soil moisture (RZSM) product (0 to 40 cm depth) covering the contiguous United States. The study area included most of Oklahoma and Kansas, a region where SMERGE exhibited superior performance. The time frame examined was the warm season from 2008 to 2019. In this study, evaluation of a prototype downscaled (500 m) version of SMERGE was made using (1) Ranked correlation (R²) benchmarking against Normalized Difference Vegetation Index (NDVI) datasets and (2) Ranked correlation (R²) analysis of antecedent RZSM with storm-event streamflow across a range of precipitation intensities (5 to >35 mm/day) at a watershed scale. In the NDVI benchmarking, all three downscaled products outperformed (0.52 to 0.59) default SMERGE (0.44). EXtreme Gradient Boosting (XGB) and Gradient Boost recorded a higher ranked correlation (0.59) than Random Forest (0.52). Within the study area, ranked correlation analysis of antecedent RZSM with storm-event United States Geological Survey streamflow was examined in five watersheds. For the most intense storm events (>35 mm), antecedent XGB downscaled SMERGE (0.64) outperformed antecedent streamflow (0.43) and all other versions of SMERGE (0.52 to 0.56) as a predictor of storm event response. The results of this study demonstrated broad-scale benefits of Machine Learning-assisted downscaling, providing proof of concept for the development of state-based SMERGE products across the US Great Plains. Full article

The SDG 15.3.1 framework provides a standardized approach using land use/land cover (LULC) change, land productivity, and soil organic carbon (SOC) dynamics to assess land degradation. However, SDG 15.3.1. faces limitations like coarse resolutions of Landsat-8 and Sentinel-2, particularly for fine-scale studies. Accordingly, this paper integrates Very Deep Super-Resolution (VDSR) for downscaling Landsat-8 imagery to 1 m resolution and the Vegetation Health Index (VHI) into SDG 15.3.1 to enhance detection in the heterogeneous Loiret region, France—a temperate agricultural hub featuring mixed croplands and peri-urban interfaces—using 2017 as baseline and 2024 as target. Results demonstrated that 1 m resolution detected more degraded LULC areas than coarser scales. SOC degradation was minimal (0.15%), concentrated in transitioned zones. VHI reduced overestimation of productivity declines compared to the Normalized Difference Vegetation Index by identifying more stable areas and 2.69 times less degradation in integrated assessments. The “One Out, All Out” rule classified 2.6% (using VHI) and 7.1% (using NDVI) of the region as degraded, mainly in peri-urban and cropland hotspots. This approach enables metre-scale land degradation mapping that remains effective in heterogeneous landscapes where fine-scale LULC changes drive degradation and would be missed at lower resolutions. However, future ground validation and longer timelines are essential to enhance the presented methodology. Full article

Biological invasions are major threats to global biodiversity, and mapping their distribution is essential to prioritizing management efforts. The Pinaceae family (hereafter pines) includes invasive trees, particularly in Southern Hemisphere regions where they are non-native. These invasions can increase the severity of fires in wildland–urban interfaces (WUIs). We mapped pine invasion in the Bariloche WUI (≈150,000 ha, northwest Patagonia, Argentina) using supervised land cover classification of Sentinel-2 imagery with a Random Forest algorithm on Google Earth Engine, achieving 90% overall accuracy but underestimating the pine invasion area by about 25%. We then assessed in which main vegetation context pine invasions occurred relying on major vegetation units across the precipitation gradient of our study area. Invasions cover 2% of the study area, mainly in forests (61%), steppes (25.4%), and shrublands (13.4%). Most invaded areas (89.1%) are on private land; nearly 70% are on large properties (>10 ha), where state financial incentives could support removal. Another 13.5% occur on many small properties (<1 ha), where awareness campaigns could enable decentralized, low-effort control. Our land cover map can be developed further to integrate invasion dynamics, inform fire risk and behavior models, optimize management actions, and guide territorial planning. Overall, it provides a valuable tool for targeted, scale-appropriate strategies to mitigate ecological and fire-related impacts of invasive pines. Full article

Nature reserves serve as core spatial units for maintaining regional ecological security and biodiversity. Owing to their high ecosystem integrity, extensive vegetation cover, and low levels of disturbance, they play a crucial role in sustaining ecological processes and ensuring functional stability. Taking the Giant Panda National Park (GPNP), which spans the provinces of Gansu, Sichuan, and Shaanxi in China, as the study region, the vegetation net primary productivity (NPP) during 2001–2023 was simulated using the Carnegie–Ames–Stanford Approach (CASA) model. Spatial and temporal variations in NPP were examined using Moran’s I, Getis-Ord Gi* hotspot analysis, Theil–Sen trend estimation, and the Mann–Kendall test. In addition, the Optimal Parameters-based Geographical Detector (OPGD) model was applied to quantitatively assess the relative contributions of natural and anthropogenic factors to NPP dynamics. The results demonstrated that: (1) The mean annual NPP within the GPNP reached 646.90 gC·m⁻²·yr⁻¹, exhibiting a fluctuating yet generally upward trajectory, with an average growth rate of approximately 0.65 gC·m⁻²·yr⁻¹, reflecting the positive ecological outcomes of national park establishment and ecological restoration projects. (2) NPP exhibits significant spatial heterogeneity, with higher NPP values in the northern, while the central and western regions and some high-altitude areas remain at relatively low levels. Across the four major subregions of the GPNP, the Qinling has the highest mean annual NPP at 758.89 gC·m⁻²·yr⁻¹, whereas the Qionglai–Daxiaoxiangling subregion shows the lowest value at 616.27 gC·m⁻²·yr⁻¹. (3) Optimal NPP occurred under favorable temperature and precipitation conditions combined with relatively high solar radiation. Low elevations, gentle slopes, south facing aspects, and leached soils facilitated productivity accumulation, whereas areas with high elevation and steep slopes exhibited markedly lower productivity. Moderate human disturbance contributed to sustaining and enhancing NPP. (4) Factor detection results indicated that elevation, mean annual temperature, and land use were the dominant drivers of spatial heterogeneity when considering all natural and anthropogenic variables. Their interactions further enhanced explanatory power, particularly the interaction between elevation and climatic factors. Overall, these findings reveal the complex spatiotemporal characteristics and multi-factorial controls of vegetation productivity in the GPNP and provide scientific guidance for strengthening habitat conservation, improving ecological restoration planning, and supporting adaptive vegetation management within the national park systems. Full article

Climate regulation ecosystem services (CRESs) play a crucial role in maintaining ecological balance and promoting regional sustainability. Previous studies have primarily focused on the total volume or per-unit-area quantity of CRESs, with limited attention given to their underlying driving mechanisms. This neglect overlooks their multidimensional attributes and dynamic complexity. Such simplifications often overlook the multidimensional attributes and dynamic complexity inherent in these services. Therefore, this study introduces a multidimensional evaluation framework to reveal the characteristic of the spatiotemporal evolution of CRESs. By integrating a multiscale geographically weighted regression (MGWR) model, the intensity and effective distance of theireffects are quantitatively identified, thereby providing a scientific and refined cognitive foundation for regional sustainable development. The results showed the following: (1) Between 2002 and 2022, CRESs in Guizhou Province showed an upward trend, with 64% of counties experiencing positive trends, whereas 51% of counties remained below average in terms of output and efficiency. (2) The spatial pattern of CRESs varied significantly, with stabilization in hotspots, improvement in coldspots, and the highest proportion of “A progress zones” in the east (45%). (3) Vegetation cover and annual precipitation were the two mainpositive factors that most strongly influenced the intensity of the CRESs, with values of 1.494 and 1.196, respectively; GDP had the most significant negative effect, with a value of −0.189; and population density had the largest range of effects, with a bandwidth of 1629. (4) Except for annual rainfall and aspect, the remaining eight influencingfactors, including population density, GDP, altitude, NPP, vegetation cover, annual temperature, and annual humidity, had positive and negative bidirectional effects on CRESs. Overall, this study emphasizes the need for differentiated, sustainability-oriented management strategies to better integrate ecosystem service evaluations into regional planning and sustainable policy development. Full article

Vegetation heterogeneity supports biodiversity, while homogeneity limits it. In the Great Plains, fire and herbivory enhance ecosystem function by increasing spatial heterogeneity. However, quantifying their effects on plant functional traits and spectral diversity remains challenging due to landscape complexity and scaling limitations. Hyperspectral remote sensing offers a high-resolution approach to assessing these dynamics, improving the evaluations of post-fire recovery and vegetation function. This study examines the impact of fire on plant functional traits and spectral diversity within a savanna landscape in the Edwards Plateau, Texas, using airborne hyperspectral and multispectral imagery. Specifically, it aims to (1) quantify the spatial patterns of plant functional traits and spectral diversity, (2) assess fire’s effects on these patterns, and (3) evaluate how soil type, woody structure, and burn patterns mediate fire responses. High-resolution airborne images from 2018 (pre-fire) and 2020 (post-fire) were analyzed to classify burned and unburned areas, pre-fire woody cover, and derive spectral indices representing plant functional traits, β-diversity components, and spectral evenness. The results indicate that temporal patterns in spectral diversity were driven primarily by soil properties and weather, with limited evidence that fire altered spectral evenness or β-diversity across soils. In contrast, spectral indices showed clearer—but still soil-dependent—fire effects: declines in canopy structure, greenness, and chlorophyll content were less pronounced in burned areas, indicating that fire partially moderated late-season senescence. Fire had a substantial influence on spatial patterns of spectral evenness (but not β-diversity) and vegetation spectral functional traits, and fire and dry-down increased spatial heterogeneity in spectral evenness and in spectral indices indicative of biophysical and biochemical traits across scales. These findings demonstrate that environmental drivers, particularly soil–moisture interactions and interannual moisture variability, exert a stronger control over post-fire spectral diversity than fire alone. Hyperspectral imaging effectively captured these dynamics, supporting its role in monitoring post-fire vegetation responses. In addition to the use of hyperspectral imaging, fire management strategies should consider broader ecological drivers, including soil and weather interactions, to improve the assessments of ecosystem resilience and recovery. Full article

The use of aircraft for cloud seeding to enhance rainfall serves as an effective meteorological intervention and plays a vital role in ensuring ecological security within the context of the low-altitude economy. This study utilized ground-based precipitation observations from the Shiyang River Basin, in conjunction with Landsat satellite remote sensing imagery (2000–2024), regional historical regression, vegetation index retrieval, and spectral mixture analysis, to evaluate the effectiveness of aircraft-based cloud seeding for enhancing rainfall. The normalized difference vegetation index and the fraction of vegetation cover were calculated to examine the spatiotemporal dynamics and growth patterns of surface vegetation before and after the implementation of this rainfall enhancement measure, thus offering a quantitative assessment of the ecological restoration effect in the Shiyang River Basin. A novel application of cloud-seeding technology for ecological recovery has been developed. It provides one of the first quantitative assessments of aircraft-based cloud seeding in inland river basins of China, linking meteorological intervention directly to measurable ecological restoration outcomes. The findings indicate that: (1) Aircraft-based cloud seeding for rainfall enhancement has yielded significant results, with an average relative precipitation increase of 20.8% (p < 0.1%) in the operational area; (2) Following the commencement of this rainfall enhancement practice in 2010, normalized difference vegetation index and fraction of vegetation cover values within the study area have shown a marked increase, with the percentage of regions with low vegetation coverage declining from 30.36% to 25.21%; and (3) Since the implementation of this measure in 2010, vegetation conditions in the Shiyang River Basin have generally stabilized, demonstrating substantial improvement and a reduction in degradation. The percentage of regions classified as improved or slightly improved increased significantly, from 14.20% before the implementation of this measure to 36.24%, indicating a transition in the vegetation ecosystem from localized enhancement to overall improvement. These results demonstrate that ecological restoration efforts in the Shiyang River Basin have shown considerable improvement after the introduction of aircraft-based cloud-seeding operations, resulting in significant increases in vegetation coverage throughout extensive regions of the basin. The research connects scientific results to policy and management, suggesting that low-altitude economy-based cloud seeding can play a key role in water resource management, ecological stability, and climate resilience. Full article

In the context of global climate change and rapid urbanization, the Urban Heat Island (UHI) effect has become a pressing environmental and public health concern, particularly in semiarid regions. This study evaluates the microclimatic performance of various urban design strategies aimed at enhancing thermal comfort along a densely built-up street in Van, a medium-sized city located in Turkey’s semiarid climate zone. Using ENVI-met 5.7.2, nine alternative scenarios were simulated, incorporating different configurations of vegetation cover (0%, 25%, 50%, 75%), ground surface materials, and green roof applications (0%, 25%, 50%, 75%). Physiological Equivalent Temperature (PET) and other thermal comfort indicators were assessed at multiple time intervals on the hottest summer day. Results indicate that increasing vegetation cover substantially reduces PET values, with a maximum reduction of 3.0 °C observed in the 75% vegetation scenario. While the scenario with no vegetation but light-colored pavements achieved a 1.8 °C reduction in air temperature at 2:00 p.m., the maximum PET value remained unchanged. Conversely, using dark-colored asphalt decreased the average air temperature by 1 °C and improved the thermal comfort level by reducing the PET by 0.4 °C compared to a non-vegetated scenario. The scenario with the highest overall greenery led to a 2.9 °C drop in air temperature and a 12.8 °C reduction in average PET at 2:00 p.m. compared to other scenarios. The study provides evidence-based recommendations for human-centered urban planning and advocates for the integration of microclimate simulation tools in the early stages of urban development. Full article

There is growing interest in uncrewed aircraft system (UAS) technology to supplement coastal restoration monitoring, yet it’s unclear how UAS data products compare to traditional field monitoring data that are fundamental to restoration programs. In this study, wetland vegetation classifications were generated from UAS imagery, lidar data, and supervised methods at restoration sites (LaBranche and Spanish Pass, Louisiana) and compared to traditional field survey data. Analyses examined model factors, method (maximum likelihood and random forest), data source (5- and 10-band imagery plus lidar data), and plot, on classification performance for (1) taxa richness: factors did not affect model comparisons, except for method at Spanish Pass; (2) community assemblage: LaBranche models were more similar to field data, though plot was a factor at both sites and method was a factor at Spanish Pass; (3) species presence identification: LaBranche models performed moderately better, but were species dependent; and (4) percent cover: plot was a factor at both sites, though underestimations were more frequent. Data source did not affect performance, method had variable influence on select metrics, and plots with higher taxa richness or complex canopy structure showed reduced model performance at LaBranche and Spanish Pass, respectively. Capabilities and limitations of UAS technology for wetland vegetation classification are highlighted, offering an understanding of its utility in assessing restoration outcomes related to vegetation. Full article

Mine closure by flooding initiates hydrogeological changes that affect land stability, soil moisture, and surface ecosystems, further shaped by regional climatic trends that increase pressure on water resources. This study examines the Olkusz–Pomorzany mine (Poland), flooded between 2021 and 2022, focusing on the links between groundwater rebound, land movement, and environmental transformation after closure. This analysis combines EGMS-based land movement (2018–2023), groundwater levels (2022–2024), meteorological records (1981–2024), and Sentinel-2-derived Normalized Difference Vegetation Index, Normalized Difference Water Index, and Moisture Index time series (2016–2024). Land cover changes were assessed using Sentinel-2 data for 2019–2024. Results show climate-driven subsidence of less than 1 mm/year across the area and a shift to uplift within the mining zone, with maximum groundwater rebound of 103 m in the central depression cone and uplift of up to 3.6 mm/year. Climatic water balance remained negative, with Vertical Water Exchange averaging −11.6 mm/month in 2022–2024. Hydrospectral indices indicate seasonal variability and modest increases in vegetation activity and moisture after flooding. Land cover analysis shows an expansion of surface water and wetlands where historical drainage and rebound overlap. These findings confirm that groundwater recovery is already reshaping surface conditions and highlight the need for integrated monitoring in post-mining areas. Full article

Amid China’s dual-carbon goals and widening regional disparities, land-use/cover change (LUCC)-induced volatility in carbon storage (CS) has emerged as a binding constraint on emission reduction and the low-carbon transition in resource-based regions. Yet integrated historical-scenario assessments and rigorous evidence on spatial-heterogeneity mechanisms remain limited, which hampers targeted spatial governance. Using Shanxi Province, a resource-based province, as the study area, this study develops a coupled PLUS-InVEST framework under SSP-RCP scenarios. It integrates spatial autocorrelation, geographically weighted regression (GWR), and structural equation modeling (SEM) to characterize spatiotemporal responses of CS to LUCC and to identify underlying drivers. The results indicate that: (1) Regional CS follows an inverted U-shaped trajectory, initially increasing due to ecological restoration projects and subsequently declining owing to industrial development and urban expansion; (2) By 2030, forestland expansion under SSP126 is projected to enhance CS, whereas accelerated urbanization under SSP585 is expected to intensify CS losses; (3) Significant spatial clustering of CS remains consistent from historical periods to future projections, underscoring its sensitivity to topography, vegetation patterns, and human activities; and (4) CS is jointly shaped by natural and anthropogenic drivers, with DEM and slope providing stable protection, while population density and transport-network configuration cause ongoing disturbances. The study provides an integrated historical-scenario assessment and reveals the underlying mechanisms for resource-based regions, offering quantitative evidence to support optimization of the Ecological Conservation Redline, managing urban growth boundaries, and implementing zoned ecological restoration. Full article

Since 2009, China has implemented two important place-based policies to promote e-commerce development in selected cities: “Building National E-commerce Demonstration Cities” and “Comprehensive Pilot Zones for Cross-Border E-commerce”. Previous studies reported that these two e-commerce development policies generated local environmental benefits by reducing air pollution and carbon emissions in the policy implementation areas. However, whether these policies have spatial spillover effects on environmental quality in other regions and the extent of such effects have not been sufficiently analyzed. This study aims to empirically assess the environmental spatial spillover effects of these two policies. Based on panel data from 221 prefecture-level cities in China from 2000 to 2021, this study utilizes a spatial econometric regression method to evaluate the policy effects. The study yields three main findings. (1) The policies significantly reduced air pollution concentrations and carbon emissions while increasing vegetation greenness in non-policy implementation areas. Specifically, the policies led to reductions in carbon monoxide (CO), nitrogen dioxide (NO₂), fine particulate matter (PM_2.5), sulfur dioxide (SO₂), and the emissions of carbon dioxide (CO₂), as well as increases in the fractional vegetation cover (FVC), normalized difference vegetation index (NDVI), and net primary productivity (NPP). Our findings indicate that the environmental effects of e-commerce development policies extend beyond the policy-implementing areas. (2) Further heterogeneity tests reveal that the beneficial spatial spillover impacts of e-commerce development policies were observed in cities with different geographical locations, servicification levels, economic scale, and population densities. (3) Mechanism analysis shows that although the policies did not alter the environmental regulation stringency in non-policy regions, they promoted industrial structure upgrading, technological advancement, and green innovation in these areas, thereby explaining the detected spatial spillover effects. Full article