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Keywords = tube MPC

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15 pages, 2356 KiB  
Article
Tube-Based Robust Model Predictive Control for Autonomous Vehicle with Complex Road Scenarios
by Yang Chen, Youping Sun, Junming Li, Jiangmei He and Chengwei He
Appl. Sci. 2025, 15(12), 6471; https://doi.org/10.3390/app15126471 - 9 Jun 2025
Viewed by 563
Abstract
This study proposes a Tube-based Robust Model Predictive Control (Tube-RMPC) strategy for autonomous vehicle control to address model parameter uncertainties and variations in road–tire adhesion coefficients in complex road scenarios. More specifically, the proposed approach improves the representation of vehicle dynamic behavior by [...] Read more.
This study proposes a Tube-based Robust Model Predictive Control (Tube-RMPC) strategy for autonomous vehicle control to address model parameter uncertainties and variations in road–tire adhesion coefficients in complex road scenarios. More specifically, the proposed approach improves the representation of vehicle dynamic behavior by introducing a unified vehicle–tire modeling framework. To facilitate computational tractability and algorithmic implementation, the model is systematically linearized and discretized. Furthermore, the Tube-based Robust Model Predictive Control strategy is developed to improve adaptability to uncertainty in the road surface adhesion coefficient. The Tube-based Robust Model Predictive controller ensures robustness by establishing a robust invariant tube around the nominal trajectory, effectively mitigating road surface variations and enhancing stability. Finally, a co-simulation platform integrating CarSim and Simulink is employed to validate the proposed method’s effectiveness. The experimental results demonstrate that Tube-RMPC improves the path-tracking performance, reducing the maximum tracking error by up to 9.17% on an S-curve and 2.25% in a double lane change, while significantly lowering RMSE and enhancing yaw stability compared to MPC and PID. Full article
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23 pages, 3921 KiB  
Article
Optimization of Renewable Energy Frequency Regulation Processes Considering Spatiotemporal Power Fluctuations
by Xiangli Deng and Congying Chen
Processes 2025, 13(4), 1225; https://doi.org/10.3390/pr13041225 - 17 Apr 2025
Viewed by 312
Abstract
Active frequency response (AFR) plays a crucial role in addressing the challenge of insufficient frequency regulation caused by the spatiotemporal distribution of power grid frequency. However, power fluctuations in renewable energy sources impact the frequency regulation performance of renewable energy units participating in [...] Read more.
Active frequency response (AFR) plays a crucial role in addressing the challenge of insufficient frequency regulation caused by the spatiotemporal distribution of power grid frequency. However, power fluctuations in renewable energy sources impact the frequency regulation performance of renewable energy units participating in AFR, and there is a lack of systematic assessment of their frequency regulation capabilities. This paper proposes a process-optimized AFR method for renewable energy based on distributed model predictive control (DMPC) using tube and robust control barrier functions (RCBF). The method integrates tube MPC for renewable energy units in fault regions and constrains control parameters in normal regions using RCBF, forming an enhanced DMPC-based coordination process for interconnected systems. This optimization ensures that both conventional and renewable energy units can effectively perform AFR under fluctuating renewable energy conditions. Furthermore, within the AFR online decision-making process, the optimal deloading rate for renewable energy is determined to maintain sufficient power reserves and frequency regulation capabilities. Finally, simulations of an interconnected system with a high proportion of renewable energy validate the effectiveness of this process-driven approach in enhancing the AFR capabilities of renewable energy sources. Full article
(This article belongs to the Section Energy Systems)
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23 pages, 1194 KiB  
Article
A Data-Driven Approach to Set-Theoretic Model Predictive Control for Nonlinear Systems
by Francesco Giannini and Domenico Famularo
Information 2024, 15(7), 369; https://doi.org/10.3390/info15070369 - 23 Jun 2024
Cited by 4 | Viewed by 2506
Abstract
In this paper, we present a data-driven model predictive control (DDMPC) framework specifically designed for constrained single-input single-output (SISO) nonlinear systems. Our approach involves customizing a set-theoretic receding horizon controller within a data-driven context. To achieve this, we translate model-based conditions into data [...] Read more.
In this paper, we present a data-driven model predictive control (DDMPC) framework specifically designed for constrained single-input single-output (SISO) nonlinear systems. Our approach involves customizing a set-theoretic receding horizon controller within a data-driven context. To achieve this, we translate model-based conditions into data series of available input and output signals. This translation process leverages recent advances in data-driven control theory, enabling the controller to operate effectively without relying on explicit system models. The proposed framework incorporates a robust methodology for managing system constraints, ensuring that the control actions remain within predefined bounds. By means of time sequences, the controller learns the underlying system dynamics and adapts to changes in real time, providing enhanced performance and reliability. The integration of set-theoretic methods allows for the systematic handling of uncertainties and disturbances, which are common when the trajectory of a nonlinear system is embedded inside a linear trajectory state tube. To validate the effectiveness of our DDMPC framework, we conduct extensive simulations on a nonlinear DC motor system. The results demonstrate significant improvements in control performance, highlighting the robustness and adaptability of our approach compared to traditional model-based MPC techniques. Full article
(This article belongs to the Special Issue Second Edition of Predictive Analytics and Data Science)
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29 pages, 7167 KiB  
Article
A Tube-Based Model Predictive Control for Path Tracking of Autonomous Articulated Vehicle
by Taeyeon Lee and Yonghwan Jeong
Actuators 2024, 13(5), 164; https://doi.org/10.3390/act13050164 - 1 May 2024
Cited by 6 | Viewed by 3116
Abstract
This paper presents tube-based Model Predictive Control (MPC) for the path and velocity tracking of an autonomous articulated vehicle. The target platform of this study is an autonomous articulated vehicle with a non-steerable axle. Consequently, the articulation angle and wheel torque input are [...] Read more.
This paper presents tube-based Model Predictive Control (MPC) for the path and velocity tracking of an autonomous articulated vehicle. The target platform of this study is an autonomous articulated vehicle with a non-steerable axle. Consequently, the articulation angle and wheel torque input are determined by the tube-based MPC. The proposed MPC aims to achieve two objectives: minimizing path tracking error and enhancing robustness to disturbances. Furthermore, the lateral stability of the autonomous articulated vehicle is considered to reflect its dynamic characteristics. The vehicle model for the MPC is formulated using local linearization to minimize modeling errors. The reference state is determined using a virtual controller based on the linear quadratic regulator to provide the optimal reference for the MPC solver. The proposed algorithm was evaluated through a simulation study with base algorithms under noise injection into the sensor signal. Simulation results demonstrate that the proposed algorithm achieved the smallest path tracking error, compared to the base algorithms. Additionally, the proposed algorithm demonstrated robustness to external noise for multiple signals. Full article
(This article belongs to the Special Issue Integrated Intelligent Vehicle Dynamics and Control)
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16 pages, 3705 KiB  
Article
A Tube Linear Model Predictive Control Approach for Autonomous Vehicles Subjected to Disturbances
by Jianqiao Chen and Guofu Tian
Appl. Sci. 2024, 14(7), 2793; https://doi.org/10.3390/app14072793 - 27 Mar 2024
Cited by 1 | Viewed by 1693
Abstract
The path tracking performance of autonomous vehicles is degraded by common disturbances, especially those that affect the safety of autonomous vehicles (AVs) in obstacle avoidance conditions. To improve autonomous vehicle tracking performances and their computational efficiency when subjected to common disturbances, this paper [...] Read more.
The path tracking performance of autonomous vehicles is degraded by common disturbances, especially those that affect the safety of autonomous vehicles (AVs) in obstacle avoidance conditions. To improve autonomous vehicle tracking performances and their computational efficiency when subjected to common disturbances, this paper proposes a tube linear model predictive controller (MPC) framework for autonomous vehicles. A bicycle vehicle dynamics model is developed and employed in the tube MPC control design in the proposed framework. A robust invariant set is calculated with an efficient linear programming (LP) method, and it is used to guarantee that the constraints are satisfied under common disturbance conditions. The results show that the computational cost of robust positively invariant sets that are constructed by the LP method is much less than that obtained by the traditional method. In addition, all the trajectories of the tube linear MPC successfully avoided obstacles when under disturbance conditions, but only about 80% of the trajectories obtained with the traditional MPC successfully avoided obstacles under disturbance conditions. The proposed framework is effective. Full article
(This article belongs to the Special Issue Mobile Robotics and Autonomous Intelligent Systems)
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19 pages, 2768 KiB  
Article
Tube-Based Event-Triggered Path Tracking for AUV against Disturbances and Parametric Uncertainties
by Yuheng Chen and Yougang Bian
Electronics 2023, 12(20), 4248; https://doi.org/10.3390/electronics12204248 - 13 Oct 2023
Cited by 5 | Viewed by 1797
Abstract
In order to enhance the performance of disturbance rejection in AUV’s path tracking, this paper proposes a novel tube-based event-triggered path-tracking strategy. The proposed tracking strategy consists of a speed control law and an event-triggered tube model predictive control (tube MPC) scheme. Firstly, [...] Read more.
In order to enhance the performance of disturbance rejection in AUV’s path tracking, this paper proposes a novel tube-based event-triggered path-tracking strategy. The proposed tracking strategy consists of a speed control law and an event-triggered tube model predictive control (tube MPC) scheme. Firstly, the speed control law using linear model predictive control (LMPC) technology is obtained to converge the nominal path-tracking deviation. Secondly, the event-triggered tube MPC scheme is used to calculate the optimal control input, which can enhance the performance of disturbance rejection. Considering the nonlinear hydrodynamic characteristics of AUV, a linear matrix inequality (LMI) is formulated to obtain tight constraints on the AUV and the feedback matrix. Moreover, to enhance real-time performance, tight constraints and the feedback matrix are all calculated offline. An event-triggering mechanism is used. When the surge speed change command does not exceed the upper bound, adaptive tight constraints are obtained. Finally, numerical simulation results show that the proposed tube-based event-triggered path-tracking strategy can enhance the performance of disturbance rejection and ensure good real-time performance. Full article
(This article belongs to the Special Issue Recent Advances in Motion Planning and Control of Autonomous Vehicles)
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22 pages, 5822 KiB  
Article
Constrained DNN-Based Robust Model Predictive Control Scheme with Adjustable Error Tube
by Shizhong Yang, Yanli Liu and Huidong Cao
Symmetry 2023, 15(10), 1845; https://doi.org/10.3390/sym15101845 - 29 Sep 2023
Viewed by 1328
Abstract
This paper proposes a novel robust model predictive control (RMPC) scheme for constrained linear discrete-time systems with bounded disturbance. Firstly, the adjustable error tube set, which is affected by local error and error variety rate, is introduced to overcome uncertainties and disturbances. Secondly, [...] Read more.
This paper proposes a novel robust model predictive control (RMPC) scheme for constrained linear discrete-time systems with bounded disturbance. Firstly, the adjustable error tube set, which is affected by local error and error variety rate, is introduced to overcome uncertainties and disturbances. Secondly, the auxiliary control rate associated with the cost function is designed to minimize the discrepancy between the actual system and the nominal system. Finally, a constrained deep neural network (DNN) architecture with symmetry properties is developed to address the optimal control problem (OCP) within the constrained system while conducting a thorough convergence analysis. These innovations enable more flexible adjustments of state and control tube cross-sections and significantly improve optimization speed compared to the homothetic tube MPC. Moreover, the effectiveness and practicability of the proposed optimal control strategy are illustrated by two numerical simulations. In practical terms, for 2-D systems, this approach achieves a remarkable 726.23-fold improvement in optimization speed, and for 4-D problems, it demonstrates an even more impressive 7218.07-fold enhancement. Full article
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19 pages, 11347 KiB  
Article
A Polishing Processes Optimization Method for Ring-Pendulum Double-Sided Polisher
by Shuning Liang, Bo Xiao, Chunyang Wang, Lin Wang and Zishuo Wang
Appl. Sci. 2023, 13(13), 7893; https://doi.org/10.3390/app13137893 - 5 Jul 2023
Cited by 1 | Viewed by 1370
Abstract
This paper presents an optimization method that aims to mitigate disturbances in the radial-feed system of the ring-pendulum double-sided polisher (RDP) during processing. We built a radial-feed system model of an RDP and developed a single-tube robust model predictive control system to enhance [...] Read more.
This paper presents an optimization method that aims to mitigate disturbances in the radial-feed system of the ring-pendulum double-sided polisher (RDP) during processing. We built a radial-feed system model of an RDP and developed a single-tube robust model predictive control system to enhance the disturbance rejection capability of the radial-feed system. To constrain the system states inside the terminal constraint set and further enhance the system’s robustness, we added the ε-approximation to approach the single-tube terminal constraint set. Finally, the effectiveness of the proposed method for the RDP radial-feed system was verified through simulations and experiments. These findings demonstrate the potential of the proposed method for improving the performance of the RDP radial-feed system in practical applications. The polish processing results demonstrated a substantial improvement in the accuracy of the surface shape measurements obtained by applying the STRMPC method. Compared to the MPC method, the PV value decreased from 1.49 λ PV to 0.99 λ PV, indicating an improvement in the convergence rate of approximately 9.78%. Additionally, the RMS value decreased from 0.257 λ RMS to 0.163 λ RMS, demonstrating a remarkable 35.6% enhancement in the convergence rate. Full article
(This article belongs to the Special Issue Advanced Manufacturing and Precision Machining)
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23 pages, 1524 KiB  
Article
A Tube Model Predictive Control Method for Autonomous Lateral Vehicle Control Based on Sliding Mode Control
by Yong Dai and Duo Wang
Sensors 2023, 23(8), 3844; https://doi.org/10.3390/s23083844 - 9 Apr 2023
Cited by 7 | Viewed by 3614
Abstract
This paper aims to enhance the lateral path tracking control of autonomous vehicles (AV) in the presence of external disturbances. While AV technology has made significant strides, real-world driving scenarios often pose challenges such as slippery or uneven roads, which can adversely affect [...] Read more.
This paper aims to enhance the lateral path tracking control of autonomous vehicles (AV) in the presence of external disturbances. While AV technology has made significant strides, real-world driving scenarios often pose challenges such as slippery or uneven roads, which can adversely affect the lateral path tracking control and reduce driving safety and efficiency. Conventional control algorithms struggle to address this issue due to their inability to account for unmodeled uncertainties and external disturbances. To tackle this problem, this paper proposes a novel algorithm that combines robust sliding mode control (SMC) and tube model predictive control (MPC). The proposed algorithm leverages the strengths of both MPC and SMC. Specifically, MPC is used to derive the control law for the nominal system to track the desired trajectory. The error system is then employed to minimize the difference between the actual state and the nominal state. Finally, the sliding surface and reaching law of SMC are utilized to derive an auxiliary tube SMC control law, which helps the actual system keep up with the nominal system and achieve robustness. Experimental results demonstrate that the proposed method outperforms conventional tube MPC, linear quadratic regulator (LQR) algorithms, and MPC in terms of robustness and tracking accuracy, especially in the presence of unmodeled uncertainties and external disturbances. Full article
(This article belongs to the Special Issue Rehabilitation Robots: Design, Development, and Control)
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23 pages, 8373 KiB  
Article
Model Predictive Control of Parabolic PDE Systems under Chance Constraints
by Ruslan Voropai, Abebe Geletu and Pu Li
Mathematics 2023, 11(6), 1372; https://doi.org/10.3390/math11061372 - 12 Mar 2023
Cited by 2 | Viewed by 2628
Abstract
Model predictive control (MPC) heavily relies on the accuracy of the system model. Nevertheless, process models naturally contain random parameters. To derive a reliable solution, it is necessary to design a stochastic MPC. This work studies the chance constrained MPC of systems described [...] Read more.
Model predictive control (MPC) heavily relies on the accuracy of the system model. Nevertheless, process models naturally contain random parameters. To derive a reliable solution, it is necessary to design a stochastic MPC. This work studies the chance constrained MPC of systems described by parabolic partial differential equations (PDEs) with random parameters. Inequality constraints on time- and space-dependent state variables are defined in terms of chance constraints. Using a discretization scheme, the resulting high-dimensional chance constrained optimization problem is solved by our recently developed inner–outer approximation which renders the problem computationally amenable. The proposed MPC scheme automatically generates probability tubes significantly simplifying the derivation of feasible solutions. We demonstrate the viability and versatility of the approach through a case study of tumor hyperthermia cancer treatment control, where the randomness arises from the thermal conductivity coefficient characterizing heat flux in human tissue. Full article
(This article belongs to the Special Issue Stochastic Control Systems: Theory and Applications)
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11 pages, 6587 KiB  
Article
Experimental Study of RF–Plasma Interaction Using a Low-Pressure DC Glow Discharge Tube for MPC
by Asif Mehmood Khan, Muhammad Mansoor Ahmed and Umair Rafique
Electronics 2023, 12(3), 551; https://doi.org/10.3390/electronics12030551 - 20 Jan 2023
Cited by 1 | Viewed by 3637
Abstract
This paper aims to perform experimental validation of RF–plasma interaction behaviors for the purposes of wave transmission and reflection. Wave reflection from plasma is of interest as it finds applications in pulse compression and RF polarizer-based systems. Simulations are performed using a combination [...] Read more.
This paper aims to perform experimental validation of RF–plasma interaction behaviors for the purposes of wave transmission and reflection. Wave reflection from plasma is of interest as it finds applications in pulse compression and RF polarizer-based systems. Simulations are performed using a combination of Magic3D and COMSOL multiphysics to characterize the plasma–wave interaction and discharge tube properties. The goal is to generate plasma with characteristics that wholly reflect the incident electromagnetic wave. A glass tube of inner diameter 22 mm and length 100 mm, with 12 mm brass electrodes, is fabricated for plasma generation. Argon-based DC glow discharge is sustained at 500 volts at a pressure of 3.8 Torr. Plasma density is calculated to be 2.529×1019 m3, with a corresponding plasma frequency of 7.18 GHz. Due to this higher frequency, a 3 GHz incident RF wave is reflected, as measured through S-parameter measurements using a network analyzer. Off and on states of the tube correspond to S11=40 dB and S11=13 dB, which show wave transmission and reflection, respectively. When the plasma column is ignited, the reflected wave has a phase difference of 180. Full article
(This article belongs to the Special Issue Advanced RF, Microwave Engineering, and High-Power Microwave Sources)
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16 pages, 6017 KiB  
Article
Synthesis and Electrochemical Performance of Microporous Hollow Carbon from Milkweed Pappus as Cathode Material of Lithium–Sulfur Batteries
by Jun-Ki Kim, Yunju Choi, Euh Duck Jeong, Sei-Jin Lee, Hyun Gyu Kim, Jae Min Chung, Jeom-Soo Kim, Sun-Young Lee and Jong-Seong Bae
Nanomaterials 2022, 12(20), 3605; https://doi.org/10.3390/nano12203605 - 14 Oct 2022
Cited by 4 | Viewed by 2001
Abstract
Microtube-like porous carbon (MPC) and tube-like porous carbon–sulfur (MPC-S) composites were synthesized by carbonizing milkweed pappus with sulfur, and they were used as cathodes for lithium–sulfur batteries. The morphology and uniformity of these materials were characterized using X-ray powder diffraction, Raman spectroscopy, scanning [...] Read more.
Microtube-like porous carbon (MPC) and tube-like porous carbon–sulfur (MPC-S) composites were synthesized by carbonizing milkweed pappus with sulfur, and they were used as cathodes for lithium–sulfur batteries. The morphology and uniformity of these materials were characterized using X-ray powder diffraction, Raman spectroscopy, scanning electron microscopy, transmission electron microscopy with an energy-dispersive X-ray analyzer, thermogravimetric analysis, and X-ray photoelectron spectrometry. The electrochemical performance of the MPC-S cathodes was measured using the charge/discharge cycling performance, C rate, and AC impedance. The composite cathodes with 93.8 wt.% sulfur exhibited a stable specific capacity of 743 mAh g−1 after 200 cycles at a 0.5 C. Full article
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24 pages, 3950 KiB  
Article
Control of Heat Transfer in a Vertical Ground Heat Exchanger for a Geothermal Heat Pump System
by Khaled Salhein, C. J. Kobus and Mohamed Zohdy
Energies 2022, 15(14), 5300; https://doi.org/10.3390/en15145300 - 21 Jul 2022
Cited by 11 | Viewed by 5511
Abstract
This paper presents a mathematical model of heat transfer behavior between the liquid inside vertical underground geothermal pipes and the surrounding ground for heating (in the winter) and cooling (in the summer) modes in a ground heat exchanger (GHE) that can optimize its [...] Read more.
This paper presents a mathematical model of heat transfer behavior between the liquid inside vertical underground geothermal pipes and the surrounding ground for heating (in the winter) and cooling (in the summer) modes in a ground heat exchanger (GHE) that can optimize its output temperature. The GHE’s output temperature reaches the appropriate value when the water velocity is lowered enough. Subsequently, the proposed model was applied to a case study of a 400-ton geothermal heat pump system (GHPS) at Oakland University, in both the heating and cooling modes, to assess its validity and improve the GHE’s performance. The model was implemented in MATLAB using an ordinary differential equation (ODE) solver. Four different water velocities were used to demonstrate the significant effect of velocity on the loop exit temperature. Model predictive control (MPC) was designed to optimize the GHE’s output temperature by controlling the water velocity, which could reduce the energy consumption used for heat and water circulating pumps. The results reveal that the acceptable range of the water velocity for Oakland University’s GHE was between 0.35 and 0.45 m/s, which ensured that the heat pump system delivered the proper temperature to provide the Human Health Building (HHB) with a comfortable temperature regardless of the season. The suggested water velocity ranges in vertical single U-tube pipes with diameters of De 25 mm, De 32 mm, and De 40 mm are between 0.33 and 0.43 m/s, 0.35 to 0.45 m/s, and 0.38 to 0.48 m/s, respectively. Full article
(This article belongs to the Topic Geothermal Energy Technology and Current Status)
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26 pages, 21160 KiB  
Article
Hysteretic Behavior on Asymmetrical Composite Joints with Concrete-Filled Steel Tube Columns and Unequal High Steel Beams
by Jing Ji, Wen Zeng, Liangqin Jiang, Wen Bai, Hongguo Ren, Qingru Chai, Lei Zhang, Hongtao Wang, Yunhao Li and Lingjie He
Symmetry 2021, 13(12), 2381; https://doi.org/10.3390/sym13122381 - 10 Dec 2021
Cited by 6 | Viewed by 2687
Abstract
In order to acquire the hysteretic behavior of the asymmetrical composite joints with concrete-filled steel tube (CFST) columns and unequal high steel beams, 36 full-scale composite joints were designed, and the CFST hoop coefficient (ξ), axial compression ratio (n0 [...] Read more.
In order to acquire the hysteretic behavior of the asymmetrical composite joints with concrete-filled steel tube (CFST) columns and unequal high steel beams, 36 full-scale composite joints were designed, and the CFST hoop coefficient (ξ), axial compression ratio (n0), concrete cube compressive strength (fcuk), steel tube strength (fyk), beam, and column section size were taken as the main control parameters. Based on nonlinear constitutive models of concrete and the double broken-line stress-hardening constitutive model of steel, and by introducing the symmetric contact element and multi-point constraint (MPC), reduced-scale composite joints were simulated by ABAQUS software. By comparing with the test curves, the rationality of the modeling method was verified. The influence of various parameters on the seismic performance of the full-scale asymmetrical composite joints was investigated. The results show that with the increasing of fcuk, the peak load (Pmax) and ductility of the specimens gradually increased. With the increasing of n0, the Pmax of the specimens gradually increases firstly and then gradually decreases after reaching a peak point. The composite joints have good energy dissipation capacity and the characteristic of stiffness degradation. The oblique struts force mechanism in the full-scale asymmetrical composite joint domain is proposed. By introducing influence coefficients (ξ1 and ξ2), the expression of shear bearing capacity of composite joints is obtained by statistical regression, which can provide theoretical support for the seismic design of asymmetrical composite joints. Full article
(This article belongs to the Special Issue Symmetry in Applied Mechanics Analysis on Smart Optical Fiber Sensors)
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15 pages, 2645 KiB  
Article
The Grafting of Multifunctional Antithrombogenic Chemical Networks on Polyurethane Intravascular Catheters
by Yael Roth and Dan Y. Lewitus
Polymers 2020, 12(5), 1131; https://doi.org/10.3390/polym12051131 - 15 May 2020
Cited by 9 | Viewed by 3674
Abstract
Intravascular catheters (IVCs) and other medical tubing are commonly made of polymeric materials such as polyurethane (PU). Polymers tend to be fouled by surface absorption of proteins and platelets, often resulting in the development of bacterial infections and thrombosis during catheterization, which can [...] Read more.
Intravascular catheters (IVCs) and other medical tubing are commonly made of polymeric materials such as polyurethane (PU). Polymers tend to be fouled by surface absorption of proteins and platelets, often resulting in the development of bacterial infections and thrombosis during catheterization, which can lead to embolism and death. Existing solutions to fouling are based on coating the IVCs with hydrophilic, anti-thrombogenic, or antimicrobial materials. However, the delamination of the coatings themselves is associated with significant morbidity, as reported by the United States Food and Drug Administration (FDA). We developed a lubricious, antimicrobial, and antithrombogenic coating complex, which can be covalently attached to the surface of industrial PU catheters. The coating complex is pre-synthesized and comprises 2-methacryloyloxyethyl phosphorylcholine (MPC) as an antifouling agent, covalently attached to branched polyethyleneimine (bPEI) as a lubricating agent. The two-step coating procedure involves PU-amine surface activation using a diisocyanate, followed by chemical grafting of the bPEI-S-MPC complex. Compared with neat PU, the coating was found to reduce the coefficient of friction of the IVC surface by 30% and the hemolysis ratio by more than 50%. Moreover, the coating exhibited a significant antimicrobial activity under JIS Z2801:2000 standard compared with neat PU. Finally, in in-vivo acute rabbit model studies, the coating exhibited significant antithrombogenic properties, reducing the thrombogenic potential to a score of 1.3 on coated surfaces compared with 3.3 on uncoated surfaces. The materials and process developed could confer lubricious, antithrombogenic, and antimicrobial properties on pre-existing PU-based catheters. Full article
(This article belongs to the Special Issue Hybrid Adhesive and Coatings for Medical Applications)
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