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32 pages, 9710 KiB  
Article
Early Detection of ITSC Faults in PMSMs Using Transformer Model and Transient Time-Frequency Features
by Ádám Zsuga and Adrienn Dineva
Energies 2025, 18(15), 4048; https://doi.org/10.3390/en18154048 - 30 Jul 2025
Viewed by 248
Abstract
Inter-turn short-circuit (ITSC) faults in permanent magnet synchronous machines (PMSMs) present a significant reliability challenge in electric vehicle (EV) drivetrains, particularly under non-stationary operating conditions characterized by inverter-driven transients, variable loads, and magnetic saturation. Existing diagnostic approaches, including motor current signature analysis (MCSA) [...] Read more.
Inter-turn short-circuit (ITSC) faults in permanent magnet synchronous machines (PMSMs) present a significant reliability challenge in electric vehicle (EV) drivetrains, particularly under non-stationary operating conditions characterized by inverter-driven transients, variable loads, and magnetic saturation. Existing diagnostic approaches, including motor current signature analysis (MCSA) and wavelet-based methods, are primarily designed for steady-state conditions and rely on manual feature selection, limiting their applicability in real-time embedded systems. Furthermore, the lack of publicly available, high-fidelity datasets capturing the transient dynamics and nonlinear flux-linkage behaviors of PMSMs under fault conditions poses an additional barrier to developing data-driven diagnostic solutions. To address these challenges, this study introduces a simulation framework that generates a comprehensive dataset using finite element method (FEM) models, incorporating magnetic saturation effects and inverter-driven transients across diverse EV operating scenarios. Time-frequency features extracted via Discrete Wavelet Transform (DWT) from stator current signals are used to train a Transformer model for automated ITSC fault detection. The Transformer model, leveraging self-attention mechanisms, captures both local transient patterns and long-range dependencies within the time-frequency feature space. This architecture operates without sequential processing, in contrast to recurrent models such as LSTM or RNN models, enabling efficient inference with a relatively low parameter count, which is advantageous for embedded applications. The proposed model achieves 97% validation accuracy on simulated data, demonstrating its potential for real-time PMSM fault detection. Additionally, the provided dataset and methodology contribute to the facilitation of reproducible research in ITSC diagnostics under realistic EV operating conditions. Full article
(This article belongs to the Special Issue Application of Artificial Intelligence in Power and Energy Systems)
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39 pages, 13464 KiB  
Article
Micro-Doppler Signal Features of Idling Vehicle Vibrations: Dependence on Gear Engagements and Occupancy
by Ram M. Narayanan, Benjamin D. Simone, Daniel K. Watson, Karl M. Reichard and Kyle A. Gallagher
Signals 2025, 6(3), 35; https://doi.org/10.3390/signals6030035 - 24 Jul 2025
Viewed by 338
Abstract
This study investigates the use of a custom-built 10 GHz continuous wave micro-Doppler radar system to analyze external vibrations of idling vehicles under various conditions. Scenarios included different gear engagements with one occupant and parked gear with up to four occupants. Motivated by [...] Read more.
This study investigates the use of a custom-built 10 GHz continuous wave micro-Doppler radar system to analyze external vibrations of idling vehicles under various conditions. Scenarios included different gear engagements with one occupant and parked gear with up to four occupants. Motivated by security concerns, such as the threat posed by idling vehicles with multiple occupants, the research explores how micro-Doppler signatures can indicate vehicle readiness to move. Experiments focused on a mid-size SUV, with similar trends seen in other vehicles. Radar data were compared to in situ accelerometer measurements, confirming that the radar system can detect subtle frequency changes, especially during gear shifts. The system’s sensitivity enables it to distinguish variations tied to gear state and passenger load. Extracted features like frequency and magnitude show strong potential for use in machine learning models, offering a non-invasive, remote sensing method for reliably identifying vehicle operational states and occupancy levels in security or monitoring contexts. Spectrogram and PSD analyses reveal consistent tonal vibrations around 30 Hz, tied to engine activity, with harmonics at 60 Hz and 90 Hz. Gear shifts produce impulse signatures primarily below 20 Hz, and transient data show distinct peaks at 50, 80, and 100 Hz. Key features at 23 Hz and 45 Hz effectively indicate engine and gear states. Radar and accelerometer data align well, supporting the potential for remote sensing and machine learning-based classification. Full article
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17 pages, 4206 KiB  
Article
Influence of Particle Size on the Dynamic Non-Equilibrium Effect (DNE) of Pore Fluid in Sandy Media
by Yuhao Ai, Zhifeng Wan, Han Xu, Yan Li, Yijia Sun, Jingya Xi, Hongfan Hou and Yihang Yang
Water 2025, 17(14), 2115; https://doi.org/10.3390/w17142115 - 16 Jul 2025
Viewed by 259
Abstract
The dynamic non-equilibrium effect (DNE) describes the non-unique character of saturation–capillary pressure relationships observed under static, steady-state, or monotonic hydrodynamic conditions. Macroscopically, the DNE manifests as variations in soil hydraulic characteristic curves arising from varying hydrodynamic testing conditions and is fundamentally governed by [...] Read more.
The dynamic non-equilibrium effect (DNE) describes the non-unique character of saturation–capillary pressure relationships observed under static, steady-state, or monotonic hydrodynamic conditions. Macroscopically, the DNE manifests as variations in soil hydraulic characteristic curves arising from varying hydrodynamic testing conditions and is fundamentally governed by soil matrix particle size distribution. Changes in the DNE across porous media with discrete particle size fractions are investigated via stepwise drying experiments. Through quantification of saturation–capillary pressure hysteresis and DNE metrics, three critical signatures are identified: (1) the temporal lag between peak capillary pressure and minimum water saturation; (2) the pressure gap between transient and equilibrium states; and (3) residual water saturation. In the four experimental sets, with the finest material (Test 1), the peak capillary pressure consistently precedes the minimum water saturation by up to 60 s. Conversely, with the coarsest material (Test 4), peak capillary pressure does not consistently precede minimum saturation, with a maximum lag of only 30 s. The pressure gap between transient and equilibrium states reached 14.04 cm H2O in the finest sand, compared to only 2.65 cm H2O in the coarsest sand. Simultaneously, residual water saturation was significantly higher in the finest sand (0.364) than in the coarsest sand (0.086). The results further reveal that the intensity of the DNE scales inversely with particle size and linearly with wetting phase saturation (Sw), exhibiting systematic decay as Sw decreases. Coarse media exhibit negligible hysteresis due to suppressed capillary retention; this is in stark contrast with fine sands, in which the DNE is observed to persist in advanced drying stages. These results establish pore geometry and capillary dominance as fundamental factors controlling non-equilibrium fluid dynamics, providing a mechanistic framework for the refinement of multi-phase flow models in heterogeneous porous systems. Full article
(This article belongs to the Section Soil and Water)
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19 pages, 4441 KiB  
Article
Short-Term Probiotic Colonization Alters Molecular Dynamics of 3D Oral Biofilms
by Nadeeka S. Udawatte, Chun Liu, Reuben Staples, Pingping Han, Purnima S. Kumar, Thiruma V. Arumugam, Sašo Ivanovski and Chaminda J. Seneviratne
Int. J. Mol. Sci. 2025, 26(13), 6403; https://doi.org/10.3390/ijms26136403 - 3 Jul 2025
Viewed by 493
Abstract
Three-dimensional (3D) scaffold systems have proven instrumental in advancing our understanding of polymicrobial biofilm dynamics and probiotic interactions within the oral environment. Among oral probiotics, Streptococcus salivarius K12 (Ssk12) has shown considerable promise in modulating microbial homeostasis; however, its long-term therapeutic [...] Read more.
Three-dimensional (3D) scaffold systems have proven instrumental in advancing our understanding of polymicrobial biofilm dynamics and probiotic interactions within the oral environment. Among oral probiotics, Streptococcus salivarius K12 (Ssk12) has shown considerable promise in modulating microbial homeostasis; however, its long-term therapeutic benefits are contingent upon successful and sustained colonization of the oral mucosa. Despite its clinical relevance, the molecular mechanisms underlying the adhesion, persistence, and integration of Ssk12 into the native oral microbiome/biofilm remain inadequately characterized. In this pilot study, we explored the temporal colonization dynamics of Ssk12 and its impact on the structure and functional profiles of salivary-derived biofilms cultivated on melt-electrowritten poly(ε-caprolactone) (MEW-mPCL) scaffolds, which emulate the native oral niche. Colonization was monitored via fluorescence in situ hybridization (smFISH), confocal microscopy, and RT-qPCR, while shifts in community composition and function were assessed using 16S rRNA sequencing and meta-transcriptomics. A single administration of Ssk12 exhibited transient colonization lasting up to 7 days, with detectable presence diminishing by day 10. This was accompanied by short-term increases in Lactobacillus and Bifidobacterium populations. Functional analyses revealed increased transcriptional signatures linked to oxidative stress resistance and metabolic adaptation. These findings suggest that even short-term probiotic colonization induces significant functional changes, underscoring the need for strategies to enhance probiotic persistence. Full article
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23 pages, 3011 KiB  
Article
Comprehensive Diagnostic Assessment of Inverter Failures in a Utility-Scale Solar Power Plant: A Case Study Based on Field and Laboratory Validation
by Karl Kull, Bilal Asad, Muhammad Usman Naseer, Ants Kallaste and Toomas Vaimann
Sensors 2025, 25(12), 3717; https://doi.org/10.3390/s25123717 - 13 Jun 2025
Viewed by 512
Abstract
Recurrent catastrophic inverter failures significantly undermine the reliability and economic viability of utility-scale photovoltaic (PV) power plants. This paper presents a comprehensive investigation of severe inverter destruction incidents at the Kopli Solar Power Plant, Estonia, by integrating controlled laboratory simulations with extensive field [...] Read more.
Recurrent catastrophic inverter failures significantly undermine the reliability and economic viability of utility-scale photovoltaic (PV) power plants. This paper presents a comprehensive investigation of severe inverter destruction incidents at the Kopli Solar Power Plant, Estonia, by integrating controlled laboratory simulations with extensive field monitoring. Initially, detailed laboratory experiments were conducted to replicate critical DC-side short-circuit scenarios, particularly focusing on negative DC input terminal faults. The results consistently showed these faults rapidly escalating into multi-phase short-circuits and sustained ground-fault arcs due to inadequate internal protection mechanisms, semiconductor breakdown, and delayed relay response. Subsequently, extensive field-based waveform analyses of multiple inverter failure events captured identical fault signatures, thereby conclusively validating laboratory-identified failure mechanisms. Critical vulnerabilities were explicitly identified, including insufficient isolation relay responsiveness, inadequate semiconductor transient ratings, and ineffective internal insulation leading to prolonged arc conditions. Based on the validated findings, the paper proposes targeted inverter design enhancements—particularly advanced DC-side protective schemes, rapid fault-isolation mechanisms, and improved internal insulation practices. Additionally, robust operational and monitoring guidelines are recommended for industry-wide adoption to proactively mitigate future inverter failures. The presented integrated methodological framework and actionable recommendations significantly contribute toward enhancing inverter reliability standards and operational stability within grid-connected photovoltaic installations. Full article
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28 pages, 12651 KiB  
Article
Horizontal Shale Oil Production Wells Experience Hydraulic Fracture Choking Effect Under Closure Stress
by I. Yucel Akkutlu and Mengyue Yang
Energies 2025, 18(8), 1875; https://doi.org/10.3390/en18081875 - 8 Apr 2025
Viewed by 488
Abstract
The choke effect of hydraulic fractures on a horizontal shale oil well during production is shown using a coupled matrix–fracture–wellbore flow simulation model. The effect is the consequence of a significant loss in hydraulic fracture conductivity near the wellbore due to fracture closure [...] Read more.
The choke effect of hydraulic fractures on a horizontal shale oil well during production is shown using a coupled matrix–fracture–wellbore flow simulation model. The effect is the consequence of a significant loss in hydraulic fracture conductivity near the wellbore due to fracture closure stress. A consequence of the choke effect is that the fluid pressure in the fractures is maintained high enough to keep gas in the solution. The gas leaves the solution only after the choke region is passed when the oil with its solution gas begins the flow in the wellbore, and when it abruptly experiences a steep pressure gradient. This phenomenon has a long period of producing a constant gas–oil ratio (flat GOR) as its signature. The influence of the choke effect on the wellbore flow regimes is also investigated in the hydraulic-fractured horizontal section of the reservoir. During horizontal pipe flow, a distributed–intermittent flow sequence develops from the toe to the heel of the shale oil well over the production time. However, in the presence of the hydraulic fractures, a sequence of distributed–intermittent–transient–segregated flows develops. This indicates that the choke has the potential to affect the flow regimes in the horizontal section. Full article
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22 pages, 7905 KiB  
Article
Detecting Particle Contamination in Bearings of Inverter-Fed Induction Motors: A Comparative Evaluation of Monitoring Signals
by Tomas Garcia-Calva, Óscar Duque-Perez, Rene J. Romero-Troncoso, Daniel Morinigo-Sotelo and Ignacio Martin-Diaz
Machines 2025, 13(4), 269; https://doi.org/10.3390/machines13040269 - 25 Mar 2025
Cited by 1 | Viewed by 444
Abstract
In induction motor bearings, distributed faults are prevalent, often resulting from factors such as inadequate lubrication and particle contamination. Unlike localized faults, distributed faults produce complex and unpredictable motor signal behaviors. Although existing research predominantly addresses localized faults in mains-fed motors, particularly single-point [...] Read more.
In induction motor bearings, distributed faults are prevalent, often resulting from factors such as inadequate lubrication and particle contamination. Unlike localized faults, distributed faults produce complex and unpredictable motor signal behaviors. Although existing research predominantly addresses localized faults in mains-fed motors, particularly single-point defects, a comprehensive investigation into particle contamination in bearings of inverter-fed motors is essential for a more accurate understanding of real-world bearing issues. This paper conducts a comparative analysis of vibration, stator current, speed, and acoustic signals to detect particle contamination through signal analysis across three domains: time, frequency, and time-frequency. These domains are analyzed to assess and compare the characteristics of each monitored signal in the context of bearing wear detection. The data were collected from both steady-state and startup transients of an induction motor controlled by a variable frequency drive. The experimental results highlight the most significant characteristics of each monitored signal, evaluated across the different domains of analysis. The primary conclusion indicates that, in inverter-fed motors, sound and vibration signals exhibit abnormal levels when the bearing is damaged but the related-fault signature becomes complicated. Additionally, the findings demonstrate that the analysis of startup stator current and speed signals presents the potential to detect distributed bearing damage in inverter-fed induction motors. Full article
(This article belongs to the Special Issue Vibration Detection of Induction and PM Motors)
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20 pages, 4324 KiB  
Article
A Secure and Scalable Authentication and Communication Protocol for Smart Grids
by Muhammad Asfand Hafeez, Kazi Hassan Shakib and Arslan Munir
J. Cybersecur. Priv. 2025, 5(2), 11; https://doi.org/10.3390/jcp5020011 - 21 Mar 2025
Viewed by 1110
Abstract
The growing adoption of smart grid systems presents significant advancements in the efficiency of energy distribution, along with enhanced monitoring and control capabilities. However, the interconnected and distributed nature of these systems also introduces critical security vulnerabilities that must be addressed. This study [...] Read more.
The growing adoption of smart grid systems presents significant advancements in the efficiency of energy distribution, along with enhanced monitoring and control capabilities. However, the interconnected and distributed nature of these systems also introduces critical security vulnerabilities that must be addressed. This study proposes a secure communication protocol specifically designed for smart grid environments, focusing on authentication, secret key establishment, symmetric encryption, and hash-based message authentication to provide confidentiality and integrity for communication in smart grid environments. The proposed protocol employs the Elliptic Curve Digital Signature Algorithm (ECDSA) for authentication, Elliptic Curve Diffie–Hellman (ECDH) for secure key exchange, and Advanced Encryption Standard 256 (AES-256) encryption to protect data transmissions. The protocol follows a structured sequence: (1) authentication—verifying smart grid devices using digital signatures; (2) key establishment—generating and securely exchanging cryptographic keys; and (3) secure communication—encrypting and transmitting/receiving data. An experimental framework has been established to evaluate the protocol’s performance under realistic operational conditions, assessing metrics such as time, throughput, power, and failure recovery. The experimental results show that the protocol completes one server–client request in 3.469 ms for a desktop client and 41.14 ms for a microcontroller client and achieves a throughput of 288.27 requests/s and 24.30 requests/s, respectively. Furthermore, the average power consumed by the protocol is 37.77 watts. The results also show that the proposed protocol is able to recover from transient network disruptions and sustain secure communication. Full article
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21 pages, 16183 KiB  
Article
Fusing Gradient, Intensity Accumulation, and Region Contrast for Robust Infrared Dim-Small Target Detection
by Liqi Liu, Rongguo Zhang, Xinyue Ni, Liyuan Li, Xiaofeng Su and Fansheng Chen
Appl. Sci. 2025, 15(6), 3373; https://doi.org/10.3390/app15063373 - 19 Mar 2025
Viewed by 333
Abstract
Existing infrared small target detection methods often fail due to limited exploitation of spatiotemporal information, leading to missed detections and false alarms. To address these limitations, we propose a novel framework called Spatial–Temporal Fusion Detection (STFD), which synergistically integrates three original components: gradient-enhanced [...] Read more.
Existing infrared small target detection methods often fail due to limited exploitation of spatiotemporal information, leading to missed detections and false alarms. To address these limitations, we propose a novel framework called Spatial–Temporal Fusion Detection (STFD), which synergistically integrates three original components: gradient-enhanced spatial contrast, adaptive temporal intensity accumulation, and temporal regional contrast. In the temporal domain, we introduce Temporal Regional Contrast (TRC), the first method to quantify target-background dissimilarity through adaptive region-based temporal profiling, overcoming the rigidity of conventional motion-based detection. Concurrently, Regional Intensity Accumulation (RIA) uniquely accumulates weak target signatures across frames while suppressing transient noise, addressing the critical gap in detecting sub-SNR-threshold targets that existing temporal filters fail to resolve. For spatial analysis, we propose the Gradient-Enhanced Local Contrast Measure (GELCM), which innovatively incorporates gradient direction and magnitude coherence into contrast computation, significantly reducing edge-induced false alarms compared with traditional local contrast methods. The proposed TRC, RIA, and GELCM modules complement each other, enabling robust detection through their synergistic interactions. Specifically, our method achieves significant improvements in key metrics: SCRG increases by up to 36.59, BSF improves by up to 9.48, and AUC rises by up to 0.027, reaching over 0.99, compared with the best existing methods, indicating a substantial enhancement in detection effectiveness. Full article
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15 pages, 415 KiB  
Article
Haemodynamic Patterns in Reflex Syncope: Insights from Head-Up Tilt Tests in Adults and Children
by Sergio Laranjo, Helena Fonseca, Ana Clara Felix, Alexandre V. Gourine, Fátima F. Pinto, Mario Oliveira and Isabel Rocha
J. Clin. Med. 2025, 14(6), 1874; https://doi.org/10.3390/jcm14061874 - 11 Mar 2025
Viewed by 755
Abstract
Introduction: Vasovagal syncope is a prevalent condition marked by transient loss of consciousness due to abrupt decreases in systemic blood pressure and/or heart rate. Despite its clinical impact, the underlying haemodynamic mechanisms remain poorly defined, and data on age-related differences are limited and [...] Read more.
Introduction: Vasovagal syncope is a prevalent condition marked by transient loss of consciousness due to abrupt decreases in systemic blood pressure and/or heart rate. Despite its clinical impact, the underlying haemodynamic mechanisms remain poorly defined, and data on age-related differences are limited and sometimes contradictory. Objectives: This study aimed to characterise haemodynamic adaptation patterns during a head-up tilt (HUT) test in adult (≥18 years) and paediatric (<18 years) patients with recurrent reflex syncope, compared with healthy adult controls. We sought to identify distinct temporal haemodynamic signatures and clarify potential age-related differences in syncope mechanisms. Methods: In this prospective observational study, participants underwent continuous beat-to-beat monitoring of cardiac output (CO), stroke volume (SV), heart rate (HR), and total peripheral resistance (TPR) during HUT. Linear mixed-effects models were used to examine time-by-group interactions, and post-hoc analyses were adjusted for multiple comparisons. Effect sizes and confidence intervals (CIs) were reported to quantify the magnitude of differences. Results: A total of 187 fainters (paediatric n = 81, adult n = 106) and 108 non-fainters (including 30 healthy controls) were studied. Compared to adult fainters, paediatric fainters showed a 24% larger decline in CO from baseline (mean difference of 1.1 L/min [95% CI: 0.5–1.7], p = 0.003) and a 15–20 bpm higher peak HR (p = 0.001) during presyncope. Both subgroups experienced significant drops in TPR, which were more pronounced in paediatric fainters (effect size = 0.27, 95% CI: 0.12–0.42). Non-fainters (including controls) maintained relatively stable haemodynamics, with no significant decrease in CO or TPR (p > 0.05). Age-related comparisons indicated a heavier reliance on HR modulation in paediatric fainters, leading to an earlier transition from compensated to pre-syncopal states. Conclusions: These findings demonstrate that paediatric fainters exhibit more abrupt decreases in CO and TPR than adults, alongside higher HR responses during orthostatic stress. Targeted interventions that address this heightened chronotropic dependency—such as tilt-training protocols or strategies to improve venous return—may be particularly beneficial in younger patients. An age-specific approach to diagnosis and management could improve risk stratification, minimise recurrent episodes, and enhance patient outcomes. Full article
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14 pages, 2028 KiB  
Article
Metabolically Healthy Obesity Is Characterized by a Distinct Proteome Signature
by Fayaz Ahmad Mir, Houari B. Abdesselem, Farhan Cyprian, Ahmad Iskandarani, Asmma Doudin, Mutasem AbdelRahim Shraim, Bader M. Alkhalaf, Meis Alkasem, Ibrahem Abdalhakam, Ilham Bensmail, Hamza A. Al Halabi, Shahrad Taheri and Abdul-Badi Abou-Samra
Int. J. Mol. Sci. 2025, 26(5), 2262; https://doi.org/10.3390/ijms26052262 - 4 Mar 2025
Viewed by 1471
Abstract
Obesity is commonly associated with metabolic diseases including type 2 diabetes, hypertension, and dyslipidemia. Moreover, individuals with obesity are at increased risk of cardiovascular disease. However, a subgroup of individuals within the obese population presents without concurrent metabolic disorders. Even though this group [...] Read more.
Obesity is commonly associated with metabolic diseases including type 2 diabetes, hypertension, and dyslipidemia. Moreover, individuals with obesity are at increased risk of cardiovascular disease. However, a subgroup of individuals within the obese population presents without concurrent metabolic disorders. Even though this group has a stable metabolic status and does not exhibit overt metabolic disease, this status may be transient; these individuals may have subclinical metabolic derangements. To investigate the latter hypothesis, an analysis of the proteome signature was conducted. Plasma samples from 27 subjects with obesity but without an associated metabolic disorder (obesity only (OBO)) and 15 lean healthy control (LHC) subjects were examined. Fasting samples were subjected to Olink proteomics analysis targeting 184 proteins enriched in cardiometabolic and inflammation pathways. Our results distinctly delineated two groups with distinct plasma protein expression profiles. Specifically, a total of 24 proteins were differentially expressed in individuals with obesity compared to LHC. Among these, 13 proteins were downregulated, whereas 11 proteins were upregulated. The pathways that were upregulated in the OBO group were related to chemoattractant activity, growth factor activity, G protein-coupled receptor binding, chemokine activity, and cytokine activity, whereas the pathways that were downregulated include regulation of T cell differentiation, leukocyte differentiation, reproductive system development, inflammatory response, neutrophil, lymphocyte, monocyte and leukocyte chemotaxis, and neutrophil migration. The study identifies several pathways that are altered in individuals with obesity compared to healthy control subjects. These findings provide valuable insights into the underlying mechanisms, potentially paving the way for the identification of therapeutic targets aimed at improving metabolic health in individuals with obesity. Full article
(This article belongs to the Special Issue Advances in Cell Metabolism in Endocrine Diseases)
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19 pages, 8593 KiB  
Article
A Metabolomic Approach to Unexplained Syncope
by Susanna Longo, Ilaria Cicalini, Damiana Pieragostino, Vincenzo De Laurenzi, Jacopo M. Legramante, Rossella Menghini, Stefano Rizza and Massimo Federici
Biomedicines 2024, 12(11), 2641; https://doi.org/10.3390/biomedicines12112641 - 19 Nov 2024
Viewed by 1037
Abstract
Background: This study aims to identify a metabolomic signature that facilitates the classification of syncope and the categorization of the unexplained syncope (US) to aid in its management. Methods: We compared a control group (CTRL, n = 10) with a transient loss of [...] Read more.
Background: This study aims to identify a metabolomic signature that facilitates the classification of syncope and the categorization of the unexplained syncope (US) to aid in its management. Methods: We compared a control group (CTRL, n = 10) with a transient loss of consciousness (TLC) group divided into the OH group (n = 23) for orthostatic syncope, the NMS group (n = 26) for neuromediated syncope, the CS group (n = 9) for cardiological syncope, and the US group (n = 27) for US defined as syncope without a precise categorization after first- and second-level diagnostic approaches. Results: The CTRL and the TLC groups significantly differed in metabolic profile. A new logistic regression model has been developed to predict how the US will be clustered. Using differences in lysophosphatidylcholine with 22 carbon atom (C22:0-LPC) levels, 96% of the US belongs to the NMS and 4% to the CS subgroup. Differences in glutamine and lysine (GLN/LYS) levels clustered 95% of the US in the NMS and 5% in the CS subgroup. Conclusions: We hypothesize a possible role of C22:0 LPC and GLN/LYS in re-classifying US and differentiating it from cardiological syncope. Full article
(This article belongs to the Section Endocrinology and Metabolism Research)
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24 pages, 14320 KiB  
Article
Localized Bearing Fault Analysis for Different Induction Machine Start-Up Modes via Vibration Time–Frequency Envelope Spectrum
by Jose E. Ruiz-Sarrio, Jose A. Antonino-Daviu and Claudia Martis
Sensors 2024, 24(21), 6935; https://doi.org/10.3390/s24216935 - 29 Oct 2024
Cited by 1 | Viewed by 1793
Abstract
Bearings are the most vulnerable component in low-voltage induction motors from a maintenance standpoint. Vibration monitoring is the benchmark technique for identifying mechanical faults in rotating machinery, including the diagnosis of bearing defects. The study of different bearing fault phenomena under induction motor [...] Read more.
Bearings are the most vulnerable component in low-voltage induction motors from a maintenance standpoint. Vibration monitoring is the benchmark technique for identifying mechanical faults in rotating machinery, including the diagnosis of bearing defects. The study of different bearing fault phenomena under induction motor transient conditions offers interesting capabilities to enhance classic fault detection techniques. This study analyzes the low-frequency localized bearing fault signatures in both the inner and outer races during the start-up and steady-state operation of inverter-fed and line-started induction motors. For this aim, the classic vibration envelope spectrum technique is explored in the time–frequency domain by using a simple, resampling-free, Short Time Fourier Transform (STFT) and a band-pass filtering stage. The vibration data are acquired in the motor housing in the radial direction for different load points. In addition, two different localized defect sizes are considered to explore the influence of the defect width. The analysis of extracted low-frequency characteristic frequencies conducted in this study demonstrates the feasibility of detecting early-stage localized bearing defects in induction motors across various operating conditions and actuation modes. Full article
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13 pages, 2025 KiB  
Article
Immune Cell Profiles of Patients with Sickle Cell Disease during Parvovirus B19–Induced Transient Red Cell Aplasia
by E. Kaitlynn Allen, Rhiannon R. Penkert, Jane S. Hankins, Sherri L. Surman, Lee-Ann Van de Velde, Alyssa Cotton, Randall T. Hayden, Li Tang, Xiaomeng Yuan, Ying Zheng, Paul G. Thomas and Julia L. Hurwitz
Vaccines 2024, 12(9), 984; https://doi.org/10.3390/vaccines12090984 - 29 Aug 2024
Viewed by 1869
Abstract
Parvovirus B19 frequently infects children and targets cells of the erythroid lineage. Although healthy children rarely suffer severe disease, children with sickle cell disease (SCD) can experience transient red cell aplasia (TRCA), hospitalization, and life-threatening anemia upon first virus exposure. Given that children [...] Read more.
Parvovirus B19 frequently infects children and targets cells of the erythroid lineage. Although healthy children rarely suffer severe disease, children with sickle cell disease (SCD) can experience transient red cell aplasia (TRCA), hospitalization, and life-threatening anemia upon first virus exposure. Given that children with SCD can also suffer chronic inflammation and that parvovirus B19 has been associated with autoimmune disease in other patient populations, we asked if parvovirus B19 infections contributed to acute and chronic immune abnormalities in children with SCD. Nineteen hospitalized patients with SCD and parvovirus B19–induced TRCA were evaluated. Blood tests included CBC, flow cytometry, and total antibody isotype analyses. Cytokine/chemokine analyses were performed on nasal wash (NW) samples, representing a common site of viral entry. Unusually high white blood cell count (WBC) and absolute neutrophil count (ANC) values were observed in some patients. A correlation matrix with Day 0 values from the 19 patients then identified two mutually exclusive phenotype clusters. Cluster 1 included WBC, ANC, absolute reticulocyte count (ARC), absolute lymphocyte count (ALC), lactate dehydrogenase (LDH), NW cytokines/chemokines, % naïve cells among B cell and T cell populations, and parvovirus-specific IgG. This cluster was negatively associated with virus load, suggesting a signature of successful adaptive immunity and virus control. Cluster 2 included virus load, % CD38+CD24 cells among CD19+ B cells (termed ‘plasmablasts’ for simplicity), % HLA-DRlow cells among CD19+ B cells, IgG4, and % memory phenotypes among B cell and T cell populations. Plasmablast percentages correlated negatively with parvovirus-specific IgG, possibly reflecting a non-specific trigger of cell activation. All patients were released from the hospital within 1 week after admission, and the highest WBC and ANC values were eventually reduced. Nonetheless, a concern remained that the acutely abnormal immune profiles caused by parvovirus B19 infections could exacerbate chronic inflammation in some patients. To avoid the numerous sequelae known to affect patients with SCD following hospitalizations with parvovirus B19, rapid development of a parvovirus B19 vaccine is warranted. Full article
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17 pages, 6903 KiB  
Article
‘X-Currents’ and Extreme Brightening in Dayside Aurora
by Gerard Fasel, Abrielle Wang, Audrey Daucher, Lou-Chuang Lee, Julia Pepperdine, Owen Bradley, John Mann, Minji Kim, Benjamin Swonger, Fred Sigernes and Dag Lorentzen
Universe 2024, 10(5), 216; https://doi.org/10.3390/universe10050216 - 14 May 2024
Viewed by 1438
Abstract
Solar-terrestrial interaction is a dynamic process that manifests itself in the ionosphere. Interplanetary (IP) shocks or solar wind dynamic pressure pulses can generate enhanced brightening in dayside aurora. Foreshock transients are capable of inducing pressure changes, larger in magnitude than solar wind pressure [...] Read more.
Solar-terrestrial interaction is a dynamic process that manifests itself in the ionosphere. Interplanetary (IP) shocks or solar wind dynamic pressure pulses can generate enhanced brightening in dayside aurora. Foreshock transients are capable of inducing pressure changes, larger in magnitude than solar wind pressure pulses, which also contribute to intensifying dayside aurora. These pressure variations can accelerate particles into the ionosphere, generating field-aligned currents that produce magnetic impulse events and enhanced dayside auroral activity with periods of increased brightening. This study presents several dayside auroral brightening events that are not associated with IP shocks or solar wind dynamic pressure pulses. The dayside auroral brightening events are associated with a green (557.7 nm) to red (630.0 nm) ratio which is greater than 15. These extreme brightening events (EBEs) begin on the eastern or western end of a pre-existing dayside auroral arc. Periodic pulses of enhanced brightening are correlated with large sharp increases in the X-component (points toward the north-geographic pole) from ground magnetometers in the IMAGE network. EBEs occur predominately before magnetic noon and with X-component signatures from high-latitude stations. Ground-based data were obtained from the Kjell Henriksen Observatory in Longyearbyen and the IMAGE magnetometer network. Full article
(This article belongs to the Section Planetary Sciences)
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