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2,954 Results Found

  • Article
  • Open Access
3 Citations
9,133 Views
18 Pages

The prevalence of human trafficking for the purposes of sexual exploitation and forced labour in the Pacific Northwest has been well documented in recent years. This paper focuses specifically on trafficking for sex work across the British Columbia a...

  • Article
  • Open Access
24 Citations
16,919 Views
17 Pages

13 October 2014

This paper argues that the feminisation of migration has heightened the awareness of human trafficking, yet the feminisation of poverty is a social concept that is yet to be fully understood within the context of human trafficking. The false notion o...

  • Article
  • Open Access
5 Citations
5,843 Views
26 Pages

11 January 2022

There is a lack of contributions in sex trafficking the academic literature from Christian evangelical leaders despite their prominence in global counter-trafficking activism. Given that the academic literature influences professional and pedagogical...

  • Concept Paper
  • Open Access
2 Citations
4,577 Views
11 Pages

30 March 2023

The disparity between sex and labor federal prosecutions in the United States underscores the significant degree to which labor trafficking investigations and prosecutions have been marginalized since the Trafficking Victims Protection Act (TVPA) was...

  • Article
  • Open Access
1 Citations
4,009 Views
16 Pages

23 May 2023

The late Rev. Margaret Fowler, United Church Minister, was a key supporter of LGBTQ rights and a vocal advocate against human trafficking in Jamaica. As the founder of the Theodora Project, Rev. Fowler served many persons coerced into sex work or sub...

  • Review
  • Open Access
8 Citations
5,240 Views
24 Pages

Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex

  • Matías Lira,
  • Rodrigo G. Mira,
  • Francisco J. Carvajal,
  • Pedro Zamorano,
  • Nibaldo C. Inestrosa and
  • Waldo Cerpa

3 November 2020

Cells comprise several intracellular membrane compartments that allow them to function properly. One of these functions is cargo movement, typically proteins and membranes within cells. These cargoes ride microtubules through vesicles from Golgi and...

  • Systematic Review
  • Open Access
1 Citations
7,442 Views
39 Pages

23 October 2024

The share of boys and men among detected victims of human trafficking is increasing globally, yet there is limited evidence on the specific experiences of these populations. The knowledge gap on mental health outcomes and support needs is particularl...

  • Review
  • Open Access
21 Citations
4,205 Views
23 Pages

2 July 2021

(Lymph)angiogenesis into the cornea prior to and after corneal transplantation is a critical risk factor for allograft rejection. Lymphatic vessels even more than blood vessels seem important in mediating immune responses, as they facilitate allograf...

  • Review
  • Open Access
3 Citations
5,145 Views
11 Pages

21 June 2023

Human trafficking is a complex global problem that demands current and scientifically grounded knowledge capable of coordinating interventions among various sectors of society. To address this issue, a systematic collection of scientific articles was...

  • Article
  • Open Access
2 Citations
114,921 Views
18 Pages

Combating Sex Trafficking: The Role of the Hotel—Moral and Ethical Questions

  • Chu-Chuan Jeng,
  • Edward Huang,
  • Sarah Meo and
  • Louise Shelley

2 February 2022

Legitimate companies are key facilitators of human trafficking. These corporate facilitators include not only websites providing advertisements for commercial sex services but also hotels and motels. Analysis of all active federal criminal sex traffi...

  • Review
  • Open Access
6 Citations
4,389 Views
16 Pages

Do All Coccidia Follow the Same Trafficking Rules?

  • Virginia Marugan-Hernandez,
  • Gonzalo Sanchez-Arsuaga,
  • Sue Vaughan,
  • Alana Burrell and
  • Fiona M. Tomley

31 August 2021

The Coccidia are a subclass of the Apicomplexa and include several genera of protozoan parasites that cause important diseases in humans and animals, with Toxoplasma gondii becoming the ‘model organism’ for research into the coccidian molecular and c...

  • Article
  • Open Access
39 Citations
19,174 Views
11 Pages

The debate over trafficking of human beings for the purpose of organ removal (THBOR) remains largely absent from policy debates, as its crime is hardly detected, reported and sparsely researched. However, criminal networks continue to exploit vulnera...

  • Article
  • Open Access
3 Citations
3,584 Views
12 Pages

5 November 2024

Offenders convicted of trafficking human beings for sexual exploitation involve a high percentage of women compared to other similar offenses. Previous studies have searched for explanations for the dynamics of the illegal sex market and the coercion...

  • Review
  • Open Access
11 Citations
4,539 Views
11 Pages

Targeting Membrane Trafficking as a Strategy for Cancer Treatment

  • Nydia Tejeda-Muñoz,
  • Kuo-Ching Mei,
  • Pooja Sheladiya and
  • Julia Monka

Membrane trafficking is emerging as an attractive therapeutic strategy for cancer. Recent reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V-ATPase, lysosomal activity, and macropinocytosis through the canonical W...

  • Review
  • Open Access
6 Citations
3,403 Views
10 Pages

13 May 2021

Cells use membrane-bound carriers to transport cargo molecules like membrane proteins and soluble proteins, to their destinations. Many signaling receptors and ligands are synthesized in the endoplasmic reticulum and are transported to their destinat...

  • Review
  • Open Access
3 Citations
9,487 Views
16 Pages

6 December 2022

Brazil has seen a rise in children in narco-trafficking due to increased conflicts between factions and local law enforcement. Mainstream media and scholars tend to frame actions of these factions as organized crime, ignoring the generalized violence...

  • Article
  • Open Access
1 Citations
9,965 Views
14 Pages

11 September 2023

Current perspectives on the intractability of child trafficking in Africa considers the problem as a failure of law enforcement or a lack of political will by state actors. In response, these works tend to suggest the need for strengthened institutio...

  • Review
  • Open Access
21 Citations
5,481 Views
26 Pages

The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking

  • Yang Zhao,
  • Ka Ka Ting,
  • Paul Coleman,
  • Yanfei Qi,
  • Jinbiao Chen,
  • Mathew Vadas and
  • Jennifer Gamble

6 April 2021

The effectiveness of immunotherapy against solid tumours is dependent on the appropriate leucocyte subsets trafficking and accumulating in the tumour microenvironment (TME) with recruitment occurring at the endothelium. Such recruitment involves inte...

  • Review
  • Open Access
20 Citations
5,298 Views
26 Pages

Targeting Notch Trafficking and Processing in Cancers

  • Luca Pagliaro,
  • Claudia Sorrentino and
  • Giovanni Roti

29 September 2020

The Notch family comprises a group of four ligand-dependent receptors that control evolutionarily conserved developmental and homeostatic processes and transmit signals to the microenvironment. NOTCH undergoes remodeling, maturation, and trafficking...

  • Review
  • Open Access
25 Citations
4,010 Views
11 Pages

Autophagy in HCV Replication and Protein Trafficking

  • Ja Yeon Kim Chu and
  • Jing-hsiung James Ou

22 January 2021

Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular auto...

  • Article
  • Open Access
11 Citations
21,689 Views
29 Pages

12 January 2015

The purpose of this study is to better understand how the complex problem of human trafficking is addressed in international debates. How the discussion about human trafficking develops and how it is debated ultimately influences how the decision-mak...

  • Feature Paper
  • Review
  • Open Access
38 Citations
7,562 Views
11 Pages

ER-to-Golgi Trafficking and Its Implication in Neurological Diseases

  • Bo Wang,
  • Katherine R. Stanford and
  • Mondira Kundu

11 February 2020

Membrane and secretory proteins are essential for almost every aspect of cellular function. These proteins are incorporated into ER-derived carriers and transported to the Golgi before being sorted for delivery to their final destination. Although ER...

  • Article
  • Open Access
3 Citations
7,271 Views
20 Pages

11 November 2022

Because of supply and demand factors, human trafficking for sexual exploitation has always been a profitable industry. Turkey, as a host country for immigrants from both former Soviet countries and the Middle East, combines supply and demand together...

  • Review
  • Open Access
23 Citations
11,216 Views
19 Pages

5 September 2013

Small GTPases largely control membrane traffic, which is essential for the survival of all eukaryotes. Among the small GTP-binding proteins, ARF1 (ADP-ribosylation factor 1) and SAR1 (Secretion-Associated RAS super family 1) are commonly conserved am...

  • Article
  • Open Access
1 Citations
2,598 Views
15 Pages

Raising Awareness about Sex Trafficking among School Personnel

  • Elena Savoia,
  • Amy Liu,
  • Amy Leffler,
  • Léa Kay Nadril Churchill and
  • Maxwell Su

Background: We aimed to (1) understand the level of knowledge about sex trafficking of minors among school personnel and the determinants of such knowledge and (2) test the efficacy of short educational videos in increasing knowledge (awareness level...

  • Article
  • Open Access
3 Citations
4,098 Views
20 Pages

Team Approaches to Addressing Sex Trafficking of Minors: Promising Practices for a Collaborative Model

  • Andrea Nichols,
  • Sarah Slutsker,
  • Melissa Oberstaedt and
  • Kourtney Gilbert

11 March 2023

The extant research literature is lacking in its focus on community-based responses (CBRs) to sex trafficking involving minors in the juvenile justice system. To address this research gap, the present study draws from 35 interviews with social servic...

  • Article
  • Open Access
26 Citations
9,956 Views
16 Pages

The Prevalence and Correlates of Labor and Sex Trafficking in a Community Sample of Youth Experiencing Homelessness in Metro-Atlanta

  • Eric R. Wright,
  • Ana LaBoy,
  • Kara Tsukerman,
  • Nicholas Forge,
  • Erin Ruel,
  • Renee Shelby,
  • Madison Higbee,
  • Zoe Webb,
  • Melanie Turner-Harper and
  • Cody Wallace
  • + 1 author

21 January 2021

Research suggests that runaway and homeless youth (RHY) in the United States are vulnerable to sex and labor trafficking. In this paper, we report and analyze estimates of sex and labor trafficking collected as part of the Atlanta Youth Count 2018, a...

  • Article
  • Open Access
1 Citations
2,553 Views
15 Pages

19 June 2024

In recent decades, an anti-trafficking legislative and policy framework has been developed in Spain, coupled with the funding of initiatives related to the protection of trafficked persons, especially women, largely carried out by faith-based and sec...

  • Review
  • Open Access
51 Citations
14,939 Views
35 Pages

Sperm Differentiation: The Role of Trafficking of Proteins

  • Maria E. Teves,
  • Eduardo R. S. Roldan,
  • Diego Krapf,
  • Jerome F. Strauss III,
  • Virali Bhagat and
  • Paulene Sapao

Sperm differentiation encompasses a complex sequence of morphological changes that takes place in the seminiferous epithelium. In this process, haploid round spermatids undergo substantial structural and functional alterations, resulting in highly po...

  • Article
  • Open Access
1,651 Views
17 Pages

Molecular Determinants of TMC Protein Biogenesis and Trafficking

  • Dedong Shao,
  • Jinru Tan,
  • Xiaozhi Fan,
  • Yilai Shu,
  • Qianhui Qu and
  • Yi-Quan Tang

Transmembrane channel-like (TMC) proteins are essential for hearing and balance; however, the molecular mechanisms that regulate their proper folding and membrane targeting remain poorly understood. Here, we establish Caenorhabditis elegans as a gene...

  • Article
  • Open Access
3 Citations
3,564 Views
13 Pages

Megalin Orchestrates FcRn Endocytosis and Trafficking

  • Eileen Dahlke,
  • Yaman Anan,
  • Lea Maximiliane Klie,
  • Ariane Elisabeth Hartkopf and
  • Franziska Theilig

22 December 2022

The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is...

  • Article
  • Open Access
3 Citations
6,530 Views
23 Pages

23 June 2025

Human trafficking, a grave violation of human rights, frequently intersects with financial crimes, notably identity theft and coercive debt accumulation. This creates complex challenges for victims, survivors, and law enforcement. Victims of human tr...

  • Review
  • Open Access
3,582 Views
21 Pages

Intracellular membrane trafficking that transports proteins, lipids, and other substances between organelles is crucial for maintaining cellular homeostasis and signal transduction. The imbalance of membrane trafficking leads to various diseases. It...

  • Article
  • Open Access
4 Citations
4,799 Views
17 Pages

Vulnerability to Sex Trafficking: Adult Women’s Experiences While They Were Adolescents

  • Karla Lorena Andrade-Rubio,
  • José Moral-de-la-Rubia and
  • Simón Pedro Izcara-Palacios

11 April 2024

The concept of vulnerability to sex trafficking has been the subject of intense academic debate. It is well documented in the literature that child sex trafficking is facilitated by the abuse of a position of vulnerability, though limited research ha...

  • Review
  • Open Access
111 Citations
18,310 Views
17 Pages

Membrane Trafficking in the Yeast Saccharomyces cerevisiae Model

  • Serge Feyder,
  • Johan-Owen De Craene,
  • Séverine Bär,
  • Dimitri L. Bertazzi and
  • Sylvie Friant

9 January 2015

The yeast Saccharomyces cerevisiae is one of the best characterized eukaryotic models. The secretory pathway was the first trafficking pathway clearly understood mainly thanks to the work done in the laboratory of Randy Schekman in the 1980s. They ha...

  • Concept Paper
  • Open Access
48 Citations
44,055 Views
13 Pages

28 April 2014

The purpose of this paper is to discuss human trafficking within the broader framework of socio-economic inequality. The presence of socio-economic inequality in the world creates a system where those in power very easily dominate and take advantage...

  • Article
  • Open Access
4 Citations
5,208 Views
21 Pages

Human Trafficking and Gender Inequality: How Businesses Can Lower Risks and Costs

  • Donald L. Ariail,
  • Katherine Taken Smith and
  • Lawrence Murphy Smith

Human trafficking continues to be a profitable multi-billion dollar business. People are either callous toward human rights or they are unaware of the crime occurring. Many businesses may unknowingly facilitate human trafficking by providing services...

  • Article
  • Open Access
5 Citations
13,307 Views
10 Pages

20 May 2024

Human trafficking thrives in the shadows, and the rise of social media has provided traffickers with a powerful and unregulated tool. This paper delves into how these criminals exploit online platforms to target and manipulate vulnerable populations....

  • Article
  • Open Access
4 Citations
4,233 Views
17 Pages

Lessons Learned from the Colorado Project to Comprehensively Combat Human Trafficking

  • Annie Miller,
  • Julie Laser,
  • Annjanette Alejano-Steele,
  • Kara Napolitano,
  • Nevita George,
  • Natcha Connot and
  • Amanda Finger

22 February 2023

Countering human trafficking at a statewide level requires a combination of knowledge from lived experience, inter-sector collaborations, and evidence-based tools to measure progress. Since 2010, the nonprofit Laboratory to Combat Human Trafficking (...

  • Review
  • Open Access
17 Citations
8,825 Views
30 Pages

Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System

  • Yi-Yang Cao,
  • Ling-Ling Wu,
  • Xiao-Nan Li,
  • Yu-Lian Yuan,
  • Wan-Wei Zhao,
  • Jing-Xuan Qi,
  • Xu-Yu Zhao,
  • Natalie Ward and
  • Jiao Wang

21 December 2023

Synaptic plasticity enhances or reduces connections between neurons, affecting learning and memory. Postsynaptic AMPARs mediate greater than 90% of the rapid excitatory synaptic transmission in glutamatergic neurons. The number and subunit compositio...

  • Review
  • Open Access
83 Citations
16,909 Views
16 Pages

10 October 2019

Insulin receptor (INSR) has been extensively studied in the area of cell proliferation and energy metabolism. Impaired INSR activities lead to insulin resistance, the key factor in the pathology of metabolic disorders including type 2 diabetes mellit...

  • Review
  • Open Access
13 Citations
5,923 Views
13 Pages

Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics

  • Pau Doñate-Macián,
  • Jennifer Enrich-Bengoa,
  • Irene R. Dégano,
  • David G. Quintana and
  • Alex Perálvarez-Marín

27 November 2019

Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critica...

  • Review
  • Open Access
9 Citations
9,384 Views
13 Pages

Regulation of Neuronal Protein Trafficking and Translocation by SUMOylation

  • Anja Berndt,
  • Kevin A. Wilkinson and
  • Jeremy M. Henley

14 May 2012

Post-translational modifications of proteins are essential for cell function. Covalent modification by SUMO (small ubiquitin-like modifier) plays a role in multiple cell processes, including transcriptional regulation, DNA damage repair, protein loca...

  • Review
  • Open Access
63 Citations
10,367 Views
11 Pages

28 April 2019

Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its f...

  • Review
  • Open Access
16 Citations
5,300 Views
15 Pages

4 February 2021

Intrahepatic cholestasis is characterized by the accumulation of compounds in the serum that are normally secreted by hepatocytes into the bile. Genes associated with familial intrahepatic cholestasis (FIC) include ATP8B1 (FIC1), ABCB11 (FIC2), ABCB4...

  • Article
  • Open Access
1 Citations
7,501 Views
35 Pages

16 August 2023

Faith-based organizations (FBOs) are substantially involved in the anti-human trafficking movement. Yet, limited research is available on their crucial roles in the field. This study explored their input in anti-trafficking policy implementation in t...

  • Review
  • Open Access
33 Citations
7,969 Views
20 Pages

The cellular constitution of Zn-proteins and Zn-dependent signaling depend on the capacity of Zn2+ to find specific binding sites in the face of a plethora of other high affinity ligands. The most prominent of these is metallothionein (MT). It serves...

  • Article
  • Open Access
10 Citations
5,881 Views
12 Pages

BIG3 and BIG5 Redundantly Mediate Vesicle Trafficking in Arabidopsis

  • Yiping Suo,
  • Fenhong Hu,
  • Haojie Zhu,
  • Di Li,
  • Rui Qi,
  • Jirong Huang and
  • Wenjuan Wu

Vesicle trafficking plays an important role in delivering a diverse range of cargoes between different membranous systems in eukaryotes. It is well documented that the brefeldin A (BFA)-inhibited guanine nucleotide exchange factor (GEF), named BIG, r...

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