Search Results (9,112)

The mental health issues of medical postgraduate students are increasingly prominent, and it is urgently necessary to explore the stressors and protective factors. This study adopted an integrative approach to examine the moderating role of psychological flexibility in the relationship between multiple types of life stress and mental health. A total of 5819 medical postgraduate students from a medical university and its affiliated hospitals in Beijing were surveyed in a multi-center cross-sectional study. Measures included psychological worry, supervisory relationship, work–life balance, school support, psychological flexibility, and psychological health. The results showed that all four types of stressors were significantly associated with mental health. Psychological worry was positively associated with psychological distress, while the other three variables were negatively associated with it. Psychological flexibility was negatively associated with psychological distress and the relationship between each stressor and psychological health was weaker with higher levels of psychological flexibility. These findings highlight the heterogeneity in the pathways by which different stressors affect psychological health, underscore the critical role of psychological flexibility in coping with internally generated cognitive stress, and provide theoretical and practical implications for psychological interventions among medical postgraduates. Full article

Background/Objectives: Lower extremity peripheral artery disease (PAD) is recognized as a significant public health issue, particularly due to its strong association with adverse cardiovascular events. Despite this, little attention has been given to its influence on left ventricular (LV) and left atrial (LA) function in patients with chronic heart failure (CHF). This study aims to examine the relationship between femoral plaque burden and structural and functional properties of the LV and LA in patients with CHF. Methods: Study design: cross-sectional observational single-center study. A total of 89 patients with CHF underwent comprehensive assessments, including duplex ultrasonography of lower extremity arteries and two-dimensional echocardiography. Analysis focused on evaluating femoral plaque burden, left ventricular deformation, and ventricular–arterial coupling. Results: Findings indicated that increased femoral plaque burden was associated with reductions in LA deformation and increases in LA stiffness. Similarly, there was evidence of impaired LV mechanics and elevated arterial loading, suggesting impaired ventricular–arterial coupling in patients with CHF and significant lower extremity atherosclerosis. Conclusions: Femoral plaque burden is closely linked to detrimental changes in LA and LV function, as well as disturbances in ventricular–arterial coupling, underscoring the importance of addressing lower extremity atherosclerosis in managing CHF patients. Full article

Introduction: Muscle function is influenced by hydroelectrolytic mechanisms that regulate cellular volume beyond isolated plasma electrolyte concentrations. However, the role of integrated hydration and electrolyte regulation profiles in muscle function among older adults remains insufficiently understood. Objective: To identify which physiological domains of hydroelectrolytic regulation are most strongly associated with muscle strength and functional performance in community-dwelling older adults. Methods: A cross-sectional study was conducted in 96 community-dwelling individuals aged ≥ 70 years. Markers of cellular hydration and membrane integrity were assessed using bioelectrical impedance analysis, together with first-morning fasting plasma and urinary sodium and chloride concentrations. Principal component analysis (PCA) was applied as a data-driven approach to identify latent domains of coordinated hydroelectrolytic regulation. Associations between component scores and handgrip strength and Timed Up and Go (TUG) were examined using two sequential multivariable regression models: Model 1 adjusted for sex and fat-free mass index (FFMI); Model 2 additionally adjusted for age, hypertension, and diuretic use. Results: Three principal components were retained, explaining 77.5% of total variance: PC1 (renal–cellular domain), PC2 (plasma electrolyte domain), and PC3 (cellular volume domain). For handgrip strength, Model 1 showed significant associations for PC3 (β = 0.152; p = 0.025) and PC1 (β = 0.180; p = 0.050). In Model 2, only PC3 remained independently associated (β = 0.146; p = 0.036). For TUG, Model 1 showed associations for PC1 (β = −0.262; p = 0.049) and PC3 (β = −0.238; p = 0.015). In Model 2, PC1 (β = −0.308; p = 0.019) and PC2 (β = −0.190; p = 0.046) remained independently associated, whereas PC3 was not. Conclusions: Maximal force production appears primarily associated with cellular volume regulation, whereas functional performance reflects broader multi-compartmental hydroelectrolytic integration involving renal and plasma domains. These findings suggest that multidimensional hydration profiling may complement isolated biochemical markers in the functional assessment of older adults, warranting validation in longitudinal studies. Full article

Background: This cross-sectional observational study aimed to describe the position-specific kinanthropometric characteristics of Mexican professional American football players competing in the 2019–2020 seasons of the Liga de Fútbol Americano. Methods: A total of 189 athletes were assessed following International Society for the Advancement of Kinanthropometry standards. Twenty-six anthropometric variables were measured to estimate body composition (five-way fractionation), somatotype, proportionality indices, and tissue-specific masses. Positional differences were examined using ANOVA or Kruskal–Wallis tests with corresponding effect sizes (η² or ε²). An exploratory stepwise discriminant analysis identified the anthropometric dimensions contributing most to positional differentiation, and classification accuracy was calculated. Results: Offensive and defensive linemen showed the greatest absolute size and higher adipose, muscle, and bone mass compared with other positions. The overall somatotype corresponded to a balanced endomorphic mesomorph (3.8–7.0–0.8), with wide receivers and defensive backs presenting lower endomorphy. The discriminant model identified arm relaxed girth, biiliocristal breadth, and sitting height as the variables contributing most to positional differentiation, achieving a classification accuracy of 57.7%. Given its exploratory nature and the absence of cross-validation, the discriminatory capacity of the model should be interpreted with caution. Somatotype Attitudinal Mean indicated greater interpositional heterogeneity among linemen. Conclusions: This study provides population-specific reference data for Mexican professional American football players, highlighting clear positional morphological characteristics. These findings may support talent identification and positional profiling; however, the exploratory discriminant model and league-specific sample limit generalization to other populations. Full article

Background and Aim: Low back pain (LBP) represents an important public health issue, with approximately 20% of acute cases progressing to chronic low back pain (CLBP). In addition to pain, patients with CLBP also suffer from reduced cognitive performance, depressive symptoms and catastrophic thoughts. Central sensitization (CS) is considered a key point in pain persistence. This study examines CS and its impact on cognitive, emotional, and behavioral functioning in patients with CLBP. Methods: In this cross-sectional study, 67 patients with CLBP were classified using the Central Sensitization Inventory (CSI) into groups with (WCS, n = 32) and without central sensitization (WoCS, n = 35). Cognitive functioning was assessed using the Montreal Cognitive Assessment (MoCA), emotional functioning using the Center for Epidemiologic Studies Depression Scale (CES-D), and behavioral functioning using the Pain Catastrophizing Scale (PCS), including helplessness, rumination, and magnification domains. Normality was assessed using the Shapiro–Wilk test. Between-group comparisons were performed using Mann–Whitney U, chi-square, or Welch’s t-tests. Multivariable linear regression analyses adjusted for age and gender were conducted. Results: Compared with the WoCS group, patients with central sensitization were older (median 58 vs. 50 years, p = 0.001) and more frequently female (71.9% vs. 40.0%, p = 0.018). The WCS group showed higher PCS total scores (31.8 ± 14.2 vs. 16.0 ± 11.9), higher helplessness (14.3 ± 6.1 vs. 6.9 ± 5.5), rumination (12.7 ± 6.2 vs. 7.0 ± 4.8), and magnification scores (4.8 ± 2.4 vs. 2.1 ± 2.1), higher CES-D scores (26.3 ± 10.4 vs. 11.7 ± 7.2), and lower MoCA scores (23.6 ± 3.0 vs. 26.1 ± 2.1) (all p < 0.001). All associations remained significant after adjustment for age and gender. Conclusions: Central sensitization in CLBP is independently associated with greater pain catastrophizing across all domains, increased depressive symptoms, and reduced cognitive performance, supporting its role as a multidimensional clinical phenotype. Full article

Background/Objectives: Long COVID has emerged as a significant public health concern, characterized by persistent symptoms following SARS-CoV-2 infection. Cognitive impairment is a common sequela, particularly among older adults (OAs). Although olfactory dysfunction and malnutrition have been previously associated with cognitive decline, it remains elusive to what extent sex-specific variations in these and additional factors will be pivotal to guiding targeted interventions in a sex-specific manner. To fill this gap in knowledge, we undertook a study with the purpose of investigating the contribution of sex-specific risk factors to the development of cognitive impairment (CI) in a cohort of OAs hospitalized with long COVID. Methods: We undertook a cross-sectional study among OAs hospitalized at a geriatric care unit. Olfactory function was assessed using the Sniffin’ Stick Test. Cognitive impairment was evaluated by the Mini-Mental State Examination, and nutritional status was assessed with the Mini Nutritional Assessment (MNA). Statistical analyses included linear regression. Results: A total of 45 patients with long COVID were included, of whom 51% were female. The prevalence of CI was lower in men compared to women. In the single variable analysis, nutritional factors were associated with CI only in women; importantly, the loss of olfactory function was associated with CI in the whole group and to CI in women after multivariate analysis. Conclusions: Olfactory dysfunction is a potential biomarker for cognitive impairment in OAs with long COVID in a sex-specific manner. In our study nutritional status and probable obesity could be additional factors associated with CI; nevertheless, this was not confirmed in our multivariate analysis; therefore, this hypothesis would need to be tested in larger studies. Full article

Background/Objectives: Gambling disorder (GD) is a behavioral addiction characterized by persistent and repetitive gambling behaviors that cause significant psychological distress and functional impairment. Increasing evidence indicates that difficulties in emotion regulation are a key factor in the development and persistence of GD. This systematic review aimed to summarize and critically evaluate the existing literature on the relationship between emotion regulation strategies and gambling disorder, with a specific focus on studies using the Emotion Regulation Questionnaire (ERQ) and the Cognitive Emotion Regulation Questionnaire (CERQ). Methods: The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. Systematic searches were performed in PubMed and Scopus databases for studies published between 25 October 2015 and 25 October 2025. The methodological quality and risk of bias of the included studies were evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist and JBI Checklist for Randomized Controlled Trials. Data extraction and synthesis were performed manually by two independent reviewers. Eligible studies included adult participants (≥18 years) diagnosed with gambling disorder or pathological gambling and using the ERQ or CERQ to assess emotion regulation. Results: Nine studies met the inclusion criteria, comprising a total of 607 patients with GD. Across studies, individuals with GD consistently showed reduced cognitive reappraisal, greater expressive suppression, and higher use of maladaptive cognitive strategies such as rumination, catastrophizing, and self-blame. All studies identified impulsivity, emotion dysregulation, alexithymia, or gambling-related cognitive distortions as significant predictors of gambling severity. Neuroimaging evidence from one study further revealed altered activation of frontal regions during negative emotion regulation. Conclusions: This review highlights the central role of emotion regulation in GD. However, the limited available ERQ/CERQ studies in GD were mostly cross-sectional, limiting causal inferences. Second, samples were predominantly male, reducing generalizability to women. Finally, only one study used neurobiological measures, hindering integration of self-report and neural data. These findings emphasize the importance of integrating emotion regulation-based interventions within therapeutic programs for gambling disorder, with ERQ and CERQ being useful tools to assess the pathology. Full article

Objectives: This study aimed to determine whether adults with tinnitus exhibit altered phase-specific mandibular kinematics during saliva swallowing and increased prevalence of tongue thrust and Eustachian-tube insufficiency versus tinnitus-free controls. Methods: This was a cross-sectional case–control study including adults with tinnitus and controls. Standardized computerized kinesiography recorded three spontaneous saliva swallows per participant. Primary outcomes were opening/closing time (OCT) and post-closure stabilization time (STT); total swallowing time (SWT) was secondary. Tongue thrust (TT) and tubal insufficiency (TI) were assessed clinically. Distributional assumptions were checked with Shapiro–Wilk; between-group comparisons used two-sided Mann–Whitney U tests and Fisher’s exact tests (TT, TI). Effect sizes included rank-biserial correlation (r), Hodges–Lehmann median difference (Δ), and odds ratios (ORs) with 95% confidence intervals. Co-occurrence of TT and TI and their relationships with OCT, STT, and SWT were evaluated within strata (cases vs. controls) using Fisher’s exact test, φ, Mann–Whitney U tests, and Spearman’s ρ. Given the marked imbalance in age and sex between groups, unadjusted non-parametric comparisons were complemented by multivariable models with adjustment for age and sex. An omnibus non-parametric combination test summarized case–control differences across OCT, STT, and SWT. Results: Statistical analysis was performed on 77 cases with tinnitus and 78 controls. Tinnitus cases showed longer OCT (1.75 ± 0.92 vs. 1.12 ± 0.62 s; p < 0.001; r ≈ 0.40; Δ ≈ +0.60 s) and STT (1.44 ± 0.88 vs. 0.84 ± 0.62 s; p < 0.001; r ≈ 0.42; Δ ≈ +0.60 s), while SWT differed modestly and was not significant (2.75 ± 0.69 vs. 2.57 ± 0.65 s; p = 0.115; r ≈ 0.15; Δ ≈ +0.18 s). TT was more frequent in cases (18.2%) than controls (6.4%; OR = 3.05, 95% CI 1.08–8.61; p = 0.029), whereas TI occurred in 16.9% of cases and 0% of controls (corrected OR = 32.85, 95% CI 1.92–563.49; p < 0.001). Within tinnitus cases, TT and TI did not show meaningful co-occurrence (φ ≈ −0.03; p = 1.00). TT+ tinnitus patients exhibited markedly prolonged OCT compared with TT− (median 2.22 vs. 1.45 s; Δ ≈ +0.88 s; r ≈ 0.60; p < 0.001), whereas STT and SWT were minimally affected; TI was not materially associated with any swallowing-time parameter. Spearman analyses confirmed a moderate monotonic association between TT and OCT in tinnitus cases (ρ ≈ 0.40; p < 0.001), with all other correlations small and clinically negligible. Age- and sex-adjusted analyses confirmed longer OCT and STT in tinnitus cases, whereas SWT remained non-significant; TT and TI also remained more frequent in cases after adjustment. The omnibus test indicated a clear global separation between groups across OCT, STT, and SWT (permutation p < 0.001). Conclusions: Adults with tinnitus exhibit a distinct swallowing signature characterized by prolonged OCT and STT, together with higher prevalence of TT and TI. TT in tinnitus patients is specifically linked to a pronounced prolongation of OCT, while STT and SWT remain largely unchanged, and TI shows no relevant impact on kinematic indices. Full article

Background/Objectives: Vitamin D plays a role in cellular regulation and immune processes relevant to cervical carcinogenesis, yet data on vitamin D status and its determinants in high-burden settings such as South Africa remain scarce. This paper therefore describes the prevalence of vitamin D deficiency, insufficiency, and sufficiency, and explores associated factors among women with cervical lesions. Methods: A descriptive cross-sectional study was conducted among 103 women aged 18–81 years. Women were referred to Nelson Mandela Academic Hospital due to cervical cancer, high-grade squamous intraepithelial lesions (HSILs), or atypical squamous cells—cannot exclude HSIL, or low-grade squamous intraepithelial lesions, or atypical squamous cells of undetermined significance. The total serum 25(OH)D (D₂ + D₃) was quantified using the MAGLUMI 25-OH Vitamin D chemiluminescent immunoassay kit on the MAGLUMI X3 Fully Automatic Chemiluminescence Immunoassay Analyzer (Snibe Diagnostic, Shenzhen New Industries Biomedical Engineering Co., Ltd., Shenzhen, China). Serum vitamin D was categorized according to the Endocrine Society Task Force guidelines. Results: Vitamin D insufficiency was observed in 46.60% of participants and deficiency in 26.21% while only 27.18% had sufficient levels. Overall, vitamin D deficiency or insufficiency was more common than sufficiency (72.82%; 27.18%, p < 0.0001). Among HIV-positive women, 78.26% had vitamin D deficiency or insufficiency compared with 63.33% of HIV-negative women; however, this difference was not statistically significant. Vitamin D deficiency was most prevalent in women with healthy body mass index (BMI, 46.40%) values and decreased significantly with increasing BMI values (p = 0.008). Conclusions: Vitamin D deficiency and insufficiency were common among women with cervical lesions in this rural South African population. Associations with BMI suggest context-specific influences on vitamin D status. Owing to the study’s cross-sectional design and lack of normal cervical cytology participants, the findings are descriptive and exploratory, underscoring the need for longitudinal and comparative research to better define the role of vitamin D in cervical disease. Full article

The traditional Discrete Element Method (DEM) can track the motion details of individual particles, but its computational cost becomes excessively high when simulating large-scale systems involving millions or even billions of particles. In this study, a coarse-grained DEM approach was employed to analyze the flow behavior of mixed particles in a coal powder silo. This method maintains reasonable simulation accuracy while effectively reducing the total number of computational particles and significantly improving computational efficiency. After conducting investigations on the mesh-to-particle size ratio and model validation, this paper focuses on examining the effects of coal particle size distribution and mixing ratio on the characteristics of particle motion. The results indicate that during the discharge process of mixed particles, the downward velocity of particles in the central axis region near the outlet is significantly higher than that in the wall region, exhibiting typical funnel flow characteristics. The particle size distribution has a notable impact on the particle descent velocity. The uniform distribution case shows the highest descent velocity, the linear distribution case the lowest, while the normal distribution case falls between the two. Notably, in the normal distribution case, the descent velocity in the central axis region is similar to that of the uniform distribution, while the descent velocity in the wall region approaches that of the linear distribution. This presents a combined characteristic of the two extreme distributions rather than a simple transitional state. In contrast, the particle mixing ratio has a relatively minor influence on the overall motion characteristics. The mass flow rate of particles and the cross-sectional velocity distribution remain largely consistent, with only slight differences observed in the velocity within the central axis region. Full article

Background: Arterial hypertension (AH) is a frequent comorbidity in patients with osteoarthritis (OA). Among antihypertensive agents, angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers (CCBs), angiotensin II receptor blockers (ARBs), and beta-blockers (βBs) have been suggested to influence OA progression and symptomatology. The aim of this study was to assess whether the duration of effectiveness (DE) of viscosupplementation (VS) differs between patients with knee OA who are receiving antihypertensive treatment and those who are not. Methods: This post hoc analysis was conducted using data from a cross-sectional clinical trial (ClinicalTrials.gov Identifier: NCT04988698). The study included consecutive patients with knee OA who came for consultation at the Rheumatology Department and had received intra-articular hyaluronic acid injections within the past three years. The primary outcome was DE, self-reported by patients as the number of weeks of symptom relief. Associations between DE and various factors, including demographics, disease duration, radiographic OA severity (Kellgren–Lawrence grade and affected compartments), comorbidities, OA treatment history, antihypertensive therapy, physical activity level, and prior VS sessions, were analyzed using bivariate and multivariate models. Results: A total of 105 patients (65 women, 149 treated knees) were included. The mean age was 66.1 ± 13.2 years, and the mean body mass index (BMI) was 27.5 kg/m². Thirty-eight percent of patients were receiving antihypertensive treatment (mean number of agents: 1.9; range: 1–4), including CCBs (n = 15), ACE inhibitors (n = 13), ARBs (n = 7), βBs (n = 6), and diuretics (n = 2). The overall mean DE of VS was 48.2 ± 24.8 weeks, with a trend toward longer DE in hypertensive patients compared to non-hypertensive patients (53.1 ± 31.3 vs. 45.4 ± 19.8 weeks, p = 0.06). Bivariate analysis identified significantly longer DE in patients with BMI < 27.5 kg/m² (p = 0.002), Kellgren–Lawrence grade < 4 (p = 0.008), an active lifestyle (p = 0.005), unicompartmental OA (p = 0.01), medial tibiofemoral joint space narrowing (p = 0.046), and fewer than four prior VS sessions (p = 0.02). In multivariate analysis, AH was strongly associated with prolonged DE (p < 0.001), despite AH patients having a higher BMI (29.8 ± 5.5 vs. 25.2 ± 5.2 kg/m², p = 0.001) and being more frequently sedentary (25.5% vs. 13.8%, p = 0.07). A trend toward longer DE was observed in patients treated with βBs and ARBs but not with CCBs or ACE inhibitors. Additional independent predictors of longer DE included BMI < 27.5 kg/m² (p < 0.001), unicompartmental OA (p = 0.02), fewer than four prior VS sessions (p = 0.02), and an active lifestyle (p = 0.027). Conclusions: These findings suggest that antihypertensive treatment may extend the effectiveness of viscosupplementation in knee OA. However, the sample size was insufficient to determine whether specific classes of antihypertensive agents provide greater benefits. Further large-scale, prospective studies are warranted to clarify the potential impact of antihypertensive medications on viscosupplementation outcomes in knee OA. Full article

Spaceborne synthetic aperture radar (SAR) absolute radiometric calibration relies on point targets with a known radar cross-section (RCS), such as triangular trihedral corner reflectors (TTCRs). Traditionally, radiometric calibration using TTCRs requires precise alignment of the corner reflector (CR) boresight to the radar line-of-sight (LOS), leading to frequent field operations and high labor dependency. In this study, a novel compact bidirectional trapezoidal CR is proposed to eliminate such alignment reorientations. The novel CR adopts three design considerations: a scalene shape to optimize the boresight elevation angle and enhance the peak RCS; a bidirectional configuration with azimuth fine-tuning to align with the radar LOS for both ascending and descending passes; and trapezoidal plate trimming to reduce the volume and weight without sacrificing RCS performance. An in-orbit validation is conducted in Xi’an, China, using the SuperView Neo 2-03 satellite. The results demonstrate that the imaging quality of the bidirectional trapezoidal CRs is comparable to that of conventional TTCRs, with all the parameters meeting system specifications. The radiometric calibration constant of the bidirectional trapezoidal CR differs from that of the conventional TTCR by no more than 0.27 dB, with a total uncertainty of ~0.33 dB (1σ)—demonstrating that it achieves equivalent radiometric calibration accuracy to TTCRs. The experiment confirms the feasibility and engineering applicability of the bidirectional trapezoidal CR for X-band SAR radiometric calibration. Full article

Background/Objectives: Current musculoskeletal health assessment expanded beyond bone mineral density (BMD) at central DXA to include, for instance, trabecular bone score (TBS) and emergent biomarkers, such as adipokines and myokines (e.g., irisin) assays. A current gap in their application is reflected in limited research regarding adrenal tumors, especially non-functional adrenal tumors/mild autonomous cortisol secretion (NFATs/MACS). To assess this current gap, we aimed to explore beyond BMD, specifically, TBS and circulating irisin, in relation to the adrenal status in NFATs/MACS. Methods: This is a prospective, cross-sectional, single-center, exploratory study, conducted between October 2024 and December 2025. Results: A total of 81 menopausal women were included (mean age of 63.26 ± 8.82 years, 15.86 ± 9.5 years since menopause, average BMI of 30.69 ± 5.76 kg/sqcm. Out of them, 33.33% had NFATs/MCAS (group AI) and 66.67% were controls (group C), with similar age, years since menopause, and BMI. The prevalence of type 2 diabetes was 66.67% versus 68.52% (p = 0.865). TBS correlated with lumbar BMD/T-score (N = 33), while age and lumbar BMD were independent TBS predictors (N = 81), but not type 2 diabetes nor NFAs/MCAS. TBS correlated with the five-year age groups (r = −0.273, p = 0.003). Irisin correlated with osteocalcin (r = −0.252, p = 0.007), P1NP (r = −0.187, p = 0.049) and CrossLaps (r = −0.209, p = 0.026) in tumor-free controls. In the AI group, a higher irisin was associated with a higher second-day cortisol after 1 mg DST (r = 0.11, p = 0.584) and a lower ACTH (r = −0.716, p < 0.001). The rate of low TBS (based on 1.350 cutoffs) was 48.15% versus 38.89% in group AI versus C. In the AI group, patients with low TBS had lower osteocalcin, P1NP, and CrossLaps than those with normal TBS, with a similar rate of type 2 diabetes (which might reduce the bone turnover markers) and MACS-positive prevalence (between 25 and 28%). Conclusions: The median glycated hemoglobin A1c (5.78% versus 5.93%, p = 0.94) and median HOMA-IR (1.53 versus 1.42, p = 0.948) suggest a certain level of glucose control, which might not be reflected in severely damaged bone microarchitecture, as shown by TBS. Irisin may be one of the additional factors in these tumors reflecting the hormonal burden. Irisin was statistically significantly elevated with the increase in BMI groups. To our best awareness, this is the first synchronous analysis of TBS and irisin levels in this type of tumor to address the bone status in relation to the glucose profile and adrenal panel. Noting this is an exploratory, hypothesis-generating study, further research will highlight the true value of TBS and irisin for practitioners in the adrenal field, including multi-layered models of bone status prediction. Full article

(1) Background: The families of military personnel preparing for deployment are exposed to anticipatory stressors that may adversely affect their psychological well-being. This study aimed to examine the associations between anxiety, psychological resilience, and trait hope among the family members of military personnel during the pre-deployment period. (2) Methods: A cross-sectional online survey was conducted between 20 September and 20 December 2025 and included 73 Romanian adult participants. From a psychiatric perspective, anxiety during the pre-deployment phase represents a clinically relevant form of anticipatory distress that may benefit from early identification and preventive intervention. Anxiety was assessed using the Generalized Anxiety Disorder 7-item scale (GAD-7), psychological resilience with the Brief Resilience Scale (BRS), and trait hope with the Adult Hope Scale (Agency and Pathways subscales). Pearson correlation analyses, multivariable linear regression, and hierarchical regression models were applied. (3) Results: Participants reported moderate anxiety levels (GAD-7 mean 7.52 ± 4.98). Anxiety was strongly negatively correlated with psychological resilience (r = −0.75, p < 0.001) and moderately negatively correlated with total hope (r = −0.67, p < 0.001), Agency (r = −0.61, p < 0.001), and Pathways (r = −0.64, p < 0.001). Psychological resilience emerged as a significant negative predictor of anxiety (β = −0.64, p < 0.001). Hierarchical regression showed that trait hope explained additional variance in anxiety severity beyond resilience and sociodemographic variables (ΔR² = 0.07, p < 0.001). (4) Conclusions: Psychological resilience and trait hope were independently and jointly associated with lower pre-deployment anxiety in military families, underscoring their relevance to preventive and community psychiatry as modifiable resources for early screening and non-pharmacological intervention. Full article

Genetic and metabolic factors contribute to hypertension, yet integrated sex-specific models remain limited. In this cross-sectional study, we developed sex-specific models to discriminate prevalent hypertension discrimination by integrating genetic risk scores (GRSs) with metabolic and vascular biomarkers. From 2075 Korean adults, the final models were evaluated using model-specific complete-case datasets (total n = 775; males n = 382; females n = 397). Blood pressure-related single-nucleotide polymorphisms (SNPs) were screened using genome-wide association analyses (p < 1 × 10⁻⁵), and selected variants were used to construct weighted GRSs. Models integrating GRSs with body mass index (BMI), brachial–ankle pulse wave velocity (ba-PWV), and urinary 8-epi-prostaglandin F_2α (8-epi-PGF_2α) were evaluated by multivariable logistic regression and receiver operating characteristic analysis, with 1000-bootstrap internal validation. Three SNPs formed the total-sample GRS (rs13175330, rs117559502, rs62099117; adjusted odds ratio [OR] = 3.20) and three formed the female GRS (rs13175330, rs6001482, rs62099117; adjusted OR = 2.80); no stable male-specific GRS met prespecified criteria. The final discrimination models achieved an area under the curve of 0.833 in the total sample and 0.913 in females (BMI + ba-PWV + 8-epi-PGF_2α + GRS), and 0.758 in males (BMI + ba-PWV + 8-epi-PGF_2α). These findings support sex-aware hypertension risk characterization and warrant external and prospective validation. Full article