Search Results (3,446)

Background/Objectives: Peripheral artery disease (PAD) impacts more than 200 million individuals globally and leads to mortality and morbidity secondary to progressive limb dysfunction and amputation. However, clinical management of PAD remains suboptimal, in part because of the lack of standardized biomarkers to predict patient outcomes. Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine that has been studied extensively in cardiovascular disease, but its investigation in PAD remains limited. This study aimed to use explainable statistical and machine learning methods to assess the prognostic value of GDF15 for limb outcomes in patients with PAD. Methods: This prognostic investigation was carried out using a prospectively enrolled cohort comprising 454 patients diagnosed with PAD. At baseline, plasma GDF15 levels were measured using a validated multiplex immunoassay. Participants were monitored over a two-year period to assess the occurrence of major adverse limb events (MALE), a composite outcome encompassing major lower extremity amputation, need for open/endovascular revascularization, or acute limb ischemia. An Extreme Gradient Boosting (XGBoost) model was trained to predict 2-year MALE using 10-fold cross-validation, incorporating GDF15 levels along with baseline variables. Model performance was primarily evaluated using the area under the receiver operating characteristic curve (AUROC). Secondary model evaluation metrics were accuracy, sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV). Prediction histogram plots were generated to assess the ability of the model to discriminate between patients who develop vs. do not develop 2-year MALE. For model interpretability, SHapley Additive exPlanations (SHAP) analysis was performed to evaluate the relative contribution of each predictor to model outputs. Results: The mean age of the cohort was 71 (SD 10) years, with 31% (n = 139) being female. Over the two-year follow-up period, 157 patients (34.6%) experienced MALE. The XGBoost model incorporating plasma GDF15 levels and demographic/clinical features achieved excellent performance for predicting 2-year MALE in PAD patients: AUROC 0.84, accuracy 83.5%, sensitivity 83.6%, specificity 83.7%, PPV 87.3%, and NPV 86.2%. The prediction probability histogram for the XGBoost model demonstrated clear separation for patients who developed vs. did not develop 2-year MALE, indicating strong discrimination ability. SHAP analysis showed that GDF15 was the strongest predictive feature for 2-year MALE, followed by age, smoking status, and other cardiovascular comorbidities, highlighting its clinical relevance. Conclusions: Using explainable statistical and machine learning methods, we demonstrated that plasma GDF15 levels have important prognostic value for 2-year MALE in patients with PAD. By integrating clinical variables with GDF15 levels, our machine learning model can support early identification of PAD patients at elevated risk for adverse limb events, facilitating timely referral to vascular specialists and aiding in decisions regarding the aggressiveness of medical/surgical treatment. This precision medicine approach based on a biomarker-guided prognostication algorithm offers a promising strategy for improving limb outcomes in individuals with PAD. Full article

Hundreds of Japanese features of war (field positions, tunnels, and fortifications) were constructed in Hong Kong during World War II. However, most of them were poorly documented and were left unknown but still in relatively good condition because of their durable design, workmanship, and remoteness. These features of war form parts of Hong Kong’s brutal history. Conservation, at least in digital form, is worth considering. With the authors coming from multidisciplinary and varied backgrounds, this paper aims to explore these features using a scientific workflow. First, we reviewed the surviving archival sources of the Imperial Japanese Army and Navy. Second, airborne LiDAR data were used to form territory digital terrain models (DTM) based on the Red Relief Image Map (RRIM) for identifying suspected locations. Third, field expeditions of searching for features of war were conducted through guidance of Global Navigation Satellite System—Real-Time Kinetics (GNSS-RTK). Fourth, the found features were 3D-laser scanned to generate mesh models as a digital archive and validate the findings of DTM-RRIM. This study represents a reverse-engineering effort to reconstruct the planned Japanese defense tactics of guerilla fight and Kamikaze grottos that were never used in Hong Kong. Full article

Driven by stringent emission regulations, advanced combustion modes utilizing turbulent jet ignition technology are pivotal for enhancing the performance of marine low-speed natural gas dual-fuel engines. This review focuses on three novel combustion modes, yielding key conclusions: (1) Compared to the conventional DJCDC mode, the TJCDC mode exhibits a significantly higher swirl ratio and turbulence kinetic energy in the main chamber during initial combustion. This promotes natural gas jet development and combustion acceleration, leading to shorter ignition delay, reduced combustion duration, and a combustion center (CA50) positioned closer to the Top Dead Center (TDC), alongside higher peak cylinder pressure and a faster early heat release rate. Energetically, while TJCDC incurs higher heat transfer losses, it benefits from lower exhaust energy and irreversible exergy loss, indicating greater potential for useful work extraction, albeit with slightly higher indicated specific NOx emissions. (2) In the high-compression ratio TJCPC mode, the Liquid Pressurized Natural Gas (LPNG) injection parameters critically impact performance. Delaying the start of injection (SOI) or extending the injection duration degrades premixing uniformity and increases unburned methane (CH₄) slip, with the duration effects showing a load dependency. Optimizing both the injection timing and duration is, therefore, essential for emission control. (3) Increasing the excess air ratio delays the combustion phasing in TJCPC (longer ignition delay, extended combustion duration, and retarded CA50). However, this shift positions the heat release more optimally relative to the TDC, resulting in significantly improved indicated thermal efficiency. This work provides a theoretical foundation for optimizing high-efficiency, low-emission combustion strategies in marine dual-fuel engines. Full article

In this research work, the authors propose an approach for analyzing a traffic accident involving a motorcycle and a pedestrian. The study was conducted under the condition that there are objects in the accident area that limit the visibility of the participants. For this purpose, a three-dimensional simulation model was developed to determine the relative positions of the pedestrian and the motorcycle-driver system at discrete moments, examining the period of time from the moment the pedestrian steps onto the roadway to the moment of contact between the participants. Data from a real traffic accident were used. Full article

To investigate the group behavioral characteristics of Schizothorax wangchiachii during the spawning period, we used acoustic telemetry to track 10 mature individuals (4 females, 12 males) in a semi-controlled stream section (28.1 m × 5.8 m) simulating natural spawning microhabitats from 23 to 26 January 2024. By integrating trajectory similarity analysis and wavelet transform, we examined the aggregation patterns and activity rhythms during natural spawning events. The population formed two relatively stable subgroups, with significantly shorter inter-individual distances during the day (1.69 ± 0.72 m) than at night (2.54 ± 0.85 m, p < 0.01). Aggregation behavior exhibited a dominant ultradian rhythm of 16.5 h, with stable clustering between 09:00 and 16:00 (spawning window: 13:40–14:20) and dispersal from 19:00 to 00:00. Group activity followed a decreasing-then-increasing trend, with higher nighttime activity. Males were more active than females (F = 51.89, p < 0.01); female activity peaked on the spawning day and was influenced by reproductive progression, while male activity was mainly driven by diel rhythms (p < 0.01). A weak positive correlation was found between active time and inter-individual distance in both sexes (r = 0.32, p < 0.05), indicating reduced activity when aggregated. These findings provide insight into the temporal coordination and spatial regulation of reproductive behavior under semi-controlled conditions. However, due to the short monitoring period and experimental setup, caution is warranted when generalizing to the full reproductive season or fully natural habitats. Full article

Ensuring food security necessitates a high level of coordinated development between agricultural trade and production. Based on China’s provincial panel data from 2010 to 2023, this study constructs an evaluation index system for agricultural trade and production, employing an entropy-weighted TOPSIS model to measure their development levels. On this basis, a coupling coordination degree model and Moran’s I indices are used to analyze the coordinated development level’s temporal changes and spatial effects. The research finds that the development levels of China’s agricultural trade and production show an upward trend but currently still exhibit the pattern of higher levels in Eastern China and lower levels in Western China. The coupling coordination level between them demonstrates an increasing trend, yet the overall level remains relatively low, with an average value of only 0.445, consistently staying in a marginal disorder “running-in stage” and spatially presenting a distinct “east-high–west-low” stepped distribution pattern. Furthermore, from a spatial perspective, the Global Moran’s index decreased from 0.293 to 0.280. The coupling coordination degree of agricultural trade and production in China generally exhibits a positive spatial autocorrelation, but this effect has been weakening over time. Most provinces show spatial clustering characteristics of high–high and low–low agglomeration in local space, and this feature is relatively stable. Building on these insights, this study proposes a refinement of the coordination mechanisms between agricultural trade and production, alongside the implementation of differentiated regional coordinated development strategies, to promote the coupled and coordinated advancement of agricultural trade and production. Full article

Inductive Wireless Power Transfer (WPT) technologies are advancing significantly in the electric vehicle (EV) charging applications. Misalignment between transmitting and receiving coils can considerably affect power transmission efficiency in WPT systems. Prior research involved power electronics as well as electromagnetic couplers. This work focuses on the coil design aspect of electromagnetic couplers. A relatively new concept of Symmetrical Cross Double-D (SCDD) type of the coil design is introduced specifically to maximize tolerance to misalignment while sustaining significant amount of power transferred. Mutual inductance was determined for the perfect alignment and misalignment positions of the SCDD coils. Mutual inductance obtained from the simulation was validated from the experimental measurements. The SCDD electromagnetic coupler demonstrated almost 2.5 times superior tolerance to misalignment of coils compared to the conventional circular coupler while maintaining at least 78% of maximum power transfer even at a lateral misalignment of 40 mm. Full article

Background/Objectives: The accurate localization of interfascial planes is critical for effective regional anesthesia, yet current techniques relying on ultrasound guidance can be challenging, especially in obese or pediatric patients. Previous cadaveric and clinical studies have suggested that injection pressure varies depending on needle placement relative to fascial and neural structures. This pilot study aimed to evaluate whether the continuous monitoring of injection pressure can reliably differentiate interfascial spaces from surrounding anatomical structures in a porcine tissue model. Methods: A custom-built pressure monitoring system was used to continuously measure saline injection pressure during regional block procedures performed on porcine thighs. Injections were guided by ultrasound and conducted using an infusion pump. Needle positions were classified as intramuscular, resting on fascia, or interfascial. Statistical comparisons of pressure levels, variability, and temporal trends were conducted using Wilcoxon signed-rank tests and regression analysis. Results: Mean intramuscular pressure was significantly higher than the mean interfascial pressure (p < 1 × 10⁻¹³). Interfascial injections demonstrated lower pressure variability (p = 2.1 × 10⁻⁴) and an increasing trend in pressure over time (p = 2.1 × 10⁻⁴), whereas intramuscular injections exhibited a decreasing pressure trend (p = 3.15 × 10⁻³). Conclusions: Continuous pressure monitoring effectively distinguishes interfascial from intramuscular and fascial penetration phases during regional anesthesia. The method demonstrates potential as a real-time, objective tool for enhancing needle guidance and improving the safety and accuracy of interfascial plane blocks. Further cadaveric and clinical studies are warranted to validate these findings. Full article

Optimizing water resource utilization is a critical challenge to meet the dramatic increase in food demand. Therefore, continuous studies to minimize water demand for plants are highly needed. This study aims to employ HYDRUS (2D/3D) software to simulate the effects of continuous and intermittent water flow on soil water distribution under a subsurface point source. The constant parameters included loamy sand soil, a water application time of 30 min, and an emitter discharge of 3.41 L/h. The variable parameters consisted are two pipe depths (25 cm and 35 cm), three ratios of ON:OFF times (1ON:1OFF, 1ON:3OFF, and 1ON:5OFF), and five water application cycles (WF1C, WF2C, WF3C, WF4C, and WF5C, with WF1C as for the continuous water flow). The results revealed that, in 30 min of water application, continuous water flow and ON:OFF ratios of 1ON:1OFF and 1ON:3OFF achieved maximum water retention in the vicinity of the emitter. In 60 min, increasing cycles enhanced retention for 1ON:1OFF and 1ON:3OFF, yet the 1ON:5OFF time ratio achieved the highest water content near the emitter. In 120 min, the 1ON:1OFF ratio showed an insignificant effect with cycle variations, but 1ON:3OFF and 1ON:5OFF exhibited increased retention. Similarly, in 180 min, 1ON:1OFF was unaffected by cycles, whereas 1ON:3OFF and 1ON:5OFF significantly improved retention. After 360 min, all treatments displayed equal water retention relative to the emitter position. Also, the results revealed that increasing water application cycles and ON:OFF time ratios lead to more holding soil water content, especially at soil levels of 20, 30, and 40 cm. These results affirm that positioning the emitters line at 25 cm enhances water retention more effectively than at 35 cm. Ultimately, statistical analysis confirmed that the combination of pipe depth, water application cycles, and ON:OFF ratios significantly affects the retention of soil water content in the vicinity of the emitter. Full article

Oral narratives play a crucial role in shaping the historical consciousness of Indigenous communities in Northeast India, where history writing is a relatively recent phenomenon. Among the Mizos, Nagas, Khasis, Kuki-Chins, and other Indigenous tribes of Northeast India, including the Bodos, the Garos, the Dimasas, or the Karbis of Assam, much of what is considered written history emerged during British colonial rule. Native historians later continued it in postcolonial India. However, written history, especially when based on fragmented colonial records, includes interpretive gaps. In such contexts, oral traditions provide complementary, and frequently, more authoritative frameworks rooted in cultural memory and collective transmission. Oral narratives, including ritual poetry, folk songs, myths, and folktales, serve as vital mediums for reconstructing the past. Scholars such as Jan Vansina view oral narratives as essential for understanding the histories of societies without written records, while Paul Thompson sees them as both a discovery and a recovery of cultural memory. Romila Thapar argues that narratives become indicative of perspectives and conditions in societies of the past, functioning as a palimpsest with multiple layers of meaning accruing over generations as they are recreated or reiterated over time. The folk narratives of the Mizos and Angami Nagas not only recount their origins and historical migrations, but also map significant geographical and cultural landmarks, such as Khezakheno and Lungterok in Nagaland, Rounglevaisuo in Manipur, and Chhinlung or Rih Dil on the Mizoram–Myanmar border. These narratives constitute a cultural understanding of the past, aligning with Greg Dening’s concept of “public knowledge of the past,” which is “culturally shared.” Additionally, as Linda Tuhiwai Smith posits, such stories, as embodiments of the past, and of socio-cultural practices of communities, create spaces of resistance and reappropriation of Indigenous identities even as they reiterate the marginalization of these communities. This paper deploys these ideas to examine how oral narratives can be used to decolonize grand narratives of history, enabling Indigenous peoples, such as the Mizos and the Angamis in North East India, to reaffirm their positionalities within the postcolonial nation. Full article

Steel lazy wave risers (SLWRs) are critical in offshore hydrocarbon transport for linking subsea wells to floating production facilities in deep-water environments. The incorporation of buoyancy modules reduces curvature-induced stress concentrations in the touchdown zone (TDZ); however, extended operational exposure under cyclic environmental and operational loads results in repeated seabed contact. This repeated interaction modifies the seabed soil over time, gradually forming a trench and altering the riser configuration, which significantly impacts stress patterns and contributes to fatigue degradation. Accurately reconstructing the riser’s evolving profile in the TDZ is essential for reliable fatigue life estimation and structural integrity evaluation. This study proposes a simulation-based framework for the autonomous tracking of SLWRs using a fin-actuated autonomous underwater vehicle (AUV) equipped with a monocular camera and multibeam echosounder. By fusing visual and acoustic data, the system continuously estimates the AUV’s relative position concerning the riser. A dedicated image processing pipeline, comprising bilateral filtering, edge detection, Hough transform, and K-means clustering, facilitates the extraction of the riser’s centerline and measures its displacement from nearby objects and seabed variations. The framework was developed and validated in the underwater unmanned vehicle (UUV) Simulator, a high-fidelity underwater robotics and pipeline inspection environment. Simulated scenarios included the riser’s dynamic lateral and vertical oscillations, in which the system demonstrated robust performance in capturing complex three-dimensional trajectories. The resulting riser profiles can be integrated into numerical models incorporating riser–soil interaction and non-linear hysteretic behavior, ultimately enhancing fatigue prediction accuracy and informing long-term infrastructure maintenance strategies. Full article

Background: An effective vaccine against Nipah virus (NiV) is crucial due to its high fatality rate and recurrent outbreaks in South and Southeast Asia. Vaccine development is challenged by the lack of validated accessible neutralization assays, as virus culture requires BSL-4 facilities, restricting implementation in resource-limited settings. To address this, we standardized and validated a pseudotyped virus neutralization assay (PNA) for assessing NiV-neutralizing antibodies in BSL-2 laboratories. Methods: The NiV-PNA was validated following international regulatory standards, using a replication-defective recombinant Vesicular stomatitis virus (rVSV) backbone dependent pseudotyped virus. Assessments included sensitivity, specificity, dilutional linearity, relative accuracy, precision, and robustness. The assay was calibrated using the WHO International Standard for anti-NiV antibodies and characterized reference sera to ensure reliable performance. Findings: Preliminary evaluation of the developed NiV-PNA showed 100% sensitivity and specificity across 10 serum samples (5 positive, 5 negative), with a positive correlation to a calibrated reference assay (R² = 0.8461). Dilutional linearity (R² = 0.9940) and accuracy (98.18%) were confirmed across the analytical titer range of 11-1728 IU/mL. The assay also exhibited high precision, with intra-assay and intermediate precision geometric coefficients of variation of 6.66% and 15.63%, respectively. Robustness testing demonstrated minimal variation across different pseudotyped virus lots, incubation times, and cell counts. Conclusions: The validated NiV-PNA is a reproducible and scalable assay platform for quantifying NiV neutralizing antibodies, offering a safer alternative to virus culture. Its validation and integration into the CEPI Centralized Laboratory Network will enhance global capacity for vaccine evaluation and outbreak preparedness. Full article

Background/Objectives: Lung cancer screening with low-dose computed tomography (LDCT) has reduced lung cancer mortality in high-risk smokers. However, the evidence on LDCT screening in the elderly is limited, with there being few older participants in major trials and ongoing debate about the benefits, risks, and appropriate age limits of LDCT. This study aimed to investigate the prevalence of pulmonary nodules and lung cancer detection rates in men aged 70 and above who underwent a single round of LDCT screening. Methods: We retrospectively analyzed data from elderly male participants aged 70 years or older who underwent a single low-dose CT lung cancer screening at the Veterans Health Service Medical Center between 2010 and 2023. The participants included those who requested screening or were asymptomatic but recommended by physicians. Individuals with prior lung cancer, symptoms suggestive of lung cancer, or suspicious findings on previous imaging were excluded. The nodule prevalence, lung cancer diagnoses, pathological subtypes, and clinical stages were reviewed. Results: A total of 1409 individuals with a mean age of 74.2 years were included. The median follow-up duration was 3.6 years. Among the included individuals, 1304 (92.6%) had a history of smoking. Positive nodules were detected in 179 patients (12.7%, 95% CI: 11.0–14.5%), and lung cancer was diagnosed in 31 patients (2.2%, 95% CI: 1.5–3.1%). Of the diagnosed cases, 14 (45.2%) were adenocarcinomas and 12 (38.7%) were squamous cell carcinomas. Nineteen patients (51.3%) were diagnosed with stage I or II cancer, while seven (22.6%) were diagnosed at stage IV. Conclusions: A single round of LDCT screening in elderly men resulted in a relatively high lung cancer detection rate, with over half of the diagnosed cases being identified at an early stage. This highlights the potential clinical benefit of even one-time screening in enabling timely treatment, which may still be feasible in older adults. However, potential harms such as overdiagnosis should also be considered. Full article

Seasonal climate variability and agronomic management profoundly influence both the productivity and nutritive value of temperate hay meadows. We analyzed five years of data (2019, 2020, 2022–2024) from 15 meadows in the central Spanish Pyrenees to quantify how environmental variables (January–June minimum temperatures, rainfall), management variables (fertilization rates (N, P, K), livestock load, cutting date), and vegetation (plant biodiversity (Shannon index)) drive total biomass yield (kg ha⁻¹), protein content (%), and Relative Feed Value (RFV). Using Random Forest regression with rigorous cross-validation, our yield model achieved an R² of 0.802 (RMSE = 983.8 kg ha⁻¹), the protein model an R² of 0.786 (RMSE = 1.71%), and the RFV model an R² of 0.718 (RMSE = 13.86). Variable importance analyses revealed that March rainfall was the dominant predictor of yield (importance = 0.430), reflecting the critical role of early-spring moisture in tiller establishment and canopy development. In contrast, cutting date exerted the greatest influence on protein (importance = 0.366) and RFV (importance = 0.344), underscoring the sensitivity of forage quality to harvest timing. Lower minimum temperatures—particularly in March and May—and moderate livestock densities (up to 1 LU) were also positively associated with enhanced protein and RFV, whereas higher biodiversity (Shannon ≥ 3) produced modest gains in feed quality without substantial yield penalties. These findings suggest that adaptive management—prioritizing soil moisture conservation in early spring, timely harvesting, balanced grazing intensity, and maintenance of plant diversity—can optimize both the quantity and quality of hay meadow biomass under variable climatic conditions. Full article

The construction of pit-in-pit has become increasingly challenging due to the bad geological conditions, particularly in collapsible loess strata. To understand its supporting characteristics and failure mode, it is necessary to study the composite instability mechanism in the loess strata. This research systematically investigates the interacting instability modes of pit-in-pit under a collapsible loess stratum, studies the effects of different reinforcement parameters through physical model tests, analyzes the significance level of each reinforcement factor, and monitors the displacement of the foundation pit during construction in a pit project in Zhengzhou. The result shows that the soil pressure distribution law of the pit in a collapsible loess formation is a complex function of soil parameters, the relative positional relationship between the inner and outer foundation pits, and the time of immersion. The model test shows that the width and depth of reinforced soil have the most significant influence. The reinforcement measures proposed in this paper can effectively control the displacement of each measuring point during the foundation pit excavation, which can provide a reference for similar projects. Full article