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24 pages, 3707 KiB  
Article
Comparison of a Continuous Forest Inventory to an ALS-Derived Digital Inventory in Washington State
by Thomas Montzka, Steve Scharosch, Michael Huebschmann, Mark V. Corrao, Douglas D. Hardman, Scott W. Rainsford, Alistair M. S. Smith and The Confederated Tribes and Bands of the Yakama Nation
Remote Sens. 2025, 17(10), 1761; https://doi.org/10.3390/rs17101761 - 18 May 2025
Viewed by 527
Abstract
The monitoring and assessment of forest conditions has traditionally relied on continuous forest inventory (CFI) plots, where all plot trees are regularly measured at discrete locations, then plots are grouped as representative samples of forested areas via stand-based inventory expectations. Remote sensing data [...] Read more.
The monitoring and assessment of forest conditions has traditionally relied on continuous forest inventory (CFI) plots, where all plot trees are regularly measured at discrete locations, then plots are grouped as representative samples of forested areas via stand-based inventory expectations. Remote sensing data acquisitions, such as airborne laser scanning (ALS), are becoming more widely applied to operational forestry to derive similar stand-based inventories. Although ALS systems are widely applied to assess forest metrics associated with crowns and canopies, limited studies have compared ALS-derived digital inventories to CFI datasets. In this study, we conducted an analysis of over 1000 CFI plot locations on ~611,000 acres and compared it to a single-tree derived inventory. Inventory metrics from CFI data were forward modeled from 2016 to 2019 using the USDA Forest Service Forest Vegetation Simulator (FVS) to produce estimates of trees per acre (TPA), basal area (BA) per tree or per plot, basal area per acre (BAA), and volume per acre (VPA) and compared to the ALS-derived Digital Inventory® (DI) of 2019. The CFI data provided greater on-plot tree counts, BA, and volume compared to the DI when limited to trees ≥5 inches DBH. On-plot differences were less significant for taller trees and increasingly diverged for shorter trees (<20 feet tall) known to be less detectable by ALS. The CFI volume was found to be 44% higher than the ALS-derived DI suggesting mean volume per acre as derived from plot sampling methods may not provide accurate results when expanded across the landscape given variable forest conditions not captured during sampling. These results provide support that when used together, CFI and DI datasets represent a powerful set of tools within the forest management toolkit. Full article
(This article belongs to the Special Issue Remote Sensing and Lidar Data for Forest Monitoring)
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14 pages, 1613 KiB  
Article
Ultrasound Assessment and Sexual Dimorphism of Thyroid Nodules: Bringing Gender Medicine to Clinical Practice
by Marina Valenzano, Ruth Rossetto Giaccherino, Loredana Pagano, Sara Garberoglio and Roberto Garberoglio
Endocrines 2025, 6(2), 15; https://doi.org/10.3390/endocrines6020015 - 1 Apr 2025
Viewed by 924
Abstract
Background/Objectives: Understanding sex-based differences in both the pathophysiology and clinical presentation of diseases is necessary to improve health care towards precision medicine. The endocrine system is deeply involved in human health, and endocrine diseases may be influenced by steroidal hormone exposure. Thyroid [...] Read more.
Background/Objectives: Understanding sex-based differences in both the pathophysiology and clinical presentation of diseases is necessary to improve health care towards precision medicine. The endocrine system is deeply involved in human health, and endocrine diseases may be influenced by steroidal hormone exposure. Thyroid nodular disease and differentiated thyroid cancer, in particular, show a high prevalence in the female sex; however, little is known about sex-related differences in risk factors and clinical presentation. This study aims to assess whether morphological differences, which can be detected by ultrasound examination, can be related to sex in order to refine diagnostic approaches and oncological risk classification. Methods: A retrospective observational study on 1355 ultrasound images of thyroid nodules obtained from 2017 to 2020 at a single university center was conducted. The images were reviewed by a single observer blinded to the patient’s sex and the cytological nature of the nodules. The qualitative description, size, anatomical location and oncological risk classification were assessed. Results: A taller-than-wide shape (anteroposterior/craniocaudal axis ratio > 1) was found to be more frequent in men than in women (6.7% vs. 3.6%, p = 0.027); the nodular volume was significantly larger in males (p << 0.01) than in females. Significant tropism for the upper lobe and isthmus was described in women (26% vs. 16.5%, p = 0.011) and for medium–lower thyroid lobes in men (83.5% vs. 73.8%, p = 0.011). Background thyroiditis was more common in women, while the number of cytological diagnoses of malignant or likely malignant nodules was higher than expected in men (9% vs. 6%, p = 0.01). Conclusions: Thyroid nodules show different distributions, in terms of a larger volume, more frequent taller-than-wide shape and lobular caudal location, in men vs. women. These results should be confirmed by further investigations, and the underlying mechanism should be clarified. However, our explorative research is of interest due to its novelty and possible future clinical implications. Full article
(This article belongs to the Section Thyroid Endocrinology)
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26 pages, 16996 KiB  
Article
Spatial Differentiation in Urban Thermal Environment Pattern from the Perspective of the Local Climate Zoning System: A Case Study of Zhengzhou City, China
by Jinghu Pan, Bo Yu and Yuntian Zhi
Atmosphere 2025, 16(1), 40; https://doi.org/10.3390/atmos16010040 - 2 Jan 2025
Cited by 1 | Viewed by 1176
Abstract
In order to assess the spatial and temporal characteristics of the urban thermal environment in Zhengzhou City to supplement climate adaptation design work, based on the Landsat 8–9 OLI/TIRS C2 L2 data for 12 periods from 2019–2023, combined with the lLocal climate zone [...] Read more.
In order to assess the spatial and temporal characteristics of the urban thermal environment in Zhengzhou City to supplement climate adaptation design work, based on the Landsat 8–9 OLI/TIRS C2 L2 data for 12 periods from 2019–2023, combined with the lLocal climate zone (LCZ) classification of the urban subsurface classification, in this study, we used the statistical mono-window (SMW) algorithm to invert the land surface temperature (LST) and to classify the urban heat island (UHI) effect, to analyze the differences in the spatial distribution of thermal environments in urban areas and the aggregation characteristics, and to explore the influence of LCZ landscape distribution pattern on surface temperature. The results show that the proportions of built and natural landscape types in Zhengzhou’s main metropolitan area are 79.23% and 21.77%, respectively. The most common types of landscapes are wide mid-rise (LCZ 5) structures and large-ground-floor (LCZ 8) structures, which make up 21.92% and 20.04% of the study area’s total area, respectively. The main urban area’s heat island varies with the seasons, pooling in the urban area during the summer and peaking in the winter, with strong or extremely strong heat islands centered in the suburbs and a distribution of hot and cold spots aggregated with observable features. As building heights increase, the UHI of common built landscapes (LCZ 1–6) increases and then reduces in spring, summer, and autumn and then decreases in winter as building heights increase. Water bodies (LCZ G) and dense woods (LCZ A) have the lowest UHI effects among natural settings. Building size is no longer the primary element affecting LST as buildings become taller; instead, building connectivity and clustering take center stage. Seasonal variations, variations in LCZ types, and variations in the spatial distribution pattern of LCZ are responsible for the spatial differences in the thermal environment in the study area. In summer, urban areas should see an increase in vegetation cover, and in winter, building gaps must be appropriately increased. Full article
(This article belongs to the Section Biometeorology and Bioclimatology)
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14 pages, 2283 KiB  
Article
Cancer Risk in Thyroid Nodules: An Analysis of Over 1000 Consecutive FNA Biopsies Performed in a Single Canadian Institution
by Elsabe J. Smit, Sana Samadi, Mitchell P. Wilson and Gavin Low
Diagnostics 2024, 14(24), 2775; https://doi.org/10.3390/diagnostics14242775 - 10 Dec 2024
Cited by 1 | Viewed by 3733
Abstract
Objective: To determine the cancer risk in thyroid nodules using ACR TI-RADS. Methods: A retrospective analysis of all thyroid biopsies was performed over a 3-year period (2021 to 2023). Variables including gender, age, history of thyroid cancer or neck irradiation, nodule size and [...] Read more.
Objective: To determine the cancer risk in thyroid nodules using ACR TI-RADS. Methods: A retrospective analysis of all thyroid biopsies was performed over a 3-year period (2021 to 2023). Variables including gender, age, history of thyroid cancer or neck irradiation, nodule size and location, TR level, and sonographic features such as punctate echogenic foci (PEF), a very hypoechoic appearance, taller-than-wide shape, and suspected extrathyroidal extension were analyzed. Results: A total of 1140 nodules were assessed in 993 patients, including 740 females (74.5%) and 253 males (25.5%). The mean patient age was 57.1 ± 15.4 years. Variables significantly associated with nodule malignancy included (1) younger age, (2) a prior history of thyroid cancer or neck irradiation, (3) a higher TR level, (4) a taller-than-wide shape in nodules <1 cm, (5) PEF, (6) a very hypoechoic appearance, and (5) suspected extrathyroidal extension (p < 0.05). Gender, nodule location and size were not associated with a higher cancer risk (p > 0.05). Malignancy was found in 40.7% of TR5, 4.8% of TR4, 0.3% of TR3, and 0% of TR1 and 2 nodules. The odds ratios (ORs) for cancer were as follows: TR4 or 5, OR = 19; PEF, OR = 11; a very hypoechoic appearance, OR = 13.3; and suspected extrathyroidal extension, OR = 27.2 (p < 0.01). Conclusions: Higher TR levels, PEF, a very hypoechoic appearance, and suspected extrathyroidal extension are important features for predicting cancer risk. These findings affirm the effectiveness of ACR TI-RADS in nodule risk stratification. Full article
(This article belongs to the Special Issue Diagnosis and Management of Thyroid Disorders)
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28 pages, 625 KiB  
Review
A Risk Management Approach to Global Pandemics of Infectious Disease and Anti-Microbial Resistance
by Annie Sparrow, Meghan Smith-Torino, Samuel M. Shamamba, Bisimwa Chirakarhula, Maranatha A. Lwaboshi, Christine Stabell Benn and Konstantin Chumakov
Trop. Med. Infect. Dis. 2024, 9(11), 280; https://doi.org/10.3390/tropicalmed9110280 - 18 Nov 2024
Cited by 3 | Viewed by 3788
Abstract
Pandemics of infectious disease and growing anti-microbial resistance (AMR) pose major threats to global health, trade, and security. Conflict and climate change compound and accelerate these threats. The One Health approach recognizes the interconnectedness of human, animal, and environmental health, but is grounded [...] Read more.
Pandemics of infectious disease and growing anti-microbial resistance (AMR) pose major threats to global health, trade, and security. Conflict and climate change compound and accelerate these threats. The One Health approach recognizes the interconnectedness of human, animal, and environmental health, but is grounded in the biomedical model, which reduces health to the absence of disease. Biomedical responses are insufficient to meet the challenges. The COVID-19 pandemic is the most recent example of the failure of this biomedical model to address global threats, the limitations of laboratory-based surveillance, and the exclusive focus on vaccination for disease control. This paper examines the current paradigm through the lens of polio and the global campaign to eradicate it, as well as other infectious threats including mpox and drug-resistant tuberculosis, particularly in the context of armed conflict. Decades before vaccines became widely available, public health measures—ventilation, chlorination, nutrition and sanitation— led to longer, healthier, and even taller lives. Chlorine, our primary tool of public health, conquered cholera and transformed infection control in hospitals. The World Health Organization (WHO), part of the One Health alliance, focuses mainly on antibiotics and vaccines to reduce deaths due to superbugs and largely ignores the critical role of chlorine to control water-borne diseases (including polio) and other infections. Moreover, the One Health approach ignores armed conflict. Contemporary wars are characterized by indiscriminate bombing of civilians, attacks targeting healthcare, mass displacement and lack of humanitarian access, conditions which drive polio outbreaks and incubate superbugs. We discuss the growing trend of attacks on healthcare and differentiate between types: community-driven attacks targeting vaccinators in regions like Pakistan, and state-sponsored attacks by governments such as those of Syria and Russia that weaponize healthcare to deliberately harm whole populations. Both fuel outbreaks of disease. These distinct motivations necessitate tailored responses, yet the WHO aggregates these attacks in a manner that hampers effective intervention. While antimicrobial resistance is predictable, the escalating pandemic is the consequence of our reliance on antibiotics and commitment to a biomedical model that now borders on pathological. Our analysis reveals the international indenture to the biomedical model as the basis of disease control is the root driver of AMR and vaccine-derived polio. The unique power of vaccines is reduced by vaccination-only strategy, and in fact breeds vaccine-derived polio. The non-specific effects of vaccines must be leveraged, and universal vaccination must be supplemented by international investment in water chlorination. This will reduce health costs and strengthen global health security. While vaccines are an important weapon to combat pandemics and AMR, they must be accompanied by the entire arsenal of public health interventions. Full article
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15 pages, 7381 KiB  
Article
Genome-Wide Association Studies for Wheat Height Under Different Nitrogen Conditions
by Tingzhi Yang, Wenjiao Zhang, Yutao Cui, Yalin Wang, Huimin Qin, Xinru Lv, Xiaohan Xie, Fulin Yang, Kangzhen Ren, Jinlan Ni, Xuehuan Dai, Jianbin Zeng, Wenxing Liu, Wujun Ma, Hongsheng Zhang and Dengan Xu
Agriculture 2024, 14(11), 1998; https://doi.org/10.3390/agriculture14111998 - 7 Nov 2024
Viewed by 1392
Abstract
Lodging causes a reduction in wheat (Triticum aestivum L.) yield and quality. A shorter plant height (PH) can reduce the incidence of lodging. The overuse of nitrogen promotes excessive vegetative growth, leads to taller plants, and increases lodging risk. Here, we utilized [...] Read more.
Lodging causes a reduction in wheat (Triticum aestivum L.) yield and quality. A shorter plant height (PH) can reduce the incidence of lodging. The overuse of nitrogen promotes excessive vegetative growth, leads to taller plants, and increases lodging risk. Here, we utilized genome-wide association studies (GWASs) to explore the genetic basis of PH and the nitrogen effect index (NEI), a parameter to estimate the responses of PH under varying nitrogen conditions, using 21,201 SNP markers from the Illumina Wheat 90K SNP array. A total of 191 wheat varieties from Yellow and Huai Valley regions of China, as well as other global regions, were analyzed across two growing seasons under four nitrogen treatments, namely N0 (0 kg/ha), N150 (150 kg/ha), N210 (210 kg/ha), and N270 (270 kg/ha). GWAS results showed that 30 genetic markers were associated with PH, explaining phenotypic variance from 5.92% to 13.69%. Additionally, nine significant loci were associated with the NEI. Notably, markers on chromosomes 1A and 6B were linked to both PH and the NEI, which were insensitive to low- and high-nitrogen fertilizers. In addition, the PH of the three cultivars (Zhoumai16, Zhoumai13, and Bima1) showed little variation in four nitrogen fertilizer levels. This study identified key genetic markers associated with wheat PH and the NEI, providing insights for optimizing nitrogen use in wheat breeding. Full article
(This article belongs to the Special Issue Genetic Diversity Assessment and Phenotypic Characterization of Crops)
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13 pages, 1045 KiB  
Article
Growing Media pH and Nutrient Concentrations for Fostering the Propagation and Production of Lingonberry (Vaccinium vitis-idaea L.)
by Mehdi Sharifi, Samir C. Debnath, Monireh Hajiaghaei-Kamrani, Bill Rabie and Jillian Forsyth
Agronomy 2024, 14(11), 2533; https://doi.org/10.3390/agronomy14112533 - 28 Oct 2024
Viewed by 1054
Abstract
The lingonberry (Vaccinium vitis-idaea L.), recognized for its nutritional value and adaptability to cold climates, faces cultivation challenges, particularly in soil pH and fertility optimization. In a greenhouse study, lingonberry transplants were grown in media with pH levels of 6.5 (3:1:1 PRO-MIX [...] Read more.
The lingonberry (Vaccinium vitis-idaea L.), recognized for its nutritional value and adaptability to cold climates, faces cultivation challenges, particularly in soil pH and fertility optimization. In a greenhouse study, lingonberry transplants were grown in media with pH levels of 6.5 (3:1:1 PRO-MIX BX/peat moss/perlite) and 5.2 (2:1 peat moss/perlite). Seven months post-exposure to different media pH, various fertility treatments (NPK) were tested, including a control (0–0–0), a balanced 5–5–5 kg ha−1 rate, a standard 36–24–48 kg ha−1 rate, and both higher (up to 54–36–72 kg ha−1) and lower (down to 9–6–12 kg ha−1) rates, applied every three weeks for fifteen weeks across six replications with a standard micronutrient rate. Results showed that media pH significantly affected plant height and volume, with plants at pH 6.5 growing 27% taller and larger than plants at pH 5.2. Fertility levels influenced plant volume, peaking at a moderate fertility rate (18–12–24 kg ha−1) before declining at higher rates. Interactions between pH and fertility significantly impacted shoot biomass, where higher fertility rates (above 36–24–48 kg ha−1) had a more pronounced negative effect on shoot biomass at pH 6.5 compared to pH 5.2. Root dry biomass was consistently 1.2–2.3 times greater than shoot dry biomass and less influenced by the treatments. Shoot death rates increased sharply at fertility rates above 18–12–24 kg ha−1, peaking at 21–35%. Nitrogen concentration in shoots and roots increased with higher fertilizer rates, peaking at 1.74% in the 45–30–60 kg ha−1 treatment. Fertility treatments raised growing media’s electrical conductivity (EC, 1:20 ratio), with a maximum of 1.41 dS m−1 in the 54–36–72 kg ha−1 treatment, though pH remained unchanged. Growing media nitrate levels increased with higher N rates, while ammonium levels were unaffected. Shoot death rates rose significantly with higher nitrate concentrations, particularly above 17.5 mg L−1, but showed no link to ammonium levels. Lingonberries can survive and thrive across a wide range of pH levels. These results indicate that lingonberries are resilient and low maintenance, requiring modest nutrient levels, and excessive fertilization hampers their growth. Full article
(This article belongs to the Section Soil and Plant Nutrition)
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10 pages, 577 KiB  
Article
Diagnostic Accuracy of Ultrasound and Fine-Needle Aspiration Cytology in Thyroid Malignancy
by Maria Boudina, Michael Katsamakas, Angeliki Chorti, Panagiotis Panousis, Eleni Tzitzili, Georgios Tzikos, Alexandra Chrisoulidou, Rosalia Valeri, Aris Ioannidis and Theodossis Papavramidis
Medicina 2024, 60(5), 722; https://doi.org/10.3390/medicina60050722 - 26 Apr 2024
Cited by 3 | Viewed by 2985
Abstract
Introduction: Thyroid nodule incidence is increasing due to the widespread application of ultrasonography. Fine-needle aspiration cytology is widely applied for the detection of malignancies. The aim of this study was to evaluate the predictive value of ultrasonography in thyroid cancer. Methods: [...] Read more.
Introduction: Thyroid nodule incidence is increasing due to the widespread application of ultrasonography. Fine-needle aspiration cytology is widely applied for the detection of malignancies. The aim of this study was to evaluate the predictive value of ultrasonography in thyroid cancer. Methods: This retrospective study included patients that underwent total thyroidectomy for benign thyroid disease or well-differentiated thyroid carcinoma from January 2017 to December 2022. The study population was divided into groups: the well-differentiated thyroid cancer group and the control group with benign histopathological reports. Results: In total, 192 patients were enrolled in our study; 159 patients were included in the well-differentiated thyroid cancer group and 33 patients in the control group. Statistical analysis demonstrated that ultrasonographic findings such as microcalcifications (90.4%), hypoechogenicity (89.3%), irregular margins (92.2%) and taller-than-wide shape (90.5%) were correlated to malignancy (p < 0.001). Uni- and multivariate analysis revealed that both US score (OR: 2.177; p < 0.001) and Bethesda System (OR: 1.875; p = 0.002) could predict malignancies. In terms of diagnostic accuracy, the US score displayed higher sensitivity (64.2% vs. 33.3%) and better negative predictive value (34.5% vs. 24.4%) than the Bethesda score, while both scoring systems displayed comparable specificities (90.9% vs. 100%) and positive predictive values (97.1% vs. 100%). Discussion: The malignant potential of thyroid nodules is a crucial subject, leading the decision for surgery. Ultrasonography and fine-needle aspiration cytology are pivotal examinations in the diagnostic process, with ultrasonography demonstrating better negative predictive value. Full article
(This article belongs to the Special Issue Recent Clinical and Basic Research on Endocrine Surgery)
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30 pages, 14007 KiB  
Article
Stability Analysis of Cofferdam with Double-Wall Steel Sheet Piles under Wave Action from Storm Surges
by Yan Zhu, Jingchao Bi, Haofeng Xing, Ming Peng, Yu Huang, Kaifang Wang and Xinyu Pan
Water 2024, 16(8), 1181; https://doi.org/10.3390/w16081181 - 20 Apr 2024
Cited by 2 | Viewed by 2373
Abstract
Double-wall steel sheet piles (DSSPs) are widely used in large-span cofferdams for docks due to their good performance against wave action during storm surges. This paper describes a study of the dynamic behavior of a DSSP cofferdam under wave action through flume tests [...] Read more.
Double-wall steel sheet piles (DSSPs) are widely used in large-span cofferdams for docks due to their good performance against wave action during storm surges. This paper describes a study of the dynamic behavior of a DSSP cofferdam under wave action through flume tests and a numerical simulation that combined computational fluid dynamics (CFD) and the finite element method. The influences of the water level and wave height on the DSSP cofferdam were investigated experimentally and numerically. Tall waves in shallow water broke upon and impacted the seaside pile with large dynamic wave pressure, dramatically increasing the stress and displacement of the seaside pile. The overlap of the traveling and reflected waves increased the excess pore water pressure near the seaside pile due to taller overlapped waves and higher wave frequency. The DSSP cofferdam failed under the combined actions of the dynamic wave pressure and erosion of the landside seabed. The leakage and overflow of the breaking waves resulted in significant erosion of the landside seabed and greatly weakened the support of the seabed. The dynamic wave pressure then pushed the DSSP cofferdam until it failed. The simulation with the combined methods of CFD and FEM resulted in trends that were similar to those of the test measurements. Compared to the quasi-static method and pseudo-dynamic method, the results of the simulation via the present method were much closer to the test results because the simulation included the effects of breaking waves. The reinforced measure worked well to prevent the DSSP cofferdam in a sandy seabed foundation from continuous failures of deformation–leakage–erosion–tilting. However, it failed in a clay interlayer seabed foundation due to the large settlement. Full article
(This article belongs to the Special Issue Wave–Structure Interaction in Coastal and Ocean Engineering)
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11 pages, 951 KiB  
Article
Thyroid Imaging Reporting and Data Systems: Applicability of the “Taller than Wide” Criterium in Primary/Secondary Care Units and the Role of Thyroid Scintigraphy
by Manuela Petersen, Simone A. Schenke, Franziska Veit, Rainer Görges, Philipp Seifert, Michael Zimny, Roland S. Croner, Michael C. Kreissl and Alexander R. Stahl
J. Clin. Med. 2024, 13(2), 514; https://doi.org/10.3390/jcm13020514 - 17 Jan 2024
Cited by 1 | Viewed by 1600
Abstract
Background: To examine the applicability of the “taller than wide” (ttw) criterium for risk assessment of thyroid nodules (TNs) in primary/secondary care units and the role of thyroid scintigraphy therein. Methods: German bicenter study performed in a setting of primary/secondary care. Patient recruitment [...] Read more.
Background: To examine the applicability of the “taller than wide” (ttw) criterium for risk assessment of thyroid nodules (TNs) in primary/secondary care units and the role of thyroid scintigraphy therein. Methods: German bicenter study performed in a setting of primary/secondary care. Patient recruitment and analysis in center A was conducted in a prospective manner. In center B, patient data were retrieved from a database that was originally generated by prospective data collection. TNs were assessed by ultrasound and thyroid scans, mostly fine needle biopsy and occasionally surgery and others. In center A, only patients who presented for the first time were included. The inclusion criterion was any TN ≥ 10 mm that had at least the following two sonographic risk features: solidity and a ttw shape. In center B, consecutive patients who had at least ttw and hypofunctioning nodules ≥ 10 mm were retrieved from the above-mentioned database. The risk of malignancy was determined according to a mixed reference standard and compared with literature data. Results: In center A, 223 patients with 259 TNs were included into the study. For further analysis, 200 nodules with a reference standard were available. The overall malignancy rate was 2.5% (upper limit of the 95% CI: 5.1%). After the exclusion of scintigraphically hyperfunctioning nodules, the malignancy rate increased slightly to 2.8% (upper limit of the 95% CI: 5.7%). Malignant nodules exhibited sonographic risk features additional to solidity and ttw shape more often than benign ones. In addition to the exclusion of hyperfunctioning nodules, when considering only nodules without additional US risk features, i.e., exclusively solid and ttw-nodules, the malignancy rate decreased to 0.9% (upper limit 95% CI: 3.7%). In center B, from 58 patients, 58 ttw and hypofunctioning TNs on thyroid scans with a reference standard were available. Malignant nodules from center B were always solid and hypoechoic. The overall malignancy rate of hypofunctioning and ttw nodules was 21%, with the lower limit of the 95% CI (one-sided) being 12%. Conclusions: In primary/secondary care units, the lowest TIRADS categories for indicating FNB, e.g., applying one out of five sonographic risk features, may not be appropriate owing to the much lower a priori malignancy risk in TNs compared to tertiary/quaternary care units. Even the combination of two sonographic risk features, “solidity” and “ttw”, may only be appropriate in a limited fashion. In contrast, the preselection of TNs according to hypofunctioning findings on thyroid scans clearly warranted FNB, even when applying only one sonographic risk criterion (“ttw”). For this reason, thyroid scans in TNs may not only be indicated to rule out hyperfunctioning nodules from FNB but also to rule in hypofunctioning ones. Full article
(This article belongs to the Section Nuclear Medicine & Radiology)
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12 pages, 4063 KiB  
Article
Variation and Driving Mechanisms of Bark Thickness in Larix gmelinii under Surface Fire Regimes
by Qiang Zhu, Yanhong Liu, Yingda Wu and Lijun Guo
Forests 2024, 15(1), 96; https://doi.org/10.3390/f15010096 - 4 Jan 2024
Cited by 3 | Viewed by 1491
Abstract
Bark is vital for woody plants, providing protection, transporting nutrients and water, and storing essential resources. For fire-prone ecosystems, bark thickness is a key adaptive trait conferring fire resistance. Few studies have been conducted on the drivers of variation in bark thickness of [...] Read more.
Bark is vital for woody plants, providing protection, transporting nutrients and water, and storing essential resources. For fire-prone ecosystems, bark thickness is a key adaptive trait conferring fire resistance. Few studies have been conducted on the drivers of variation in bark thickness of the widely distributed Larix gmelinii (Rupr.) Kuzen in the Great Xing’an Mountains region, on the southern edge of East Siberia, where surface fire disturbances are frequent. To elucidate the relationships between variation in bark thickness (inner vs. outer bark) of L. gmelinii and plant size, environmental factors, and co-variation with other fire-tolerance traits, we selected 26 sites to set up plots and carried out a survey and bark sampling. Results showed that stem diameter primarily determines variation in bark thickness, especially outer bark. The proportion of outer bark to total bark increased accordingly as the tree increased in size. We also observed stronger correlated variation in outer bark thickness, tree height, and self-pruning capacity, implying that larger trees have thicker protective outer bark and taller heights with greater self-pruning, mitigating crown fire risks. Environmental factors appear to have a relatively limited effect on changes in bark thickness in L. gmelinii. Mean air temperature, annual precipitation, and total soil nitrogen content had some effect on outer bark thickness, and mean air temperature had some effect on inner bark thickness. Full article
(This article belongs to the Section Natural Hazards and Risk Management)
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16 pages, 2165 KiB  
Article
Diagnostic Performance of ACR TI-RADS and ATA Guidelines in the Prediction of Thyroid Malignancy: A Prospective Single Tertiary Center Study and Literature Review
by Ashkan Torshizian, Fatemeh Hashemi, Nastaran Khoshhal, Alireza Ghodsi, Houra Rastegar, Zohreh Mousavi, Maliheh Dadgar Moghadam and Masoud Mohebbi
Diagnostics 2023, 13(18), 2972; https://doi.org/10.3390/diagnostics13182972 - 18 Sep 2023
Cited by 4 | Viewed by 4908
Abstract
Aim: This study sought to compare two common risk stratification systems in terms of their diagnostic performance for the evaluation of thyroid malignancy. Methods: The American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS) and the American Thyroid Association (ATA) [...] Read more.
Aim: This study sought to compare two common risk stratification systems in terms of their diagnostic performance for the evaluation of thyroid malignancy. Methods: The American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS) and the American Thyroid Association (ATA) guidelines were compared among 571 thyroid nodules with definitive fine needle aspiration (FNA) cytology or postoperative histopathology. Ultrasound characteristics such as composition, echogenicity, shape, margin, size, and vascularity were assessed for each thyroid nodule. Diagnostic performance measures were determined and compared through receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). Results: Of 571 nodules, 65 (11.4%) were malignant. The AUC, sensitivity, specificity, positive predictive value, and negative predictive value were 0.691, 49.2%, 84.9%, 29.6%, and 92.8% for ATA guideline, and 0.776, 72.3%, 79.2%, 30.9%, and 95.7%, for ACR TI-RADS, respectively. ACR TI-RADS was more sensitive (p = 0.003), while the ATA guideline was more specific (p < 0.001). DCA demonstrated that the ACR TI-RADS provided a greater net benefit than the ATA guideline. In addition, the net reduction in unnecessary biopsies is higher for ACR TI-RADS than ATA guidelines. The total number of indicated biopsies and unnecessary FNA rates were lower in ACR TI-RADS compared to ATA guideline (293 vs. 527 and 80.2 vs. 87.8). ACR TI-RADS presented no biopsy indication in seven malignant nodules (all categorized as TR2), whereas ATA guideline missed one. Hypoechogenicity was the most significant predictor of malignancy (OR = 8.34, 95% CI: 3.75–19.45), followed by a taller-than-wide shape (OR = 6.73, 95% CI: 3.07–14.77). Conclusions: Our findings suggest that each system has particular advantages in the evaluation of thyroid nodules. ACR TI-RADS reduces unnecessary FNA rates, however, malignant nodules categorized as TR2 might be missed using this system. Further evaluation of this group of nodules using Doppler and other ultrasound modalities is recommended. Full article
(This article belongs to the Special Issue Advances in Head and Neck Ultrasound)
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14 pages, 3757 KiB  
Article
Characteristics of Breast Charcoal Granuloma: A Delayed Complication Following Tattoo Localization
by Jeongju Kim, Eun Young Ko, Boo-Kyung Han, Eun Sook Ko, Ji Soo Choi, Haejung Kim and Myoung Kyoung Kim
Diagnostics 2023, 13(17), 2800; https://doi.org/10.3390/diagnostics13172800 - 29 Aug 2023
Cited by 4 | Viewed by 1952
Abstract
Rationale and Objective: To evaluate the characteristic clinical and imaging findings of charcoal granuloma and suggest features that may differentiate charcoal granuloma from breast cancer. Materials and Methods: This retrospective study included 18 patients with a histologically confirmed breast charcoal granuloma [...] Read more.
Rationale and Objective: To evaluate the characteristic clinical and imaging findings of charcoal granuloma and suggest features that may differentiate charcoal granuloma from breast cancer. Materials and Methods: This retrospective study included 18 patients with a histologically confirmed breast charcoal granuloma between 2005 and 2021 at a single institution. All patients had a history of breast surgery after ultrasound (US)-guided charcoal marking. Two radiologists analyzed the radiologic findings of charcoal granulomas, including the presence of a mass or calcification; the shape, margin and density of the masses on mammography; and the location, size, shape, margin, orientation, echogenicity, vascularity, presence of an echogenic halo, and posterior acoustic shadowing on US. In cases with available follow-up images, we also investigated whether the size and shape had changed. Results: The median interval between breast surgery and the diagnosis of charcoal granuloma was 2.3 years (range, 0.7–18.3 years). Thirteen lesions (72.2%) were detected on screening images. In 11 (61.1%) cases, the surgical incision was not made in the tattooed skin area. Mammography showed positive findings in 10/15 patients, and most lesions were isodense masses (70%). There were no cases with calcification. On US, all lesions were masses and showed a taller-than-wide orientation (61.1%), round or oval shape (55.6%), and iso- or hyperechogenicity (83.3%). Echogenic halo (27.8%) and posterior acoustic shadowing (16.7%) were uncommon. On Doppler US, only four cases (22.2%) showed increased vascularity. Most were classified as BI-RADS 3 (38.9%) or 4A (50.0%). After biopsy, 12 patients had follow-up mammography and US. The size of the lesion decreased in nine cases and remained unchanged in three cases. A decrease in the lesion size after biopsy showed a negative correlation with the interval between detection on imaging and biopsy (p = 0.04). Conclusion: Charcoal granuloma is most commonly found 2–3 years after surgery and occurs more frequently when the incision site is different from the tattooed skin area. US findings of tall and round or oval masses with iso- or hyperechogenicity without increased vascularity could help to differentiate them from malignancies. Full article
(This article belongs to the Section Medical Imaging and Theranostics)
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15 pages, 1722 KiB  
Article
The Role of “Critical” Ultrasound Reassessment in the Decision-Making of Bethesda III Thyroid Nodules
by Giuseppina Orlando, Giuseppa Graceffa, Sergio Mazzola, Fabrizio Vassallo, Maria Pia Proclamà, Pierina Richiusa, Stefano Radellini, Nunzia Cinzia Paladino, Giuseppina Melfa and Gregorio Scerrino
Medicina 2023, 59(8), 1484; https://doi.org/10.3390/medicina59081484 - 17 Aug 2023
Cited by 4 | Viewed by 2062
Abstract
Background and Objectives: Bethesda III (BIII) thyroid nodules have an expected malignancy rate of 5–15%. Our purpose was to assess which US criteria are most associated with cancer risk, and the value of critical ultrasound (US) reassessment. Methods: From 2018 to [...] Read more.
Background and Objectives: Bethesda III (BIII) thyroid nodules have an expected malignancy rate of 5–15%. Our purpose was to assess which US criteria are most associated with cancer risk, and the value of critical ultrasound (US) reassessment. Methods: From 2018 to 2022, 298 BIII nodules were enrolled for thyroidectomy (79 malignancies). We evaluated ultrasonographic data: hechogenicity, intralesional vascularization, spiculated margins, micro-calcifications, “taller than wide” shape, extra-thyroidal growth, size increase, as well as their association with histology. We also evaluated if the ultrasound reassessment modified the strategy. Results: Spiculated margins and microcalcification were significantly correlated with malignancy risk. Spiculated margins showed a specificity of 0.95 IC95% (0.93–0.98); sensitivity 0.70 IC95% (0.59–0.80). Microcalcifications showed a sensitivity of 0.87 CI95% (0.80–0.94); specificity 0.75 CI95% (0.72–0.83). The presence of these signs readdressed the strategy in 76/79 cases Then, the indication for surgery was appropriate in 75% of cases. Conclusions: Microcalcifications and spiculated margins should be routinely sought during a final ultrasound reassessment in BIII nodules. These signs allowed for a modification of the strategy in favor of surgery in 96% of the cases that were not otherwise referred to surgery. The importance of integrating ultrasound and cytology in the evaluation of BIII thyroid nodules is confirmed. Reassessment with ultrasound of BIII nodules allowed for a redirection of the surgical choice. Full article
(This article belongs to the Section Surgery)
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21 pages, 13187 KiB  
Article
Potential of Low-Cost Light Detection and Ranging (LiDAR) Sensors: Case Studies for Enhancing Visitor Experience at a Science Museum
by Nobuyuki Umezu, Shohei Koizumi, Kohki Nakagawa and Saku Nishida
Electronics 2023, 12(15), 3351; https://doi.org/10.3390/electronics12153351 - 5 Aug 2023
Cited by 7 | Viewed by 3383
Abstract
A low-cost light detection and ranging (LiDAR) device has several advantages including being able to perform a wide range of angle measurements, less privacy concerns, and robustness to illumination variance owing to its use of infrared (IR) light. In this study, to enhance [...] Read more.
A low-cost light detection and ranging (LiDAR) device has several advantages including being able to perform a wide range of angle measurements, less privacy concerns, and robustness to illumination variance owing to its use of infrared (IR) light. In this study, to enhance the visitor experience at a science museum, three case studies using low-cost LiDAR sensors are presented: (1) an interactive floor projection to learn about the phases of the Moon; (2) an information kiosk with touchless interaction and visitor tracking; and (3) a visitor tracking box with horizontal and vertical scanning. The proposed kiosk system uses a mirror to reflect a portion of the scanning plane of the LiDAR sensor, to allow the capture of touchless interactions, track visitor positions, and count the number of nearby visitors. The visitor tracking box also uses two detection planes reflected by a mirror: the vertical plane is for counting visitors crossing the scanning plane and the horizontal plane is for tracking visitor positions to generate the corresponding heat maps for the visualization of museum hotspots. A series of evaluation experiments were conducted at a science museum, whereby an accuracy of 85% was obtained to estimate the number of visitors, with an accuracy increasing in counting people taller than 140 cm. The interactive floor received a visitor rating of 4.3–4.4 on a scale of 1–5. Full article
(This article belongs to the Special Issue XRiM: XR Technologies in Future Museums)
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