Search Results (20,946)

There are close relationships between vertical positions in space and auditory experiences of fundamental frequency (F0), which even very young children seem to use. Like adults, they associate higher or rising F0 values with upper positions in space and vice versa for lower or falling F0 values. Here, we tested whether caregivers’ speech capitalizes on these associations to guide the attention of very young children (18 to 24 months). Together with their child, caregivers saw four different objects (in the corners of a computer screen). Caregivers produced standardized sentences (e.g., “Look at the hat.”). We observed a significantly increased maximum F0 (but no differences in mean or minimum F0) at the onset of the utterance when the to be named object appeared at an upper position compared to the same object at a lower position. Furthermore, exploratory analyses of F0 dynamics of caregivers’ utterances indicated that the higher F0 maximum was part of a more prominent F0 increase for objects appearing at an upper compared to a lower position. Adults without a child present and less experience in interacting with children did not show systematic pitch modulation when addressing an imagined child in the same study set-up. Thus, caregivers appear to systematically modulate F0 dynamics to provide an effective language environment when they are interacting with their child. Full article

Background and Objectives: The lateral pterygoid muscle (LPM) is typically described as a two-headed muscle within the infratemporal fossa. However, cadaveric and imaging studies have revealed substantial variability in the number of heads, insertion patterns, and relations to neurovascular structures. Materials and Methods: An observational study of 250 brain computed tomography angiographies (CTAs) was performed to assess LPM morphology. Additionally, a systematic review and meta-analysis were conducted in accordance with PRISMA 2020 and Evidence-based Anatomy guidelines. Pooled prevalence estimates were calculated with random-effects models. Results: The current study included 250 CTAs for the original study and 1702 muscles for the meta-analytic evidence. During the original study, the two-headed configuration was most common (74.4%), followed by three-headed (14%), one-headed (10.8%), and four-headed (0.8%) morphologies. Symmetry was observed in 75.2% of patients. Meta-analysis confirmed the predominance of the two-headed type (73.98%, 95% CI: 68.22–79.38), with three-headed (16.82%), one-headed (4.37%), and four-headed (<0.01%) variants occurring less frequently. Subgroup analyses showed no significant differences by study type or sample size, though European populations exhibited a higher prevalence of one-headed forms. Conclusions: The LPM demonstrates considerable morphological variability, extending beyond the traditional two-headed model. Recognition of these variants is essential for understanding temporomandibular joint function, interpreting imaging, and planning surgical or interventional procedures within the infratemporal fossa. Advanced imaging provides a reliable tool for individualized anatomical assessment, supporting safer clinical practice. Full article

Smartphone addiction has emerged as a significant public health concern, particularly among adolescents and young adults. This narrative review, conducted in line with the ANDJ checklist, synthesizes evidence from 25 systematic reviews and meta-analyses, complemented by randomized controlled trials and clinical studies, to provide a structured overview of the field. The study selection flow and publication trends reveal a rapidly expanding research landscape, with most evidence produced in the last decade, reflecting both the ubiquity of smartphones and increasing awareness of their health impacts. The synthesis highlights converging findings across reviews: excessive smartphone use is consistently associated with psychosocial, behavioral, and academic challenges, alongside sleep disturbances and mental health symptoms. Common messages include the recognition of smartphone addiction as a multidimensional phenomenon, while emerging themes point to heterogeneity in definitions, tools, and methodological approaches. Comparative analysis of reviews underscores both shared risk factors—such as emotional dysregulation and social isolation—and differences in study designs and target populations. Importantly, this review identifies critical gaps, including the lack of standardized definitions, limited longitudinal evidence, and scarce cross-cultural validation. At the same time, promising opportunities are noted, from lifestyle-based interventions (e.g., physical activity) to educational and policy-level strategies fostering digital literacy and self-regulation. The post-pandemic context further emphasizes the need for sustained monitoring and adaptive responses. Overall, this review calls for youth-centered, multi-sector interventions aligned with WHO recommendations, supporting coordinated, evidence-based action across health, education, and policy domains. Full article

Background/Objectives: Beetroot supplementation is a rich source of inorganic nitrate and has been proposed to enhance nitric oxide bioavailability and support cardiovascular recovery after exercise. This study aimed to evaluate the effects of beetroot supplementation on post-exercise cardiovascular and autonomic recovery in postmenopausal women. Methods: A systematic review and meta-analysis were conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Searches were performed in PubMed, Scopus, and Web of Science databases from inception to July 2025. Ten trials involving postmenopausal women were included. Outcomes assessed included cardiovascular measures (blood pressure and vascular function), autonomic parameters derived from heart rate variability (HRV)—specifically the root mean square of successive differences (RMSSD), the standard deviation of normal-to-normal intervals (SDNN), and high-frequency power (HF)—as well as physical performance (peak oxygen uptake [VO_2peak or VO_2max] and functional fitness tests). Four independent reviewers extracted data, assessed risk of bias, and evaluated the certainty of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. Results: Pooled analyses from two trials (n = 54) revealed a statistically significant improvement in RMSSD with beetroot supplementation (mean difference: 6.68 ms; 95% CI: 0.86 to 12.50; p = 0.02), suggesting enhanced parasympathetic reactivation after exercise. No significant effects were detected for HF (mean difference: 61.75 ms²; 95% CI: −70.92 to 194.43; p = 0.36) or SDNN (mean difference: 6.20 ms; 95% CI: −9.69 to 22.09; p = 0.44). Substantial to considerable heterogeneity was identified across outcomes (I² = 73–86%). Certainty of evidence was rated moderate for RMSSD, low for SDNN, and very low for HF. Conclusions: Beetroot supplementation may enhance post-exercise autonomic recovery in postmenopausal women, primarily through improvements in RMSSD. However, further trials with standardized protocols, larger samples, and longer intervention durations are required to clarify its impact on broader HRV domains, cardiovascular function, and clinical outcomes. Full article

This study aims to elucidate the molecular mechanisms underlying cyanogenic glycoside accumulation in flax. As an important oil and fiber crop, the nutritional value of flax is compromised by the toxicity of cyanogenic glycoside. To clarify the key genetic regulators and temporal patterns of cyanogenic glycoside biosynthesis, transcriptomic sequencing was performed on seeds from high- and low-cyanogenic glycoside flax varieties (‘MONTANA16’ and ‘Xilibai’) at three developmental stages: bud stage, full flowering stage, and capsule-setting stage. A total of 127.25 Gb of high-quality data was obtained, with an alignment rate exceeding 87.80%. We identified 31,623 differentially expressed genes (DEGs), which exhibited distinct variety- and stage-specific expression patterns. Principal component analysis (PCA) and hierarchical clustering demonstrated strong reproducibility among biological replicates and revealed the seed pod formation stage as the period with the most significant varietal differences, suggesting it may represent a critical regulatory window for cyanogenic glycoside synthesis. GO and KEGG enrichment analyses indicated that DEGs were primarily involved in metabolic processes (including secondary metabolism and carbohydrate metabolism), oxidoreductase activity, and transmembrane transport functions. Of these, the cytochrome P450 pathway was most significantly enriched at the full bloom stage (H2 vs. L2). A total of 15 LuCYP450 and 13 LuUGT85 family genes were identified, and their expression patterns were closely associated with cyanogenic glycoside accumulation: In high-cyanogenic varieties, LuCYP450-8 was continuously upregulated, and LuUGT85-12 was significantly activated during later stages. Conversely, in low-cyanogenic varieties, high expression of LuCYP450-2/14 may inhibit synthesis. These findings systematically reveal the genetic basis and temporal dynamics of cyanogenic glycoside biosynthesis in flax and highlight the seed pod formation stage as a decisive regulatory window for cyanogenic glycoside synthesis. This study provides new insights into the coordinated regulation of cyanogenic pathways and establishes a molecular foundation for breeding flax varieties with low CNG content without compromising agronomic traits. Full article

This study investigates the structural and magnetic properties of CoFe₂O₄ nanoparticles prepared by five different synthesis methods: coprecipitation, ultrasound-assisted coprecipitation, coprecipitation coupled with mechanochemical treatment, microemulsion and microwave-assisted hydrothermal synthesis. The produced powders were additionally functionalized with starch to improve biocompatibility and colloidal stability. The starch-coating procedure itself by sonication in starch solution, as well as its result, affects the structural and magnetic properties of functionalized nanoparticles. The resulting changes of properties in the process of ligand addition depend significantly on the starting nanoparticles, or rather, on the method of their synthesis. The structural, magnetic and spectroscopic properties of the resulting materials were systematically investigated using X-ray diffraction (XRD), Raman spectroscopy, Mössbauer spectroscopy and magnetic measurements. Taken together, XRD, Raman and Mössbauer spectroscopy show that starch deposition reduces structural disorder and internal stress, resulting in nanoparticles with a more uniform size distribution. These changes, in turn, affect all magnetic properties—magnetization, coercivity and magnetic anisotropy. Magnetic responses are preserved what is desirable for future biomedical applications. This work emphasizes the importance of surface modification for tailoring the properties of magnetic nanoparticles while maintaining their desired functionality. Full article

Gold nanoparticles (AuNPs) are attracting more and more attention in life sciences, especially due to their versatile physicochemical properties whereby their colloidal stability in water and organic solvents is crucial. In this study, a systematic comparison of different polymers, synthesis methods and solvents was carried out. The AuNPs were synthesized using the ligand exchange reaction/postsynthetic addition reaction (PAR) and the one-pot synthesis with the polymers poly(vinyl alcohol) (PVA), poly(ethylene glycol) (PEG), poly(vinylpyrrolidone) (PVP) and poly(acrylic acid) (PAA), each with different molar weight averages. Analysis of the AuNP@Polymer conjugates by transmission electron microscopy (TEM) finds essentially unchanged gold nanoparticle core sizes of 11–18 or 11–19 nm in water and ethanol, respectively. The hydrodynamic diameter from dynamic light scattering (DLS) lies largely in the range from 20 to 70 nm and ultraviolet-visible spectroscopy (UV-Vis) showed gold plasmon resonance band maxima between 517 and 531 nm over both synthesis methods and solvents for most samples. The polymer PVA showed the best colloidal stability in both synthesis methods, both in water and after transfer to ethanol. An increased instability in ethanol could only be noted for the PEG coated samples. For the polymers PVP and PAA, the stability depended more specifically on the combination of synthesis method, polymer molecular weight and solvent. Full article

Introduction: 3D-printing is an emerging technology in the field of prosthetics, offering advantages such as cost-effectiveness, ease of customization, and improved accessibility. While previous reviews have focused on limited aspects, the aim of this systematic review is to provide a comprehensive evaluation of the clinical outcomes of 3D-printed prostheses for both upper and lower limbs. Methods: A search was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines across six databases (PubMed, Web of Science, EBSCO, Scopus, Cochrane Library, and Sage). Studies on 3D-printed prostheses in human rehabilitation that focused on the clinical outcomes of the device were included, while studies lacking clinical data, 3D printing details, or focusing on traditional manufacturing methods were excluded. Finally, the risk of bias was assessed using the modified Downs & Black Checklist. Results: A total of 1420 studies were identified, with 11 meeting the inclusion criteria. The included studies assessed different 3D-printed prosthetic types and upper and lower limb prostheses. The main clinical outcomes analyzed were functional performance, design and material integrity, and overall effectiveness of 3D-printed prostheses. Studies on upper limb prostheses reported improved dexterity, range of motion (ROM), and user satisfaction, despite some durability limitations. Lower limb prostheses showed enhancements in comfort, gait parameters, and customization, particularly in amphibious and partial foot designs. Conclusions: 3D-printed prostheses show potential to improve functional performance, patient satisfaction, fit, and implementation feasibility compared to conventional methods. However, limitations such as small sample sizes, variability in assessment tools, and limited high-quality evidence highlight the need for further research to support broader clinical adoption. Full article

Biodegradable plastics are not a primary solution to plastic pollution, and empirical evidence on whether they are environmentally friendly remains lacking. In this study, we systematically compared the toxic effects of traditional microplastics (polypropylene, PP; polystyrene, PS) with biodegradable microplastics (polylactic acid, PLA; polyhydroxyalkanoates, PHA) on the haplic phaeozem ecosystem. Through mathematical modeling analysis, it was found that earthworms initially rely on antioxidant enzymes to resist stress, mid-term activation of detoxifying enzymes to repair damage, and maintaining physiological balance through metabolic regulation and immune enhancement in later stages. We elucidated their mechanism differences: PLA and PP caused severe damage to the antioxidant system and cell membrane, with PLA mainly relying on POD to clear peroxides and PP relying on GST. In addition, PLA and PS can induce early neurotoxicity (AChE), while PHA induces late neurotoxicity. Furthermore, this study provides direct evidence proving that biodegradable microplastics are not environmentally friendly by breaking through the one-way research framework of “microplastic biotoxicity” and innovatively constructing a path analysis model that links biological physiological responses with soil ecological functions. We also provide a scientific basis to evaluate the ecological risks of microplastic pollution in soil and the whether biodegradable plastics are truly environmentally friendly. Full article

The selection of suitable frothers in flotation processes plays a crucial role in controlling bubble formation, foam stability, and ultimately mineral recovery. Therefore, understanding the interfacial behavior of frothers is important to optimize flotation efficiency, especially for valuable sulfide minerals such as galena (PbS). In this study, the interfacial behavior and flotation performance of different frothers in PbS flotation were investigated with a particular focus on surface tension, bubble coalescence, foam stability, and flotation recovery. A high-purity crystalline PbS sample (≈96.65% PbS) obtained from Trabzon, Türkiye, was subjected to systematic experimental analyses including surface tension measurements, critical coalescence concentration (CCC) determination, dynamic foam stability (DFS) tests using the DFA100 analyzer, and micro-flotation experiments. 2-ethylhexanol (EH), polypropylene glycol 250 (PPG250), and methyl isobutyl carbinol (MIBC) were used as frothers, while potassium ethyl xanthate (PEX) was employed as a collector. The results revealed that EH had the highest surface activity (42.67 mN/m at 1000 ppm), and the lowest CCC value (~2 ppm) compared to PPG250 (~3 ppm) and MIBC (~8 ppm). According to the micro-flotation results, the flotation recovery gradually increased with increasing frother dosage; the highest recoveries were obtained with PPG250 (99.45%), EH (98.31%), and MIBC (95.17%). PPG250 and EH achieved higher flotation performance at lower dosages compared to MIBC. These findings highlight the critical role of molecular structure and interfacial properties in the effective selection of frothers for galena flotation. Full article

Cancer classification using high-dimensional genomic data presents significant challenges in feature selection, particularly when dealing with datasets containing tens of thousands of features. This study presents a new application of the Simultaneous Perturbation Stochastic Approximation (SPSA) method for feature selection on large-scale cancer datasets, representing the first investigation of the SPSA-based feature selection technique applied to cancer datasets of this magnitude. Our research extends beyond traditional SPSA applications, which have historically been limited to smaller datasets, by evaluating its effectiveness on datasets containing 35,924 to 44,894 features. Building upon established feature-ranking methodologies, we introduce a comprehensive evaluation framework that examines the impact of varying proportions of top-ranked features (5%, 10%, and 15%) on classification performance. This systematic approach enables the identification of optimal feature subsets most relevant to cancer detection across different selection thresholds. The key contributions of this work include the following: (1) the first application of SPSA-based feature selection to large-scale cancer datasets exceeding 35,000 features, (2) an evaluation methodology examining multiple feature proportion thresholds to optimize classification performance, (3) comprehensive experimental validation through comparison with ten state-of-the-art feature selection and classification methods, and (4) statistical significance testing to quantify the improvements achieved by the SPSA approach over benchmark methods. Our experimental evaluation demonstrates the effectiveness of the feature selection and ranking-based SPSA method in handling high-dimensional cancer data, providing insights into optimal feature selection strategies for genomic classification tasks. Full article

Background: Radiation-induced lower motor neuron syndrome (LMNS) represents a rare but significant delayed complication of oncologic treatment. Methods: We present the case of a 56-year-old female who developed LMNS, myokymia, and osteoradionecrosis of the hip nearly two decades after receiving pelvic radiation therapy for cervical carcinoma. To the best of our knowledge, no previous reports have described this particular triad of neurological and tissue changes following radiation therapy. This clinical presentation is analyzed within the framework of a systematic review encompassing 58 documented cases, including our own. Results: The database searches yielded 530 records. In total, 32 studies were included in the qualitative synthesis, reporting 57 unique cases of post-radiation LMNS. With the addition of our present case, the final analysis comprised 58 cases. The majority of analyzed patients were male (77.2%), and the most frequent primary malignancies were germ cell tumors (57.9%). The mean age of the analyzed patients at symptom onset was 40.5 ± 13 years, with radiotherapy administered at a mean age of 30.3 ± 12.5 years. The latency period between radiation exposure and the emergence of neurological symptoms averaged 10.2 ± 8.7 years. The mean cumulative radiation dose was 49.0 ± 14.0 Gy. Myokymic discharges were identified in 6 patients (10.3% of cases). Comparative analysis revealed no significant clinical or radiological differences across malignancy subtypes in the manifestation of post-radiation LMNS. Conclusions: These findings highlight the need for long-term surveillance of irradiated patients. Full article

Mining, mineral processing, and power generation are just a few of the industries that have made extensive use of pneumatic conveying systems in recent years. The market for pneumatic conveying is anticipated to grow to a value of $30 billion by 2025. However, problems with the pneumatic conveying process are common and include coal particle damage, pipe wall wear, and excessive system energy consumption. A new systematic framework for decision-making is created by combining the Theory of Inventive Problem Solving (TRIZ) with the Decision-Making Trial and Evaluation Laboratory (DEMATEL). This methodology employs TRIZ-Ishikawa to determine the underlying causes of issues from six different perspectives. It then suggests remedies based on TRIZ technical contradictions and uses DEMATEL to examine how the solutions interact to determine the best course of action. This study confirms the viability of this approach in recognizing fundamental contradictions, producing workable solutions, and reaching scientific conclusions in challenging issues by using instances such as wear and tear, obstructions, and low conveying efficiency in pneumatic conveying system elbows. It offers particular references for real engineering projects and suggests practical solutions like employing quick-release flanges and installing multiple sets of airflow regulators. Full article

To explore strategies for the safe utilization of farmland co-contaminated with cadmium (Cd) and lead (Pb), this field study systematically evaluated the impacts of humic acid (HA) and potassium fulvate (PF) at different application rates (0, 1500, 3000, and 4500 kg·ha⁻¹) on the growth, yield, and translocation of Cd and Pb within the soil–plant system of maize (Zea mays L.). The results showed that while HA and PF did not significantly alter total soil Cd and Pb concentrations, they markedly reduced their bioavailable fractions. This mitigation of heavy metal phytotoxicity significantly promoted maize growth and yield, with the high-dose HA treatment increasing yield by a maximum of 32.9%. Both amendments dose-dependently decreased Cd and Pb concentrations, bioconcentration factors (BCF), and translocation factors (TF) in all maize tissues, particularly in the grains. At equivalent application rates, PF was slightly more effective than HA in reducing heavy metal concentrations in the grains. Notably, a significant positive correlation was observed between Cd and Pb concentrations across all plant parts, confirming a synergistic accumulation and translocation mechanism. This synergy provides a physiological explanation for the broad-spectrum immobilization efficacy of these humic substances. In conclusion, applying HA and PF presents a dual-benefit strategy for increasing yield and reducing risks in Cd- and Pb-contaminated farmlands. This study proposes a differentiated application approach: PF is the preferred option when ensuring food-grade safety is the primary goal, whereas high-dose HA is more advantageous for maximizing yield in soils with low-to-moderate contamination risk. Full article

This exploratory study investigates preliminary trends in the optimization of mechanical properties in 3D-printed components produced via Fused Deposition Modeling (FDM) using polycarbonate (PC) and polylactic acid (PLA). Through a systematic full factorial experimental design, three critical parameters were examined: material types (PC and PLA), layer thickness (0.2 mm and 0.4 mm), and build orientation (horizontal and vertical). Preliminary trends suggest that vertically oriented specimens showed up to 64.7% higher tensile strength compared to horizontal builds, though with significantly reduced ductility. Contributing to growing evidence regarding layer thickness effects, thicker layers (0.4 mm) showed improved ultimate strength by up to 36.2% while simultaneously reducing production time by 50%. However, statistical power analysis revealed insufficient sample size (n = 1 per condition) to establish significance for orientation effects, despite large practical differences observed. PC specimens demonstrated superior strength (maximum 67.5 MPa) and fracture energy, while PLA offered better ductility (up to 22.4% strain). These exploratory findings provide promising directions for future adequately powered investigations for tailored parameter selection according to specific application requirements. Full article