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Synonymous Codon Pair Recoding of the HIV-1 env Gene Affects Virus Replication Capacity
- Ana Jordan-Paiz,
- Sandra Franco and
- Miguel Angel Martinez
Synonymous codon pair deoptimization is an efficient strategy for virus attenuation; however, the underlying mechanism remains controversial. Here, we optimized and deoptimized the codon pair bias (CPB) of the human immunodeficiency virus type 1 (HIV...