Search Results (5,156)

Repetitive temperature fluctuations during transportation and storage promote ice crystal formation in salmon flesh, leading to protein denaturation, lipid oxidation, and quality loss. Tuna skin, a major by-product of tuna processing, is a potential source of antifreeze peptides (AFPs) but remains underutilized. This study examined the cryoprotective effects of tuna skin-derived AFPs on salmon cubes subjected to repeated freeze–thaw cycles. Cubes treated with AFPs from three groups of protein hydrolysates prepared using trypsin, pepsin, or neutral protease were evaluated for texture, color, water holding capacity (WHC), volatile odor profiles, protein conformation, biochemical indices, and microstructure. AFP treatment improved textural properties, maintained color stability, and reduced thawing, cooking, and centrifugal losses. The neutral protease-treated group exhibited the optimal cryoprotective ability and it also limited aldehyde and sulfide accumulation, preserved the retention rate of α-helix structure at 49% which was higher than 39% in controls, and enhanced Ca²⁺-ATPase activity to 1.75 μmol Pi·mg⁻¹·h⁻¹ with a 45.8% increase compared to controls, and significantly inhibited protein and lipid oxidation. Microstructural analysis showed compact fibers and intact sarcolemma in the neutral protease-treated group samples, contrasting with severe disruption in controls. This study showed that tuna skin AFPs mitigate freeze–thaw damage in salmon cubes by stabilizing proteins and reducing oxidative deterioration, highlighting their potential as natural, healthy cryoprotectants for seafood preservation, meeting the growing demand of the food industry for clean-label, low-calorie preservation solutions, while advancing the circular economy of aquatic processing via the valorization of tuna skin by-products for high-value seafood applications. Full article

Recently, the occurrence of phosphine-resistant pests has been increasingly reported in many countries. In this study, the efficacy of carbonyl sulfide (COS) on phosphine-resistant and phosphine-susceptible strains of the rice weevil, Sitophilus oryzae, was evaluated to determine the applicability of COS as a fumigant to control phosphine resistance. S. oryzae at the egg, larval and adult stages was treated with phosphine and COS to determine the 50 and 99% lethal concentration time (LCt₅₀ and LCt₉₉, respectively) values. The LCt₅₀ values of phosphine for phosphine-susceptible S. oryzae at the egg, larval and adult stages were 1.44, 0.63, and 0.66 mg h/L, respectively, and those for phosphine-resistant S. oryzae were 30.65, 17.60, and 8.37 mg h/L, respectively. In contrast, the LCt₅₀ values of COS for phosphine-susceptible S. oryzae at the egg, larval, and adult stages were 284.19, 171.11 and 212.55 mg h/L, respectively, and those for phosphine-resistant S. oryzae were 289.78, 149.87 and 229.06 mg h/L, respectively. The COS-resistance ratios were 1.02, 0.88, and 1.08 for S. oryzae at the egg, larval, and adult stages, respectively. These results indicate that the efficacy of COS is similar for phosphine-susceptible and phosphine-resistant pests, suggesting that COS can be used to control phosphine-resistant grain pests. Full article

Over the past two decades, organic semiconductors have attracted significant research interest due to their advantageous features, including low-cost fabrication, lightweight properties, and portability, for photonic device applications. In this study, nickel sulfide doped with cobalt $(\mathrm{N}\mathrm{i}\mathrm{S}/\mathrm{C}\mathrm{o})$ nanocomposites were successfully synthesized via a wet-chemical processing technique and used as a dopant in the active layer of thin-film organic solar cells (TFOSCs). The poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C61-butyric acid methyl ester (PC61BM) blend was used as the active layer in this investigation. The devices were fabricated with $\mathrm{N}\mathrm{i}\mathrm{S}/\mathrm{C}\mathrm{o}$ nanocomposites at 1 wt%, 2 wt%, and 3 wt% in the active layer to determine the optimal dopant concentration. However, the experimental evidence clearly showed that the solar cell’s performance depends on the concentration of the $\mathrm{N}\mathrm{i}\mathrm{S}/\mathrm{C}\mathrm{o}$ nanocomposites. As a result, the highest power conversion efficiency (PCE) recorded in this experimental work was 6.11% at a 1% doping concentration, compared with 2.48% for the pristine reference device under AM 1.5G illumination (100 mW/cm²) in ambient conditions. The optical and electrical properties of the active layers are found to be strongly influenced by the inclusion of $\mathrm{N}\mathrm{i}\mathrm{S}/\mathrm{C}\mathrm{o}$ nanocomposites in the medium. However, the device doped with 1 wt% $\mathrm{N}\mathrm{i}\mathrm{S}/\mathrm{C}\mathrm{o}$ nanocomposite exhibits the highest absorption intensity, consistent with the better performance observed in this study, which can be attributed to the localized surface plasmon resonance (LSPR) effect. The optical and morphological characteristics of the synthesized $\mathrm{N}\mathrm{i}\mathrm{S}/\mathrm{C}\mathrm{o}$ nanocomposites were comprehensively analyzed using high-resolution transmission electron microscopy (HRTEM), high-resolution scanning electron microscopy (HRSEM), and additional complementary techniques. Full article

Background/Objectives: Clopidogrel is a widely prescribed antiplatelet prodrug that requires bioactivation, primarily by the polymorphic CYP2C19 enzyme. Genetic variation in this enzyme leads to differences in active metabolite formation and has prompted the development of pharmacogenetics-guided prescribing. However, current pharmacogenetic strategies are grounded in drug metabolism knowledge derived from mass balance studies conducted in small groups of healthy volunteers. This narrow evidence base may limit the data’s applicability to real-world settings, where factors like polypharmacy or altered organ function may influence drug response. Methods: Pharmacogenetics could benefit from real-world drug metabolism and excretion studies, which we conducted for clopidogrel in 38 kidney and 16 liver transplant recipients from the TransplantLines Biobank and Cohort Study (NCT03272841), utilizing existing LC-SWATH/MS pharmacometabolomic data. Clopidogrel-associated metabolic signals were identified using xenobiotic metabolism knowledge and literature-reported pathways. Results: Across both transplant groups, 26 clopidogrel-associated features were prioritized, of which some matched previously reported urinary metabolites, had previously been observed in plasma, or represented previously unreported metabolites. Clopidogrel carboxylic acid predominated in kidney transplant recipients, whereas its glucuronide form was most abundant in liver transplant recipients. Notably, unmetabolized clopidogrel was consistently detected across all patients. Moreover, our data support a thiol desulfurization route, aligning with emerging evidence of clopidogrel’s role as a hydrogen sulfide-releasing drug. Conclusions: More (putative) clopidogrel metabolites were detected than previously reported, demonstrating the value of pharmacometabolomics in expanding our understanding of drug metabolism. This approach provides novel data that may complement pharmacogenetics research to understand clopidogrel response variability among treated patients. Full article

Metallogeny of low-K tholeiitic magmas in volcanic arcs is poorly documented and understood. The Mutnovsky volcano in Kamchatka erupted low-K tholeiitic basalt, basaltic andesite, andesite and dacite formed through partial melting of a depleted mantle wedge beneath the active front of the Kamchatka arc, followed by fractional crystallization in subarc magmatic conduits. Mineral microinclusions in Mutnovsky lavas are dominated by Cu-Ag chlorides and sulfides (±cerussite, baryte, cassiterite and Sb oxide), which show, along with the bulk rock Ag, Sn and Sb concentrations, a general increase during magmatic differentiation. Mutnovsky rocks are characterized by higher cumulative proportions of Cu-Ag sulfides and chlorides in comparison with the neighboring rear-arc Gorely and Bakening volcanoes, emphasizing the importance of S- and Cl-bearing fluids for their metallogenic evolution. Microinclusions in Mutnovsky tholeiites display certain similarities with ore mineral associations from epithermal and porphyry deposits in Kamchatka. Together with the enrichment of Mutnovsky lavas in Ag, Cu and Sb in reference to the bulk continental crust, this indicates a potential link between low-K tholeiitic magmas and Cu-Ag (±Sb, Sn) mineralization in volcanic arcs. Full article

The growing emphasis on sustainability, regional distinctiveness, and spontaneous fermentation in winemaking necessitates a more comprehensive understanding of local yeast populations and their functional mechanisms. In total, 115 indigenous yeast strains were examined for their enzymatic activities of potential vitivinicultural significance. The yeasts were screened for chitinase activity (biocontrol potential), glycosidase activity (terpene release), β-lyases (thiol release), and sulfite reductases (off-flavor formation), followed by quantitative analysis of the selected subsets. Yeasts were further evaluated for inhibition of fungal mycelial growth, VOC-mediated inhibition, and tolerance to commonly applied fungicides. Pre-field selection was refined using the niche overlap index and grapevine leaf disc assay. The results confirmed chitinolytic activity in four species; all strains exhibited hydrolase activities, with H. uvarum 116 displaying the highest cell-associated activity (6.32 U/g), while T. delbrueckii Sut94 showed the highest extracellular activity (1.36 U/g). β-glucosidase and β-lyase activities were widespread, whereas hydrogen sulfide production was infrequent. P. guilliermondii ZIM 624 showed the most comprehensive overall enzymatic profile, together with strong inhibition patterns. A field trial on Pinot cultivars (V. vinifera L.) further evaluated P. guilliermondii ZIM 624 within an integrated disease management approach, with responses being more pronounced in ‘Pinot noir’ than in ‘Pinot gris’. Full article

Ion-selective electrodes (ISEs) are widely used analytical tools for the determination of specific ions in a variety of analytical applications due to their simplicity, selectivity, and low cost. Recent developments in materials science and digital fabrication have opened new opportunities for redesigning ISEs using modern manufacturing techniques. Here, we present a new application of 3D printing for fabricating potassium-selective electrodes using a simplified membrane composition. The 3D printing cocktail was prepared by mixing potassium tetraphenylborate, silver sulfide or graphite, and industrial ABS (acrylonitrile Butadiene Styrene) polymer. Membranes were tested both without and with the addition of ZnO nanoparticles. Incorporation of ZnO NPs significantly enhanced the electrode slope, while graphite-based membranes exhibited faster response, with potential stabilizing within 3–7 s across a concentration range of 4.88 × 10⁻⁵ mol L⁻¹ to 1.00 × 10⁻² mol L⁻¹. The optimized 3D printed membrane containing 0.6% ZnO NPs showed near-Nernstian behaviour (slope: 59.178 mV per decade and R² = 0.9989), a limit of detection of 2.06 × 10⁻⁵ mol L⁻¹ and high selectivity against common interfering ions. These results demonstrate that 3D printing combined with a suitable membrane composition and nanoparticle incorporation provides a versatile platform for rapid, reproducible, and high-performance potassium ISEs. Full article

The deep integration of machine learning technology with geological prospecting has brought to the forefront a key challenge: how to construct geological-mineralization models by fusing multi-source data, select model features with guidance from metallogenic factors, build multi-source metallogenic prediction models with geological constraints, and ultimately achieve a thorough integration of domain knowledge and machine intelligence. The Eastern-Central Tianshan region is one of China’s most important copper–nickel mineral resource bases, predominantly hosting magmatic copper–nickel sulfide deposits with significant resource potential. In this context, this paper proposes a metallogenic prediction model based on multi-modal feature fusion technology. The model employs a Residual Neural Network (ResNet) incorporating a Squeeze-and-Excitation (SE) attention mechanism and a Multi-Layer Perceptron (MLP) to extract features from different modalities. It integrates multi-source data, including geochemical information, geological metallogenic factors, and aeromagnetic data. A cross-modal feature interaction module, constructed using attention weighting and a gating mechanism, enables deep fusion of the features. After training, the model achieved a prediction accuracy of 97% on the test set. Compared to a unimodal model constructed using Random Forest, the confidence and discriminative capability of the training results were significantly enhanced, validating the effectiveness of multi-modal feature fusion. Applying the trained model to the study area, a total of 11 prospective metallogenic zones were delineated. These include 4 zones in the peripheries of known deposits and 7 zones in previously unexplored (blank) areas. Notably, some known mineral occurrences fall within the predicted blank-area targets, validating the feasibility and significant value of multi-modal feature fusion in mineral prediction. This work provides a novel methodology for the subsequent integrated processing of multi-source data. Full article

The direct thermal conversion of thiourea on fluorine-doped tin oxide (FTO) substrates is widely used to fabricate sulfur-doped carbon nitride (S-CN) photoelectrodes; however, substrate-induced effects often contribute to photoelectrochemical response. Here, we show that the sulfurization of FTO during thermal treatment leads to the in-situ formation of a tin sulfide underlayer, mainly SnS₂, which significantly contributes to the observed photoresponse. A systematic study as a function of temperature reveals that the formation of sulfur-doped carbon nitride and tin sulfide occurs within a similar temperature window, making temperature control alone insufficient to suppress substrate sulfurization. To overcome this limitation, a thin compact carbon nitride interlayer synthesized from melamine was introduced between the FTO substrate and the S-CN film. This interlayer effectively prevents tin sulfide formation and enables the growth of an adherent S-CN film. The resulting photoanodes exhibit stable photoelectrochemical performance toward water oxidation under alkaline conditions (1M KOH), with an onset potential of ~+0.4 V vs. RHE and stable photocurrents up to 40 μA·cm⁻² under AM 1.5G illumination. Electrochemical impedance spectroscopy confirms that the compact carbon nitride interlayer also acts as an effective charge-blocking barrier. This work provides a reliable strategy to avoid substrate-induced artifacts and establishes clear design guidelines to prepare truly sulfur-doped carbon nitride photoelectrodes. Full article

Platinum group elements (PGE) are six rare highly siderophile metals which have similar chemical characteristics and occur together in mineral deposits: platinum (Pt), palladium (Pd), rhodium (Rh), ruthenium (Ru), iridium (Ir) and osmium (Os). In nature, they tend to exist in a metallic state or bond with sulfur and arsenic and occur as trace accessory minerals predominantly in mafic and ultramafic rocks. High industrial demand together with their scarcity in crustal rocks has been reflected in their inclusion in 2025 US Government’s List of Critical Minerals, European Union’s List of Critical Raw Materials and Mongolian List of 11 Critical Minerals. Although Mongolia is not currently a producer, it hosts four types of potentially economic PGE deposits: (1) Podiform chromitites associated with ophiolites; (2) Ni-Cu-PGE sulfide mineralization of rift-related mafic–ultramafic intrusions; (3) Alaskan–Uralian type arc related zoned mafic–ultramafic intrusions; and (4) Placers. Particularly promising are Permian Ni-Cu-PGE sulfide bearing mafic–ultramafic intrusions of the Khangai large igneous province which bear resemblance to mineralized Permian intrusions in Russia (e.g., Norilsk-Talnakh) and N.W. China (e.g., Kalatongke; Tarim basin). In addition, sub-economic ophiolite-hosted PGE mineralization can be extracted as a by-product during chromite mining. There is also the potential for PGE recovery as a by-product in existing gold placer operations in areas hosting ophiolitic massifs and Alaskan–Uralian type intrusions. Mongolia is a promising frontier for PGE exploration and mining. Full article

The recycling of spent lithium iron phosphate (LiFePO₄, LFP) batteries is receiving increasing attention as electric-vehicle deployment accelerates worldwide. Pyrometallurgical reduction offers a viable route for large-scale recovery of iron-rich products from spent LFP batteries; however, the resulting Fe-based alloys often retain residual copper (Cu), which deteriorates alloy quality and constrains downstream utilization and refining. In this study, a sulfidation–slag refining process was developed to selectively remove Cu from an Fe–P–Cu alloy produced by dry reduction of spent LFP batteries. FeS was employed as a sulfidizing agent to promote preferential conversion of Cu into sulfide phases, while fayalite (Fe₂SiO₄) slag was introduced to enhance phase separation between metallic and sulfide/slag phases. Thermodynamic calculations coupled with high-temperature experiments were conducted at 1400–1600 °C under various Cu:FeS ratios to identify operating conditions that maximize Cu removal while minimizing Fe loss. The results indicate that Cu is selectively transferred from the metallic phase to Cu–Fe–S sulfide phases, whereas Fe remains predominantly in the metal phase. Under the optimal condition (1400 °C, Cu:FeS = 2:1), the refined metal reached an Fe content of 90.80 wt.%, achieving an Fe recovery of 87.42% and a Cu removal efficiency of 81.13%. The proposed approach provides a practical stepwise refining strategy for upgrading Fe-rich secondary resources recovered from spent LFP batteries and facilitates subsequent impurity-control processes. Full article

Catalytic materials are central to the advancement of hydrogen generation technologies, playing a pivotal role in enabling sustainable, carbon-neutral energy systems. Hydrogen can be produced via electrochemical water splitting, thermochemical reforming, or photocatalysis—each imposing unique performance requirements on catalysts in terms of activity, selectivity, stability, and efficiency. While traditional noble metals (e.g., platinum, ruthenium, iridium) provide benchmark catalytic activity, their widespread use is hindered by scarcity, high cost, and limited long-term durability. Consequently, researchers have increasingly focused on earth-abundant alternatives such as transition metals (Ni, Co, Fe, Mo), alloys, metal oxides, carbides, sulfides, nitrides, and carbon-based systems. Among these, two-dimensional materials, particularly the MXene family, have attracted significant attention due to their metallic conductivity, layered structure, and tunable surface chemistry. These features enable rapid charge transfer and abundant active sites, making MXenes and related nanostructured catalysts promising for both the Hydrogen Evolution Reaction (HER) and Oxygen Evolution Reaction (OER) across a wide range of electrochemical conditions. Parallel efforts have integrated novel semiconductors, plasmonic nanomaterials, and hybrid heterostructures to improve the efficiency of solar-to-hydrogen energy conversion. This paper reviews the main types of catalytic materials used in hydrogen production, explains their design strategies and structure–performance relationships, and discusses key engineering challenges such as integrating renewable energy sources, scaling up manufacturing, and ensuring long-term durability in real-world systems. Future research goals are also highlighted, including the development of affordable non-noble catalysts, enhancing catalyst stability through surface and defect engineering, and coupling hydrogen production with circular economy principles, all of which are essential to making hydrogen generation more efficient, scalable, and cost-effective as the world transitions to clean and sustainable energy. Full article

The separation of carbon dioxide (CO₂) and hydrogen sulfide (H₂S) from sour natural gas is an important step in gas processing and emission control. This study applies a rate-based Aspen Plus simulation to examine solvent-based CO₂/H₂S removal under conditions representative of the Shurtan Gas Chemical Complex in Uzbekistan. Monoethanolamine (MEA) and methyldiethanolamine (MDEA) are evaluated as reference solvents with respect to separation performance and energy demand. The rate-based modeling framework accounts for reaction kinetics and mass transfer effects in the absorber–regenerator system. Simulation results indicate that both solvents achieve high acid gas removal efficiencies. From an engineering perspective, the results provide practical guidance for solvent selection and energy optimization in existing acid gas removal units, supporting pilot-scale deployment under industrial operating conditions. Sensitivity analysis suggests that increasing gas throughput beyond 30 t/h leads to a gradual reduction in CO₂ capture efficiency, primarily due to mass transfer limitations. From a techno-economic perspective, the lower energy demand of the MDEA-based system may imply reduced operating costs. The captured CO₂ stream reaches a purity of around 99.5%, which is compatible with downstream soda ash production. Overall, the results provide a screening-level assessment supporting further detailed evaluation. Full article

Zinc oxide (ZnO) and zinc sulfide (ZnS) nanocomposites represent promising multifunctional photocatalysts due to their complementary band structures and synergistic charge separation. ZnO–ZnS nanocomposites with varied ZnS content were synthesized to elucidate the composition–structure–property relationships governing their multifunctional performance. Structural characterization using XRD, SEM/EDS, Raman spectroscopy, and XPS confirmed the coexistence of wurtzite crystalline phases of ZnO and ZnS. SEM analysis revealed ZnS fine deposition on the ZnO surface. XPS measurements showed a gradual increase in the amount of ZnS on the ZnO surface with increasing sulfide content and a shift in the valence band maximum from 2.32 eV (pure ZnO) to 0.77 eV (pure ZnS). Optical measurements (IR, UV–Vis diffuse reflectance, photoluminescence) demonstrated that, despite the evolution of vibrational and luminescence features characteristic of ZnS, the apparent band gap remained nearly constant at 3.16–3.18 eV across the series. Photocatalytic methylene blue (MB) degradation followed pseudo-first-order kinetics, peaking for ZN_2 (1% ZnS, k_app = 103 × 10⁻³ min⁻¹), which is 1.7 times higher than for pure ZnO. This enhanced performance is consistent with an S-scheme-like heterojunction that facilitates electron migration to the ZnS conduction band while retaining ZnO valence band holes for oxidation. Scavenging experiments confirmed that electrons dominate MB degradation (k_app up to 185.1 × 10⁻³ min⁻¹ with EDTA/t-BuOH/Ar), outperforming hole-mediated pathways. Antibacterial assays against Staphylococcus aureus revealed good antimicrobial activity for all nanoparticles. The nanocomposite’s antibacterial activity was similar across all samples and was only slightly lower than that of pure ZnS and ZnO. Full article

Mining at the Red Dog Mine generated a 60 million-tonne waste rock stockpile that produces acid rock drainage with pH values typically below 3. The drainage chemistry is controlled by the competing kinetics of acid-generating iron sulfide weathering and acid-neutralizing carbonate and phosphate dissolution. To evaluate the interaction of these reactions, waste rock was collected from the stockpile by drilling a borehole from the surface to a depth of 52 m, terminating at the shale bedrock. A temporal paste pH test was conducted to extend the utility of the static paste pH test to a continuous (30 min) measurement of pH and ORP over a 24-h period. The 24-h paste pH results revealed multiple acid-generating and acid-neutralizing reactions: pH values ranged from 3.31 to 6.96. Mineralogical analysis indicated initial acidic conditions in 12 of the depth intervals (upper and lower zones) were due to the release of stored acidity from soluble iron sulfate minerals. Subsequent pH increases were driven by calcite dissolution and likely phosphate and clay mineral acid-neutralizing reactions. Conversely, late-stage pH decreases in the lower middle zone indicated the presence of highly reactive/available iron sulfide surfaces, which allowed for earlier acid generation compared to less reactive/available iron sulfide minerals in other zones. The utility of this temporal paste pH test and associated mineral analysis is to understand the mineralogical controls on early temporal acid generation to guide batch reactor testing of remaining acid potential under saturated conditions. This sequential approach provides critical information for predicting long-term acid generation and information management of the stockpile for mine site remediation and closure. Full article