Search Results (8,166)

This study examines the relationships between green workplace mindfulness, employee productivity, green work engagement, and perceptions of a green workplace climate within healthcare organizations. Green workplace mindfulness (GWM) refers to employees’ awareness of how their daily work activities influence environmental sustainability and resource use. Drawing on the Job Demands–Resources (JD-R) and Conservation of Resources (COR) theoretical perspectives, the study proposes that sustainability-oriented mindfulness may function as a personal resource associated with employee engagement and work outcomes. Data were collected through a cross-sectional survey of 473 employees working in public and private hospitals in Libya. The study employed Partial Least Squares Structural Equation Modeling (PLS-SEM) to examine the relationships among the study variables. The findings indicate that green workplace mindfulness is positively associated with employee productivity, both directly and indirectly through green work engagement (GWE). In addition, perceptions of a supportive green work climate (GWC) perception strengthen the relationships between mindfulness, engagement, and productivity. Specifically, the indirect association between mindfulness and productivity through engagement becomes stronger when employees perceive stronger environmental support within their organizations. These findings contribute to sustainability and organizational behavior research by demonstrating how individual awareness of environmental responsibility and supportive workplace climates jointly relate to employee engagement and productivity in healthcare settings. From a practical perspective, the results suggest that healthcare organizations can encourage sustainable performance by promoting environmental awareness among employees and by developing workplace climates that support environmentally responsible practices. Such initiatives may help healthcare institutions improve operational effectiveness while contributing to broader sustainability goals. Full article

To address the application requirements of energy storage devices for new energy electric vehicles—including high energy density, high-power density, fast charging and discharging, and long-term cycling stability—traditional symmetric supercapacitors are often limited by low energy density and poor compatibility between the anode and cathode, making it difficult to meet the high-efficiency energy storage demands under the dynamic operating conditions of electric vehicles. This study focuses on the regulation of hierarchical thin-film structures and the innovative heterogeneous coating interface engineering with precise slurry coating and film-forming optimization and designs and fabricates NiCo₂O₄/NiFeO composite thin-film electrodes and Mn-doped porous carbon (Mn-PC) thin-film electrodes. The uniform, compact and stable coating formation on nickel foam substrates via controllable slurry coating facilitates the efficient integration of active materials and conductive supports. The electrode slurries were coated onto conductive nickel foam substrates, and high-performance aqueous supercapacitors were assembled using an asymmetric configuration. A systematic study was conducted covering material preparation, structural characterization, electrochemical testing, and full-device performance evaluation. Using techniques such as XRD, XPS, SEM, TEM, BET, and an electrochemical workstation, the study revealed the structure–activity relationships among material morphology, crystalline phases, pore structure, and electrochemical performance, elucidating the charge storage mechanisms of the composite electrode films and the principles of synergistic adaptation between the anode and cathode. The results indicate that NiCo₂O₄ nanowires decorated with in situ-grown NiFeO nanosheets to form a composite structure; when coated onto nickel foam, this forms a uniform, porous electrode film with a specific surface area of 171.3 m²/g, a specific capacitance as high as 1746 F/g at 1 A/g, and a capacity retention rate of 94.0% after 10,000 cycles. After coating and film formation, the Mn-PC anode introduced pseudocapacitive active sites through uniform Mn doping, resulting in a film electrode specific capacitance of 348 F/g and significantly improved rate and cycling performance. The assembled NiCo₂O₄/NiFeO//Mn-PC asymmetric supercapacitor exhibits a thin-film electrode specific capacitance of 153 F/g at 1 A/g, with a maximum energy density of 52 Wh/kg. Even at a power density of 9000 W/kg, it maintains 45 Wh/kg, and retains 89.5% of its capacity after 10,000 cycles, with overall performance outperforming most previously reported transition metal-based devices. This coating-engineered electrode fabrication strategy breaks through the interface mismatch and structural instability bottlenecks of traditional thin-film electrodes, providing a novel material system and an efficient coating assembly strategy for high-performance supercapacitor thin-film electrodes in new energy electric vehicles, and offers experimental evidence and technical references for the development and application of high-power energy storage coating devices for automotive use, as well as the innovative design of electrode coating engineering in energy storage fields. Full article

Despite extensive research on sustainable urban mobility, non-designated crossings remain underexplored, particularly in low- and middle-income countries where they are highly prevalent. This study applies agent-based simulation to analyze pedestrian crossing behavior in commercial streets. We adopted a mixed-methods approach, combining video recordings, field observations, and structured questionnaires to capture physical conditions and user perceptions in a case in Cairo. The collected data were spatially analyzed using a Geographic Information System (GIS) to identify key spatial and behavioral variables influencing crossing decisions. These variables were then incorporated into an Agent-Based Model developed using the GAMA platform to simulate pedestrian–vehicle interactions. The simulation assessed pedestrian flow, non-designated crossing rates, average vehicle speed, and traffic volume. Results indicate strong relationships between pedestrian flow and non-designated crossings, and moderate associations between increased pedestrian activity and reduced vehicle speeds, while traffic volume shows weak correlations with pedestrian-related indicators. The model reveals distinct patterns of pedestrian crossing behavior, shaped by street configuration and traffic dynamics, and highlights critical risk points in commercial streets. Based on these findings, the study proposes seven actionable strategies to enhance pedestrian safety while supporting a more sustainable urban mobility. Full article

Brownfield-transformed urban parks, particularly those derived from industrial heritage, play a critical role in both cultural preservation and public-space provision. However, existing studies often rely on linear models and general urban contexts, limiting their ability to capture nonlinear, interaction-driven perception and translate analytical results into design-oriented insights. To address this gap, this study develops an interpretable data-driven framework integrating NLP (natural language processing) with explainable machine learning. Using social media reviews from Shougang Park in Beijing, built environmental elements are identified and structured into four dimensions—Accessibility, Safety, Comfort, and Enjoyment. An XGBoost model combined with SHAP analysis is employed to examine variable importance, nonlinear relationships, and interaction effects. The results reveal that visitor satisfaction is governed by heterogeneous and nonlinear relationships rather than independent additive effects. Several variables exhibit threshold-like, diminishing, and inverted-U-shaped patterns, indicating sensitivity to intensity ranges. More importantly, spatial perception emerges from the nonlinear coupling of multiple elements, forming four representative interaction types: compensatory, inverted-U-shaped, context-dependent, and threshold-like relationships. Key interactions are concentrated around industrial landscape, leisure activities, and supporting facilities. Building on these findings, the study translates interactions into design-oriented strategies, emphasizing synergistic configuration, functional balance, moderated development intensity, and context- sensitive programming. By linking interpretable machine learning with spatial design, this research advances an interaction-oriented paradigm and provides a transferable framework for satisfaction-informed evaluation and optimization of brownfields. Full article

Mitochondria are essential organelles that perform irreplaceable functions in neurons. The degeneration of neurons in Alzheimer’s disease (AD) is associated with mitochondrial damage, and Tau pathology represents a significant pathogenic factor in AD. However, the relationship between Tau and mitochondrial dysfunction during neuronal degeneration remains unclear. In this study, we investigated the effects and mechanisms by which extracellular Tau aggregates induce neuronal mitochondrial damage and dysfunction. The results showed that extracellular Tau aggregates lead to structural damage of mitochondria in SH-SY5Y cells and disrupt mitochondrial homeostasis. Extracellular Tau aggregates can also cause mitochondrial oxidative stress and inhibit oxidative phosphorylation in SH-SY5Y cells. Concurrently, extracellular Tau aggregates promote neuronal death through an increase in cytochrome C, mtDNA leakage and activation of the cGAS/STING pathway. We also explored the effects of a single-chain variable fragment antibody (scFv T1) and found that scFv T1 alleviated mitochondrial damage and dysfunction by inhibiting the formation of Tau aggregates. These findings suggest that targeting Tau pathology may be crucial to address neuronal mitochondrial impairment and that reduction of the toxicity associated with extracellular Tau aggregates could help slow Tau pathology progression. Full article

Inclusive education (IE) aims to promote meaningful participation and a sense of belonging for all learners. However, limited research has examined how students with learning difficulties (LDs) experience inclusion in everyday school life. This study explored how primary school students with mild LDs perceive their participation, relationships with teachers and peers, and the role of inclusive classes (ICs) within mainstream Greek primary education. A qualitative design was adopted, and data were collected through semi-structured interviews with ten Grade 6 students receiving support through ICs. Transcripts were analyzed using thematic analysis. Findings indicated that participation was associated with perceived competence in academic tasks, with language-based activities frequently described as cognitively demanding and stressful. Belonging was predominantly felt through peer acceptance and supportive teacher practices rather than solely through classroom placement. The ICs were perceived as providing individualized support and emotional safety, although some ambivalence regarding withdrawal from the mainstream classroom was reported. Students stressed the need for flexible assessment and clearer instructional guidance to enhance fairness and participation. Overall, the findings show that inclusion is experienced as a dynamic interaction between academic accessibility, interpersonal relationships, and supportive learning environments. They also underline the importance of incorporating student voice into inclusive practice. Full article

Utilizing lunar regolith as a raw material for structural components offers significant potential for future lunar exploration. Direct manufacturing from unprocessed regolith reduces the need for specialized refining equipment compared to element extraction methods. At present, the mechanical properties of long-term alkali-activated CQU-1 lunar regolith simulant geopolymer (LRSG) columns have not been studied. To address this, forty-eight CQU-1 LRSG cylindrical specimens were prepared and tested under axial compression in this study. The effects of the curing temperature (60 °C and 80 °C), curing time (3 d, 7 d, 14 d and 28 d), and water–binder ratio (0.325 and 0.455) on the failure modes and stress–strain behavior were investigated. The alkali-activated CQU-1 LRSG achieved a maximum compressive strength of 33.89 MPa under optimal conditions. Elevated curing temperatures and extended curing times enhanced peak stress and elastic modulus while reducing peak and ultimate strains, indicating greater stiffness and brittleness. Conversely, increased water–binder ratios flattened stress–strain curves, diminishing slope and peak stress while elevating peak and ultimate strains. Based on these test results, the stress–strain model, elastic modulus model and peak strain model of alkali-activated CQU-1 LRSG were proposed. The proposed models can accurately predict the stress–strain relationship, compressive strength and ultimate strain of alkali-activated CQU-1 LRSG. The influence of curing temperature, curing time, and water–binder ratio on the performance of alkali-activated CQU-1 LRSG is also discussed in detail. This work confirms the viability of the alkali-activated CQU-1 LRSG and lunar regolith-based geopolymers for future extraterrestrial construction. Full article

Ulcerative colitis (UC), a chronic inflammatory bowel disease, is closely associated with disturbances in the gut microbiota. Natural polysaccharides, owing to their unique “indigestibility” and prebiotic properties, represent a potential strategy for intervening in UC by remodeling the gut microecology. This review summarizes the mechanisms by which natural polysaccharides alleviate UC through modulation of the gut microbiota, with a particular focus on the structure–activity relationship between the structural features of natural polysaccharides and their microbiota-regulating functions. Analytical studies indicate that polysaccharides with distinct structures can be recognized and degraded by specific carbohydrate-active enzymes (CAZymes) in the gut microorganisms, leading to the targeted enrichment of beneficial genera such as Roseburia, Lactobacillus, and Akkermansia, while simultaneously suppressing pro-inflammatory genera such as Escherichia–Shigella and Helicobacter. This structure-dependent microbial remodeling ultimately enhances the production of key metabolites and exerts comprehensive therapeutic effects, including repair of the intestinal barrier, suppression of excessive inflammation, and alleviation of oxidative stress, via activation of signaling pathways such as AMP-activated protein kinase (AMPK) and nuclear factor erythroid 2-related factor 2 (Nrf2) and inhibition of pathways such as nuclear factor kappa-B (NF-κB). By exploring the paradigm of “Structure–Decoding–Conversion–Effect” based on precise microecological regulation of polysaccharide structures, this paper provides a crucial theoretical foundation and design strategy for developing targeted microecological interventions. Full article

Coumarins represent a distinctive class of non-classical carbonic anhydrase inhibitors that interact with the entrance region of the catalytic pocket rather than directly coordinating the catalytic Zn²⁺ ion. In this study, a series of glycosylated coumarins was synthesized through a copper-catalyzed multicomponent reaction involving propargyl glycosides, salicylaldehyde, and tosyl azide, providing efficient access to iminocoumarin-based glycosides derived from natural carbohydrates. The inhibitory activity of the synthesized compounds was evaluated against human carbonic anhydrase isoforms I, II, IX, and XII using a stopped-flow CO₂ hydrase assay. The compounds showed negligible inhibition of the cytosolic isoforms hCA I and hCA II, while displaying moderate activity toward the tumor-associated isoforms hCA IX and hCA XII, with Ki values ranging from 12.9 to 41.8 μM. Among the series, 6-O-(2H-chromene-2-one-3-yl-methyl)-D-galactopyranose (10a) emerged as the most potent inhibitor of hCA IX and XII. Structure–activity relationship analysis indicated that deprotected glycosyl derivatives exhibit improved inhibitory activity compared to protected analogues. To rationalize these observations, molecular docking followed by molecular dynamics simulations and MM-GBSA binding free energy calculations were performed for both anomeric forms of compound 10a. The computational results revealed a clear preference for the β-anomer, particularly in hCA IX and XII, where favorable interactions with catalytic threonine residues and isoform-specific aromatic residues stabilize the ligand within the active-site entrance. These findings provide a molecular explanation for the experimentally observed selectivity and highlight glycosyl coumarins as potential starting points for further optimization toward selective inhibitors of tumor-associated carbonic anhydrases. Full article

The increasing adoption of servitization has led many manufacturing companies to operate simultaneously in manufacturing and service activities, creating dual-sector business models characterized by heightened organizational complexity. Although prior research acknowledges that both internal capabilities and contextual conditions shape organizational outcomes, fewer studies have examined these variables within the same empirical model in companies operating under both manufacturing and service logics. Drawing on the resource-based view and contingency theory, this study examines the effects of organizational culture, organizational commitment, knowledge management, environmental uncertainty, and employee retention on organizational performance in dual-sector companies, while also assessing whether these relationships vary by company size. Survey data were collected from 433 employees working in dual-sector companies and were analyzed using confirmatory factor analysis, covariance-based structural equation modeling, and supplementary hierarchical regression analysis. The findings indicate that environmental uncertainty and employee retention did not receive empirical support as independent direct predictors in the structural model. Organizational commitment, knowledge management, and two dimensions of organizational culture—consistency and adaptability—are significant positive predictors of perceived organizational performance. The moderation analysis does not provide strong evidence that company size changes these relationships, although the interaction suggests that environmental uncertainty may be more consequential in large firms. This study contributes to research on servitization by showing that, in dual-sector companies, performance is most strongly associated with internal capabilities that support coordination, shared meaning, and knowledge integration across manufacturing and service activities. For managers, the results highlight the importance of strengthening commitment, adaptive coordination, and cross-domain knowledge processes rather than relying on retention efforts alone. Full article

Tranilast, an anti-allergic drug with well-established anti-inflammatory, antifibrotic, and antiproliferative properties, suffers from poor water solubility and low bioavailability, which limit its therapeutic potential. To improve its pharmacological profile, we designed and synthesized a novel series of hydroxylated Tranilast analogues. The compounds were obtained through a green, single-step coupling reaction between activated methoxy-substituted hydroxycinnamic acids and anthranilic or hydroxyanthranilic acids, using a triethylamine–isobutyl chloroformate system in environmentally friendly solvents. Fifteen derivatives were isolated in good to excellent yields (63–94%) without chromatographic purification. The synthesized compounds were evaluated for antimicrobial, antioxidant, anti-inflammatory, and antiproliferative activities. Several analogues displayed notable antimicrobial effects against Candida albicans, Staphylococcus aureus, and Klebsiella pneumoniae, with minimum inhibitory concentrations as low as 75 µg/mL. Hydroxylated derivatives showed enhanced radical-scavenging activity in DPPH and ABTS assays compared with Tranilast. Selected compounds also demonstrated suggestive antiproliferative effects against LNCaP prostate cancer cells while maintaining low cytotoxicity toward HaCaT keratinocytes, indicating favourable selectivity. Furthermore, some derivatives significantly reduced nitric oxide production in LPS-stimulated HaCaT cells, confirming their anti-inflammatory potential. Overall, hydroxylation proves to be an effective strategy for improving the biological profile of Tranilast, yielding promising candidates for further pharmacological development. Full article

The demand for reliable, compact, and highly dependable energy conversion systems has grown significantly due to their application in renewable energy systems and electric vehicles for transportation. One of the main converters used in this type of conversion system is the DC–AC converter, known as an inverter. The common study of inverter behavior has focused on addressing, in isolation, the topologies and modulation strategies that activate/deactivate the converter switches, whose main objectives are to improve power quality, increase power density under different operating conditions, and reduce losses. Some of the above objectives were addressed by oversized passive filters, which resulted in increased system volume, high cost, and reduced adaptability. This systematic review analyzes and organizes the state of the art regarding the relationship between the selection of inverter topology, modulation strategy (ranging from conventional modulation approaches to more advanced adaptive strategies), and optimization in conjunction with passive components to observe DC bus voltage management. The review was conducted following the PRISMA 2020 guidelines. A structured search was performed in IEEE Xplore, ScienceDirect, MDPI, and Scielo databases up to 2025, retrieving 9547 records. After duplicate removal and multi-stage screening of titles, abstracts, and full-text, 104 studies met the predefined technical inclusion criteria. Eligible studies were required to report quantitative performance metrics, validated modulation techniques, and explicit focus on inverter architectures or DC bus optimization. The selected studies were examined through comparative technical analysis of topology–modulation interaction, harmonic distortion performance, efficiency, and system-level integration. The study highlights the importance of taking a comprehensive approach at the complete system level by designing the elements addressed together, rather than being optimized in isolation for renewable energy and electric vehicle applications. Full article

GM1 gangliosidosis and Morquio B are rare lysosomal storage disorders (LSDs) with significant unmet medical needs. These disorders result from mutations in the galactosidase beta 1 (GLB1) gene, leading to impaired β-galactosidase (β-Gal) activity and toxic substrate accumulation. The lack of approved disease-modifying therapies for GM1 gangliosidosis and Morquio B, along with the challenges of achieving effective central nervous system delivery, has driven interest in small-molecule pharmacological chaperones (PCs) to restore β-Gal stability and function. Using Gain Therapeutics’ Magellan™ platform, a novel allosteric binding site on β-Gal was identified, enabling the discovery of a new class of Structurally Targeted Allosteric Regulators (STARs). Medicinal chemistry optimization produced a structurally unique STAR compound series, demonstrating broad β-Gal stabilizing effects. The therapeutic potential of these compounds was evaluated in vitro using a canine fibroblast model of GM1 gangliosidosis, where they were shown to significantly reduce toxic GM1 ganglioside accumulation. Immunocytochemistry-based assays confirmed substrate clearance and provided reliable structure–activity relationships, guiding further compound development. Notably, STARs achieved greater substrate clearance than the competitive PC N-nonyl-deoxygalactonojirimycin (NN-DGJ) under the conditions tested, as demonstrated by immunocytochemistry-based assays. While these findings are encouraging, further in vivo studies are required to validate the therapeutic efficacy of these few STAR compounds, particularly in addressing the neurodegenerative aspects of GM1 gangliosidosis. This study underscores the potential of the Magellan platform in identifying STAR molecules and provides a strong foundation for further optimization and preclinical validation in GLB1-related disorders, particularly GM1 gangliosidosis. Full article

Endophytic fungi (EF) inhabit internal plant tissue in a mutually beneficial symbiotic relationship with their host plant. EF synthesizes metabolites that are structurally similar or identical to those found in their host plants, which include alkaloids, flavonoids, terpenoids, phenolic compounds, polysaccharides, proteins, lipids, and organic acids. These molecules have promising therapeutic effects, such as antimicrobial, antioxidant, anti-inflammatory, and antitumor activities. Wound healing has earned attention in recent years because of its relation to chronic pathological diseases. This systematic review scanned the available scientific literature database about the wound-healing properties of EF biomolecules. Amongst 994 works, 24 were screened after abstract and full-text reading. The studies were published between 2014 and 2026, in twelve countries. In total, 16 studies presented in vivo assays, 11 studies presented in vitro assays, and 3 studies presented both assays. Most studies identified molecules, which include melanin, benzoic acid, terpenes, sesquiterpenes (purpurolide), extracellular polysaccharides, exopolysaccharides, carotenoids, fatty acids, proteins, pyrones, quinones, and hydrocarbon acids, among others. A meta-analysis was not conducted due to high heterogeneity across extracts, methodologies, and outcomes. All studies showed wound-healing properties from EF extracts. The findings suggest a positive effect of EF extracts on wound-healing properties and the need for standardized in vitro and in vivo protocols. Full article

Background/Objectives: To address the limitations of natural curcumin, this study focuses on the functional evaluation of structurally optimized derivatives. We aimed to elucidate structure–activity relationships (SAR) and the stage-specific molecular mechanisms of adipogenesis inhibition using an in vitro cellular assay. Methods: Four novel curcuminoids were synthesized and evaluated in 3T3-L1 preadipocytes against natural curcumin (Curcuminoid I). Efficacy and mechanisms were assessed via cell viability assays, quantitative Oil Red O staining, and time-dependent transcriptional profiling (qPCR/Western blotting) of the KLF family and master regulators. Results: SAR analysis identified Curcuminoid III (symmetric 3,5-dimethoxy-4-hydroxy) as the most potent and safe candidate, whereas Curcuminoid IV exhibited cytotoxicity. Time-course analysis revealed a distinct step-wise inhibition mechanism wherein Curcuminoid III significantly upregulated the differentiation repressor KLF2 at the immediate-early phase. This rapid modulation effectively prevented the subsequent induction of pro-adipogenic factors, including KLF9, KLF15, PPARγ, and C/EBPα, in the mid-stage (3–5 d). Consequently, the expression of the maturation marker aP2 was robustly suppressed by the late stage (5–7 d). Conclusions: The symmetric 3,5-dimethoxy-4-hydroxy substitution pattern appears to confer strong anti-adipogenic activity to Curcuminoid III. Early modulation of the KLF2–PPARγ axis at the onset of differentiation may initiate a cascading inhibitory effect throughout the adipogenic program. These findings highlight the potential of structurally optimized plant-derived bioactive compounds as regulators of metabolic cell fate. Full article