Search Results (12,166)

Background/Objective: Frontline healthcare staff who contend diseases and mitigate their transmission were repeatedly exposed to high-risk conditions during the COVID-19 pandemic. They were at risk of mental health issues, in particular, psychological stress, depression, anxiety, financial stress, and/or burnout. This study aimed to investigate and evaluate the occupational stress of medical doctors, nurses, pharmacists, physiotherapists, and other hospital support crew during the COVID-19 pandemic in Saudi Arabia. Methods: We collected both qualitative and quantitative data from a survey given to public and private hospitals using methods like correspondence analysis, cluster analysis, and structural equation models to investigate the work-related stress (WRS) and anxiety of the staff. Since health-related factors are unclear and uncertain, a fuzzy association rule mining (FARM) method was created to address these problems and find out the levels of work-related stress (WRS) and anxiety. The statistical results and K-means clustering method were used to find the best number of fuzzy rules and the level of fuzziness in clusters to create the FARM approach and to predict the work-related stress and anxiety of healthcare staff. This innovative approach allows for a more nuanced appraisal of the factors contributing to work-related stress and anxiety, ultimately enabling healthcare organizations to implement targeted interventions. By leveraging these insights, management can foster a healthier work environment that supports staff well-being and enhances overall productivity. This study also aimed to identify the relevant health factors that are the root causes of work-related stress and anxiety to facilitate better preparation and motivation of the staff for reorganizing resources and equipment. Results: The results and findings show that when the financial burden (FIN) of healthcare staff increased, WRS and anxiety increased. Similarly, a rise in psychological stress caused an increase in WRS and anxiety. The psychological impact (PCG) ratio and financial impact (FIN) were the most influential factors for the staff’s anxiety. The FARM results and findings revealed that improving the financial situation of healthcare staff alone was not sufficient during the COVID-19 pandemic. Conclusions: This study found that while the impact of PCG was significant, its combined effect with FIN was more influential on staff’s work-related stress and anxiety. This difference was due to the mutual effects of PCG and FIN on the staff’s motivation. The findings will help healthcare managers make decisions to reduce or eliminate the WRS and anxiety experienced by healthcare staff in the future. Full article

Background/Objectives: Tegoprazan (TPZ) is a potassium-competitive acid blocker (P-CAB) used to treat conditions such as gastroesophageal reflux disease, peptic ulcer, and Helicobacter pylori infection. It exists in three solid forms: amorphous, Polymorph A, and Polymorph B. This study investigates the molecular basis of polymorph selection, focusing on conformational bias and solvent-mediated phase transformations (SMPTs). Methods: The conformational energy landscapes of two TPZ tautomers were constructed using relaxed torsion scans with the OPLS4 force field and validated by nuclear Overhauser effect (NOE)-based nuclear magnetic resonance (NMR). Hydrogen-bonded dimers were analyzed using DFT-D. Powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), solubility, and slurry tests were conducted using methanol, acetone, and water. Kinetic profiles were modeled with the Kolmogorov–Johnson–Mehl–Avrami (KJMA) equation. Results: Polymorph A was thermodynamically stable across all analyses. Both amorphous TPZ and Polymorph B converted to A in a solvent-dependent manner. Methanol induced direct A formation, while acetone showed a B → A transition. Crystallization was guided by solution conformers and hydrogen bonding. Conclusions: TPZ polymorph selection is governed by solution-phase conformational preferences, tautomerism, and solvent-mediated hydrogen bonding. DFT-D and NMR analyses showed that protic solvents favor the direct crystallization of stable Polymorph A, while aprotic solvents promote the transient formation of metastable Polymorph B. Elevated temperatures and humidity accelerate polymorphic transitions. This crystal structure prediction (CSP)-independent strategy offers a practical framework for rational polymorph control and the mitigation of disappearing polymorph risks in tautomeric drugs. Full article

With accelerated population aging, the importance of older adults’ self-rated health is constantly increasing. Self-rated health is influenced by complex relationships between the built environment and psychosocial factors. Therefore, this study constructs a pathway framework of “material (housing quality and environmental pollution)–psychological (depression and social capital)–self-rated health” elements to explore the influencing mechanism of older adults’ self-rated health. This study utilized the 2018 China Labor Force Dynamics Survey Database to explore the relationship between built environment factors (housing quality and environmental pollution), depression, social capital, and older adults’ self-rated health, using structural equation modeling. The heterogeneity between urban and rural areas is also analyzed. Better housing quality and less environmental pollution were found to be related to higher levels of self-rated health. Depression and social capital were important mediators in the relationship between housing quality, environmental pollution, and self-rated health. Regarding urban–rural heterogeneity, the direct impact of environmental pollution on self-rated health was only significant among urban older adults. Secondly, the multiple mediating roles of social capital were only reflected among rural older adults. The government and relevant entities should promote improvements in housing quality and reduce environmental pollution to achieve a healthy and livable environment. Full article

This research is focused on exploring the importance of STEM (Science, Technology, Engineering, and Mathematics) education in the development of critical competencies among secondary school students in the 21st century. This was aimed to assess the impact of STEM-based activities on students’ creative and computational thinking skills. A quasi-experimental design that included 77 secondary school students from public and private schools in Bandar Lampung, Indonesia, who participated in STEM interventions for over 5 weeks, was adopted. Data were collected through creative thinking tests and questionnaires on CT and STEM attitudes. The results showed that students who participated in STEM activities exhibited significantly higher creative thinking scores compared to peers taught with the traditional curriculum. Specifically, the experimental group showed a progressive increase in weekly test scores, suggesting that STEM methods improved students’ performance over time. Structural equation modeling (SEM) disclosed strong positive associations between attitudes towards STEM, CT, and creativity. The implications of these results outlined the need to integrate STEM education into curricula to foster essential skills for future challenges. This research contributes to the understanding of effective educational strategies and also advocates for a shift towards more interactive and integrative methods in secondary education to meet the demands of the contemporary workforce. Full article

The aim of this study was to compare IC and CSR and to examine ICr as a mediating variable. The study employed a relational survey design and involved participants drawn from industrial organizations based in Tehran. To evaluate participants’ perceptions of innovation climate, corporate social responsibility, and Individual Creativity, standardized questionnaires were used. In analyzing the findings, the structural equation modeling (SEM) approach was adopted, and the analyses were conducted using SPSS AMOS version 26. The analysis revealed that an Innovative Climate exerts a positive and statistically significant influence on CSR. In addition, a positive and significant association was identified between Innovative Climate and Individual Creativity. The results further demonstrated a meaningful relationship between Individual Creativity and CSR. Finally, to test the hypothesis of partial mediation, the study confirmed that Individual Creativity functions as a mediating mechanism between IC and CSR. Overall, these findings highlight the critical role of an innovative environment in enhancing CSR efforts from the perspective of Individual Creativity, and they provide insight for future studies aimed at developing strategies to strengthen creativity as a strategic means of achieving more effective CSR outcomes. The study advocates the development of an innovation-oriented mindset as a pathway to promoting socially responsible practices within Tehran’s industrial sector. Full article

We present a formal framework for modeling neural network dynamics using Category Theory, specifically through Markov categories. In this setting, neural states are represented as objects and state transitions as Markov kernels, i.e., morphisms in the category. This categorical perspective offers an algebraic alternative to traditional approaches based on stochastic differential equations, enabling a rigorous and structured approach to studying neural dynamics as a stochastic process with topological insights. By abstracting neural states as submeasurable spaces and transitions as kernels, our framework bridges biological complexity with formal mathematical structure, providing a foundation for analyzing emergent behavior. As part of this approach, we incorporate concepts from Interacting Particle Systems and employ mean-field approximations to construct Markov kernels, which are then used to simulate neural dynamics via the Ising model. Our simulations reveal a shift from unimodal to multimodal transition distributions near critical temperatures, reinforcing the connection between emergent behavior and abrupt changes in system dynamics. Full article

As urbanization intensifies, high-density communities have become a dominant urban form, making Child-Friendly Community (CFC) development crucial for sustainable urban growth. However, transforming these communities poses challenges, particularly regarding residents’ risk perceptions—an area largely overlooked in existing research. To address this gap, this study introduces “Risk Tolerance (RT)” as a key variable and constructs a multidimensional model of Child-Friendly Community Transformation Risk Tolerance (CFCTRT) to examine its structure and influencing factors. Based on survey data from residents in high-density communities in China’s first- and second-tier cities, Structural Equation Modeling (SEM) is used for empirical analysis. The results show that residents exhibit lower tolerance toward changes in safety, economy, and daily life, but higher tolerance in resource and aesthetic dimensions. Expectations for CFCs and satisfaction with current communities both positively influence CFCTRT, with satisfaction also mediating the relationship between expectations and tolerance. These findings provide a novel perspective on residents’ psychological responses to CFC transformations and offer empirical support for more inclusive and adaptive urban planning strategies. Full article

Addressing the urgent need for lightweight and reusable energy-absorbing materials in aviation impact resistance, this study introduces an innovative multi-directional braided metamaterial design enabled by 4D printing technology. This approach overcomes the dual challenges of intricate manufacturing processes and the limited functionality inherent to traditional textile preforms. Six distinct braided structural units (types 1–6) were devised based on periodic trigonometric functions (Y = A sin(12πX)), and integrated with shape memory polylactic acid (SMP-PLA), thereby achieving a synergistic combination of topological architecture and adaptive response characteristics. Compression tests reveal that reducing strip density to 50–25% (as in types 1–3) markedly enhances energy absorption performance, achieving a maximum specific energy absorption of 3.3 J/g. Three-point bending tests further demonstrate that the yarn amplitude parameter A is inversely correlated with load-bearing capacity; for instance, the type 1 structure (A = 3) withstands a maximum load stress of 8 MPa, representing a 100% increase compared to the type 2 structure (A = 4.5). A multi-branch viscoelastic constitutive model elucidates the temperature-dependent stress relaxation behavior during the glass–rubber phase transition and clarifies the relaxation time conversion mechanism governed by the Williams–Landel–Ferry (WLF) and Arrhenius equations. Experimental results further confirm the shape memory effect, with the type 3 structure fully recovering its original shape within 3 s under thermal stimulation at 80 °C, thus addressing the non-reusability issue of conventional energy-absorbing structures. This work establishes a new paradigm for the design of impact-resistant aviation components, particularly in the context of anti-collision structures and reusable energy absorption systems for eVTOL aircraft. Future research should further investigate the regulation of multi-stimulus response behaviors and microstructural optimization to advance the engineering application of smart textile metamaterials in aviation protection systems. Full article

Southwest China, with typical karst, is one of the 36 biodiversity hotspots in the world, facing extreme ecological fragility due to thin soils, limited water retention, and high bedrock exposure. This fragility intensifies under climate change and human pressures, threatening regional sustainable development. Ecological strategic areas (ESAs) are critical safeguards for ecosystem resilience, yet their spatiotemporal dynamics and driving mechanisms remain poorly quantified. To address this gap, this study constructed a multidimensional ecological health assessment framework (pattern integrity–process efficiency–function diversity). By integrating Sen’s slope, a correlated Mann–Kendall (CMK) test, the Hurst index, and fuzzy C-means clustering, we systematically evaluated ecological health trends and identified ESA differentiation patterns for 2000–2024. Orthogonal partial least squares structural equation modeling (OPLS-SEM) quantified driving factor intensities and pathways. The results revealed that ecological health improved overall but exhibited significant spatial disparity: persistently high in southern Guangdong and most of Yunnan, and persistently low in the Sichuan Basin and eastern Hubei, with 41.47% of counties showing declining/slightly declining trends. ESAs were concentrated in the southwest/southeast, whereas high-EHI ESAs increased while low-EHI ESAs declined. Additionally, the natural environmental and human interference impacts decreased, while unique geographic factors (notably the rock exposure rate, with persistently significant negative effects) increased. This long-term, multidimensional assessment provides a scientific foundation for targeted conservation and sustainable development strategies in fragile karst ecosystems. Full article

International students are an important group at German higher education institutions. Yet few studies have considered the psychosocial situation of these students. The present study combines the study demands-resources model (SD-R model) and the acculturation framework to adapt the former to the specific situation of international students, and examines the effects of study demands, institutional resources, individual resources (acculturation orientations, i.e., affective and cognitive orientations towards the home and host country), stress, and engagement on their life satisfaction as one indicator of well-being. We used cross-sectional survey data from 503 international students across more than 20 higher education institutions. Latent structural equation models showed that lower study demands were associated with lower stress and higher student engagement, which in turn predicted greater life satisfaction. Although higher institutional resources also related to increased engagement and, thus, higher life satisfaction, they were unexpectedly linked to increased stress, which was in turn associated with lower life satisfaction. Additionally, the expected positive effect of affective host country orientation on life satisfaction, mediated through perceived stress and engagement, was confirmed. The consideration of acculturation orientations in the SD-R model helps to understand the specific conditions of well-being amongst international students in Germany. Full article

Enhancing innovation capability can effectively promote the development of traditional industries. Based on Lewin’s behavioral model theory, this study investigated the relationship between industrial support policies and innovation behavior within traditional industries. Utilizing survey data collected from 152 traditional industrial enterprises in 2024 and employing structural equation modeling, the main findings are as follows: Industrial support policies can effectively alleviate the “innovation inertia” of traditional industries, with all policies being significant at the 1% confidence level. Among them, policies related to industry–university–research cooperation platforms have the most significant impact, with a standardized coefficient of 0.941, followed by fiscal and taxation policies (standardized coefficient: 0.846) and financial policies (standardized coefficient: 0.729). Innovation motivation acts as a mediating mechanism between industrial policies and innovation behavior. Industrial support policies accelerate the conversion of reserve-oriented patent portfolios into practical applications, helping to break through patent barriers and effectively alleviate innovation inertia. Consequently, the government should prioritize improving public services, and policy formulation needs to be oriented towards enhancing innovation efficiency. While ensuring industrial security, it is advisable to moderately increase competition to guide traditional industry market players towards thriving in competitive environments. Full article

This study investigates the development of cognitive, emotional, and social skills in pre-service teachers through extracurricular activities, addressing 21st century challenges in preparing educators for diverse learning environments. It was hypothesized that extracurricular activities would positively influence cognitive skills (self-efficacy, self-regulation), emotional dimensions (professional interest), social competencies (teacher–student relationships), and academic achievement. This study employed predictive correlational methodology based on an integrated theoretical framework combining Social Cognitive Theory, Self-Determination Theory, Self-Regulation Theory, and Interpersonal Relationships Theory within formal–informal learning contexts. A psychometrically robust instrument (“Scale on the Contribution of Extracurricular Activities to Professional Development”) was developed and validated through exploratory and confirmatory factor analyses, yielding a five-factor structure with strong reliability indicators (Cronbach’s α = 0.91–0.93; CR = 0.816–0.912; AVE = 0.521–0.612). Data from 775 pre-service teachers (71.1% female) across multiple disciplines at a Turkish university were analyzed using structural equation modeling (χ²/df = 2.855, RMSEA = 0.049, CFI = 0.93, TLI = 0.92). Results showed that extracurricular participation significantly influenced self-efficacy (β = 0.849), professional interest (β = 0.418), self-regulation (β = 0.191), teacher–student relationships (β = 0.137), and academic achievement (β = 0.167). Notably, an unexpected negative relationship emerged between self-efficacy and academic achievement (β = −0.152). The model demonstrated strong explanatory power for self-efficacy (R² = 72.8%), professional interest (R² = 78.7%), self-regulation (R² = 77.2%), and teacher–student relationships (R² = 63.1%) while explaining only 1.8% of academic achievement variance. This pattern reveals distinct developmental pathways for professional versus academic competencies, leading to a comprehensive practical implications framework supporting multidimensional assessment approaches in teacher education. These findings emphasize the strategic importance of extracurricular activities in teacher education programs and highlight the need for holistic approaches beyond traditional academic metrics, contributing to Sustainable Development Goal 4 by providing empirical evidence for integrating experiential learning opportunities that serve both academic researchers and educational practitioners seeking evidence-based approaches to teacher preparation. Full article

Prefabricated buildings, known for their energy efficiency, environmental benefits, and industrial advantages, play a crucial role in urban renewal. Previous studies on the carbon emissions of prefabricated buildings mainly concentrate on the assessment and auditing of carbon emissions at the materialization and construction phase. Few of them have analyzed the carbon emissions at the operational phase or the influence mechanisms of prefabricated buildings on carbon emissions in urban renewal. Thus, this paper explored the factors and mechanisms that influence carbon emissions in prefabricated buildings in China’s urban renewal. Firstly, the factors that influence the carbon emissions of prefabricated buildings in China’s urban renewal were identified through meta-analysis. Secondly, the theoretical model was developed to illustrate the influence paths of prefabricated buildings on the carbon emissions of urban renewal. Finally, the structural equation model (SEM) was used to test the hypotheses in the theoretical model using data collected from questionnaires. The results show that the carbon emission reduction potential of prefabricated buildings is influenced by four aspects, namely, socioeconomic factors, policy regulations, building operation, and materialization. Policy regulations have the greatest impact on the carbon emissions of prefabricated buildings. They not only directly affect the carbon emissions of urban renewal but also influence carbon emissions indirectly through the social economy aspect. The direct impact of social economy on the carbon emissions of prefabricated buildings is insignificant, while it can indirectly affect the carbon emission reduction in prefabricated buildings by influencing building operations and the materialization stage. The findings could help provide strategies for prefabrication and enhance the reduction potential of urban renewal. Full article

Resilience refers to an enduring and yet fluid characteristic that enhances children’s adaptation. It is a dynamic developmental process that is highly promoted by individuals’ internal characteristics, such as self-efficacy and locus of control. The present study examined whether self-efficacy mediates the relationship between locus of control and resilience among Greek primary school students. Participants were 690 students aged 9–12 years who were enrolled at primary schools in Greece in Grades 4, 5, and 6. Participants completed a questionnaire including measures assessing resilience, locus of control, and self-efficacy. Structural equation modeling using AMOS 26.0 was used to analyze the data. The results indicated that locus of control and self-efficacy function as significant predictors for all dimensions of resilience, while demographic characteristics such as gender and grade only predict some dimensions of resilience. The hypothesized model was a good fit to the data, and self-efficacy partially mediates the relationship between locus of control and resilience. Psychologists, instructors, and practitioners can develop and apply intervention programs in order to strengthen children’s resilience by enhancing their self-efficacy and helping them adopt an internal locus of control. Full article

This study investigates the interconnected roles of financial planning, environmental consciousness, and artificial intelligence (AI) in fostering sustainable entrepreneurship among merchants in Machala, Ecuador. Through structural equation modeling analysis of data from 300 entrepreneurs, we found that financial planning positively influences both sustainable entrepreneurship (β = 0.508, p < 0.001) and environmental consciousness (β = 0.421, p < 0.001). Environmental consciousness demonstrates a significant impact on sustainable business development (β = 0.504, p < 0.001), while AI integration emerges as a powerful enabler of both financial planning (β = 0.345, p < 0.001) and sustainable entrepreneurship (β = 0.664, p < 0.001). The findings reveal how AI technologies can democratize access to sophisticated sustainability planning tools in resource-constrained environments, potentially transforming how emerging market entrepreneurs approach environmental challenges. This research advances our understanding of sustainable entrepreneurship by demonstrating that successful environmental business practices in developing economies require an integrated approach combining financial literacy, ecological awareness, and technological adoption. The results suggest that policy interventions supporting sustainable entrepreneurship should simultaneously address financial capabilities, environmental education, and technological accessibility to maximize their impact on sustainable development. Full article