Search Results (4,245)

This study investigated the effects of asparagus powder supplementation on blood glucose regulation, insulin, lipid profile, and oxidative stress in overweight and obese individuals. Forty-four adults aged 18–59 years participated in a 12-week randomized controlled trial and were randomly assigned to receive either asparagus powder (40 mg/kg/day) or a placebo (maltodextrin, 40 mg/kg/day). Assessments included an oral glucose tolerance test (OGTT), fasting blood glucose (FBG), insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), lipid profile, and oxidative stress markers (malondialdehyde [MDA], protein carbonyl, and superoxide dismutase [SOD]). In the asparagus group, OGTT at 30 min and low-density lipoprotein cholesterol (LDL-C) significantly decreased, while SOD activity significantly increased (all p < 0.05). In contrast, the placebo group showed significant increases in OGTT at 30 min, insulin, HOMA-IR, HOMA-B, triglycerides (TG), the TG/high-density lipoprotein cholesterol (HDL-C) ratio, and the total cholesterol (TC)/HDL-C ratio (all p < 0.05). Between-group comparisons indicated that FBG, area under the BG curve at 30–120 min, TG, TG/HDL-C, and MDA levels were significantly lower in the asparagus group than in the placebo group (all p < 0.05), whereas OGTT, LDL-C, SOD activity, insulin, HOMA-IR, HOMA-B, and TC/HDL-C did not differ significantly. Other indices, including TC, HDL-C, and protein carbonyl, showed no significant within- or between-group differences. In conclusion, 12 weeks of asparagus powder supplementation partially improved glycemic control, lipid profile, and oxidative stress in overweight and obese individuals. These findings suggest a potential role of asparagus as a complementary nutritional strategy to reduce the risk of diabetes and cardiovascular disease in this population. Full article

Hydrogen-assisted fatigue cracking presents a critical challenge to the structural integrity of legacy carbon steel natural gas pipelines being repurposed for hydrogen transport, posing a major barrier to the deployment of hydrogen infrastructure. This study systematically evaluates the fatigue crack growth (FCG) behavior of API 5L X60 pipeline steel under varying hydrogen–natural gas (H₂–NG) blending conditions to assess its suitability for long-term hydrogen service. Experiments are conducted using a custom-designed autoclave to replicate field-relevant environmental conditions. Gas mixtures range from 0% to 100% hydrogen by volume, with tests performed at a constant pressure of 6.9 MPa and a temperature of 25 °C. A fixed loading frequency of 8.8 Hz and load ratio (R) of 0.60 ± 0.1 are applied to simulate operational fatigue loading. The test matrix is designed to capture FCG behavior across a broad range of stress intensity factor values (ΔK), spanning from near-threshold to moderate levels consistent with real-world pipeline pressure fluctuations. The results demonstrate a clear correlation between increasing hydrogen concentration and elevated FCG rates. Notably, at 100% hydrogen, API X60 specimens exhibit crack propagation rates up to two orders of magnitude higher than those in 0% hydrogen (natural gas) conditions, particularly within the Paris regime. In the lower threshold region (ΔK ≈ 10 MPa·√m), the FCG rate (da/dN) increased nonlinearly with hydrogen concentration, indicating early crack activation and reduced crack initiation resistance. In the upper Paris regime (ΔK ≈ 20 MPa·√m), da/dNs remained significantly elevated but exhibited signs of saturation, suggesting a potential limiting effect of hydrogen concentration on crack propagation kinetics. Fatigue life declined substantially with hydrogen addition, decreasing by ~33% at 50% H₂ and more than 55% in pure hydrogen. To complement the experimental investigation and enable predictive capability, a modular machine learning (ML) framework was developed and validated. The framework integrates sequential models for predicting hydrogen-induced reduction of area (RA), fracture toughness (FT), and FCG rate (da/dN), using CatBoost regression algorithms. This approach allows upstream degradation effects to be propagated through nested model layers, enhancing predictive accuracy. The ML models accurately captured nonlinear trends in fatigue behavior across varying hydrogen concentrations and environmental conditions, offering a transferable tool for integrity assessment of hydrogen-compatible pipeline steels. These findings confirm that even low-to-moderate hydrogen blends significantly reduce fatigue resistance, underscoring the importance of data-driven approaches in guiding material selection and infrastructure retrofitting for future hydrogen energy systems. Full article

Following restrictions on antibiotic growth promoters in poultry production, there is growing interest in natural feed additives that support health and productivity. Among these, black cumin (Nigella sativa) has emerged as a promising candidate due to its antioxidant, antimicrobial, and immunomodulatory properties. Most studies report that black cumin, in the form of whole seeds, seed meal, or seed oil, improves body weight gain and feed conversion ratio, enhances antioxidant and immune status, and provides additional benefits on lipid profiles, liver enzymes, and cecal microbial balance. This review provides a focused synthesis of recent studies (2014–2025) on black cumin supplementation in broiler chickens, considering its various forms (whole seeds, seed meal, seed oil, and nano-formulations) and production contexts (healthy, heat-stressed, and disease-challenged birds). Specifically, this review compares responses across different forms and doses, evaluates effects on growth performance, immune function, gut health, antioxidant status, liver metabolism, and meat and carcass quality, and highlights inconsistencies among studies. Additionally, it identifies key research gaps to guide future investigations, including optimal dosing, long-term safety, and practical applications in commercial production. Overall, black cumin shows potential as a natural alternative to antibiotics, but further standardized, large-scale studies are needed to confirm its efficacy and feasibility in sustainable poultry farming. Full article

The dead-time effect seriously affects the soft-switching performance and operating efficiency of the dual-active-bridge converter, and also causes problems such as reduced duty cycle, distortion of voltage and current waveforms, and narrowed transmission power range. The proposal of the five-degree-of-freedom modulation strategy transforms the working voltage waveforms of the primary and secondary sides as well as the inductor current waveform of the DAB converter from symmetric to asymmetric, while the dead-time issue still persists. Based on the five-degree-of-freedom modulation strategy, this paper analyzes the electrical characteristics of the converter before and after the introduction of dead time, designs switch drive pulses to avoid the dead time, and proposes a dead-time compensation modulation strategy based on five-degree-of-freedom phase shift. The results show that the proposed dead-time compensation control strategy can avoid problems such as voltage and current waveform distortion and reduction in the soft-switching power range caused by dead time, realizing dead-time compensation in the full power range. Experimental measurements show that, for different voltage transmission ratios, the maximum efficiency improvement is approximately 3.8–4% and the current stress is reduced by 2.11% to 3.13% under low-power operating conditions. The maximum efficiency improvement is approximately about 1.4–2.8% and the current stress is reduced by 1.84% to 2.53% under high-power operating conditions. Full article

Current standard treatments for osteosarcoma have not been changed for decades and have limited and variable success. The advancement of precision medicine technologies, along with the drug-repurposing and fast drug-screening methodologies available, has opened new avenues for the development of more effective therapeutic strategies. In this study, we evaluated the effectiveness of halogenated boroxine (HB) and dextran-coated cerium oxide nanoparticles—DexCeNPs (SD2)—in an in vitro osteosarcoma model. Both agents were tested individually and in combination. The research encompassed assessments of treatment-related cytotoxicity and cell viability, oxidative stress, and apoptotic and necrotic responses, as well as the effects on 3D spheroid models. The results demonstrated that the effects of HB and SD2 were strongly influenced by the dose, exposure time, and cell type. Both exhibited distinguished antitumor activity through cytotoxicity and specific reactive oxygen species (ROS) induction. The combined treatment produced modulated responses that were dependent on the treatment ratio and cell line, suggesting potential synergistic or selective interactions. Notably, the outcomes of the analysis conducted in 3D models revealed reduced toxicity toward non-tumor cells. These findings suggest the improved efficacy of HB and SD2 used in combination as a selective and novel antitumor strategy and underscore the need for further mechanistic studies at the transcriptomic and proteomic levels to elucidate the underlying pathways and clarify the mechanisms of action. Full article

As an important technology to enhance nutrient use efficiency and reduce agricultural non-point source pollution, controlled-release fertilizers (CRFs) have been widely applied in modern agriculture. However, during packaging, transportation, and field application, CRF particles are prone to mechanical impacts, which can lead to particle fragmentation and damage to the controlled-release coating. This compromises the release kinetics, increases nutrient loss risk, and ultimately exacerbates environmental issues such as eutrophication. Currently, studies on the impact-induced fragmentation behavior of CRF particles remain limited, and there is an urgent need to investigate their fragmentation susceptibility mechanisms from the perspective of internal stress evolution. In this study, the mechanical properties of CRF particles were first experimentally determined to obtain essential parameters. A two-layer finite element model representing the coating and core structure of the particles was then constructed, and a fragmentation susceptibility index was proposed as the key evaluation criterion. The index, defined as the ratio of fractured volume to peak impact energy, reflects the efficiency of energy conversion at the critical moment of particle rupture (1–5). An explicit dynamic simulation framework incorporating multiple influencing factors—equivalent diameter, sphericity, impact material, velocity, and angle—was developed to analyze fragmentation behavior from the perspective of energy transformation. Based on the observed effects of these variables on fragmentation susceptibility, three regression models were developed using response surface methodology to quantitatively predict fragmentation susceptibility. Comparative analysis between the simulation and experimental results showed a fragmentation rate error range of 0–11.47%. The findings reveal the relationships between particle fragmentation modes and energy responses under various impact conditions. This research provides theoretical insights and technical guidance for optimizing the mechanical stability of CRFs and developing environmentally friendly fertilization strategies. Full article

Modern gas turbines for aeroengines operate at ever-increasing inlet temperatures to maximize thermal efficiency, power, output and thrust, subjecting turbine blades to severe thermal and mechanical stresses. To ensure component durability, effective cooling strategies are indispensable, yet they strongly influence the underlying aerothermal behavior, particularly in transonic regimes where shock–boundary layer interactions are critical. In this work, a comprehensive Reynolds-Averaged Navier–Stokes (RANS) investigation is carried out on the LS89 transonic turbine cascade, considering both adiabatic and cooled wall conditions. Three operating cases, spanning progressively higher outlet Mach numbers (0.84, 0.875, and 1.020), are analyzed using multiple turbulence closures. To mitigate the well-known model dependence of RANS predictions, a model-averaging strategy is introduced, providing a more robust prediction framework and reducing the uncertainty associated with single-model results. A systematic mesh convergence study is also performed to ensure grid-independent solutions. The results show that while wall pressure and isentropic Mach number remain largely unaffected by wall cooling, viscous near-wall quantities and wake characteristics exhibit a pronounced sensitivity to the wall-to-recovery temperature ratio. To support further research and model benchmarking, the complete RANS database generated in this work is released as an open-source resource and made publicly. Full article

The present study examined the impact of adding methionine (Met) and its conjugated form (Met-Met) on Cornu aspersum snails. The primary focus was on the animals’ growth performance, the chemical composition of their carcass (whole body without the shell), the mineral profile, and the mechanical properties of their shells. In two experiments conducted under controlled laboratory conditions, diets supplemented with varying levels of Met addition (0.3, 0.6, 1.4 g/kg feed) were used, and the effects of free methionine, Met-Met and their mixture (1.4 g/kg feed) were compared. The study incorporated measurements of body weight, shell width, and mortality of snails. Analyses encompassing protein, fat, sulphur amino acids, glutathione levels, oxidative stress indices (DPPH, TAC, TBARS), and macro- and micronutrient content of carcass and shells were conducted. The findings demonstrated that adding 1.4 g Met/kg feed significantly enhanced the shells’ weight gain (+56% vs. Control), shell weight (+56%) and crushing force (+135%). Furthermore, an increase in the Met content of the carcass was observed (+18%), along with elevated carcass Ca (+28%) and P (+30%) and higher shell Ca (+12%) and Zn (+87%), alongside reduced carcass Fe (−38%) and Cu (−19%). In Experiment II, the Met-Met group exhibited the highest carcass weight (+16% vs. Control), the greatest carcass-to-body weight ratio, and the highest proportion of mature individuals (+27%). Moreover, Met-Met supplementation improved Cu absorption and retention in the carcass (+19%). Also, the results suggest that the conjugated form of methionine may improve Cu absorption and storage in the carcass (+19%). The study’s findings indicate that methionine addition, especially in Met-Met form, can substantially impact the efficiency of C. aspersum farming, enhancing both the productivity outcomes and the quality of the product. That is particularly important in increasing the shell’s mechanical resistance and the carcass’s nutritional value. Full article

Peatlands are vital carbon reservoirs, but their ecological roles are increasingly being compromised by land use change. While tropical peatlands are often associated with lowlands, distinct highland peatlands also occur, they remain insufficiently explored. The Humbang Hasundutan peatlands formed on the southern flank of the Toba caldera following the ~74 ka super-eruption, where persistent waterlogging in cool, wet uplands enabled accumulation of predominantly woody peats. This study investigated the effects of recent land use changes on the chemical and biological properties of peat soils in Humbang Hasundutan (elevation 1350–1430 m.a.s.l.), comparing forests, open lands, and cultivated areas. Soil samples were collected from three sub-districts (Dolok Sanggul, Pollung, Lintong Nihuta) at two depths (10 cm and 40 cm) and analysed for carbon (C), nitrogen (N), pH, and microbial respiration. Results revealed the significant degradation in cultivated lands, with C content dropping to 10–15%, compared to 57.30% in forests. Nitrogen levels were highest in Dolok Sanggul (1.38% in cultivated land) and Pollung (1.32% in open land). C:N ratio varied from 66 in forests to 34 in cropping lands. Soil pH varied by land use, with cultivated areas showing elevated pH (5.09) due to mineral soil mixing, while natural forests retained acidic conditions (pH 3.9–4.4). Microbial respiration was highest in forests (5.49 mg CO₂/day) but decreased in disturbed areas. These results stress the climate-mitigation value of intact highland peat forests and the urgency of tailored restoration via rewetting and native revegetation, alongside cautious agroecological management. Full article

The immiscibility of most polymers leads to poor interfacial adhesion in blends, a critical challenge that often limits the mechanical performance of polymer composites. This research introduces shape-forming elements (SFEs), a novel class of coextrusion dies designed to create additional geometric complexity and control over interfacial architecture. Specifically inspired by Julia Set and T-Square fractals, SFEs were simulated, prototyped, and found to be effective in coextrusion of different-colored polymer clays. The SFEs were employed to coextrude architected composites consisting of a liquid crystalline polymer (Vectra A950) and a cycloaliphatic polyamide (Trogamid CX7323). Mechanical testing revealed a strong positive correlation between the draw ratio and both the tensile modulus (adjusted R² = 0.94) and tensile stress at break (adjusted R² = 0.84). However, experimental cross-sections significantly differed from simulation results. These discrepancies were attributed to interfacial instabilities caused by material incompatibility between the two polymers and potential moisture-induced defects. This finding highlights critical challenges that arise during practical processing, emphasizing the importance of addressing polymer compatibility and moisture management to realize the full potential of SFEs in designing advanced polymer composites with targeted properties. Full article

The coupling of partial root-zone drying (PRD) with nitrogen forms exerts an interactive “water-promoted fertilization” effect, which enhances rice (Oryza sativa L.) growth and development, improves water use efficiency (WUE), mediates the expression of aquaporins (AQPs), and alters root water conductivity. In this study, gene cloning and CRISPR-Cas9 technologies were employed to construct overexpression and knockout vectors of the OsPIP2;1 gene, which were then transformed into rice (cv. Meixiangzhan 2). Three water treatments were set: normal irrigation (CK); partial root-zone drying (PRD); and 10% PEG-simulated water stress (PEG), combined with a nitrogen form ratio of ammonium nitrogen (NH₄⁺) to nitrate nitrogen (NO₃⁻) at 50:50 (A50/N50) for the coupled treatment of rice seedlings. The results showed that under the coupled treatment of PRD and the aforementioned nitrogen form, the expression level of the OsPIP2;1 gene in roots was upregulated by 0.62-fold on the seventh day, while its expression level in leaves was downregulated by 1.84-fold. Overexpression of OsPIP2;1 enabled Meixiangzhan 2 to maintain a higher abscisic acid (ABA) level under different water conditions, which helped rice reduce water potential and enhance water absorption. Compared with the CK treatment, overexpression of OsPIP2;1 increased the superoxide dismutase (SOD) activity of rice under PRD by 26.98%, effectively alleviating tissue damage caused by excessive accumulation of O₂⁻. The physiological and biochemical characteristics of OsPIP2;1-overexpressing rice showed correlations under PRD and A50/N50 nitrogen form conditions, with WUE exhibiting a significant positive correlation with transpiration rate, chlorophyll content, nitrogen content, and Rubisco enzyme activity. Overexpression of OsPIP2;1 could promote root growth and increase the total biomass of rice plants. The application of the OsPIP2;1 gene in rice genetic engineering modification holds great potential for improving important agricultural traits of crops. This study provides new insights into the mechanism by which the AQP family regulates water use in rice and has certain significance for exploring the role of AQP genes in rice growth and development as well as in response to water stress. Full article

Proppant crushing seriously affects the efficiency and effectiveness of oil and gas production. In conventional studies, multi-particle crushing research often adopts the particle replacement method; however, this method results in a relatively rough and discontinuous crushing simulation process, making energy conservation difficult to maintain before and after crushing, neglects complex mechanical behaviors such as internal stress distribution and crack propagation of particles, and thus lacks mechanical authenticity. Thus, this study employs the bonded crushing method and establishes a calibration method for mesoscopic parameters. By constructing a particle flow numerical model, the force and crushing processes of proppants under different mesoscopic parameter conditions for both single-particle clusters and multi-particle clusters are simulated, enabling comprehensive monitoring of internal crack propagation within particle clusters. The study systematically analyzes and investigates the influence of key mesoscopic parameters including the tensile strength of parallel bonds (pb-ten), cohesion of parallel bonds (pb-coh), effective modulus (emod), and stiffness ratio (kratio) on the maximum force required for particle crushing. Additionally, orthogonal experiment analysis is used to study the influence of different mesoscopic parameters on the proppant crushing rate. The results show that the larger the pb-ten and pb-coh, the less likely the proppant particle clusters are to crush; conversely, the higher the emod, the more likely the particle clusters are to crush. Within a certain range, pb-ten has the most significant impact on the proppant crushing rate, followed by pb-coh and emod, while kratio has a smaller impact. Based on the research results regarding the influence of laws of different mesoscopic parameters on proppant crushing performance, the mesoscopic parameters of the proppant were calibrated using the post-experiment proppant crushing rate as the fitting index. The simulation results were then compared with the experimental results, verifying the accuracy of the model. The findings of this study clarify the influence of laws of mesoscopic parameters on proppant crushing performance, providing a basis for the subsequent calibration of mesoscopic parameters for numerical proppants and helping to accurately characterize the macroscopic crushing performance of numerical proppants. Full article

The fatigue behavior of continuous fiber-reinforced composite materials is still not fully understood, particularly under multiaxial out-of-phase loading conditions. This study assesses the multiaxial fatigue behavior of thin-walled carbon fiber-reinforced polymer (CFRP) tubular specimens fabricated by filament winding (FW). A comprehensive experimental study is presented, investigating axial-torsion loads, phase shifts (0°, 45°, and 90°), and load ratios (−1, 0.05, and 0.5). Simultaneously, the acoustic emission (AE) method provides supplementary data for assessing fatigue damage accumulation. Consequently, a shear nonlinear material model and progressive damage in a shell-based finite element model were applied for stress analysis. The experimental results demonstrate the negative influence of a 90° out-of-phase load and the detrimental effect of mean stress for investigated positive load ratios. These findings offer valuable insights into the impact of phase shift (δ) and load ratio (R) in filament-wound carbon composites. These are essential for accurately modeling the fatigue behavior of composite materials under complex multiaxial loading. Full article

Metamaterial lattice structures based on a Triply Periodic Minimal Surface (TPMS) structure have attracted much attention due to their excellent mechanical properties and energy absorption capabilities. In this study, a novel TPMS lattice metamaterial structure (IWP-X) is designed to enhance the axial mechanical properties by fusing an X-shaped plate with an IWP surface structure. A selective laser melting (SLM) machine was utilized to print the designed lattice structures with Ti6Al4V powder. The thickness of the plate and the density of the IWP are varied to explore the responsivity of the mechanical and energy absorption properties with the volume ratio of IWP-X. The finite element simulation analysis is used to effectively predict the stress distribution and fracture site of each structure in the compression test. The results show that the IWP-X structure obtains the ultimate compressive strength of 122.06% improvement, and the energy absorption of 282.03% improvement. The specific energy absorption (SEA) reaches its maximum value in the plate-to-IWP volume ratio of 0.7 to 0.8. Full article

Background/Objectives: Total hip arthroplasty (THA) is a widely accepted and effective intervention for advanced degenerative hip disease. However, prosthetic dislocation remains one of the most common postoperative complications. This study aimed to evaluate the biomechanical consequences of implant positioning variations and their influence on prosthetic stability. Methods: A three-dimensional finite element model (FEM) of the pelvis and hip joint was developed using SolidWorks Professional 2025, based on CT imaging of an anatomically normal adult. Multiple implant configurations were simulated, varying acetabular cup inclination and anteversion angles, femoral stem depth, and femoral offset. Muscle force vectors replicating single-leg stance conditions were applied according to biomechanical reference data. The mechanical performance of each configuration was quantified using the safety factor (SF), defined as the ratio of allowable material stress to calculated stress in the model. Results: The configuration with 45° cup inclination, 15° anteversion, standard femoral offset, and optimal stem depth demonstrated the highest SF values (9–12), indicating a low risk of mechanical failure or dislocation. In contrast, malpositioned implants—particularly those with low or high anteversion, excessive offset, or shallow stem insertion—resulted in a marked decrease in SF values (2–5), especially in the anterosuperior and posterosuperior quadrants of the acetabular interface. Conclusions: The findings underscore the critical importance of precise implant alignment in THA. Even moderate deviations from optimal positioning can substantially compromise biomechanical stability and increase the risk of dislocation. These results support the need for individualized preoperative planning and the use of assistive technologies during surgery to enhance implant placement accuracy and improve clinical outcomes. Full article