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Keywords = sound field synthesis

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28 pages, 19935 KiB  
Article
Effects of Violin Back Arch Height Variations on Auditory Perception
by Luca Jost, Mehmet Ercan Altinsoy and Hannes Vereecke
Acoustics 2025, 7(2), 27; https://doi.org/10.3390/acoustics7020027 - 14 May 2025
Viewed by 1533
Abstract
One of the quintessential goals of musical instrument acoustics is to improve the perceived sound produced by, e.g., a violin. To achieve this, the connections between physical (mechanical and geometrical) properties and perceived sound output need to be understood. In this article, a [...] Read more.
One of the quintessential goals of musical instrument acoustics is to improve the perceived sound produced by, e.g., a violin. To achieve this, the connections between physical (mechanical and geometrical) properties and perceived sound output need to be understood. In this article, a single facet of this complex problem will be discussed using experimental results obtained for six violins of varying back arch height. This is the first investigation of its kind to focus on back arch height. It may serve to inform instrument makers and researchers alike about the variation in sound that can be achieved by varying this parameter. The test instruments were constructed using state-of-the-art methodology to best represent the theoretical case of changing back arch height on a single instrument. Three values of back arch height (12.1, 14.8 and 17.5 mm) were investigated. The subsequent perceptual tests consisted of a free sorting task in the playing situation and three two-alternative forced choice listening tests. The descriptors “round” and “warm” were found to be linked to back arch height. The trend was non-linear, meaning that both low- and high-arch height instruments were rated as possessing more of these descriptors than their medium-arch height counterparts. Additional results were obtained using stimuli created by hybrid synthesis. However, these could not be linked to those using real playing or recordings. The results of this study serve to inform violin makers about the relative importance of back arch height and its specific influence on sound output. The discussion of the applied methodology and interpretation of results may serve to inform researchers about important new directions in the field of musical instrument acoustics. Full article
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18 pages, 14199 KiB  
Article
Enhanced Virtual Sound Source Construction Based on Wave Field Synthesis Using Crossfade Processing with Electro-Dynamic and Parametric Loudspeaker Arrays
by Yuting Geng, Ayano Hirose, Mizuki Iwagami, Masato Nakayama and Takanobu Nishiura
Appl. Sci. 2024, 14(24), 11911; https://doi.org/10.3390/app142411911 - 19 Dec 2024
Cited by 1 | Viewed by 1098
Abstract
Wave field synthesis (WFS) can be used to construct virtual sound sources (VSSs) with a loudspeaker array. Conventional methods using a single type of loudspeaker showed limited performance in distance perception. For example, WFS with electro-dynamic loudspeakers (EDLs) has the advantage of constructing [...] Read more.
Wave field synthesis (WFS) can be used to construct virtual sound sources (VSSs) with a loudspeaker array. Conventional methods using a single type of loudspeaker showed limited performance in distance perception. For example, WFS with electro-dynamic loudspeakers (EDLs) has the advantage of constructing VSSs near the loudspeaker, while WFS with parametric array loudspeakers (PALs) has the advantage of constructing VSSs far from the loudspeaker. In this paper, we propose a VSS construction method utilizing crossfade processing with both EDLs and PALs. The contribution of EDLs and PALs was balanced to better synthesize the target sound field. We carried out experiments to evaluate the sound pressure, frequency characteristic, and sound image perception. The experimental results demonstrated that the proposed method can enhance these aspects of the VSS. Full article
(This article belongs to the Special Issue Applied Audio Interaction)
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16 pages, 1422 KiB  
Article
Limitations and Performance Analysis of Spherical Sector Harmonics for Sound Field Processing
by Hanwen Bi, Shaoheng Xu, Fei Ma, Thushara D. Abhayapala and Prasanga N. Samarasinghe
Appl. Sci. 2024, 14(22), 10633; https://doi.org/10.3390/app142210633 - 18 Nov 2024
Viewed by 970
Abstract
Developing spherical sector harmonics (SSHs) benefits sound field decomposition and analysis over spherical sector regions. Although SSHs demonstrate potential in the field of spatial audio, a comprehensive investigation into their properties and performance is absent. This paper seeks to close this gap by [...] Read more.
Developing spherical sector harmonics (SSHs) benefits sound field decomposition and analysis over spherical sector regions. Although SSHs demonstrate potential in the field of spatial audio, a comprehensive investigation into their properties and performance is absent. This paper seeks to close this gap by revealing three key limitations of SSHs and exploring their performance in two aspects: sector sound field radial extrapolation and sector sound field decomposition and reconstruction. First, SSHs are not solutions to the Helmholtz equation, which is their main limitation. Then, due to the violation of the Helmholtz equation, SSHs lack the ability to conduct sound field radial extrapolation, especially for interior cases. Third, when using SSHs to decompose and reconstruct a sound field, the shifted associated Legendre polynomials and scaled exponential function in SSHs result in severe distortion around the edge of the sector region. In light of these three limitations, the future implementation of SSHs should focus on processing and analyzing the measurement sector region without any extrapolation process, and the measurement region should be larger than the target sector region. Full article
(This article belongs to the Special Issue Spatial Audio and Sound Design)
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21 pages, 8818 KiB  
Article
A Time-Domain Wavenumber Integration Model for Underwater Acoustics Based on the High-Order Finite Difference Method
by Xiang Xu, Wei Liu and Guojun Xu
J. Mar. Sci. Eng. 2024, 12(5), 728; https://doi.org/10.3390/jmse12050728 - 27 Apr 2024
Viewed by 1385
Abstract
Simulating the acoustic field excited by pulse sound sources holds significant practical value in computational ocean acoustics. Two primary methods exist for modeling underwater acoustic propagation in the time domain: the Fourier synthesis technique based on frequency decomposition and the time-domain underwater acoustic [...] Read more.
Simulating the acoustic field excited by pulse sound sources holds significant practical value in computational ocean acoustics. Two primary methods exist for modeling underwater acoustic propagation in the time domain: the Fourier synthesis technique based on frequency decomposition and the time-domain underwater acoustic propagation model (TD-UAPM). TD-UAPMs solve the wave equation in the time domain without requiring frequency decomposition, providing a more intuitive explanation of the physical process of sound energy propagation over time. However, time-stepping numerical methods can accumulate numerical errors, making it crucial to improve the algorithm’s accuracy for TD-UAPMs. Herein, the time-domain wavenumber integration model SPARC was improved by replacing the second-order finite element method (FEM) with the high-order accuracy finite difference method (FDM). Furthermore, the matched interface and boundary (MIB) method was used to process the seabed more accurately. The improved model was validated using three classic underwater acoustic benchmarks. By comparing the acoustic solutions obtained using the FDM and the FEM, it is evident that the improved model requires fewer grid points while maintaining the same level of accuracy, leading to lower computational costs and faster processing compared to the original model. Full article
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41 pages, 3493 KiB  
Review
Advances in Nanoarchitectonics: A Review of “Static” and “Dynamic” Particle Assembly Methods
by Karaneh Eftekhari, Bogdan V. Parakhonskiy, Dmitry Grigoriev and Andre G. Skirtach
Materials 2024, 17(5), 1051; https://doi.org/10.3390/ma17051051 - 24 Feb 2024
Cited by 14 | Viewed by 3349
Abstract
Particle assembly is a promising technique to create functional materials and devices from nanoscale building blocks. However, the control of particle arrangement and orientation is challenging and requires careful design of the assembly methods and conditions. In this study, the static and dynamic [...] Read more.
Particle assembly is a promising technique to create functional materials and devices from nanoscale building blocks. However, the control of particle arrangement and orientation is challenging and requires careful design of the assembly methods and conditions. In this study, the static and dynamic methods of particle assembly are reviewed, focusing on their applications in biomaterial sciences. Static methods rely on the equilibrium interactions between particles and substrates, such as electrostatic, magnetic, or capillary forces. Dynamic methods can be associated with the application of external stimuli, such as electric fields, magnetic fields, light, or sound, to manipulate the particles in a non-equilibrium state. This study discusses the advantages and limitations of such methods as well as nanoarchitectonic principles that guide the formation of desired structures and functions. It also highlights some examples of biomaterials and devices that have been fabricated by particle assembly, such as biosensors, drug delivery systems, tissue engineering scaffolds, and artificial organs. It concludes by outlining the future challenges and opportunities of particle assembly for biomaterial sciences. This review stands as a crucial guide for scholars and professionals in the field, fostering further investigation and innovation. It also highlights the necessity for continuous research to refine these methodologies and devise more efficient techniques for nanomaterial synthesis. The potential ramifications on healthcare and technology are substantial, with implications for drug delivery systems, diagnostic tools, disease treatments, energy storage, environmental science, and electronics. Full article
(This article belongs to the Special Issue Nanoarchitectonics in Materials Science)
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26 pages, 7723 KiB  
Article
A Feasibility Study for a Hand-Held Acoustic Imaging Camera
by Danilo Greco
Appl. Sci. 2023, 13(19), 11110; https://doi.org/10.3390/app131911110 - 9 Oct 2023
Cited by 3 | Viewed by 2676
Abstract
Acoustic imaging systems construct spatial maps of sound sources and have potential in various applications, but large, cumbersome form factors limit their adoption. This paper investigates methodologies to miniaturize acoustic camera systems for improved mobility. Our approach optimizes planar microphone array design to [...] Read more.
Acoustic imaging systems construct spatial maps of sound sources and have potential in various applications, but large, cumbersome form factors limit their adoption. This paper investigates methodologies to miniaturize acoustic camera systems for improved mobility. Our approach optimizes planar microphone array design to achieve directional sensing capabilities on significantly reduced footprints compared to benchmarks. The current prototype utilizes a 128−microphone, 50 × 50 cm2 array with beamforming algorithms to visualize acoustic fields in real time but its stationary bulk hampers portability. We propose minimizing the physical aperture by carefully selecting microphone positions and quantities with tailored spatial filter synthesis. This irregular array geometry concentrates sensitivity toward target directions while avoiding aliasing artefacts. Simulations demonstrate a 32−element, ≈20 × 20 cm2 array optimized this way can outperform the previous array in directivity and noise suppression in a sub-range of frequencies below 4 kHz, supporting a 4× surface factor reduction with acceptable trade-offs. Ongoing work involves building and testing miniature arrays to validate performance predictions and address hardware challenges. The improved mobility of compact acoustic cameras could expand applications in car monitoring, urban noise mapping and other industrial fields limited by current large systems. Full article
(This article belongs to the Special Issue New Advances in Audio Signal Processing)
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14 pages, 2523 KiB  
Article
AI Enhancements for Linguistic E-Learning System
by Jueting Liu, Sicheng Li, Chang Ren, Yibo Lyu, Tingting Xu, Zehua Wang and Wei Chen
Appl. Sci. 2023, 13(19), 10758; https://doi.org/10.3390/app131910758 - 27 Sep 2023
Cited by 3 | Viewed by 3140
Abstract
E-learning systems have been considerably developed after the COVID-19 pandemic. In our previous work, we developed a linguistic interactive E-learning system for phonetic transcription learning. In this paper, we propose three artificial-intelligence-based enhancements to this system from different aspects. Compared with the original [...] Read more.
E-learning systems have been considerably developed after the COVID-19 pandemic. In our previous work, we developed a linguistic interactive E-learning system for phonetic transcription learning. In this paper, we propose three artificial-intelligence-based enhancements to this system from different aspects. Compared with the original system, the first enhancement is a disordered speech classification module; this module is driven by the MFCC-CNN model, which aims to distinguish disordered speech and nondisordered speech. The accuracy of the classification is about 83%. The second enhancement is a grapheme-to-phoneme converter. This converter is based on the transformer model and designed for teachers to better generate IPA words from the regular written text. Compared with other G2P models, our transformer-based G2P model provides outstanding PER and WER performance. The last part of this paper focuses on a Tacotron2-based IPA-to-speech synthesis system, this deep learning-based TTS system can help teacher generate high-quality speech sounds from IPA characters which significantly improve the functionality of our original system. All of these three enhancements are related to the phonetic transcription process. and this work not only provides a better experience for the users of this system but also explores the utilization of artificial intelligence technologies in the E-learning field and linguistic field. Full article
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16 pages, 9716 KiB  
Article
Novel Tool Path Generation Method for Pocket Machining Using Sound Field Synthesis Theory
by Xuefeng Yang, Xulin Cai, Wenan Yang and Youpeng You
Machines 2023, 11(2), 131; https://doi.org/10.3390/machines11020131 - 18 Jan 2023
Cited by 1 | Viewed by 2699
Abstract
Contour parallel tool paths have been proved to be a preferred machining strategy for their advantage of less tool retractions and less sharp turns. The traditional geometrical algorithm-based tool path generation method often makes it hard to simply and simultaneously solve the problems [...] Read more.
Contour parallel tool paths have been proved to be a preferred machining strategy for their advantage of less tool retractions and less sharp turns. The traditional geometrical algorithm-based tool path generation method often makes it hard to simply and simultaneously solve the problems of self-intersection, no residual, and smoothness at the same time due to their contradictions. To address this issue, a contoured parallel tool path generation method for pocket machining is developed in this study. It is based on sound field synthesis theory inspired by the phenomenon of sound wave propagation. Firstly, the simplified medial axis (SMA) tree of the pocket is extracted and the propagation direction of each SMA segment is calculated on account of the geometric characteristics of the pocket boundary. Secondly, the final tool path is obtained through the synthesis of the sound field. Finally, the novel method is verified on five different pockets to generate a contoured parallel milling tool path. After machining these pockets and measuring the machining time, roughness, and cutting force, the experimental results demonstrate that the tool path obtained by the novel method has advantages in improving machining quality and efficiency. Full article
(This article belongs to the Topic Advanced Manufacturing and Surface Technology)
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14 pages, 3419 KiB  
Article
DIA-TTS: Deep-Inherited Attention-Based Text-to-Speech Synthesizer
by Junxiao Yu, Zhengyuan Xu, Xu He, Jian Wang, Bin Liu, Rui Feng, Songsheng Zhu, Wei Wang and Jianqing Li
Entropy 2023, 25(1), 41; https://doi.org/10.3390/e25010041 - 26 Dec 2022
Cited by 9 | Viewed by 5024
Abstract
Text-to-speech (TTS) synthesizers have been widely used as a vital assistive tool in various fields. Traditional sequence-to-sequence (seq2seq) TTS such as Tacotron2 uses a single soft attention mechanism for encoder and decoder alignment tasks, which is the biggest shortcoming that incorrectly or repeatedly [...] Read more.
Text-to-speech (TTS) synthesizers have been widely used as a vital assistive tool in various fields. Traditional sequence-to-sequence (seq2seq) TTS such as Tacotron2 uses a single soft attention mechanism for encoder and decoder alignment tasks, which is the biggest shortcoming that incorrectly or repeatedly generates words when dealing with long sentences. It may also generate sentences with run-on and wrong breaks regardless of punctuation marks, which causes the synthesized waveform to lack emotion and sound unnatural. In this paper, we propose an end-to-end neural generative TTS model that is based on the deep-inherited attention (DIA) mechanism along with an adjustable local-sensitive factor (LSF). The inheritance mechanism allows multiple iterations of the DIA by sharing the same training parameter, which tightens the token–frame correlation, as well as fastens the alignment process. In addition, LSF is adopted to enhance the context connection by expanding the DIA concentration region. In addition, a multi-RNN block is used in the decoder for better acoustic feature extraction and generation. Hidden-state information driven from the multi-RNN layers is utilized for attention alignment. The collaborative work of the DIA and multi-RNN layers contributes to outperformance in the high-quality prediction of the phrase breaks of the synthesized speech. We used WaveGlow as a vocoder for real-time, human-like audio synthesis. Human subjective experiments show that the DIA-TTS achieved a mean opinion score (MOS) of 4.48 in terms of naturalness. Ablation studies further prove the superiority of the DIA mechanism for the enhancement of phrase breaks and attention robustness. Full article
(This article belongs to the Special Issue Machine and Deep Learning for Affective Computing)
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15 pages, 8499 KiB  
Article
The Tacotron-Based Signal Synthesis Method for Active Sonar
by Yunsu Kim, Juho Kim, Jungpyo Hong and Jongwon Seok
Sensors 2023, 23(1), 28; https://doi.org/10.3390/s23010028 - 20 Dec 2022
Cited by 4 | Viewed by 2764
Abstract
The importance of active sonar is increasing due to the quieting of submarines and the increase in maritime traffic. However, the multipath propagation of sound waves and the low signal-to-noise ratio due to multiple clutter make it difficult to detect, track, and identify [...] Read more.
The importance of active sonar is increasing due to the quieting of submarines and the increase in maritime traffic. However, the multipath propagation of sound waves and the low signal-to-noise ratio due to multiple clutter make it difficult to detect, track, and identify underwater targets using active sonar. To solve this problem, machine learning and deep learning techniques that have recently been in the spotlight are being applied, but these techniques require a large amount of data. In order to supplement insufficient active sonar data, methods based on mathematical modeling are primarily utilized. However, mathematical modeling-based methods have limitations in accurately simulating complicated underwater phenomena. Therefore, an artificial intelligence-based sonar signal synthesis technique is proposed in this paper. The proposed method modified the major modules of the Tacotron model, which is widely used in the field of speech synthesis, in order to apply the Tacotron model to the field of sonar signal synthesis. To prove the validity of the proposed method, spectrograms of synthesized sonar signals are analyzed and the mean opinion score was measured. Through the evaluation, we confirmed that the proposed method can synthesize active sonar data similar to the trained one. Full article
(This article belongs to the Special Issue Recent Advances in Underwater Signal Processing)
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22 pages, 6578 KiB  
Article
Diversity and Exploration of Endophytic Bacilli for the Management of Head Scab (Fusarium graminearum) of Wheat
by Noyonika Kaul, Prem Lal Kashyap, Sudheer Kumar, Deepti Singh and Gyanendra Pratap Singh
Pathogens 2022, 11(10), 1088; https://doi.org/10.3390/pathogens11101088 - 23 Sep 2022
Cited by 5 | Viewed by 3338
Abstract
Fusarium graminearum causing head scab (HS) or head blight (HB) disease in wheat is one of the nasty fungi reported to cause significant grain quality and yield loss. Biological control using endophytic bacteria has emerged as a prospective option for containing fungal diseases [...] Read more.
Fusarium graminearum causing head scab (HS) or head blight (HB) disease in wheat is one of the nasty fungi reported to cause significant grain quality and yield loss. Biological control using endophytic bacteria has emerged as a prospective option for containing fungal diseases in an environmentally benevolent, durable, and sustainable manner. In this regard, 112 endophytic bacilli were isolated from the anthesis stage (Zadok’s growth stage 65) from five different wheat genotypes with an aim to identify prospective antagonistic strains against F. graminearum. The molecular identity of the strains was confirmed by matching 16S rRNA sequences of bacterial strains with the gene sequences of type strains available in the National Center for Biotechnology Information database and reported 38 different species of Bacillus in all the five wheat cultivars. Further, it has been observed that only fourteen strains (B. clarus NOK09, B. mojavensis NOK16, B. subtilis NOK33, B. rugosus NOK47, B. mojavensis NOK52, B. clarus NOK59, B. coahuilensis NOK72, B. cabrialesii NOK78, B. cabrialesii NOK82, B. rugosus NOK85, B. amyloliquefaciens NOK89, B. australimaris NOK95, B. pumilus NOK103, and B. amyloliquefaciens NOK109) displayed in-vitro antagonistic effect against Fusarium graminearum fungus. Furthermore, the three endophytic Bacillus strains showing the strongest antagonistic effect (>70% of growth inhibition of fungal mycelium) under in-vitro antagonistic assay were selected for field experiments. In a two-year consecutive field study, a combination of three strains (B. clarus NOK09 + B. subtilis NOK33 + B. amyloliquefaciens NOK109) displayed a remarkable reduction in HS disease index by 81.47% and 77.85%, respectively. Polymerase chain reaction assay detected three genes (ituD, bmyC, and srfA) involved in antibiotic biosynthesis pathways. Additional attributes such as potassium solubilization, siderophore release, and hydrolytic enzyme (protease, lipase, amylase, chitinase, and pectinase) synthesis have been observed in these strains. Overall, the present study was successful in profiling endophytic bacilli and selecting the combination of effective antagonistic endophytic Bacillus strains that could be the best alternative for the sustainable and ecological sound management of HS disease in wheat under field conditions. Full article
(This article belongs to the Special Issue Current Research on Fusarium)
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13 pages, 1579 KiB  
Article
Ear Centering for Accurate Synthesis of Near-Field Head-Related Transfer Functions
by Ayrton Urviola, Shuichi Sakamoto and César D. Salvador
Appl. Sci. 2022, 12(16), 8290; https://doi.org/10.3390/app12168290 - 19 Aug 2022
Cited by 2 | Viewed by 2611
Abstract
The head-related transfer function (HRTF) is a major tool in spatial sound technology. The HRTF for a point source is defined as the ratio between the sound pressure at the ear position and the free-field sound pressure at a reference position. The reference [...] Read more.
The head-related transfer function (HRTF) is a major tool in spatial sound technology. The HRTF for a point source is defined as the ratio between the sound pressure at the ear position and the free-field sound pressure at a reference position. The reference is typically placed at the center of the listener’s head. When using the spherical Fourier transform (SFT) and distance-varying filters (DVF) to synthesize HRTFs for point sources very close to the head, the spherical symmetry of the model around the head center does not allow for distinguishing between the ear position and the head center. Ear centering is a technique that overcomes this source of inaccuracy by translating the reference position. Hitherto, plane-wave (PW) translation operators have yield effective ear centering when synthesizing far-field HRTFs. We propose spherical-wave (SW) translation operators for ear centering required in the accurate synthesis of near-field HRTFs. We contrasted the performance of PW and SW ear centering. The synthesis errors decreased consistently when applying SW ear centering and the enhancement was observed up to the maximum frequency determined by the spherical grid. Full article
(This article belongs to the Special Issue Immersive 3D Audio: From Architecture to Automotive)
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16 pages, 4923 KiB  
Article
The Role of Transmission Electron Microscopy in the Early Development of Mesoporous Materials for Tissue Regeneration and Drug Delivery Applications
by María Luisa Ruiz-González, Almudena Torres-Pardo and José M. González-Calbet
Pharmaceutics 2021, 13(12), 2200; https://doi.org/10.3390/pharmaceutics13122200 - 20 Dec 2021
Cited by 1 | Viewed by 3912
Abstract
For the last 20 years, silica-based mesoporous materials have provided a sound platform for the development of biomedical technology applied to tissue engineering and drug delivery. Their unique structural and textural characteristics, chiefly, the ordered distribution of homogeneous and tunable pores with high [...] Read more.
For the last 20 years, silica-based mesoporous materials have provided a sound platform for the development of biomedical technology applied to tissue engineering and drug delivery. Their unique structural and textural characteristics, chiefly, the ordered distribution of homogeneous and tunable pores with high surface areas and large pore volume, and their excellent biocompatibility provide an excellent starting point for bone tissue regeneration on the mesoporous surface, and also to load species of interest inside the pores. Adequate control of the synthesis conditions and functionalization of the mesoporous surface are critical factors in the design of new systems that are suitable for use in specific medical applications. Simultaneously, the use of appropriate characterization techniques in the several stages of design and manufacture of mesoporous particles allows us to ascertain the textural, structural and compositional modifications induced during the synthesis, functionalization and post-in vitro assays processes. In this scenario, the present paper shows, through several examples, the role of transmission electron microscopy and associated spectroscopic techniques in the search for useful information in the early design stages of mesoporous systems, with application in the fields of tissue regeneration and drug delivery systems. Full article
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11 pages, 779 KiB  
Review
Fatty Acids and Oxylipins as Antifungal and Anti-Mycotoxin Agents in Food: A Review
by Mei Qiu, Yaling Wang, Lijun Sun, Qi Deng and Jian Zhao
Toxins 2021, 13(12), 852; https://doi.org/10.3390/toxins13120852 - 30 Nov 2021
Cited by 19 | Viewed by 3341
Abstract
Fungal contamination of food, especially by mycotoxigenic fungi, not only reduces the quality of the food, but can also cause serious diseases, thus posing a major food safety challenge to humans. Apart from sound food control systems, there is also a continual need [...] Read more.
Fungal contamination of food, especially by mycotoxigenic fungi, not only reduces the quality of the food, but can also cause serious diseases, thus posing a major food safety challenge to humans. Apart from sound food control systems, there is also a continual need to explore antifungal agents that can inhibit fungal growth and mycotoxin production in food. Many types of fatty acids (FAs) and their oxidized derivatives, oxylipins, have been found to exhibit such effects. In this review, we provide an update on the most recent literature on the occurrence and formation of FAs and oxylipins in food, their effects on fungal growth and mycotoxin synthesis, as well as the genetic and molecular mechanisms of actions. Research gaps in the field and needs for further studies in order to realizing the potential of FAs and oxylipins as natural antifungal preservatives in food are also discussed. Full article
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17 pages, 5658 KiB  
Article
The Synthesis Methodology of PEGylated Fe3O4@Ag Nanoparticles Supported by Their Physicochemical Evaluation
by Magdalena Kędzierska, Piotr Potemski, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, Magdalena Głąb, Beata Grabowska, Dariusz Mierzwiński and Bożena Tyliszczak
Molecules 2021, 26(6), 1744; https://doi.org/10.3390/molecules26061744 - 20 Mar 2021
Cited by 19 | Viewed by 4216
Abstract
Many investigations are currently being performed to develop the effective synthesis methodology of magnetic nanoparticles with appropriately functionalized surfaces. Here, the novelty of the presented work involves the preparation of nano-sized PEGylated Fe3O4@Ag particles, i.e., the main purpose was [...] Read more.
Many investigations are currently being performed to develop the effective synthesis methodology of magnetic nanoparticles with appropriately functionalized surfaces. Here, the novelty of the presented work involves the preparation of nano-sized PEGylated Fe3O4@Ag particles, i.e., the main purpose was the synthesis of magnetic nanoparticles with a functionalized surface. Firstly, Fe3O4 particles were prepared via the Massart process. Next, Ag+ reduction was conducted in the presence of Fe3O4 particles to form a nanosilver coating. The reaction was performed with arabic gum as a stabilizing agent. Sound energy-using sonication was applied to disintegrate the particles’ agglomerates. Next, the PEGylation process aimed at the formation of a coating on the particles’ surface using PEG (poly(ethylene glycol)) has been performed. It was proved that the arabic gum limited the agglomeration of nanoparticles, which was probably caused by the steric effect caused by the branched compounds from the stabilizer that adsorbed on the surface of nanoparticles. This effect was also enhanced by the electrostatic repulsions. The process of sonication caused the disintegration of aggregates. Formation of iron (II, III) oxide with a cubic structure was proved by diffraction peaks. Formation of a nanosilver coating on the Fe3O4 nanoparticles was confirmed by diffraction peaks with 2θ values 38.15° and 44.35°. PEG coating on the particles’ surface was proven via FT-IR (Fourier Transform Infrared Spectroscopy) analysis. Obtained PEG–nanosilver-coated Fe3O4 nanoparticles may find applications as carriers for targeted drug delivery using an external magnetic field. Full article
(This article belongs to the Special Issue Polymer Molecules and Biopolymers in Drug Delivery)
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