Search Results (5,490)

Histopathological evaluation of tissue sections remains the gold standard for the diagnosis, classification, and grading of breast cancer (BC). The widespread adoption of whole-slide imaging (WSI) has enabled the digitization of histological slides and facilitated the development of artificial intelligence (AI) approaches for computational pathology. In recent years, machine learning and deep learning (DL) algorithms have been increasingly investigated for the analysis of hematoxylin and eosin (H&E)-stained images, with potential applications in tumor detection, histological classification, prognostic stratification, and prediction of treatment response. This narrative review summarizes recent developments in AI-driven models applied to BC histopathology and discusses their potential role in supporting diagnostic and prognostic assessment. Several studies have demonstrated the promising performance of DL algorithms in tasks such as the detection of lymph node metastases, assessment of residual tumor after neoadjuvant therapy, and prediction of clinical outcomes from histopathological images. Emerging research has also explored the possibility of inferring molecular and biomarker information from histology images, although these approaches currently identify statistical associations rather than direct molecular measurements. Despite the rapid expansion of this research field, significant barriers remain before routine clinical implementation can be achieved. Key challenges include dataset bias, variability in staining and image acquisition, limited external validation across institutions, and the need for transparent and reproducible model development. In addition, the translation of AI-based systems into clinical practice requires compliance with regulatory frameworks governing software used for medical purposes, such as those established by the U.S. Food and Drug Administration. Overall, AI represents a promising research direction in computational pathology and may contribute to decision-support tools capable of assisting pathologists in the analysis of digital slides. Continued efforts toward methodological rigor, large multicenter datasets, and prospective validation studies will be essential to determine the future role of AI in BC histopathology. Full article

Background/Objectives: Leishmaniasis is a group of diseases caused by obligate intracellular parasites of the Leishmania genus and is classified by the World Health Organization as a category I neglected tropical disease. Leishmania infantum predominantly affects children under five years of age and shows an increasing incidence of cutaneous and visceral forms. The development of new therapeutic alternatives remains challenging, making in silico approaches valuable for accelerating antileishmanial drug discovery. This study aimed to identify new compounds with potential activity against Leishmania infantum amastigotes using artificial intelligence-based classification models. Methods: A curated database of compounds with reported biological activity was constructed. Molecular representation employed zero- to two-dimensional descriptors calculated with Dragon software (v 7.0.10). Unsupervised k-means cluster analysis was applied to define training and external prediction sets. Supervised models were developed on the WEKA platform using IBk, J48, multilayer perceptron, and sequential minimal optimization algorithms. Model performance was assessed through internal cross-validation and external validation procedures. Results: All models achieved classification accuracies above eighty percent for both training and prediction sets, indicating consistent predictive performance and good generalization ability. The validated models were applied to virtual screening of the DrugBank database and a collection of synthetic compounds. This screening campaign enabled the identification of one hundred twenty compounds with potential activity against the amastigote form of Leishmania infantum. Conclusions: Artificial intelligence-based QSAR models proved to be useful tools for prioritizing antileishmanial candidates. The integration of molecular descriptors, machine learning, and virtual screening offers an efficient strategy for drug discovery. Full article

Nano-aerial vehicles have emerged as pivotal tools in modern robotics research, offering a safe and scalable means to validate complex algorithms in resource-constrained environments. This scoping review synthesizes the extensive body of work on the Crazyflie nano-quadcopter and evaluates its potential for drone application development in research and academia. The Crazyflie quadcopter has emerged as a leading open-source platform for education and research in aerial robotics due to its modularity and low cost. Despite its rapid evolution, there is currently no comprehensive synthesis mapping its diverse applications across hardware configurations and research domains. This evaluation systematically charts existing research on the Crazyflie platform, outlining its development, identifying relevant hardware and software configurations, categorizing major research topics, and identifying knowledge gaps. A systematic search was performed on three major databases, Scopus, Web of Science and Google Scholar, for studies published between 2015 and 2025. The results indicate a rapid growth in scientific production, an involved research community and very diverse thematic approaches. Expansion decks for the Crazyflie have been analyzed together with their relation to specific fields of research. While control systems remain the primary research theme, there is a significant shift toward artificial intelligence and swarm robotics. Full article

Cement concrete is a critical pavement construction material. However, under prolonged exposure to heavy traffic loads and the combined effects of multiple factors, it frequently exhibits premature slab failure and concurrent multiple defects, severely limiting its service performance and lifespan. The dynamic behavior of cement concrete pavement under heavy-load conditions and the influence of subgrade geometry and pavement width on dynamic bearing performance remain insufficiently understood. To address this issue, this study employs finite element software Abaqus 2020 to construct a three-dimensional finite element model of heavy-duty cement concrete pavement under six typical conditions, including uncut and unfilled subgrade, low embankment, high embankment, cut slope, and different pavement widths. Utilizing an implicit dynamic algorithm, the model simulates and analyzes the acceleration response, dynamic stress distribution, and evolution of strain energy density within the pavement structure under vehicle dynamic loading. The results indicate that the peak acceleration is highest for the uncut subgrade (159.214 m/s²) and lowest under the cut condition (146.566 m/s²), demonstrating that the cutting structure can effectively suppress pavement vibration intensity. Among subgrade types, high embankments exhibit the greatest capacity for reducing strain energy concentration; at the slab corners, the baseline strain energy density of 8.882 J/m³ is reduced by 4.2%, 7.8%, and 5.0% under low embankment, high embankment, and cut conditions, respectively. Regarding pavement width, wider configurations reduce slab vibration intensities, stored strain energy, peak stresses, and stress concentrations, benefiting long-term service life, but concurrently elevate slab corner strain energy accumulation, increasing the risk of corner fracture and compromising load-bearing capacity. These findings provide scientific and technical support for the structural design and performance optimization of heavy-duty cement concrete pavements. Full article

(1) Background: Robotics and advanced control architectures are increasingly central to the development of precision agriculture (PA), supporting automated, efficient, and data-driven farm management. This review offers a comprehensive analysis of scientific literature on robotic control systems applied to PA, focusing on technological progress, methodological approaches, and emerging research trends. (2) Methods: A systematic review was conducted according to PRISMA guidelines, combined with a bibliometric analysis using VOSviewer to examine term co-occurrences, thematic clusters, and topic evolution over time. Publications indexed in Scopus between 1976 and 2025 were analyzed. (3) Results: Results reveal a sharp growth in publications after 2010, with a strong acceleration from 2015 onward, reflecting advances in autonomous systems and the integration of artificial intelligence, sensor technologies, and distributed software frameworks. Three principal clusters emerged: algorithmic and control methods (e.g., neural networks, path tracking, simulation); sensing and infrastructure technologies (e.g., LiDAR, SLAM, IMU, ROS, deep learning-based perception); and agronomic applications, including crop monitoring, irrigation, yield estimation, and farm management. Citation trends indicate a shift from foundational control theory to AI-driven solutions. (4) Conclusions: Overall, control architectures are evolving toward modular, scalable, and interoperable systems enabling autonomous decision-making in complex agricultural environments. Full article

The rapid proliferation of mobile devices, particularly smartphones and tablets, has transformed digital entertainment, with mobile gaming emerging as one of the fastest-growing digital segments. Such applications are inherently latency-sensitive and require effective resource management and seamless mobility support. To overcome these issues, this paper suggests a four-layered infrastructure that combines edge, fog, and cloud computing with Software-Defined Networking (SDN) and is assisted by a lightweight proximity-aware heuristic placement strategy and mobility management. The suggested structure follows a microservices contained breakdown of the gaming functionality and uses clustering algorithms to permit coordinated access to resources by edge and fog nodes. A dynamic lightweight proximity-aware virtual machine placement algorithm is presented to deploy application modules nearer to the users depending on the availability and mobility of the resources. The proposed work is simulated using IFogSim2. The proposed model reduces the latency by up to 73 percent and the rate of task completion by 25 percent relative to baseline configurations in the case of dynamic mobility of users. These results indicate that the suggested strategy can be effective in improving the latency-sensitive mobile gaming applications performance in the edge-fog networks. Full article

The rapid proliferation of single-phase non-linear loads, such as LED lighting and IT equipment, in modern Smart Buildings has introduced significant power quality challenges in low-voltage electrical installations. A critical but often underestimated consequence is the severe overloading of the neutral conductor caused by triplen harmonics (particularly the 3rd harmonic), which sum algebraically even in balanced three-phase systems. This paper analyzes the electrical and thermal impact of these distortions using a detailed MATLAB/Simulink model of a 400/230 V (3P + N) network. The simulation results demonstrate that under highly distorted conditions (Scenario S3), the neutral current can reach 180% of the nominal phase current (18 A vs. 10 A). Furthermore, the Joule losses analysis reveals a thermal stress more than three times higher on the neutral conductor (peak ~65 W) compared to the phase conductor (~20 W), challenging the traditional design practice of neutral undersizing. To address these safety issues, this study proposes a novel neutral-to-phase current ratio index (k_N) and a proactive decision matrix for Building Management Systems (BMS). Unlike traditional mitigation strategies that rely on static hardware oversizing, passive filters, or specialized transformers, the proposed approach offers a dynamic, cost-effective, and software-driven solution that can be easily integrated into the existing automation infrastructure of modern Smart Buildings. The model identifies a critical tipping point at a 3rd harmonic content of 35.3%, where k_N ≥ 1. By continuously monitoring the k_N parameter, the proposed algorithm enables a transition from passive protection to active power management, triggering automated responses to prevent insulation degradation and mitigate fire hazards. Full article

Ship design is a particularly complex and time-consuming process, comprising a series of phases from concept to detail design. Ideally, the designer needs to deliver a design that complies with the operational and regulatory requirements, while at the same time being optimized with respect to one or more specified objectives. The aim of the present study is to describe an innovative design framework for the parametric modelling of large oil tankers, enabling the elaboration and assessment of numerous design alternatives in search of the optimum design. The hull form, internal layout, and 3D structural arrangement of each design alternative are generated automatically in NAPA^® software. Suitable tools have been developed, assessing the ship’s hydrodynamic performance, structural integrity, compliance with regulatory requirements, and economic viability, facilitating the evaluation of large numbers of variants in a practically acceptable computing time. The developed parametric model has been linked with suitable optimization algorithms, enabling the systematic optimization of the design of large oil tankers, subject to user-specified operational requirements and constraints. Typical application results from the optimization of Suezmax oil tankers are presented and discussed. Full article

Measurement of material thermodynamic parameters plays a crucial role in understanding the interactions between host materials and guest species. Therefore, developing a general-purpose system for thermodynamic parameter measurement is of great significance. In this work, a complete gas–solid interface thermodynamic parameter measurement platform was developed based on isothermal adsorption and a resonant microcantilever testing platform. Unlike conventional adsorption measurement systems that rely on manual, multi-cycle adsorption–desorption processes, the proposed platform integrates an automated hardware–software architecture together with a stepwise concentration-gradient protocol and on-chip thermal desorption, enabling continuous and efficient acquisition of adsorption isotherms. The study includes: (i) construction of an improved thermodynamic parameter extraction model based on the Sips model, (ii) development of an integrated resonant microcantilever control and acquisition module using a modified Fourier algorithm, and (iii) implementation of an automated testing and data analysis software framework developed in LabVIEW based on the Queued Message Handler (QMH) architecture. The system was validated from both hardware performance and material testing perspectives using CO₂ adsorption on H-SSZ-13 as a representative case. The results show that the system achieves a maximum sampling rate of 10,000 pts (points per second), with minimum root-mean-square (RMS) noise levels of 0.0083 Hz for frequency and 0.0109 °C for temperature. The PID temperature-control settling time (0.1%) is 24.9 ms, and the frequency-response settling time (0.01%) is 9.6 ms. Thermodynamic parameters including entropy change (ΔS), enthalpy change (ΔH), and Gibbs free energy change (ΔG) were successfully extracted during CO₂ adsorption at 294.15 K under different relative uptakes. Reproducibility was verified across three independent samples, yielding a standard deviation of 9.1 J·mol⁻¹ for ΔS at 2% relative uptake and relative standard deviations of 6.85% and 8.12% for ΔH and ΔG, respectively. These results demonstrate that the proposed thermodynamic measurement platform features a simple architecture, superior performance, and high reproducibility in gas–solid interface thermodynamic studies, showing strong potential for future commercialization. Full article

The increasing interest in the development and integration of navigation and positioning services across a wide range of receivers has exposed them to various security threats, including GNSS jamming and spoofing attacks. Early detection of jamming and spoofing interference is crucial to mitigating these threats and preventing service degradation. This research introduces an interference detection technique leveraging an AI algorithm applied to GNSS data utilizing various methods to enhance detection accuracy and efficiency. The objective was to use modern sensors and AI to develop an effective tool that detects, characterizes, and localizes interference, thereby reducing associated risks. These sensors and algorithms enable continuous GNSS interference monitoring and support real-time Decision-making. A server plays a crucial role in managing the entire system. Its primary function is to process data collected from various sensors referred to as nodes (e.g., static, rover, drone, and space) and from (public) GNSS networks as well as to perform localization using rotating-antenna nodes. Within the interference detection module, various methods were implemented at different points in the software receiver architecture. Each method’s certainty in identifying an interference source depends on its design and capabilities, with outcomes—whether positive or negative—being subject to potential accuracy or errors. To enhance the Decision-making process, an AI-based Decision-making block has been introduced to determine the presence of interference at a given epoch. The proposed interference monitoring methods were evaluated through experiments using GNSS signals under clean, jamming, and spoofing scenarios. The results demonstrate the techniques’ applicability across diverse scenarios, achieving high performance in interference detection, characterization, and localization. Full article

To address over-extrusion and forming defects at path corners caused by path overlap in additive manufacturing, this paper proposes an angle-adaptive look-ahead compensation algorithm based on a Sech attenuation curve. This method establishes a mapping model between the path angle and the adaptive look-ahead distance of the overlapping area, aiming to eliminate the material accumulation at the corner by precisely identifying the overlapping area and modulating the flow rate. By building a Beckhoff five-axis 3D-printing device and relying on the TwinCAT control platform, the compensation triggering logic based on PLC real-time Euclidean distance calculation was realized, and a slicing software with dynamic bias compensation was also developed. Experiments were conducted on triangular samples with extreme acute angles of 5°, universal acute angles of 85°, and 90° straight angles for printing verification. The results show that this algorithm can effectively suppress the material over-extrusion and accumulation at the path overlap in multiple angles, achieving a smooth transition of the sharp corners in the printed contour. The research confirms that the algorithm proposed in this study, together with the integrated software and hardware system, can ensure the forming accuracy of extreme and conventional geometric features while also guaranteeing the printing efficiency, providing an important reference for ensuring the quality coordination control of the formation process of extreme geometric features in additive manufacturing. Full article

This work presents the design of an attitude control experiment for onboard OPS-SAT-1 satellite execution, conceived with inherent extensibility to future mission architectures. OPS-SATs are ESA nanosatellite mission series designed as an in-orbit testbed for validating novel software and control techniques under real space conditions, OPS-SAT-1 being the first mission. Equipped with an advanced payload computer, OPS-SAT-1 enabled experimentation with innovative mission operations, including real-time attitude control strategies. Two attitude control algorithms, a modified Proportional–Integral–Derivative (mPID) and a fuzzy logic controller, were designed and implemented for the OPS-SAT-1. The design methodology applied to these controllers consisted of (i) modelling the space environment and satellite characteristics, (ii) assessing actuator feasibility, (iii) determining the operational ranges for attitude error and angular velocity, (iv) parametrizing controllers within these ranges, (v) fine-tuning controllers using multi-objective genetic optimization, and (vi) robustness analysis using the Monte Carlo method. Despite the technical issues related to communication with the OPS-SAT-1 hardware, which prevented the execution of the experiment in orbit, this work presents the simulation results that were obtained. These results indicate that fuzzy logic controllers may outperform PID controllers in terms of the accumulated error, settling time and steady-state error, whereas power efficiency appears to be less robust than in the PID. This suggest that a large uncertainty in the model could lead the PID to become more efficient. Near the nominal scenario, the fuzzy controller achieves superior error–cost trade-offs, enabling precise attitude stabilization with lower energy consumption. These findings suggest the potential advantages of modern control approaches compared to classical methods, which will be further assessed through future in-orbit experiments. Full article

This research investigates the optimization of surface integrity in powder-mixed electrical discharge machining (PMEDM) through the innovative use of Jatropha biodielectric fluid enhanced with titanium dioxide (TiO₂) nanoparticles. A comprehensive experimental framework was developed using design expert software (DOE) with Response Surface Methodology (RSM) to systematically analyze the machining of AISI D2 tool steel using copper electrodes. The study examined five critical process parameters, gap current (Ip), pulse-on duration (Ton), pulse-off time (Toff), gap voltage (V), and powder concentration, evaluating their combined effects on surface roughness (SR), surface crack density (SCD), and residual stress characteristics. Advanced characterization techniques including scanning electron microscopy (SEM) were employed to analyze surface topography and subsurface microstructural changes. The optimization process successfully identified optimal machining conditions of current = 9 A, Ton = 100 µs, Toff = 10 µs, and gap voltage = 65 V, achieving exceptional surface quality with a minimum surface roughness of 3.22 µm. Remarkably, these optimized parameters resulted in crack-free surfaces with zero surface crack density and minimal residual stress values across the 2θ range of 90° to 180°. To enhance predictive capabilities, supervised machine learning algorithms were implemented to model surface roughness behavior. Comparative analysis of classification algorithms demonstrated that Support Vector Machine (SVM), k-Nearest Neighbors (kNNs), and Gaussian Naïve Bayes achieved superior performance with F1-scores of 0.88 and prediction accuracies of 90%. The integration of sustainable Jatropha biodielectric with TiO₂ nanoparticles represents a significant advancement in environmentally conscious precision machining, while the machine learning approach establishes a robust framework for intelligent process optimization and quality prediction in advanced manufacturing applications. Full article

A symbolic method is presented for examining the solvability and constructing the exact solution to boundary value problems for systems of linear ordinary loaded differential equations and loaded integro-differential equations with nonlocal boundary conditions. The method uses the inverse of the differential operator involved in the system of loaded differential or integro-differential equations. A solvability criterion based on the determinant of a matrix and an exact analytical matrix-form solution formula are presented. For the implementation of the method into computer algebra system software, two algorithms are provided. The effectiveness of the method is demonstrated by solving several problems. The theoretical and practical results obtained complement the existing literature on the subject. Full article

Objective: The objective of this study was to map and critically synthesize empirical evidence on ML/AI applications across surface mining unit operations, and to characterize models, validation practices, and evidence gaps. Eligibility criteria: Our eligibility criteria comprised peer-reviewed studies (2020–2025) applying ML/AI to surface mining activities, training/validating models on empirical datasets, and reporting quantitative performance metrics. Information sources: Scopus, ScienceDirect, Dimensions, and Web of Science were our information sources, last searched December 2025 and supplemented by website and citation snowballing. Risk of bias: Risk of bias was assessed using an adapted domain-based approach based on PROBAST, used to interpret findings without excluding studies. Synthesis method: Our research employed a narrative synthesis (no meta-analysis due to heterogeneity in datasets, algorithms, contexts, and metrics), grouped by application domain. Results: From 5317 records, 57 studies were included, concentrated in blasting (43), followed by load and haul (6), post-dismantling management (4), extraction (2), and overall exploitation (2). Studies predominantly reported statistical metrics (e.g., R², RMSE, and MAE), with limited operational performance indicators; validation was frequently site-specific. Dataset sizes were not reported consistently across studies. Limitations: This study’s limitations were database coverage, restricted timeframe, and incomplete reporting (e.g., software/tooling). Conclusions: ML/AI shows strong potential, especially in blasting, but scalable deployment is constrained by site specificity, inconsistent reporting, and heterogeneous validation; standardized reporting and operational indicators are priorities. Registration: The systematic review protocol was registered in OSF with DOI 10.17605/OSF.IO/5UMKB. Funding: EU Erasmus+ STRIM project (1010832727). Full article