Search Results (3,873)

Background: Pain is a complex phenomenon characterized by unpleasant experiences with profound heterogeneity influenced by biological, psychological, and social factors. According to the National Health Interview Survey, 50.2 million U.S. adults (20.5%) experience pain on most days, with the annual cost of prescription medication for pain reaching approximately USD 17.8 billion. Theranostic pain nanomedicine therefore emerges as an attractive analgesic strategy with the potential for increased efficacy, reduced side-effects, and treatment personalization. Theranostic nanomedicine combines drug delivery and diagnostic features, allowing for real-time monitoring of analgesic efficacy in vivo using molecular imaging. However, clinical translation of these nanomedicines are challenging due to complex manufacturing methodologies, lack of standardized quality control, and potentially high costs. Quality by Design (QbD) can navigate these challenges and lead to the development of an optimal pain nanomedicine. Our lab previously reported a macrophage-targeted perfluorocarbon nanoemulsion (PFC NE) that demonstrated analgesic efficacy across multiple rodent pain models in both sexes. Here, we report PFC-free, biphasic nanoemulsions formulated with a biocompatible and non-immunogenic plant-based coconut oil loaded with a COX-2 inhibitor and a clinical-grade, indocyanine green (ICG) near-infrared fluorescent (NIRF) dye for parenteral theranostic analgesic nanomedicine. Methods: Critical process parameters and material attributes were identified through the FMECA (Failure, Modes, Effects, and Criticality Analysis) method and optimized using a 3 × 2 full-factorial design of experiments. We investigated the impact of the oil-to-surfactant ratio (w/w) with three different surfactant systems on the colloidal properties of NE. Small-scale (100 mL) batches were manufactured using sonication and microfluidization, and the final formulation was scaled up to 500 mL with microfluidization. The colloidal stability of NE was assessed using dynamic light scattering (DLS) and drug quantification was conducted through reverse-phase HPLC. An in vitro drug release study was conducted using the dialysis bag method, accompanied by HPLC quantification. The formulation was further evaluated for cell viability, cellular uptake, and COX-2 inhibition in the RAW 264.7 macrophage cell line. Results: Nanoemulsion droplet size increased with a higher oil-to-surfactant ratio (w/w) but was no significant impact by the type of surfactant system used. Thermal cycling and serum stability studies confirmed NE colloidal stability upon exposure to high and low temperatures and biological fluids. We also demonstrated the necessity of a solubilizer for long-term fluorescence stability of ICG. The nanoemulsion showed no cellular toxicity and effectively inhibited PGE2 in activated macrophages. Conclusions: To our knowledge, this is the first instance of a celecoxib-loaded theranostic platform developed using a plant-derived hydrocarbon oil, applying the QbD approach that demonstrated COX-2 inhibition. Full article

The introduction of mobile banking is essential in today’s financial sector, where technological innovation plays a critical role. To remain competitive in the current market, businesses must analyze client attitudes and perspectives, as these influence long-term demand and overall profitability. While previous studies have explored general adoption behaviors, limited research has examined how individual factors such as social influence, lifestyle compatibility, financial technology self-efficacy, and perceived usage cost affect mobile banking adoption among specific generational cohorts. This study addresses that gap by offering insights into these variables, contributing to the growing literature on mobile banking adoption, and presenting actionable recommendations for financial institutions targeting younger market segments. Using a structured questionnaire survey, data were collected from both users and non-users of mobile banking among the Gen Z population in the United States. The regression model significantly predicts mobile banking adoption, with an intercept of $-0.548$ ($p < 0.001$). Among the independent variables, perceived cost of usage has the strongest positive effect on adoption ($B=0.857$, $\beta =0.722$, $p < 0.001$), suggesting that adoption increases when mobile banking is perceived as more affordable. Social influence also has a significant positive impact ($B=0.642$, $\beta =0.643$, $p < 0.001$), indicating that peer influence is a central driver of adoption decisions. However, self-efficacy shows a significant negative relationship ($B=-0.343$, $\beta =-0.339$, $p < 0.001$), and lifestyle compatibility was found to be statistically insignificant ($p=0.615$). These findings suggest that reducing perceived costs, through lower fees, data bundling, or clearer communication about affordability, can directly enhance adoption among Gen Z consumers. Furthermore, leveraging peer influence via referral rewards, Partnerships with influencers, and in-app social features can increase user adoption. Since digital self-efficacy presents a barrier for some, banks should prioritize simplifying user interfaces and offering guided assistance, such as tutorials or chat-based support. Future research may employ longitudinal designs or analyze real-life transaction data for a more objective understanding of behavior. Additional variables like trust, perceived risk, and regulatory policies, not included in this study, should be integrated into future models to offer a more comprehensive analysis. Full article

During the course of genome mining initiatives, we identified a marine-derived Micromonospora, assigned here as strain WMMD956; the genome of WMMD956 appeared to contain a number of features associated with everninomicins, well-known antimicrobial orthosomycins. In addition, LCMS-based hierarchical clustering analysis and principal component analysis (hcapca) revealed that WMMD956 displayed an extreme degree of metabolomic and genomic novelty. Dereplication of high-resolution tandem mass spectrometry (HRMS/MS) and Global Natural Product Social molecular networking platform (GNPS) analysis of WMMD956 resulted in the identification of several analogs of the previously known everninomicin. Chemical structures were unambiguously confirmed by HR-ESI-MS, 1D and 2D NMR experiments, and the use of MS/MS data. The isolated metabolites, 1–3, were evaluated for their antibacterial activity against methicillin-resistant Staphalococcus aureus (MRSA). Full article

This paper explores emotional analysis in Hebrew texts, focusing on improving machine learning techniques for depression detection by integrating psychological feature lexicons. Hebrew’s complex morphology makes emotional analysis challenging, and this study seeks to address that by combining traditional machine learning methods with sentiment lexicons. The dataset consists of over 350,000 posts from 25,000 users on the health-focused social network “Camoni” from 2010 to 2021. Various machine learning models—SVM, Random Forest, Logistic Regression, and Multi-Layer Perceptron—were used, alongside ensemble techniques like Bagging, Boosting, and Stacking. TF-IDF was applied for feature selection, with word and character n-grams, and pre-processing steps like punctuation removal, stop word elimination, and lemmatization were performed to handle Hebrew’s linguistic complexity. The models were enriched with sentiment lexicons curated by professional psychologists. The study demonstrates that integrating sentiment lexicons significantly improves classification accuracy. Specific lexicons—such as those for negative and positive emojis, hostile words, anxiety words, and no-trust words—were particularly effective in enhancing model performance. Our best model classified depression with an accuracy of 84.1%. These findings offer insights into depression detection, suggesting that practitioners in mental health and social work can improve their machine learning models for detecting depression in online discourse by incorporating emotion-based lexicons. The societal impact of this work lies in its potential to improve the detection of depression in online Hebrew discourse, offering more accurate and efficient methods for mental health interventions in online communities. Full article

Facial expression recognition (FER) is a critical research direction in artificial intelligence, which is widely used in intelligent interaction, medical diagnosis, security monitoring, and other domains. These applications highlight its considerable practical value and social significance. Face expression recognition models often need to run efficiently on mobile devices or edge devices, so the research on lightweight face expression recognition is particularly important. However, feature extraction and classification methods of lightweight convolutional neural network expression recognition algorithms mostly used at present are not specifically and fully optimized for the characteristics of facial expression images, yet fail to make full use of the feature information in face expression images. To address the lack of facial expression recognition models that are both lightweight and effectively optimized for expression-specific feature extraction, this study proposes a novel network design tailored to the characteristics of facial expressions. In this paper, we refer to the backbone architecture of MobileNet V2 network, and redesign LightExNet, a lightweight convolutional neural network based on the fusion of deep and shallow layers, attention mechanism, and joint loss function, according to the characteristics of the facial expression features. In the network architecture of LightExNet, firstly, deep and shallow features are fused in order to fully extract the shallow features in the original image, reduce the loss of information, alleviate the problem of gradient disappearance when the number of convolutional layers increases, and achieve the effect of multi-scale feature fusion. The MobileNet V2 architecture has also been streamlined to seamlessly integrate deep and shallow networks. Secondly, by combining the own characteristics of face expression features, a new channel and spatial attention mechanism is proposed to obtain the feature information of different expression regions as much as possible for encoding. Thus improve the accuracy of expression recognition effectively. Finally, the improved center loss function is superimposed to further improve the accuracy of face expression classification results, and corresponding measures are taken to significantly reduce the computational volume of the joint loss function. In this paper, LightExNet is tested on the three mainstream face expression datasets: Fer2013, CK+ and RAF-DB, respectively, and the experimental results show that LightExNet has 3.27 M Parameters and 298.27 M Flops, and the accuracy on the three datasets is 69.17%, 97.37%, and 85.97%, respectively. The comprehensive performance of LightExNet is better than the current mainstream lightweight expression recognition algorithms such as MobileNet V2, IE-DBN, Self-Cure Net, Improved MobileViT, MFN, Ada-CM, Parallel CNN(Convolutional Neural Network), etc. Experimental results confirm that LightExNet effectively improves recognition accuracy and computational efficiency while reducing energy consumption and enhancing deployment flexibility. These advantages underscore its strong potential for real-world applications in lightweight facial expression recognition. Full article

Autobrewery syndrome is a rare condition characterized by the endogenous fermentation of carbohydrates by gut microbiota, which exceeds the liver’s detoxification capacity and leads to signs and symptoms of acute alcohol intoxication. This condition has significant clinical, social, and legal implications. Beyond the acute effects, the role of excessive endogenous ethanol production in the progression of chronic diseases—particularly liver disease—is still under investigation. In this review, we aim to describe the key clinical features of autobrewery syndrome, identify the main microbial pathogens involved, and explore the potential impact of endogenous ethanol production on the development and progression of chronic liver disease. Although robust data and standardized treatment protocols are currently lacking, we discuss the general principles of management and outline possible therapeutic strategies and future perspectives. Full article

Background/Objectives: In late 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a pandemic called the ‘coronavirus disease 2019’ (COVID-19). After the acute SARS-CoV-2 infection, many individuals (up to 33%) complained of unexplained symptoms involving multiple organ systems and were diagnosed as having Long COVID-19 (LC-19). Currently, LC-19 is inadequately defined, requiring the formation of consistent diagnostic parameters to provide a foundation for ongoing and future studies of epidemiology, risk factors, clinical characteristics, and therapy. LC-19 represents a significant burden on multiple levels. The reduced ability of workers to return to work or compromised work efficiency has led to consequences at national, economic, and societal levels by increasing dependence on community services. On a personal scale, the isolation and helplessness caused by the disease and its subsequent impact on the patient’s mental health and quality of life are incalculable. Methods: In this paper, we used Walker and Avants’ eight-step approach to perform a concept analysis of the term “Long COVID-19” and define its impact across these parameters. Results: Using this methodology, we provide an improved definition of LC-19 by connecting the clinical symptomology with previously under-addressed factors, such as mental, psychological, economic, and social effects. This definition of LC-19 features can help improve diagnostic procedures and help plan relevant healthcare services. Conclusions: LC-19 represents a complex and pressing public health challenge with diverse symptomology, an unpredictable timeline, and complex pathophysiology. This concept analysis serves as a tool for improving LC-19 definition, but it remains a dynamic disease with evolving diagnostic and therapeutic approaches, requiring deeper investigation and understanding of its long-term effects. Full article

Online reviews increasingly shape experiential travel decisions. This study investigates how structural and linguistic features of user-generated content influence peer endorsement in wine tourism. While prior research has explored review valence and credibility, limited attention has been paid to how micro-level textual and identity cues affect social approval metrics such as likes. Grounded in the Elaboration Likelihood Model, the analysis draws on 7942 TripAdvisor reviews using automated web scraping, readability metrics, and multivariate regression. Results indicate that location disclosure significantly increases likes, while higher textual complexity reduces endorsement. Title length and reviewer contributions function as peripheral cues, with an interaction between complexity and title length compounding cognitive effort. Findings refine dual-process persuasion theory and offer practical insights for content optimization in post-pandemic tourism engagement. Full article

Social network platforms have a big impact on the development of companies by influencing clients’ behaviors and sentiments, which directly affect corporate reputations. Analyzing this feedback has become an essential component of business intelligence, supporting the improvement of long-term marketing strategies on a larger scale. The implementation of powerful sentiment analysis models requires a comprehensive and in-depth examination of each stage of the process. In this study, we present a new comparative approach for several feature extraction techniques, including TF-IDF, Word2Vec, FastText, and BERT embeddings. These methods are applied to three multilingual datasets collected from hotel review platforms in the tourism sector in English, French, and Arabic languages. Those datasets were preprocessed through cleaning, normalization, labeling, and balancing before being trained on various machine learning and deep learning algorithms. The effectiveness of each feature extraction method was evaluated using metrics such as accuracy, F1-score, precision, recall, ROC AUC curve, and a new metric that measures the execution time for generating word representations. Our extensive experiments demonstrate significant and excellent results, achieving accuracy rates of approximately 99% for the English dataset, 94% for the Arabic dataset, and 89% for the French dataset. These findings confirm the important impact of vectorization techniques on the performance of sentiment analysis models. They also highlight the important relationship between balanced datasets, effective feature extraction methods, and the choice of classification algorithms. So, this study aims to simplify the selection of feature extraction methods and appropriate classifiers for each language, thereby contributing to advancements in sentiment analysis. Full article

Falkland Islands English (FIE) began its development in the first half of the 19th century. In part, as a consequence of its youth, FIE is an understudied variety. It shares some morphosyntactic features with other anglophone countries in the Southern Hemisphere, but it also shares lexical features with regional varieties of Spanish, including Rioplatense Spanish. Che is one of many South American words that have entered FIE through Spanish, with its spelling ranging from “chay” and “chey” to “ché”. The word has received some marginal attention in terms of its meaning. It is said to be used in a similar way to the British dear or love and the Australian mate, and it has been compared to chum or pal, and is taken as an equivalent of the River Plate, hey!, hi!, or I say!. In this work, we explore the hypothesis that che entered FIE through historical contact with Rioplatense Spanish, drawing on both linguistic and sociohistorical evidence, and presenting survey, corpus, and ethnographic data that illustrate its current vitality, usage, and social meanings among FIE speakers. In situ observations, fieldwork, and an online survey were used to look into the vitality of che. Concomitantly, by crawling social media and the local press, enough data was gathered to build a small corpus to further study its vitality. A thorough literature review was conducted to hypothesise about the borrowing process involving its entry into FIE. The findings confirm that the word is primarily a vocative, it is commonly used, and it is indicative of a sense of belonging to the Falklands community. Although there is no consensus on the origin of che in the River Plate region, it seems to be the case that it entered FIE during the intense Spanish–English contact that took place during the second half of the 19th century. Full article

The report examines food availability and demand in the Anthropocene era, exploring the connections between global population growth and carrying capacity through an extended version of Cohen’s Condorcet concept. It recalls the super-Malthus and Verhulst-type scalings, matched with the recently introduced analytic relative growth rate. It focuses particularly on the ongoing Fifth Industrial Revolution (IR) and its interaction with the concept of a sustainable civilization. In this context, the significance of innovative food preservation technologies that can yield high-quality foods with health-promoting features, while simultaneously increasing food quantities and reducing adverse environmental impacts, is discussed. To achieve this, high-pressure preservation and processing (HPP) can play a dominant role. High-pressure ‘cold pasteurization’, related to room-temperature processing, has already achieved a global scale. Its superior features are notable and are fairly correlated with social expectations of a sustainable society and the technological tasks of the Fifth Industrial Revolution. The discussion is based on the authors’ experiences in HPP-related research and applications. The next breakthrough could be HPP-related sterilization. The innovative HPP path, supported by the colossal barocaloric effect, is presented. The mass implementation of pressure-related sterilization could lead to milestone societal, pro-health, environmental, and economic benefits. Full article

Volcanic islands host exceptional geological features that illustrate complex endogenic processes and interactions with climatic and marine forces, while also being particularly vulnerable to the impacts of climate change. Despite their scientific, educational, touristic, and aesthetic values, such islands remain underrepresented within the UNESCO Global Geoparks (UGGp). This study reviews current volcanic island geoparks and evaluates territories with potential for future designation, based on documented geoheritage, geosite inventories, and geoconservation frameworks. Geoparks are categorized according to their dominant narratives—ranging from recent Quaternary volcanism to broader tectonic, sedimentary, and metamorphic histories. Through an analysis of their distribution, management strategies, and integration into territorial planning, this work highlights the challenges that insular territories face, including vulnerability to global environmental change, limited legal protection, and structural inequalities in access to international resources recognition. It concludes that volcanic island geoparks represent strategic platforms for implementing sustainable development models, especially in ecologically and socially fragile contexts. Enhancing their global representation will require targeted efforts in ecologically and socially fragile contexts. Enhancing their global representation will require targeted efforts in capacity building, funding access, and regional cooperation—particularly across the Global South. Full article

The escalating threat of climate change has intensified the global urgency to accurately predict carbon dioxide (CO₂) emissions for sustainable development, particularly in developing economies experiencing rapid industrialization and globalization. Traditional Extreme Learning Machines (ELMs) offer rapid learning but often yield unstable performance due to random parameter initialization. This study introduces a novel hybrid model, Red-Billed Blue Magpie Optimizer-tuned ELM (RBMO-ELM) which harnesses the intelligent foraging behavior of red-billed blue magpies to optimize input-to-hidden layer weights and biases. The RBMO algorithm is first benchmarked on 15 functions from the CEC2015 test suite to validate its optimization effectiveness. Subsequently, RBMO-ELM is applied to predict Indonesia’s CO₂ emissions using a multidimensional dataset that combines economic, technological, environmental, and globalization-driven indicators. Empirical results show that the RBMO-ELM significantly surpasses several state-of-the-art hybrid models in accuracy (higher R²) and convergence efficiency (lower error). A permutation-based feature importance analysis identifies social globalization, GDP, and ecological footprint as the strongest predictors underscoring the socio-economic influences on emission patterns. These findings offer both theoretical and practical implications that inform data-driven Artificial Intelligence (AI) and Machine Learning (ML) applications in environmental policy and support sustainable governance models. Full article

This paper introduces the concept of degenerative affordances to explain how social media can unintentionally destabilise family-run influencer businesses. While affordance theory typically highlights the enabling features of technology, the researchers shift the focus to its unintended, risk-laden consequences, particularly within family enterprises where professional and personal identities are deeply entangled. Drawing on platform capitalism, family business research, and intersectional feminist critiques, the researchers develop a theoretical model to examine how social media affordances contribute to role confusion, privacy breaches, and trust erosion. Using a mixed-methods design, the researchers combine narrative interviews (n = 20) with partial least squares structural equation modelling (PLS-SEM) on survey data (n = 320) from family-based influencers. This study’s findings reveal a high explanatory power (R² = 0.934) for how digital platforms mediate entrepreneurial legitimacy through interpersonal trust and role dynamics. Notably, trust emerges as a key mediating mechanism linking social media engagement to perceptions of business legitimacy. This paper advances three core contributions: (1) introducing degenerative affordance as a novel extension of affordance theory; (2) unpacking how digitally mediated role confusion and privacy breaches function as internal threats to legitimacy in family businesses; and (3) problematising the epistemic assumptions embedded in entrepreneurial legitimacy itself. This study’s results call for a rethinking of how digital platforms, family roles, and entrepreneurial identities co-constitute each other under the pressures of visibility, intimacy, and algorithmic governance. The paper concludes with implications for influencer labour regulation, platform accountability, and the ethics of digital family entrepreneurship. Full article

This study examines how language functions impact linguistic features in academic and entertainment registers. Using multi-dimensional analysis (MDA) and computing entropy values, we analyze a large-scale Chinese corpus consisting of over 19 million tokens from 1000 texts, including academic journals, dissertations, entertainment magazines, and novellas. We identify key language functions that shape linguistic features within these registers. Our results reveal five core dimensions of linguistic functional variation, narrative versus rational discourse, modification, reference, uncertainty, and prudence, which account for over 52% of the variance in language use. Certain linguistic features systematically co-occur in each dimension, forming language functions that underpin broader social networks. Entropy values further confirm the findings of multi-dimensional analysis. This study emphasizes the associations between linguistic features and language functions, offering a theoretical perspective for understanding how language functions impact linguistic features and shape different registers. The findings suggest a language variation perspective on social networks’ communication. Full article