Search Results (463)

Background: Vitamin D deficiency (VDD) is highly prevalent among people living with human immunodeficiency virus (HIV), with reported rates of insufficiency and deficiency substantially higher than in many general-population cohorts. This study aims to assess the prevalence of vitamin D deficiency and to investigate the risk factors contributing to its occurrence among people living with HIV who are receiving antiretroviral therapy (ART) and are registered at the Craiova Regional Center (CRC). Methods: A retrospective study was conducted from May 2024 to August 2024, including individuals with HIV aged 18 years and older who were registered at the CRC. Results: A total of 138 patients were included in the study. The prevalence of vitamin D deficiency (<20 ng/mL) and vitamin D insufficiency (20–29.9 ng/mL) was 36.2% and 33.3%, respectively, with an average vitamin D level of 26.4 ± 9.9 ng/mL. Vitamin D deficiency was associated with obesity (p = 0.0013), high HIV viral load (p = 0.043), low CD4 nadir (<200 cells/mm³, p = 0.006), prolonged ART exposure (p = 0.002), and the use of tenofovir disoproxil fumarate or protease inhibitor-containing regimens (p = 0.034 and p = 0.016, respectively). Conclusions: These findings indicate that monitoring vitamin D levels could be particularly relevant for patients with HIV with higher-risk profiles. However, our study included a relatively small number of participants, so further research in larger cohorts is needed to better understand these patterns. Full article

Asthma is a chronic inflammatory disorder of the airways affecting over 260 million people worldwide and remains a major clinical and socioeconomic challenge. Despite substantial advances in pharmacological management (including inhaled corticosteroids, β₂-agonists, leukotriene receptor antagonists, and biologic therapies), many patients continue to experience uncontrolled symptoms or corticosteroid resistance. This persistent unmet need has prompted interest in adjunctive and alternative treatment strategies. Oxygen therapy during asthma exacerbations and worsening pulmonary obstruction is a standard life-saving procedure. However, various forms of oxygen therapy are being considered for long-term treatment to reduce the number of exacerbations. Experimental and preliminary clinical data indicate that oxygen therapy may offer multiple benefits, including improved oxygenation, anti-inflammatory effects, reduced oxidative stress, modulation of nitric oxide signaling, enhanced immune responses, and promotion of angiogenesis. These mechanisms may collectively alleviate airway inflammation and improve pulmonary function. Nevertheless, clinical evidence on hyperbaric oxygen therapy (HBOT) in asthma remains limited. Existing small-scale studies suggest its safety but provide inconclusive results regarding its efficacy. Potential adverse effects such as barotrauma, oxygen toxicity, and transient anxiety necessitate careful patient selection and standardized treatment protocols. Further large-scale, randomized controlled trials are required to determine the therapeutic value of HBOT and to define its role as an adjunctive therapy in the comprehensive management of asthma. Full article

This paper presents an advanced signal processing framework for multi-channel forward-scatter radar (MC-FSR) systems based on the Multiple Signal Classification (MUSIC) algorithm. The proposed framework addresses the inherent limitations of FFT-based space-domain processing, such as limited angular resolution and the poor detectability of weak or closely spaced targets, which become particularly severe in low-cost FSR systems, which are typically operated with small antenna arrays. The MUSIC algorithm is adapted to operate on real-valued data obtained from the non-coherent, amplitude-based MC-FSR approach by reformulating the steering vectors and adjusting the degrees of freedom (DoFs). While compatible with arbitrary transmitting waveforms, particular emphasis is placed on Orthogonal Frequency Division Multiplexing (OFDM) signals, which are widely used in modern communication systems such as Wi-Fi and cellular networks. An analysis of the OFDM waveform’s autocorrelation properties is provided to assess their impact on target detection, including strategies to mitigate rapid target signature decay using a sub-band approach and to manage signal correlation through spatial smoothing. Simulation results, including multi-target scenarios under constrained array configurations, demonstrate that the proposed MUSIC-based approach significantly enhances angular resolution and enables reliable discrimination of closely spaced targets even with a limited number of receiving channels. Experimental validation using an S-band MC-FSR prototype implemented with software-defined radios (SDRs) and commercial Wi-Fi antennas, involving cooperative targets like people and drones, further confirms the effectiveness and practicality of the proposed method for real-world applications. Overall, the proposed MUSIC-based MC-FSR framework exhibits strong potential for implementation in low-cost, hardware-constrained environments and is particularly suited for emerging Integrated Sensing and Communication (ISAC) systems. Full article

Background/Objectives: This study presents and explores the potential of Updated Bayesian Deduction (UBD) using colorectal cancer (CRC) detection and prioritisation as a case example. Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, and its prognosis strongly depends on early detection and timely treatment. In Chile, colonoscopy waiting lists for symptomatic patients in public hospitals can exceed one year, limiting access to early diagnosis and reducing survival rates. Traditional single-test screening strategies, such as a single faecal immunochemical test (FIT), often yield uncertain results, contributing to inefficiencies in resource allocation. Methods: We propose a deductive approach that integrates evidence from multiple sequential and independent FITs to dynamically update the posterior probability of CRC. A case study is analysed with this Updated Bayesian Deduction over a four-round FIT protocol to assess how this could improve risk stratification compared to standard symptoms-based screening. Results: Our mathematical model shows that over 85% of colonoscopies for symptomatic patients were not urgent. We then demonstrate that, if 4-FIT UBD were used to screen Chile’s Metropolitan Region population, only 96 out of 100,000 people would require an urgent colonoscopy to detect the 19.6 out of 100,000 individuals with CRC in this region. Many countries cannot afford a colonoscopy-based population screening, such as what is performed in Germany. Performing 4x FITs + a very small number of colonoscopies would be much more affordable and would get more countries to adopt general CRC screening. Conclusions: In countries with limited colonoscopy availability, such as Chile, where symptomatic patients can wait over a year for treatment in public hospitals, implementing a UBD-based strategy could drastically reduce costs and optimise the use of resources. This would improve access to colonoscopies for critical cases and ultimately enhance five-year survival rates. These findings highlight UBD as a promising approach for evidence-based precision medicine in CRC screening and prioritisation that is both explainable and adaptable. Full article

Background/Objectives: People with Alzheimer’s dementia (AD) experience distressing changes in social behaviour. However, little is understood about whether social behaviour is associated with support provided by, or familiarity with, conversation partners. We aimed to explore the association between support provided by, and familiarity with, conversation partners and the social behaviour of people with mild AD during conversation. Method: We designed an exploratory within-subjects study wherein conversations between 19 participants with mild AD and a familiar informant, followed by an unfamiliar researcher, were video-recorded and double-rated using two measures of social behaviour (Social Observation Inventory and Measure of Participation in Conversation—Dementia), and one measure of support from the conversation partner (Measure of Support in Conversation—Dementia). Multilevel linear regression with within-subject clusters was used to explore adjusted associations between support and familiarity and social behaviour. Results: Greater support in conversation was associated with more appropriate participation in social conversation of participants with AD. In fully adjusted models, every 1-point increase in MSC-D score was associated with a 0.29 (95% CI: 0.14 to 0.44) increase in MPC-D score and a 1.59 (95% CI: 0.87 to 2.32) increase in SOI score. Familiarity with the conversation partner was not associated with the social behaviour of the participants with AD. Conclusions: We found evidence for an association between social behaviour in AD and support provided by unimpaired conversation partners, but the numbers were small, and this should be interpreted cautiously. Future research should continue this hypothetical lead to expand our understanding of how support and familiarity influence social behaviour to inform potential interventions. Full article

Surfactants are chemical compounds present in a large number of products that people use on a daily basis, starting with detergents for washing clothes, dishes, personal hygiene products, etc. Some products also contain certain heavy metals. Their uses cause heavy contamination of wastewater that must be purified before discharge into receivers. Given that some types of surfactants are very persistent and heavy metals are non-biodegradable and toxic even in small concentrations, the purification process requires a complex approach and a combination of different methods. Bioremediation, as an environmentally acceptable and economically clean technology, has great potential. It is based on the use of indigenous microorganisms that have developed different mechanisms for breaking down and removing or detoxifying a large number of pollutants and are excellent candidates for bioremediation of wastewater. Bacteria can degrade surfactants as sole carbon sources and exhibit tolerance to various heavy metals. This paper summarizes the most significant results, highlighting the potential of bacteria for the biodegradation of surfactants and heavy metals, with the aim of drawing attention to their insufficient practical application in wastewater treatment. Bioreactors and microbial fuel cells are described as currently relevant strategies for bioremediation. Full article

To ensure the transition to electric transport in order to reduce CO₂ emissions, a number of projects have been initiated to develop and introduce new types of locally produced vehicles. The Russian Federation market is quite conservative and has its own specifics and a special consumer model. In addition, the component base of localized components for electric vehicles is relatively small, which is justified by relatively low demand and market volumes. To create the concept of a Class C passenger vehicle with electric traction, marketing research was conducted in a group of people who are potentially ready to abandon traditional vehicles and choose electric vehicles or hybrids. The purpose of the study is to evaluate the opinion of consumers and to form the technical characteristics of a Class C hybrid car based on localized components. Methods: To obtain the results, various components of the power unit were modeled, and a balanced solution was found that meets the requirements of consumers in the region. Mathematical modeling was carried out and analytical studies of the power reserve of various configurations of power units within the WLTC cycle were carried out in the digital environment of Siemens Amesim. Analytical work on the study of the composition of cars for calculating the masses of modern components and aggregates was carried out using Autodatas. Consumer opinions were assessed through a survey using the Yandex. Forms service. The relevance of the study is confirmed by the lack of domestic models of sequential hybrids on the market and the lack of similar studies, based on the opinion of a potential consumer. The result is the technical parameters of the main components and assemblies, which should ensure the optimal cost of the final product and meet the requirements of the consumer. Conclusion: As a result of the study, a concept of a combined sequential-type power unit was developed based on available components, meeting the main consumer properties, and the technical characteristics of the components were presented. Full article

We describe the problem of estimating the speaker’s head orientation from the asynchronous multi-channel waveforms observed by microphones distributed in a room. In particular, we address a novel problem of estimating head orientation from sound captured by fewer microphones than the number of distinct head orientations to be distinguished. This is because the head orientation is an important clue indicating the speaker’s intended conversational partners. Head orientation estimation technology is an essential technology within environmental intelligence technology, which uses sensors embedded in rooms to monitor and support people’s activities. We propose a head orientation estimation method that aims to achieve high angular resolution using a small number of microphones. The proposed method achieves high estimation accuracy by using the spatial radiation pattern of the sound source as clues and by integrating information from multiple frequency bands. We conducted an experiment to estimate head orientation with an angular resolution of $15\mathrm{degrees}$ under observation conditions using six microphones. Experimental results showed that higher estimation accuracy was obtained than the conventional method using distributed microphone arrays (Oriented Global Coherence Field method) and the conventional method using distributed microphones (Radiation Pattern Matching method). The proposed method utilizing multiple frequency bands achieved the best performance with a mean absolute error of $10.58\mathrm{degrees}$ in the task of classifying 24 distinct head orientations. Full article

This paper analyzes the potential of hydrogen technologies in transport, placing it within the context of global environmental and energy challenges. Its primary purpose is to evaluate the prospects for the implementation of these technologies at international and national levels, including Poland. This study utilizes a literature review and an analysis of the results of a highly limited, exploratory pilot survey measuring public perception of hydrogen technology in transport. It is critical to note that the survey was conducted on a small, non-representative sample and exhibited a strong geographical bias, primarily collecting responses from Europe (50 people) and North America (30 people). This study also details hydrogen vehicle types (FCEV, HICE) and the essential infrastructure required (HRS). Despite solid technological foundations, the development of hydrogen technology heavily relies on non-technical factors, such as infrastructure development, support policy, and social acceptance. Globally, the number of vehicles and stations is growing but remains limited, with the pace of development correlating with the involvement of countries. The pilot survey revealed a generally positive perception of the technology (mainly due to environmental benefits) but highlighted three key barriers: limited availability of refueling infrastructure—51.5% of respondents strongly agreed on this obstacle, high purchase and maintenance costs, and insufficient public awareness. Infrastructure subsidies and tax breaks were identified as effective incentives. Hydrogen technology offers a potentially competitive and sustainable transport solution, but it demands significant systemic support, intensive investment in large-scale infrastructure expansion, and comprehensive educational activities. Further governmental engagement is crucial. The severe limitations resulting from the pilot nature of the survey should be rigorously taken into account during interpretation. Full article

Background and Objectives: Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease, and its incidence increases with age, being particularly high in people over 70 years of age. For patients with this condition, medical rehabilitation can have a profound impact, helping to improve mobility, preserve functional autonomy, and enhance quality of life. Focal vibration stimulation is a promising, well-tolerated, and easy-to-apply method with potential to facilitate motor activity and support the motor learning process, making it also useful in gait reeducation for patients with various neurological conditions. This systematic review aims to analyze the existing scientific evidence on the effectiveness of focal muscle vibration therapy in managing symptoms of Parkinson’s disease. Materials and Methods: This systematic review of the literature was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the protocol was registered in PROSPERO under the protocol registration number CRD420251120737. Searches were conducted in five databases (PubMed, PEDro, ScienceDirect, Cochrane Library, Web of Science). The selection criteria targeted original clinical studies, published in English between 2010 and the present, that investigated focal muscle vibration therapy in patients with Parkinson’s disease and were fully available, excluding review papers, meta-analyses, books, and articles inaccessible in full text. Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) was used to assess the quality of the included studies. Results: The results of the studies were interpreted individually for each study, and the main information was synthesized in a comparative table to facilitate analysis. The final analysis included five studies that investigated the effects of focal muscle vibration in patients with Parkinson’s disease. The results suggest that this form of stimulation may offer benefits for patients with gait disorders, improving balance and stability. Among the study’s limitations are the small number of included articles (n = 5) and the restriction to English-language publications, which may limit the applicability of the results. Conclusions: Given the promising results, focal muscle vibration therapy could represent a useful option in the management of Parkinson’s disease. Integrating this method into rehabilitation plans could bring significant functional benefits, but further studies are needed to confirm its long-term effectiveness and to establish standardized application protocols. No external funding was received for the conduct of this review. Full article

Climate change is increasing the frequency of extreme weather events, posing critical challenges for the resilience of specialized transportation services (STSs) that provide essential mobility for people with disabilities. In the South Korean context, heatwaves, cold spells, and heavy rainfall are particularly relevant because they directly affect health risks, trip demand, and operational reliability, making them central stressors for evaluating STS resilience in Busan. This study examines STS resilience in Busan, South Korea, focusing on three weather stressors: heatwaves, cold spells, and heavy rainfall. Large-scale operational data from the STSs of Busan were analyzed using the 4R (robustness, rapidity, redundancy, and resourcefulness) framework to classify daily service performance into distinct profiles. The analysis revealed that heatwaves coincided with reduced trip demand and shorter waiting times, yet this apparent stability reflected demand suppression rather than genuine robustness. Heavy rainfall produced the most severe disruptions, with longer and more variable waiting times that exacerbated inequities across users. Cold spells were associated with rapid recovery and the preservation of critical trips, although the small number of cases limits broader interpretation. These findings indicate that resilience in STSs is not uniform but event-specific, offering policy insights for strengthening operational stability and promoting equity in accessible transport. Full article

This review provides an overview of existing accident prevention methods by monitoring the persons’ physiological state, observing movements, and physiological parameters. Firstly, different physiological parameters monitoring systems are introduced. Secondly, various systems dealing with position recognition on pressure sensing mats are presented. We conduct an in-depth literature search and quantitative analysis of papers published in this area and focus independently of the application (drivers, office and wheelchair users, etc.). Quantitative information about the number of subjects, investigated scenarios, sensor types, machine learning usage, and laboratory vs. real-world works is extracted. In posture recognition, most works recognize at least forward, backward, left and right movements on a seat. The remaining works use the pressure sensing mat for bedridden people. In physiological parameters measurement, most works detect the heart rate and often also add respiration rate recognition. Machine learning algorithms are used in most cases and are taking on an ever-greater importance for classification and regression problems. Although all solutions use different techniques, returning satisfactory results, none of them try to detect small movements, which can pose challenges in determining the optimal sensor topology and sampling frequency required to detect fine movements. For physiological measurements, there are lots of challenges to overcome in noisy environments, notably the detection of heart rate, blood pressure, and respiratory rate at very low signal-to-noise levels. Full article

Ensete ventricosum is a morphologically gigantic, monocot, diploid sister to the banana plant species. It is commercially cultivated as a starch source, only in Ethiopia, where it feeds twenty million people. Here, the complete chloroplast (CP) genomes of 15 diverse landraces of E. ventricosum were assembled and annotated, for comparative genomics, genetic diversity analysis, and molecular marker development. The assembled E. ventricosum CP genomes ranged between 168,388 and 168,806 bp. The sampled CP genomes were quadripartite in structure and had two single-copy regions, a large single-copy region (LSC, average length 88,657 bp), and a small single-copy region (SSC, average length 11,098 bp) separated by inverted repeat regions (IR, average length 34,437 bp). The total number of annotated genes varies between 135 and 138, including 89–92 protein-coding genes, 38 tRNA genes, and 4 rRNA genes. All CP genes, including non-functional ones and intergenic regions, were transcribed with the transcriptome, covering almost 92% of the E. ventricosum CP genome. Codon usage, amino acid frequency, GC contents, and repeat nucleotides were similar among the 15 landraces. Mono- and tetranucleotide simple sequence repeats (SSRs) were found more frequently than other SSRs. An average of 71% of these SSRs were located in the LSC region, and the majority of the SSR motifs were composed of A/T nucleotides. A phylogenetic analysis of the 15 Ensete landraces indicated a common evolutionary origin, while the China sample was positioned separately, suggesting notable genetic differences. This study presents a comparative analysis of the chloroplast genomes of 15 E. ventricosum landraces, providing valuable insights into their genetic diversity and evolution. The identified SSR markers and conserved genomic features offer essential resources for future research and an improvement in Ensete conservation and breeding. Full article

Background/Objective: Video games offer an innovative tool for delivering active aging interventions. The objective of this study was to analyze the efficacy of an enhanced version of a cognitive–behavioral intervention to promote active aging, administered through a video game, on perceived health and healthy lifestyle habits. Methods: A total of 556 participants aged 45 or older (74.3% women, mean age of 60.8 [SD = 8.0]) were randomly assigned to a cognitive–behavioral intervention to promote active aging administered via an interactive, multimedia, online, and serious video game with a complementary smartphone app (CBI-V; n = 279) or to a control group receiving non-specific online information (CG; n = 277). Perceived health (General Health, Body Pain, Physical Functioning, Physical Role, Vitality, Social Functioning, Emotional Role, Mental Health, Physical and Mental Summary Indices); healthy habits, including sleep hygiene behaviors, physical activity, and eating habits; dropouts; adherence to the intervention (completed modules; total playtime; time devoted to cognitive training; number of cognitive task attempts and tasks completed between modules); and satisfaction with the intervention were assessed by independent, blind evaluators via an online platform before and after the intervention. Results: At the post-intervention, the CBI-V group obtained significantly better scores in General Health (p < 0.001), Mental Health (p = 0.015), sleep hygiene (p < 0.001), physical activity (p = 0.024), and eating habits (p = 0.001) than the CG. The effect sizes were small (d = −0.188 to 0.334). Clinically significant changes were higher in the CBI-V group than in the CG in General Health (p = 0.029), Physical Function (p = 0.028), Social Function (p = 0.011), Emotional Role (p = 0.008), Mental Health (p = 0.026), Physical Summary Index (p = 0.010), sleep hygiene (p = 0.020), and eating habits (p = 0.019). Participants reported a high level of satisfaction with the intervention, with a mean score of 25.4 (SD = 4.0) out of a maximum of 32 on the intervention satisfaction measure. Conclusions: These findings support the efficacy of a cognitive–behavioral video game intervention in enhancing perceived health and promoting healthy lifestyle habits among people aged 45 and above. Full article

Internationally, introduced invasive species inflict incalculable damage on native species and primary production. In New Zealand, wallabies, which were introduced from Australia, are damaging the native and agricultural environments, and their range is spreading. As a first step towards the long-term goal of eradicating wallabies from New Zealand, the Tipu Mātoro National Wallaby Eradication Programme has the immediate goal of restricting wallabies to containment areas designated in regional pest management plans and to eliminate outlier populations by 2025. The success of this strategy is put at risk if people catch wallabies and release them outside the containment areas. We sought to characterise the motivations, beliefs, and attitudes of members of the public who might engage in this illegal behaviour by surveying members of the New Zealand public. We discovered that a very small proportion of the public supported the illegal catch-and-release of wallabies. Respondents, including hunters, that supported catch-and-release believed that wallabies create economic benefits and do not severely damage the environment. They also believed that hunting helps control wallaby numbers. These results yielded a variety of specific policy implications required to reduce catch-and-release behaviour. Full article