Search Results (1,088)

Background: Nuclear cataracts cause visual degradation through light scattering by aggregated proteins and particles within the crystalline lens. Existing computational models mainly consider submicron scatterers, while the optical impact of micrometer-scale particles observed in human nuclear cataracts remains underexplored. Objective: This study extends a LOCS III–based computational cataract model by incorporating micrometer-scale particles and quantitatively evaluates their effects on forward and backward light scattering across nuclear cataract grades. Methods: A physics-based scattering model was implemented using optical simulation software (LightTools). Three particle populations—nanometer-scale (S-type), submicron-scale (M-type), and micrometer-scale (L-type)—were uniformly distributed within the lens. Retinal luminance reduction was analyzed for forward scattering, while slit-lamp-based backward scattering simulations were used to evaluate luminance distributions and chromaticity changes. Particle concentrations were varied within clinically reported ranges corresponding to LOCS III grades. Results: Micrometer-scale particles had minimal impact in early nuclear cataract grades but significantly increased forward scattering and luminance loss in advanced grades (NO5–NO6). Backward scattering simulations revealed pronounced luminance enhancement and yellow chromaticity shifts with increasing micrometer-scale particle concentration. One micrometer-scale particle produced a luminance-reduction effect equivalent to approximately 6–7 submicron particles, depending on cataract severity. Conclusions: Including micrometer-scale particles enables a more complete optical representation of nuclear cataracts, linking retinal image degradation with slit-lamp appearance. The model provides a physically grounded framework for offline analysis and reference data generation to support clinical interpretation of cataract grading. Full article

Background and Objectives: Tear film instability and corneal surface irregularity are important sources of variability in keratometric and corneal topographic measurements, particularly affecting astigmatic magnitude and axis. Accurate preoperative biometry is crucial for optimal refractive outcomes in cataract surgery. Dry eye disease (DED) may compromise the reproducibility of keratometric parameters, leading to errors in intraocular lens (IOL) power calculation. This study aimed to evaluate the impact of DED on the reproducibility of keratometric measurements and to assess the effect of a four-week treatment with lipid-containing artificial tears on these parameters in cataract patients. Materials and Methods: This cross-sectional study included 116 patients scheduled for cataract surgery, of whom 65 (56.0%) had DED and 51 (44.0%) served as controls. All patients underwent two preoperative keratometric measurements 10–20 min apart (IOL1 and IOL2). The control group proceeded to surgery the next day, while surgery in the DED group was postponed. Patients with DED received preoperative therapy with lipid-containing artificial tears. Follow-up assessments occurred one month after therapy (keratometric measurement named IOL3) and eight weeks postoperatively. Clinical evaluation included slit-lamp examination, dry eye testing according to Dry eye Workshop II (DEWS II) criteria: Ocular surface Disease Index (OSDI), Tear Break-Up Time (TBUT), Schirmer I, Oxford staining, and meibomian gland assessment), ocular biometry, and postoperative spherical equivalent measurement using an auto ref-keratometer. Nonparametric statistical analyses were applied to evaluate associations between parameters. Results: In the DED group, corneal astigmatism showed a significant difference between IOL1 and IOL2 (Wilcoxon signed-rank test {Z = 2.43; p = 0.015}). Significant changes in predicted IOL power were observed between pretreatment and posttreatment values (t = 2.57; p = 0.013) and between IOL2 and IOL3 (t = 2.23; p = 0.029), indicating improved keratometric stability following tear film therapy. No additional significant correlations were identified. Conclusions: DED adversely affects the reproducibility of keratometric measurements and may compromise IOL power selection. Preoperative identification and treatment of DED, followed by repeated biometry after tear film stabilization, are strongly recommended to enhance refractive accuracy and optimize surgical outcomes in cataract patients. Full article

This study characterizes the chemical defense system of the invasive longhorn beetle Aromia bungii, a destructive pest of Prunus trees, addressing the limited understanding of chemical defensive mechanisms in Cerambycidae. High-speed cameras, environmental scanning electron microscopy (ESEM), dissection, and micro-CT imaging were used to investigate defensive behavior, and the structure of the defense system, in this beetle. Both sexes of A. bungii possess a pair of triangular, sac-like defensive glands symmetrically located in the metathorax, attached to the metasternum. Upon mechanical stimulation, white liquid defensive substances are rapidly ejected through a pair of slit-shaped openings (~200 µm) at the metasternum corners, without gland eversion, reaching over 50 cm. The average weight of substances ejected in first sprays was 7.95 ± 0.79 mg for females and 8.62 ± 2.13 mg for males (mean ± se), with no significant difference between sexes. However, the weight in second sprays after 10 days was significantly lower, at 2.93 ± 0.54 mg for females and 2.22 ± 0.40 mg for males (mean ± se), suggesting that the beetles cannot re-synthesize the substances soon after spray. The weight of ejected substances had no correlation with beetle body weight. Our findings represent the first detailed morphological and functional description of a chemical defense system in Cerambycidae, revealing a specialized metasternal gland and spray mechanism. The substantial but likely non-renewable defensive substances reflect an adaptive trade-off in energy allocation between reproduction and defense in this species that exhibits high fecundity but a short lifespan at the adult stage. Full article

On-orbit cutting is a critical process for the on-orbit manufacturing of carbon fiber reinforced polyetheretherketone composites (CF/PEEK) truss structures, with pulsed laser cutting serving as one of the feasible methods. Achieving high-quality cutting of CF/PEEK remains a major challenge for on-orbit manufacturing. Therefore, the cutting process of CF/PEEK prepreg tape was studied by an ultraviolet (UV) nanosecond laser. A three-factor, five-level orthogonal experiment was carried out to analyze the influence of laser repetition rate (LRR), laser cutting speed (LCS), and laser scanning times (LCTs) on cutting quality. The ablation mechanism dominated by the photothermal effect between the UV nanosecond laser and CF/PEEK was analyzed, and the by-products in the cutting process were explored. Finally, the optimal cutting quality (the width of slit (W_s) = 41.69 ± 3.54 μm, the heat-affected zone (HAZ) = 87.27 ± 7.30 μm) was obtained under the process conditions of LRR 50 kHz-LCS 50 mm/s-LCT 16 times. The findings show that the W_S and HAZ increase with the increase in LRR and LCT and the decrease in LCS, and the carbon fiber decomposes and escapes due to the photothermal effect. Full article

Ensuring friction stir welding (FSW) joint quality typically relies on ultrasonic testing (UT) and radiographic testing (RT), but achieving complete coverage is challenging, and echo-based defect discrimination becomes difficult in dissimilar joints. Laser ultrasonics is a promising non-contact technique that remotely assesses weld quality and provides high spatial resolution at the generation and detection points. This study establishes a laser-ultrasonic method for defect detection in dissimilar Cu–Al FSW joints. Slit-like artificial defects (0.1–2.5 mm deep in 5 mm thick plates) were introduced at the Al-side interface of specimens fabricated with an Al-offset tool. Experiments and numerical simulations were used to evaluate wave modes and irradiation configurations, focusing on intensity-attenuation ratios of specific wave types, including longitudinal and Rayleigh waves. On the non-slit surface, attenuation of reflected longitudinal waves enabled detection of defects ≥0.5 mm deep. On the slit surface, Rayleigh-wave attenuation allowed identification of defects as shallow as 0.1 mm, although slit-side irradiation may be less practical during joining. These results demonstrate that defect identification in dissimilar materials can be achieved by evaluating wave-intensity attenuation rather than relying solely on the presence of reflected echoes, suggesting potential for implementing laser ultrasonics in in-process monitoring of FSW joints. Full article

Background: Descemet membrane endothelial keratoplasty (DMEK) is the most frequently performed keratoplasty procedure in many countries. One of the most common early complications is an elevation of intraocular pressure (IOP). The aim of this study was to characterize early postoperative IOP behavior following DMEK performed with 10% sulfur hexafluoride (SF₆) tamponade and to determine the frequency and timing of required IOP-lowering interventions within the first 48 h. Methods: We retrospectively reviewed postoperative outcomes of 116 consecutive DMEK procedures between May and December 2024 at the University Medical Center in Mainz, Germany. No specific exclusion criteria were applied. All surgeries included a surgical iridectomy at the 6 o’clock position, 10% (SF₆) tamponade, and maintaining a mid-normal IOP at the end of surgery. Postoperative assessments included IOP measured using Goldmann applanation tonometry, the percentage of gas fill in the anterior chamber evaluated at the slit lamp, and the need for IOP-lowering interventions as determined by the on-call resident at 3, 24, and 48 h after surgery. IOP-lowering interventions consisted of venting in cases of elevated IOP, gas fill > 90%, and/or suspected angle closure or pupillary block, as well as intravenous or oral acetazolamide in cases of moderate IOP elevation with a lower gas fill and a patent iridectomy. If a single intervention was insufficient, a combined approach was used. Results: A total of 116 eyes from 98 patients (62 female, mean age 73.0 ± 9.8 years) were analyzed. DMEK was combined with cataract surgery in 41 eyes, and 4 eyes underwent phakic DMEK. Postoperatively, all iridectomies remained patent, and no cases of pupillary block occurred. Mean IOP and gas fill were within normal limits and declined steadily during the first 48 h. IOP-lowering procedures were performed in 11 eyes (9.5%), including venting (n = 3), acetazolamide administration (n = 7), and a combination of both (n = 1). There was no difference between DMEK and triple-DMEK regarding postoperative gas fill, IOP, or the need for IOP-lowering interventions. Mean postoperative IOP was significantly higher, and IOP-lowering interventions were more frequent in glaucoma vs. non-glaucoma patients. Re-bubbling was performed in 12 eyes (10.3%). Two cases of primary graft failure (1.7%) were recorded. Conclusions: In our patient cohort, a standardized surgical approach incorporating a surgical iridectomy at the 6 o’clock position, 10% SF₆ tamponade, and maintaining a mid-normal IOP at the end of surgery effectively prevented pupillary block. We recommend early postoperative assessment of IOP and percent gas fill to promptly identify and manage impending IOP elevation, which is particularly important in patients with glaucoma. Full article

The stimulated assembly/disassembly of particles is a technique allowing for precise spatial and temporal control over the resulting structures to be realized. The application of a photosensitive liquid crystal (LC) allows the use of a photo-initiated order–disorder transition for the ordering and redistribution of dispersed nanoparticles. The semiconductor quantum dots (QDs) among them are useful for the imaging of such redistribution through simple luminescent microscopy with excitation by laser radiation at a wavelength of 532 nm. Doping the LC matrix with azo-chromophore molecules allowed us to localize the light-driven phase transition of the LC from the organized to the isotropic phase inside the spot, illuminated by ultraviolet (UV) light through a slit. The phase transition leads to a redistribution of the QDs within the matrix, followed by QD-rich region formation. After the termination of UV illumination, the QDs were found to form droplets in the region where UV illumination resulted in a homogeneous distribution of the QDs. The translation of the sample through the UV-illuminated spot resulted in QD accumulation inside the isotropic phase at the borders of the isotropic phase. The results obtained provide a good agreement with the model calculations of nanoparticle diffusion at the LC phase–isotropic liquid interface. Full article

Shale pores and throats are key factors controlling the enrichment and development efficiency of shale oil and gas. However, the characteristics and formation mechanisms of shale pores and throats remain unclear. Taking the Permian continental shales in the Mahu Sag of the Junggar Basin as an example, this paper studies the formation mechanisms of pores and throats in shales of different lithofacies through a series of experiments, such as high-pressure mercury injection and scanning electron microscopy. The results show that the Permian continental shales in the Junggar Basin are mainly composed of five lithofacies: rich siliceous shale (RSS), calcareous–siliceous shale (CSS), argillaceous–siliceous shale (ASS), siliceous–calcareous shale (SCS), and mixed-composition shale (MCS). The pores in shale are dominated by intergranular and intragranular pores. The intergranular pores are mainly primary pores and secondary dissolution pores. The primary pores are mainly slit-like and polygonal, with diameters between 40 and 1000 nm. The secondary dissolution pores formed by dissolution are irregular with serrated edges, and their diameters range from 0.1 to 10 μm. The throats are mainly pore-constriction throats and knot-like throats, with few vessel-like throats, overall exhibiting characteristics of nanometer-scale width. The mineral composition has a significant influence on the development of pores and throats. Siliceous minerals promote the development of macropores, and carbonate minerals promote the development of mesopores. Clay minerals inhibit pore development. Diagenesis regulates the development of pores and throats through mechanical compaction, cementation, and dissolution. Compaction leads to a reduction in porosity, and cementation has varying effects on the preservation of pores and throats. Dissolution is the main factor for increased pores and throats. These findings provide a lithofacies-based geological framework for evaluating effective porosity, seepage capacity, and shale oil development potential in continental shale reservoirs. Full article

Assurance of the integrity of every weld joint is highly desirable, and defect detection methods that can be applied to welds at high temperatures immediately after welding are required. The laser ultrasonic (LU) method, which generates ultrasonic waves in the target via pulsed laser irradiation, is a well-known technique for non-contact defect detection during welding. Ultrasonic waves excited in ablation mode exhibit large amplitudes and predominantly surface-normal propagation, which has driven extensive research into their application for weld inspection. However, owing to the size and weight of conventional equipment, such systems have largely been limited to bench-top experimental setups. To address this, we developed an LU robotic system incorporating a compact, lightweight laser source and an improved signal-processing system. We conducted experiments to measure signals and to detect backside slits in flat plates and blowholes in lap-fillet welds. Additionally, a method to improve the sensitivity of laser interferometers was investigated and demonstrated on smut-covered areas near weld beads. Full article

In shale oil accumulation, the sealing capacity of roof strata is a key factor controlling hydrocarbon retention, primarily governed by pore–throat structures. This study examines the Chang 7₃ sub-member roof in the Ordos Basin using core and drilling samples, combined with SEM, mercury intrusion porosimetry, nitrogen adsorption, and breakthrough pressure tests. The roof rocks are dense and mainly composed of mudstone, silty mudstone, and argillaceous siltstone, which can be further classified into clay-rich and felsic-rich types. The pore system includes organic matter pores, dissolution pores, intergranular pores, clay interlayer pores, intercrystalline pores, and microfractures. Pores are dominated by mesopores (4–10 nm), with few macropores, and display slit-like, plate-, and wedge-shaped morphologies. Breakthrough pressure averages above 20 MPa, reflecting strong sealing capacity. Although dissolution of felsic minerals generates secondary porosity that may weaken sealing, the overall complex pore–throat system, reinforced by compaction and cementation of clay minerals, forms a dense fabric and favorable sealing conditions. These features restrict hydrocarbon migration and enhance the sealing performance of the Chang 7₃ shale oil roof. Full article

During drill-and-blast construction, complex and variable rock masses are frequently encountered. Owing to the transient nature of the explosion process and the randomness of crack propagation, the response of different rock masses to explosive loading is highly intricate. This study primarily investigates the dynamic response of rock masses with varying strengths under two different charge configurations. First, four cement mortar specimens of differing strengths were prepared then subjected to general blasting and slit charge blasting, respectively. High-speed cameras and digital image correlation techniques were employed to capture and analyse stress wave propagation and crack propagation during detonation. Fractal dimension analysis was subsequently employed to quantify and compare the extent of damage in the specimens. Findings indicate that rock strength influences stress wave attenuation patterns: lower-strength rocks exhibit higher peak strains but faster decay rates. Crack propagation velocity was calculated by deploying monitoring points along fracture paths and defining fracture initiation thresholds. Higher rock strength correlates with both peak and average crack propagation velocities. Slit charge blasting effectively optimizes damage distribution, concentrating it within the intended directions while reducing chaotic fracturing. These findings provide scientific justification for blasting operations in complex rock formations. Full article

Conjunctival inflammation assessment is fundamental for diagnosing and monitoring various ocular surface diseases. This review summarizes grading scales available for conjunctival inflammation, discussing both subjective and objective methodologies. Widely used clinical grading systems include slit-lamp findings classification scale, Mandell scale for conjunctival injection, McMonnies and Champman-Davies scale, CCLRU (Cornea and Contact Lens Research Unit) scale, Efron scale, and VBR (validated bulbar redness) scale. They provide standardized frameworks for assessing conjunctival hyperemia and inflammation severity. However, these subjective methods are limited by inter-observer variability and lack of precision in detecting subtle changes. Recent technological advances have introduced objective digital imaging systems and automated algorithms that may offer improved reproducibility and sensitivity. Novel approaches include the integration of artificial intelligence for automated assessment. The validation of these scales across diverse patient populations has demonstrated varying degrees of reliability and clinical utility. Current evidence suggests that while traditional subjective scales remain clinically relevant, objective measurement systems provide superior repeatability and may better serve research applications requiring precise quantification of inflammatory changes. This review summarizes current knowledge regarding conjunctival inflammation grading methodologies and provides insights into novel developments in the field. Full article

We develop a shared denominator Carathéodory–Fejér (CF) method for efficiently evaluating linear combinations of $\phi$-functions for matrices whose spectrum lies in the negative real axis, as required in exponential integrators for large stiff ODE systems. This entire family is approximated with a single set of poles (a common denominator). The shared pole set is obtained by assembling a stacked Hankel matrix from Chebyshev boundary data for all target functions and computing a single SVD; the zeros of the associated singular-vector polynomial, mapped via the standard CF slit transform, yield the poles. With the poles fixed, per-function residues and constants are recovered by a robust least squares fit on a suitable grid of the negative real axis. For any linear combination of resolvent operators applied to right-hand sides, the evaluation reduces to one shifted linear solve per pole with a single combined right-hand side, so the dominant cost matches that of computing a single $\phi$-function action. Numerical experiments indicate geometric convergence at a rate consistent withHalphen’s constant, and for highly stiff problems our algorithm outperforms existing Taylor and Krylov polynomial-based algorithms. Full article

This article presents the design of a dual-mode resonant, dual-band textile microstrip patch antenna for bent sensing applications. The antenna has a simple, slit-perturbed circular sector patch configuration. Unlike traditional single-mode resonant bending sensor antennas, dual-mode resonance brings a unique dual-band sensing characteristic to textile antennas. It effectively covers 2.45 GHz and 5.8 GHz Industrial, Scientific and Medical (ISM) frequency bands. Experimental results demonstrate that the proposed antenna achieves −10 dB impedance bandwidths of 1.4% (2.43–2.465 GHz) and 2.4% (5.775–5.915 GHz), with maximum peak gains of 8.8 dBi and 9.1 dBi, respectively. As experimentally validated on flannel substrates, the antenna achieves maximum bent sensing sensitivities of 1.1 MHz/mm and 1.78 MHz/mm at 2.45 GHz and 5.8 GHz bands, respectively. Furthermore, the antenna is able to provide stable E-plane broadside radiation patterns in bending situations. It would be an ideal candidate for radio frequency identification (RFID), health monitoring systems, and flexible communication applications. Full article

We present a numerical implementation of the proposed Source–Detector Resonance (SDR) as a conceptual analog of a Double-Slit Interference Experiment with discrete particles. Two periodic streams of particles are emitted from two point sources at random integer multiples of a fundamental period P and corresponding frequency $\omega =2\pi /P$ and fly out towards a detection screen. The screen consists of a deep set of identical oscillators with eigenfrequency ${\omega }_0=2\pi /P_0$. In the SDR scenario, $\omega \approx {\omega }_0$. When the particles reach the screen, they implement a periodic forcing of its oscillators at the stream’s fundamental frequency ${\omega }_0$. As a result, an oscillating pattern develops along the screen. The amplitude of oscillation of each oscillator saturates at a value that is determined by the balance between the periodic particle forcing and the damping of each oscillator. This is clearly proportional to the number of particles that reach a certain oscillator per unit time times the fraction of particles that reach it at its resonant frequency. The latter fraction is equal to the ratio of the Power Spectral Density (PSD) of the time series of the particles that reach the oscillator at its resonance frequency PSD(${\omega }_0$) over the PSD at zero frequency PSD(0). If we further assume that each oscillator absorbs a particle and announces a detection with a probability that is proportional to the square of the ratio PSD(${\omega }_0$)/PSD(0); the pattern of particle detections that develops over a thick layer of oscillators is shown to be the same as that of a Double-Slit Interference Experiment. Our result shows that when macroscopic resonant detectors interact with and detect periodic streams of discrete particles, they may create the illusion of an interference measurement, as if each discrete particle manifests a phase of its own. Full article