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Article

4 Citations

3,739 Views

16 Pages

Single-Molecule Analysis of the Improved Variants of the G-Quadruplex Recognition Protein G4P

Paras Gaur,
Fletcher E. Bain,
Masayoshi Honda,
Sophie L. Granger and
Maria Spies

Int. J. Mol. Sci.2023, 24(12), 10274;https://doi.org/10.3390/ijms241210274

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17 June 2023

As many as 700,000 unique sequences in the human genome are predicted to fold into G-quadruplexes (G4s), non-canonical structures formed by Hoogsteen guanine–guanine pairing within G-rich nucleic acids. G4s play both physiological and pathologi...

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Article

24 Citations

11,545 Views

18 Pages

Application of Single Molecule Fluorescence Microscopy to Characterize the Penetration of a Large Amphiphilic Molecule in the Stratum Corneum of Human Skin

Pierre Volz,
Alexander Boreham,
Alexander Wolf,
Tai-Yang Kim,
Jens Balke,
Janna Frombach,
Sabrina Hadam,
Zahra Afraz,
Fiorenza Rancan and
Ulrike Alexiev
+ 2 authors

Int. J. Mol. Sci.2015, 16(4), 6960-6977;https://doi.org/10.3390/ijms16046960

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27 March 2015

We report here on the application of laser-based single molecule total internal reflection fluorescence microscopy (TIRFM) to study the penetration of molecules through the skin. Penetration of topically applied drug molecules is often observed to be...

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