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Keywords = shear-induced mixing

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19 pages, 13091 KB  
Article
Numerical Simulation Analysis of Gas–Liquid Two-Phase Flow in a Downhole Coupled Intensified Mixing Structure
by Zewei Zheng, Hongbao Liang, Junjie Huang, Boyu Zhang, Zhen Zhang and Peiang Huang
Modelling 2026, 7(4), 174; https://doi.org/10.3390/modelling7040174 - 19 Aug 2026
Viewed by 148
Abstract
To address the challenge of efficiently blending low-mutual-solubility gas–liquid two-phase systems, a composite structure comprising a Venturi and a static mixer was designed, and its flow field characteristics were analyzed using computational fluid dynamics (CFD) simulations. The results indicate that positioning the static [...] Read more.
To address the challenge of efficiently blending low-mutual-solubility gas–liquid two-phase systems, a composite structure comprising a Venturi and a static mixer was designed, and its flow field characteristics were analyzed using computational fluid dynamics (CFD) simulations. The results indicate that positioning the static mixer at the exit of the Venturi diffusion section yields optimal performance. This configuration prevents disruption of the jet premix flow field and facilitates the uniform dispersion of gas–liquid mixtures throughout the entire domain via six sets of SK-type single-spiral static mixer (SK) units following the initial blending. The composite structure exhibits a three-tier synergistic mechanism characterized by “suction–premix–mixing intensification”: the negative pressure zone within the throat tube induces suction of the gas phase, the diffusion section converts pressure energy to enhance shearing and crushing, and the static mixing section disrupts the axial jet through cutting and swirling effects, thereby generating secondary vortices. This process ultimately achieves uniform dispersion of gas and liquid across the entire domain. The structure’s lack of moving parts addresses the issues of low efficiency and unstable flow fields associated with traditional devices. This design facilitates enhanced crude oil recovery and low-pressure reservoir gas injection drilling. Full article
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26 pages, 4605 KB  
Article
Effects of Non-Uniform Hanging-Depth Layouts on Hydrodynamics and Mass Transport in Suspended Mussel Farms
by Yiquan Zhen, Wei Zhong, Yanjiao Li, Kaitao Zhou, Jing Zhao and Jun Lin
J. Mar. Sci. Eng. 2026, 14(15), 1418; https://doi.org/10.3390/jmse14151418 - 1 Aug 2026
Viewed by 317
Abstract
In suspended mussel farms, culture-layer food supply can be limited, whereas the 4–8 m subsurface layer is rich in particulate organic matter and seston. Using a representative aquaculture block off Gouqi Island, China, this study examined the hydrodynamic and transport effects of non-uniform [...] Read more.
In suspended mussel farms, culture-layer food supply can be limited, whereas the 4–8 m subsurface layer is rich in particulate organic matter and seston. Using a representative aquaculture block off Gouqi Island, China, this study examined the hydrodynamic and transport effects of non-uniform hanging-depth layouts. The 0° uniform-depth layout was the reference. Five configurations were modeled: V-shaped, inverted V-shaped, uniform-depth (90° inflow), V-shaped (extended), and inverted V-shaped (extended). Flume PIV validated the model. Simulations used uniform and measured velocity-profile inflows, with and without density stratification; a passive tracer tracked seston-rich water from the 4–8 m layer. Uniform-depth hanging formed a low-velocity zone in the sleeve layer, limiting water exchange. Non-uniform layouts altered drag distribution and promoted tracer redistribution into overlying 3–5 m waters. In the V-shaped configuration, water was guided upward along sleeve bottoms in the downstream half of the aquaculture block (S2), where pronounced redistribution within the aquaculture block resulted in a tracer concentration of approximately 0.1362 in the 2–3 m layer. Stratification constrained upward spreading, whereas extended configurations may limit food replenishment through enhanced upper-layer blockage and filtering effects. Low-Richardson-number regions corresponded with tracer uplift and enhanced spreading, indicating local shear. Overall, the V-shaped configuration balanced in-farm replenishment, downstream transport, and flow maintenance without additional sleeve length. Full article
(This article belongs to the Section Ocean Engineering)
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34 pages, 21620 KB  
Article
Dynamic Mechanical Properties and Damage Constitutive Model of Layered Cemented Backfill Under Blasting Disturbance
by Yuye Tan, Ziyi Zeng, Fenghao Zhu, Zhaohui Xiong and Weidong Song
Minerals 2026, 16(8), 791; https://doi.org/10.3390/min16080791 - 29 Jul 2026
Viewed by 276
Abstract
In this study, we explore the static and dynamic mechanical responses of layered cemented backfill subjected to blasting loads. Variable-rate uniaxial compression tests and Split Hopkinson Pressure Bar (SHPB) numerical simulations were performed on specimens with three different interlayer cement-to-tailings ratios. All samples [...] Read more.
In this study, we explore the static and dynamic mechanical responses of layered cemented backfill subjected to blasting loads. Variable-rate uniaxial compression tests and Split Hopkinson Pressure Bar (SHPB) numerical simulations were performed on specimens with three different interlayer cement-to-tailings ratios. All samples were cured for 28 days before testing. The test results reveal that uniaxial compressive strength rises and then falls with increasing loading rates, and mixed tensile-shear failure dominates quasi-static loading conditions. The interlayer cement-to-tailings ratio dominates the bearing capacity of backfill. At the test loading rate of 0.02 mm/s, lowering the interlayer ratio from 1:4 to 1:8 sharply reduces peak strength from 5.595 MPa to 1.285 MPa, with a total drop of 77.0%. SHPB simulation results show obvious strain-rate hardening under dynamic impact. For samples with an interlayer ratio of 1:4, dynamic compressive strength increases from 5.38 MPa to 6.16 MPa as impact velocity rises from 4 m/s to 13 m/s, a 14.5% improvement caused by rapid compaction of internal micropores. Combining damage mechanics and energy conservation principles, we establish a dynamic damage constitutive model that couples inherent layered interfacial damage with blasting-induced dynamic disturbance. Model predictions match experimental measurements well. The peak strength error is only 1.3% at a loading rate of 0.005 mm/s, and peak deviations for all test cases are controlled within 5.0%. This work quantitatively clarifies the static and dynamic mechanical evolution of layered cemented backfill, and provides solid theoretical support for mixture proportion design and blasting stability assessment in high-stage sequential backfilling mining. Full article
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20 pages, 3609 KB  
Article
The Use of Bovine Teeth as an Experimental Substrate in the Evaluation of Shear in Contemporary Adhesive Systems
by Nazire Esra Ozer, Sahin Eren Akay, Ece Irem Oguz and Sadullah Uctaslı
Polymers 2026, 18(15), 1810; https://doi.org/10.3390/polym18151810 - 24 Jul 2026
Viewed by 292
Abstract
Evaluating the shear bond strength (SBS) of contemporary universal adhesive systems on different substrates is critical for understanding their clinical applicability. In this study, the SBS of universal adhesives was assessed on 144 human and bovine tooth specimens, comparing enamel and dentin across [...] Read more.
Evaluating the shear bond strength (SBS) of contemporary universal adhesive systems on different substrates is critical for understanding their clinical applicability. In this study, the SBS of universal adhesives was assessed on 144 human and bovine tooth specimens, comparing enamel and dentin across etch-and-rinse and self-etch protocols. Following single-step or two-step adhesive application and resin cementation, the specimens were subjected to 5000 thermocycles before being evaluated with a universal testing machine. Failure modes and surface morphology were additionally characterized using stereomicroscopy and scanning electron microscopy (SEM). Statistical analyses revealed that both tissue type (p = 0.043) and tooth type (p < 0.001) significantly influenced SBS, while the main effect of the adhesive protocol was not significant (p = 0.485). A significant interaction occurred between tissue type and adhesive protocol (p = 0.013); Post hoc analyses revealed that Group A enamel had significantly higher bond strength than both Group D enamel (p = 0.026) and Group A dentin (p = 0.001). Observed failures were predominantly adhesive or mixed, and SEM confirmed expected acid-induced surface roughness. Human teeth yielded higher bond strengths than bovine teeth, meaning absolute SBS values from bovine lab studies should be used with caution. Full article
(This article belongs to the Special Issue Functional Polymer Composites: Synthesis and Application, 2nd Edition)
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21 pages, 1789 KB  
Article
Energy- and Resource-Efficient Hydrodynamic Treatment of Spent Water-Based Drilling Fluids for Process-Water Reuse
by Bulbul Mauletbekova, Bakytzhan Kaliyev, Beibit Myrzakhmetov, Garifolla Serali, Salamat Gylymuly, Vadim S. Tynchenko and Boris V. Malozyomov
Appl. Sci. 2026, 16(14), 7231; https://doi.org/10.3390/app16147231 - 20 Jul 2026
Viewed by 396
Abstract
Spent water-based drilling fluids generated during the construction of technological wells impose substantial environmental, water-management, transportation, and energy burdens. Conventional practices, including storage in temporary pits, prolonged settling, and off-site disposal, do not enable process-water recovery and require repeated handling of suspensions with [...] Read more.
Spent water-based drilling fluids generated during the construction of technological wells impose substantial environmental, water-management, transportation, and energy burdens. Conventional practices, including storage in temporary pits, prolonged settling, and off-site disposal, do not enable process-water recovery and require repeated handling of suspensions with a high solids content. This study evaluates a pressure-driven cylindrical hydrodynamic disperser as the central component of a compact on-site treatment system. Unlike conventional mechanical mixers, the disperser contains no driven shaft within the active chamber. Particle–reagent contact is intensified through controlled jet shear, vortex-induced redistribution, and the motion of freely moving steel balls. Field-derived drilling fluids containing 30–40 wt.% solids, with densities of 1.12–1.17 g/cm3, pH values of 7.4–8.2, and median particle sizes of 15–50 μm, were treated at velocity gradients of 500–1500 s−1 for 60–180 s using Superfloc N-300 dosages of 0–100 g/t. The optimal operating conditions were G = 1300 s−1, τ = 150 s, and D = 50 g/t. Under these conditions, the separation efficiency reached 91–93%, the residual suspended-solids concentration decreased to 120–130 mg/L, process-water recovery reached 80%, sludge volume decreased by 40–60%, and specific energy consumption was approximately 0.30 kWh/m3. More intensive treatment increased the separation efficiency to 94–95% but resulted in a less favorable balance among energy consumption, reagent dosage, and resource recovery. Compared with mechanical mixing, the selected treatment system reduced flocculant consumption by 37.5%, treatment time by more than threefold, and specific energy consumption by 40%. These results support the use of modular on-site systems for process-water recirculation and reduced sludge-transport requirements at remote drilling sites. Full article
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30 pages, 23125 KB  
Article
Experimental and Numerical Study of Water Effects on Mechanical and Fracture Behavior of Sandstone: A Case Study
by Xin Liang, Lihua Hu, Liyuan Yu, Kai Zhang and Jiangcheng Feng
Appl. Sci. 2026, 16(14), 7200; https://doi.org/10.3390/app16147200 - 18 Jul 2026
Viewed by 328
Abstract
Water significantly modifies rock mechanical performance and fracture characteristics through water content and water distribution. Nevertheless, the evolution laws of rock mechanical properties and underlying fracture mechanisms under variable water conditions remain incompletely clarified. In this study, uniaxial compression tests were carried out [...] Read more.
Water significantly modifies rock mechanical performance and fracture characteristics through water content and water distribution. Nevertheless, the evolution laws of rock mechanical properties and underlying fracture mechanisms under variable water conditions remain incompletely clarified. In this study, uniaxial compression tests were carried out on sandstone samples with diverse water immersion durations. Experimental observations reveal that the uniaxial compressive strength (UCS) and elastic modulus of sandstone follow negative exponential attenuation with prolonged immersion time, with maximum reductions of 50.1% and 25.6%, respectively. Under equivalent water contents, samples featuring dry exteriors and wet interiors possess lower strength than those with wet exteriors and dry interiors. A self-developed numerical code incorporating humidity diffusion effects was subsequently adopted to interpret water-controlled sandstone fracture behaviors. Numerical outputs verify that water-induced softening and heterogeneous water distribution exacerbate rock material heterogeneity and internal stress non-uniformity, triggering tensile microcracks along dry–wet interfaces. As the immersion duration rises, the rock failure mode transitions from shear-dominated mixed failure to tension-dominated failure, and finally reverts to shear-dominated mixed failure. Macroscopic rupture is predominantly governed by the gradual coalescence of tension-generated microcracks. This study offers a theoretical foundation to advance the understanding of water-triggered mechanical degradation and fracture mechanisms in sandstone. Full article
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31 pages, 13881 KB  
Article
The Spatiotemporal Correlation Between Hydraulic Loss and Liutex-Based Vortex Dynamics Across Four Stall Regimes in a Pump-Turbine
by Zekai Liu, Yonglin Qin, Boshuang Jiang, Shuangqian Han, Bowen Zhang, Haoru Zhao, Baoshan Zhu and Hongjie Wang
Energies 2026, 19(13), 3189; https://doi.org/10.3390/en19133189 - 5 Jul 2026
Viewed by 292
Abstract
Pumped-storage hydropower requires pump-turbines to operate safely and efficiently under off-design conditions, where stall-induced unsteady flows can redistribute hydraulic losses and reduce operational stability. Unlike previous analyses focused mainly on spatial correlations, this study develops a spatiotemporal framework to clarify how hydraulic loss [...] Read more.
Pumped-storage hydropower requires pump-turbines to operate safely and efficiently under off-design conditions, where stall-induced unsteady flows can redistribute hydraulic losses and reduce operational stability. Unlike previous analyses focused mainly on spatial correlations, this study develops a spatiotemporal framework to clarify how hydraulic loss (HL) and vortex evolution (VE) co-vary under different stall states at the valley point of the pump-mode hump region in a low-specific-speed, ultra-high-head pump-turbine. Detached eddy simulations (DES) were performed for an original-runner scheme (ORI) and an optimized-runner scheme (OPT), with identical stationary components, boundary conditions, and numerical settings. The comparative cases cover four representative flow states: non-stall, fixed stall, rotating stall, and mixed stall. The local hydraulic-loss rate (LHLR) was decomposed into dissipation (DIS) and transport (TRANS) terms, and Liutex-based vorticity decomposition was used to distinguish shear- and rigid-rotation-related vortex quantities. Pearson correlation analysis was then applied in both space and time. The results show that DIS is consistently associated with shear enstrophy ΩS, whereas the spatiotemporal correlation associated with TRANS and VE parameters exhibits stronger regional and stall-state dependence. These findings provide a quantitative basis for identifying loss-sensitive vortex features and support flow-control and runner-optimization strategies for improving pump-turbine efficiency and stability. Full article
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23 pages, 17284 KB  
Article
Uniaxial Compression Failure Behavior and Energy Evolution of Sandstone–Marble Waste Powder Concrete Composites
by Xiang Huang, Jiahao Cao, Shuguang Zhang, Jiaming Li, Zongyuan Pan and Shibin Tang
Sensors 2026, 26(13), 4219; https://doi.org/10.3390/s26134219 - 3 Jul 2026
Viewed by 385
Abstract
Sandstone–marble waste powder concrete composite structures serve as common load-bearing systems in tunnels, underground caverns, and similar engineering projects, where the interface roughness characteristics directly govern their overall stability and service safety. To investigate the influence of interface roughness on the failure behavior [...] Read more.
Sandstone–marble waste powder concrete composite structures serve as common load-bearing systems in tunnels, underground caverns, and similar engineering projects, where the interface roughness characteristics directly govern their overall stability and service safety. To investigate the influence of interface roughness on the failure behavior of the composite, four groups of sandstone–concrete composite specimens made with marble waste powder concrete were prefabricated with different joint roughness coefficients (JRC = 0, 7.84, 17.99, 20.79). The concrete matrix was prepared with marble waste powder incorporated at 25 wt% of the total binder, corresponding to 20.45 wt% of the total mixture, and the water-to-binder ratio was 0.20. Uniaxial compression tests were conducted with synchronous acoustic emission (AE) and digital image correlation (DIC) monitoring to examine the roughness-dependent mechanical response, energy evolution, damage activity, and strain localization of the composites. The results show that the peak stress and elastic modulus of the composite increase continuously with increasing JRC. When JRC increases from 0 to 20.79, the peak stress increases by 170.3% and the elastic modulus increases by 201.1%. The energy evolution mechanism transitions from progressive damage with gradual energy dissipation at low roughness to a three-stage mode at high roughness, characterized by initial frictional energy dissipation, intermediate energy storage, and rapid elastic energy release and dissipated energy increase near failure. DIC results further reveal that increasing interface roughness suppresses interfacial shear slip and promotes tensile-dominated strain localization, whereas excessive roughness may induce local stress concentration around asperities and increase the tendency toward abrupt post-peak instability, the failure mode changes from mixed tensile–shear failure with obvious interfacial slip to tensile-dominated failure. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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44 pages, 27226 KB  
Article
From Waste to Performance: Advancing Asphalt Recycling with Waste Oil Rejuvenators
by Bushra S. Mankhi, Saja A. Sead, Noha Shakir Kadhim, Zainab Al-Khafaji, Tameem Mohammed Hashim, Mohammed Salah Nasr and Ali Shubbar
Constr. Mater. 2026, 6(4), 40; https://doi.org/10.3390/constrmater6040040 - 26 Jun 2026
Viewed by 365
Abstract
The growing use of reclaimed asphalt pavement (RAP) in hot mix asphalt (HMA) is an important practice to achieve more sustainable pavements, as it reduces the consumption and environmental impact of virgin materials. However, aging induces binder stiffening that requires effective rejuvenation to [...] Read more.
The growing use of reclaimed asphalt pavement (RAP) in hot mix asphalt (HMA) is an important practice to achieve more sustainable pavements, as it reduces the consumption and environmental impact of virgin materials. However, aging induces binder stiffening that requires effective rejuvenation to restore overall performance. This study provides a comprehensive comparative analysis of ten chemically different waste oils—waste engine oil (WEO), waste cooking oil (WCO), yellow grease (YG), waste hydraulic oil (WHO) waste electric transformer oil (WETO), slop oil (SO), sludge-derived bio-oil (SDBO), tire pyrolysis oil (TPO), plastic pyrolysis oil (PPO), and algal residue oil (ARO)—as recycled HMA mixture rejuvenators, linking oil composition to binder regeneration and mixture performance. Binder properties were determined by rotational viscosity (RV), dynamic shear rheometer (DSR) and bending beam rheometer (BBR), whereas mixture performance was assessed in terms of Superpave mechanical properties, Hamburg wheel-tracking test (HWTT) for rutting resistance and mixture BBR for low-temperature cracking resistance. Performance grade (PG) evaluations showed that WETO and WEO restored the 50% and 75% RAP binders, respectively, to a grade close to PG 64-16 at the lowest dosages. The Superpave volumetric properties of all restored mixtures were similar to those of the control mixture, denoting corrected mixture balance and compaction level. HWTT results indicated that WETO-recycled mixtures revealed the lowest rut depth at 50% RAP, while WEO-recycled mixtures exhibited the lowest rut depth at 75% RAP after 20000 passes. Additional evidence supporting these results can be found in BBR mixture data, which demonstrated that WETO at 50% RAP and WEO/WETO at 75% RAP showed the most reduction in creep stiffness and improvement in creep rate. The correlation, regression, and PI analyses were in good agreement with the experimental results, where WETO and WEO exhibited the best overall performance at 50% and 75% RAP, respectively. In summary, these results indicate that the performance of waste oil rejuvenator in recycled HMA mixtures is highly dependent on RAP content and point to WETO and WEO as feasible, environmentally friendly options for high-RAP recycled HMA. Full article
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22 pages, 9994 KB  
Article
Time-Dependent Wellbore Stability Window of Clay-Rich Shales Exposed to Water-Based Drilling Fluid: A Tunisian Drilling Case Study
by Mohamed Arayedh, Mahmoud Khlifi, Ines Benaoun, Riadh Ahmadi and Noureddine Hamdi
Appl. Sci. 2026, 16(13), 6381; https://doi.org/10.3390/app16136381 - 25 Jun 2026
Viewed by 233
Abstract
Wellbore instability in clay-rich intervals remains a major drilling challenge, even when the selected fluid density satisfies the conventional pressure window. This study evaluates delayed instability during exposure to a low-salinity water-based drilling fluid using outcrop-derived Aleg and El Haria materials as analogs [...] Read more.
Wellbore instability in clay-rich intervals remains a major drilling challenge, even when the selected fluid density satisfies the conventional pressure window. This study evaluates delayed instability during exposure to a low-salinity water-based drilling fluid using outcrop-derived Aleg and El Haria materials as analogs for clay-rich Tunisian drilling intervals. Mineralogical, chemical, geotechnical, and shear strength data were integrated with a coupled stability analysis to link fluid exposure, pore pressure redistribution, effective stress modification, and hydration-induced strength degradation. The two materials exhibited contrasting hydro-mechanical behavior. El Haria is clay-rich, with 80% total clay mineral content, including 41% smectite and 47% illite/smectite mixed layers, and has a swelling pressure of 2112 kPa. Aleg is more carbonate-influenced, with 66% total clay mineral content, 28% calcite, and a lower swelling pressure of 576 kPa. Freshwater hydration strongly reduced the shear strength envelope; between approximately 15% and 45% water content, cohesion decreased by approximately 91% in Aleg and 70% in El Haria. The stability profiles show that El Haria reached rc/a = 1.10 after 0.3 h and the critical threshold of rc/a = 1.30 after 21.7 h, whereas Aleg remained close to rc/a = 1.03. This defines a practical temporal stability window for planning open-hole exposure during logging, casing, and cementing operations. Full article
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22 pages, 11565 KB  
Article
Three-Dimensional Mixed-Mode Fracture Analysis in Finite Structures Using a Generalized Domain Integral: Crack Front Energy Partition and Thickness Effects
by Soliman El kabir, Rostand Moutou Pitti and Naman Recho
Appl. Sci. 2026, 16(13), 6347; https://doi.org/10.3390/app16136347 - 24 Jun 2026
Viewed by 311
Abstract
This paper presents a three-dimensional generalization of the M-integral, formulated as an interaction integral based on a bilinear strain energy density, for the mixed-mode decoupling of crack front energies in finite structural components. The proposed Mθ3D integral combines real and [...] Read more.
This paper presents a three-dimensional generalization of the M-integral, formulated as an interaction integral based on a bilinear strain energy density, for the mixed-mode decoupling of crack front energies in finite structural components. The proposed Mθ3D integral combines real and virtual mechanical fields within a local spherical reference frame, enabling the separate evaluation of mode I (opening), mode II (in-plane shear) and mode III (out-of-plane shear) energy release rates along arbitrary crack front lines. The theoretical framework, derived from Noether’s theorem and the virtual work principle, is implemented in the Cast3M finite element code using a toroidal integration domain with a local theta weighting function. Numerical validations are conducted on the Mixed-Mode Crack Growth (MMCG) specimen, a geometry representative of structural components subjected to combined tension and shear. Three key findings are demonstrated: (i) practical domain independence is achieved for all three fracture modes; (ii) the three-dimensional approach converges to the plane-stress solution for thin specimens and reveals significant deviations from plane-strain assumptions; (iii) even under nominally mode I + II loading, a non-negligible mode III component emerges due to Poisson-induced out-of-plane effects, with magnitude increasing at free surfaces and for thicker geometries. These results indicate that finite-thickness and out-of-plane effects can significantly affect the partition of fracture energy between modes. For the MMCG configuration investigated here, the three-dimensional formulation shows the limitations of two-dimensional assumptions and provides an energetic basis for the analysis of mixed-mode fracture in finite-thickness components. Full article
(This article belongs to the Special Issue Application of Fracture Mechanics in Structures)
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20 pages, 8204 KB  
Article
Rectus Femoris Neuromechanical Responses to Exercise-Induced 3% Body Mass Loss by Baseline Hydration Status: A Randomized Group Comparison
by Karol Skotniczny, Artur Terbalyan, Paweł Linek and Jakub Chycki
Nutrients 2026, 18(12), 2015; https://doi.org/10.3390/nu18122015 - 21 Jun 2026
Viewed by 484
Abstract
Background: Acute dehydration impairs performance, but its effects on resting neuromuscular and tissue mechanics are unclear. We tested whether baseline hydration status and exercise-induced sweat loss alter the resting neuromechanical phenotype of the rectus femoris (RF) as well as skin, subcutaneous tissue (subQ), [...] Read more.
Background: Acute dehydration impairs performance, but its effects on resting neuromuscular and tissue mechanics are unclear. We tested whether baseline hydration status and exercise-induced sweat loss alter the resting neuromechanical phenotype of the rectus femoris (RF) as well as skin, subcutaneous tissue (subQ), and fascia overlying the RF. Methods: Thirty physically active men were randomized to hydration guidance (EXP) or habitual intake (CON). Hydration was verified weekly using first-morning urine specific gravity (USG), with targets of USG < 1.018 (EXP) and USG > 1.018 (CON). Participants performed continuous cycling at 50% maximal power output (Wmax) until ~3% body mass loss. Shear-wave elastography quantified tissue shear modulus (kPa), and tensiomyography assessed RF twitch-derived contractile properties (Dm, Tc, Tr) before and immediately after exercise. SWE data were analyzed using mixed design repeated-measures ANOVA; TMG outcomes were analyzed using non-parametric tests. Results: Baseline measures did not differ between groups. No significant group, time, or interaction effects were observed for RF muscle, skin, or subQ shear modulus. In contrast, fascia shear modulus showed a significant time effect, while TMG outcomes did not change significantly from pre- to post-exercise (all p > 0.05). Deep fascia showed a significant main effect of time, with decreased shear modulus post-exercise (F(1, 21) = 5.06, p = 0.035, η2p = 0.194; Δ = 1.25 kPa; d = 0.41; 95% CI [0.04, 0.78]), independent of hydration group. Conclusions: Under moderate-intensity cycling with approximately 3% body mass loss, we did not detect significant hydration-group differences or significant pre–post changes in resting RF twitch-derived contractile properties or in RF muscle, skin, and subQ shear modulus. Fascia shear modulus decreased after exercise irrespective of hydration group. These findings should be interpreted cautiously: the study was underpowered to detect small effects, and the fascial finding emerged from an exploratory, layer-specific analysis without correction for multiple comparisons. It should therefore be regarded as preliminary and hypothesis-generating, requiring confirmation in adequately powered, pre-registered studies. Full article
(This article belongs to the Special Issue Hydration and Nutrition Status in Human Health)
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26 pages, 19353 KB  
Article
Development and Characterization of a Stable Oil-in-Water Nanoemulsion Using Impingement Jet Mixing and Lyophilization Techniques
by Anna Shao, Jingyan Zhang, Zhaowei Jin, Yao Li, Jialin Tang, Quanmin Chen, Hongbing Wu and Jeremy Guo
Pharmaceutics 2026, 18(6), 745; https://doi.org/10.3390/pharmaceutics18060745 - 17 Jun 2026
Viewed by 602
Abstract
Nanoemulsion (NEM) is an effective adjuvant and delivery system for vaccines and nucleic acids, capable of inducing immune responses against diverse pathogens. Background/Objectives: Conventional NEM manufacture uses multi-step operations, typically high-shear homogenization and then microfluidization (HSHM), thereby increasing process complexity and contamination [...] Read more.
Nanoemulsion (NEM) is an effective adjuvant and delivery system for vaccines and nucleic acids, capable of inducing immune responses against diverse pathogens. Background/Objectives: Conventional NEM manufacture uses multi-step operations, typically high-shear homogenization and then microfluidization (HSHM), thereby increasing process complexity and contamination risk. As water-rich colloidal dispersions, NEM is prone to microbial proliferation and droplet coalescence; freezing further disrupts microstructure, causing phase fusion and separation, so NEM adjuvants are often stored separately from antigens in multi-vial formats. Lyophilization could reduce cold-chain dependence and enable single-vial products, but there is no systematic study on lyoprotectants comparation and process optimization of lyophilized NEM. Methods: An impingement jet mixing (IJM) process was evaluated as a simplified, scalable route for NEM production. Key IJM parameters, including flow ratio, total flow rate, preparation temperature, microchannel type, and shear mode—were examined to match attributes of conventional HSHM. Lyophilized and reconstituted NEM were characterized by dynamic light scattering, scanning electron microscopy, transmission electron microscopy, differential scanning calorimetry and/or in vitro potency to inform lyoprotectant selection, and Taguchi Design of Experiment (DOE) methodology guided lyophilization processes. Results: IJM yielded NEM with droplet size, polydispersity index (PDI) and morphology comparable to HSHM, with higher throughput and fewer unit operations. Optimized lyophilization technique with designed lyoprotectant and process formed closed structures to prevent the easy-to-flow monolayer of the emulsion from fusing, producing robust and stable NEM. Conclusions: Coupling IJM with targeted lyophilization establishes a scalable, lower-risk manufacturing paradigm for NEM that preserves critical quality attributes, reduces cold-chain reliance and enables single-vial adjuvanted vaccine formats with tangible industrial and clinical benefits. Full article
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22 pages, 10909 KB  
Article
Thermo-Mechanical Degradation Behavior of the Base–Subgrade Interface in Airport Pavements: A Sequentially Coupled Cohesive-Zone Study
by Weihong Yan, Chengchao Guo, Xinrui Li, Wenqiang Zhang, Yiteng Wang, Lei Qin and Leiyang Pei
Materials 2026, 19(12), 2541; https://doi.org/10.3390/ma19122541 - 12 Jun 2026
Viewed by 342
Abstract
The thermo-mechanical degradation of the base–subgrade interface in airport pavements was investigated using a three-dimensional sequentially coupled finite element framework in ABAQUS 2023, in which progressive interfacial debonding was described by a bilinear cohesive-zone model through the damage variable CSDMG. The results show [...] Read more.
The thermo-mechanical degradation of the base–subgrade interface in airport pavements was investigated using a three-dimensional sequentially coupled finite element framework in ABAQUS 2023, in which progressive interfacial debonding was described by a bilinear cohesive-zone model through the damage variable CSDMG. The results show that thermal loading markedly accelerates interface degradation when combined with moving wheel loads. Compared with the wheel-loading-only condition, thermo-mechanical coupling advances the first damage initiation from 0.04993 h to 0.00254 h and shortens the severe-degradation stage from 1.000 h to 0.00927 h. This acceleration is attributed to a thermal stress pre-weakening effect, whereby constrained thermal deformation partially consumes the available cohesive resistance and shifts the interface closer to the softening threshold before external loading is applied. A decomposition of the mixed-mode initiation criterion further indicates that the first damage event is governed by synergistic normal–shear interaction, with the normalized contribution ratio (tn/tn0)2:(ts/ts0)2 = 0.38:0.62, showing that wheel-induced shear is the dominant trigger while tensile opening induced by thermal curling provides substantial preconditioning assistance. In addition, a representative normalized comparison between simulated average CSDMG and cumulative AE hit count demonstrates a consistent stage evolution from distributed deformation to accelerated localization and residual stabilization. These findings indicate that the base–subgrade interface should be treated as a temperature-sensitive weak layer in airport pavement assessment, particularly near joints and other discontinuity-controlled regions. Full article
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17 pages, 17626 KB  
Article
Study on Material Transport Based on Particle Statistics in the CCZ Manganese Nodule Mining Area
by Bao Zhang, Xusheng Xiang, Xueqing Zhang and Li Zou
J. Mar. Sci. Eng. 2026, 14(12), 1072; https://doi.org/10.3390/jmse14121072 - 8 Jun 2026
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Abstract
To characterize the transport of the mining-induced sediment plume in the Clarion–Clipperton Zone (CCZ) nodule area, this study introduces a particle relative dispersion (RD) to assess material dispersion in 2D and 3D. In 2D, forward and backward RD results show clear sub-regional differences [...] Read more.
To characterize the transport of the mining-induced sediment plume in the Clarion–Clipperton Zone (CCZ) nodule area, this study introduces a particle relative dispersion (RD) to assess material dispersion in 2D and 3D. In 2D, forward and backward RD results show clear sub-regional differences in particle aggregation and diffusion. Forward RD reaches a maximum ridge value of 40 km in regions of strong shear and strain. Backward RD effectively identifies upstream source regions and convergence pathways. High RD values align closely with strong strain-rate gradients, indicating that particle separation and mixing are primarily driven by transition regions between flow structures rather than uniform high- or low-strain areas. In the 3D, the vertical domain was limited to the 4500–4600 m depth range above the seabed. The overall RD patterns remain broadly consistent with the 2D results, while the maximum RD increases to approximately 80 km due to the inclusion of vertical displacement and local vertical shear effects. Within the 4500–4600 m depth range, horizontal transport remains dominant, whereas vertical variations are comparatively weak, and particle trajectories exhibit only minor local differences. Compared with the 2D case, the deep-layer 3D RD distribution exhibits lower skewness values, suggesting a more spatially balanced particle separation pattern with reduced directional asymmetry. Multi scale quasi-3D RD analysis provides essential insights into material dispersion and convergence patterns, offering valuable information for evaluating transport pathways, potential pollutant spread, and ecological risks associated with deep-sea mining. Full article
(This article belongs to the Section Geological Oceanography)
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