Search Results (6,793)

Enzyme-free flexible glucose sensors hold great promise in the field of wearable health monitoring. However, their performance is limited by the balance between the catalytic interface activity and stability. This paper reports a strategy for interface gradient roughening of screen-printed carbon electrodes (SPCE) via controllable electrochemical exfoliation (EE). It systematically reveals the inherent relationships among the degree of EE treatment, electrode morphology, surface chemistry, and electrochemical performance. On this basis, the deposition of gold nanoparticles (AuNPs) with high density and uniform distribution is achieved, and a high-performance flexible enzyme-free glucose sensor is constructed. The study finds that EE treatment can significantly increase the true surface area of the electrode and introduce abundant oxygen-containing functional groups, thus effectively reducing the charge transfer resistance. Nevertheless, excessive exfoliation leads to the degradation of the conductive network, indicating the existence of a critical “performance window”. The EE-SPCE optimized with 150 cycles has both a high active area and good electrical conductivity, providing an ideal deposition substrate for AuNPs, increasing their distribution density by approximately 158% and reducing the average particle size to 125 nm. The fabricated AuNPs/EE-SPCE sensor exhibits excellent performance in glucose detection: it has a high sensitivity of 550.766 μA·mM⁻¹·cm⁻² in the range of 0.1–3 mM, a detection limit of 0.0998 mM, a wide linear range, excellent selectivity, long-term stability, and good mechanical flexibility. This research not only develops an efficient and scalable method for constructing flexible sensing interfaces but also clarifies the trade-off relationship among “roughening–conductivity–catalytic performance” at the mechanistic level, providing an important theoretical basis and a general strategy for rationally designing high-performance flexible electrochemical devices. Full article

The severity of cardiovascular disease is linked to C-reactive protein, interleukin 6, and C-type natriuretic peptide levels, stressing the need for a sensitive sensor that can detect these biomarkers at ultralow levels in real time. Whole blood samples from confirmed cardiovascular patients were analyzed for C-type natriuretic peptide, C-reactive protein, and interleukin 6 using three stochastic sensors. These sensors were designed using carbon paste matrices decorated with Ag nanoparticles (AgNPs), on which different phthalocyanines were physically immobilized. The sensors exhibited exceptionally low detection limits (1 × 10⁻²¹ g mL⁻¹) and broad linear concentration ranges (1 × 10⁻²¹ to 1 × 10⁻⁶ g mL⁻¹). The analysis conducted using the Student t-test indicated that there is no statistically significant difference between the results obtained from the three stochastic sensors used in the screening tests of whole blood, with ELISA at a confidence level of 99%. Full article

Modern interaction with smart devices is hindered by the “Midas Touch” problem, where sensors frequently misinterpret incidental physical movements as intentional commands due to a lack of human context. This research addresses this conflict by introducing the Multimodal Haptic Informatics (MHI) index within a novel Scene–Action–Trigger (SAT) framework. The goal is to contextualize mechanical movements as human intent by integrating physical, spatial, and cognitive data locally at the edge. The methodology employs an “Action-as-primary indexing” mechanism where the Action channel (IMU) serves as a temporal anchor t, triggering high-resolution Scene (computer vision) and Trigger (audio) processing only during critical haptic events. Validated through a complex origami crane task generating 29,408 data frames, the framework utilizes a three-stage informatics derivation process: single-modal scoring, score weighting, and hand state mapping. Results demonstrate that applying an adaptive “Speedometer” logic successfully reclassifies the “Transitional State”. While this state constitutes over half of the behavioral dataset (54.76% on average), it is effectively disambiguated into meaningful intent using a self-trained local Large Language Model (LLM) for semantic verification. Furthermore, the event-driven sampling of 93 keyframes reduces the processing overhead by 99.68% compared to linear annotation. This study contributes a low-latency, privacy-preserving “Protocol of Assent” that maintains user agency by providing intelligent system suggestions based on confirmed haptic intensity. Full article

A tunable diode laser absorption spectroscopy (TDLAS) sensor with a highly sensitive dual-component for methane (CH₄) and acetylene (C₂H₂) detection is reported in this paper for the first time. A multi-pass cell (MPC) design model was established employing a vector-based ray-tracing method. A dual-channel MPC with an interlaced dual hexagonal star pattern was designed to improve gas absorption and realize real-time synchronous detection of CH₄ and C₂H₂. During the simultaneous continuous monitoring of CH₄ and C₂H₂, the sensor exhibited an excellent linear response to concentration variations. The minimum detection limit (MDL) for CH₄ reached 132.08 ppb, improving to 77.32 ppb when the average time was increased to 300 s. In the case of C₂H₂, the MDL was measured at 20.19 ppb and further reduced to 3.50 ppb under the same extended average time. Full article

Adequate ventilation is essential for maintaining indoor environmental quality in schools, where ventilation standards are often based on an indoor concentration of human-generated carbon dioxide (CO₂) above ambient levels. Low-cost non-dispersive infrared (NDIR) CO₂ sensors offer a practical solution for ventilation monitoring, yet variability between sensors can compromise accuracy, particularly when applications depend on the determination of precise concentration differences. This study evaluates the performance of twenty-three low-cost CO₂ sensors, developing normalisation functions to improve comparability across sensors, introducing an accessible methodology for on-site sensor calibration without the need for laboratory-grade reference equipment. The sensors were co-located for three independent test periods in 2025 representing typical school internal conditions in Ireland. Pre-normalisation analysis showed strong linearity (coefficient of determination (R²) = 0.999) but notable variability, with a mean root mean square error (RMSE) of 18.3 ppm and 0.45% of measurements outside manufacturers stated accuracy. Normalisation models were trained and validated using a leave-one-period-out approach. Regression-based correction yielded the greatest improvement, reducing RMSE by 16%. When applied to the full dataset, final correction factors reduced RMSE by 27%, out-of-range measurements by 43%, and proportional bias by 31%. Corrected sensors demonstrated highly consistent performance, particularly within the CO₂ ranges most relevant for classroom ventilation assessment, with an RMSE = 7.4 parts per million (ppm) at ambient concentrations and 11.9 ppm at concentrations below 1500 ppm. Field-based co-location in the deployment environment across full CO₂ cycles, combined with a network-derived global reference, produced effective correction factors. Performance declined marginally above 1500 ppm and during dynamic occupancy, while overall accuracy remained strong. The study presents a practical and accessible methodology for evaluating and normalising low-cost CO₂ sensors without specialised laboratory equipment, supporting reliable ventilation assessments in schools. Full article

Background/Objectives: Identification of tools to minimize opioid-related harms is critical in the U.S. The purpose of this study was to better understand community responder and healthcare provider perceptions and preferences regarding the design and function of a potential new opioid sensor device (OSD). Methods: Adults aged ≥ 18 years employed as community responders or healthcare providers in Alabama were recruited via email to participate in an anonymous online cross-sectional survey informed by the Unified Theory of Acceptance and Use of Technology (UTAUT). Primary outcomes were assessed via multiple-choice and 7-point Likert-type scales (1 = strongly disagree, 7 = strongly agree) and included the following topics: (1) past OSD utilization (4 items); (2) perceived importance of OSD design elements (15 items); (3) OSD function and cost preferences (3 items); and (4) UTAUT measures including perceived usefulness of OSDs (3 items), ease of use (4 items), social factors (4 items), resources (4 items), concerns (3 items), and intentions (3 items). Differences in UTAUT measures across professions were assessed via Mann–Whitney U tests, and predictors of OSD utilization intention were analyzed via multiple linear regression. Results: Respondents (N = 145) included pharmacists (40.0%), nurses (23.4%), physicians (14.5%), behavioral health (4.8%), social work (4.8%), and law enforcement (0.7%). Availability in hospital emergency departments was rated as the most important device element (mean [SD] score: 6.66 [0.80]), followed by sensitivity and specificity of the test (6.42 [0.98]), rapid detection time (6.42 [0.88]), ability to detect opioids in a broad range of substance (6.42 [0.93]), and availability in law enforcement offices (6.33 [1.08]). A 2–5 min detection time was rated as reasonable by 32.6% of respondents, with 53.0% preferring to pay <USD 15 per test. There were no statistically significant differences in UTAUT scale scores across professions. Perceived usefulness (β = 0.493; p < 0.001), social acceptance (β = 0.281; p = 0.023), and resource availability (β = 0.708; p = 0.002) were positive predictors and perceived ease of use was a negative predictor (β = −0.472; p = 0.007) of intention to use an OSD. Conclusions: Newly developed OSDs should consider prioritizing accessibility in hospital emergency departments and law enforcement offices, ability to detect a broad range of opioids, detection time between 2 and 5 min, and cost less than USD 15 per test. Future research may explore perspectives from a more diverse sample across multiple states and different professional roles. Full article

A photoelectric tracking system is a typical bearing-only target tracking system that faces significant challenges arising from measurement origin uncertainty due to clutter and the discrepancy between continuous-time target dynamics and discrete-time optical sampling, as well as the inherent nonlinearity of bearing-only tracking. This paper addresses these issues by proposing a novel distributed probabilistic data association feedback particle filter (DPDA-FPF) framework. To resolve the tracking ambiguity at the local level, we extend the feedback particle filter to a continuous-discrete setting integrated with probabilistic data association. Subsequently, the local state estimates and covariances from spatially separated tracking systems are transmitted to a fusion center and integrated using an optimal linear covariance-weighted fusion rule to improve global observability and mitigate biases of individual systems. Numerical simulations in a 3D scenario with moderate clutter density demonstrate that while individual sensor tracks suffer from fluctuations, the proposed fused estimate achieves substantially lower root mean square errors in both position and velocity. The results validate the efficiency of the proposed architecture as a robust solution for photoelectric tracking applications. Full article

Accurate remaining useful life (RUL) prediction of turbofan engines is critical for aviation safety and maintenance optimization; however, deep learning approaches often lack interpretability and require extensive training data. This study proposes a framework integrating Linear Discriminant Analysis (LDA) with Kalman filtering for turbofan engine prognostics. The methodology projects high-dimensional sensor measurements onto a two-dimensional LDA subspace, where degradation trajectories are tracked using state-space estimation, with RUL predictions derived from distances to learned critical failure boundaries. A health index-based classification scheme partitions engine states into three operational regions: Critical, Warning, and Healthy. Three Kalman filter variants—Linear Kalman Filter (LKF), Extended Kalman Filter (EKF), and Unscented Kalman Filter (UKF)—were compared against an Autoregressive (AR) baseline using the NASA C-MAPSS dataset. Using the Prognostics and Health Management 2008 asymmetric scoring function, UKF achieved the best performance with a Score of 552572, representing a 54.9% improvement over AR (1224299), indicating substantially fewer late predictions. While RMSE values remained comparable across methods (36–37 cycles), the Kalman filter variants demonstrated meaningful improvements in avoiding dangerous late predictions critical for safety-oriented maintenance scheduling. EKF also demonstrated substantial improvement with 36.1% Score reduction. Classification accuracy improved from 70.72% (AR) to 73.27% (UKF). The proposed LDA–Kalman framework provides a computationally efficient and geometrically interpretable alternative to deep learning methods for real-time engine health monitoring. Full article

Accurate monitoring of intracranial pressure (ICP) is critical for the diagnosis and management of neurological disorders. Although various ICP sensors have been developed, their sensitivity is often limited, restricting their ability to detect subtle pressure variations. Therefore, there is a pressing need to develop ICP sensors with enhanced sensitivity to improve measurement accuracy and patient outcomes. In this paper, a highly sensitive and precise pressure sensor for intracranial pressure (ICP) monitoring was proposed. Theoretically, the beam-membrane-island structure was introduced and optimized to improve sensitivity and linearity compared to a flat membrane structure. The notches etched at beam end were designed for further improving sensitivity. Experimentally, the designed sensor achieved a sensitivity of 1.59 mV/V//kPa and a nonlinearity of −0.22% F.S. Additionally, the sensor can detect pressure with centimeter water column (cm H₂O) resolution, making it suitable for ICP monitoring. This technology holds broad application prospects in the field of medical devices. Full article

Severe Dengue fever can cause Dengue Hemorrhagic Fever (DHF), a life-threatening condition characterized by plasma leakage and hemoconcentration. A hematocrit (Hct) rise of ≥20% is a key indicator for medical intervention, but current monitoring is invasive and intermittent. This study aims to determine the optimal design parameters for a non-invasive optical sensor to continuously monitor hemoconcentration. We developed a high-fidelity Monte Carlo model of light transport in a multi-layered skin model, with the epidermis set to a 5% melanin volume fraction (Fitzpatrick type II/III). To ensure signal reliability, simulations were conducted with a high photon count ($1\times {10}^8$ photons), yielding a stochastic (Monte Carlo) signal-to-noise ratio of approximately 36 dB. We simulated diffuse reflectance at four characteristic wavelengths (577 nm, 660 nm, 800 nm—the isosbestic point—, and 940 nm) over source-detector separations of 0.5–8.0 mm. Sensor sensitivity was quantified as the reflectance change for a +25% relative Hct rise (e.g., 42% to 52.5%), mimicking severe hemoconcentration, and its dependence on baseline dermal blood volume fraction (BVF) was investigated. Sensor sensitivity showed a non-linear dependence on BVF, showing a direct correlation with perfusion level, reaching an optimal 6.41% for a robust 5% BVF at 8.0 mm. A dedicated sweep showed that even under low-perfusion shock conditions (1% BVF), the sensor maintains a highly significant sensitivity of 5.71% (also at 8.0 mm), indicating that sensitivity remains high across a physiologically relevant perfusion range. In the analysis, at a robust 5% BVF, the 800 nm wavelength demonstrated superior reliability, with peak sensitivity at 6.41% at 8.0 mm. Visible wavelengths (577 nm and 660 nm) exhibited high theoretical sensitivity, while 940 nm was compromised by water absorption. Based on these findings, a non-invasive optical sensor for hemoconcentration is most effective operating at 800 nm, within the evaluated spectral set, with a source-detector separation of ≥6.0 mm, targeting the deep dermis while minimizing superficial interference. This design provides an optimal balance of tissue penetration, robust sensitivity to Hct changes, and reduced sensitivity to oxygenation-related variability while maintaining signal stability. This work enables the design of a device for continuous monitoring, supporting continuous monitoring of hemoconcentration trends relevant to plasma leakage progression. Full article

Graphene-based sensors and biosensors are attractive candidates for chemical and biological threat detection due to their high surface sensitivity, rapid transduction, and low-power operation, yet real-world deployment remains constrained by cross-sensitivity, interface instability in biosensing, and limited validation under operational conditions. This review consolidates key requirements for Chemical, Biological, Radiological, and Nuclear (CBRN) detection and proposes a structured roadmap to guide the transition from laboratory demonstrations to field-relevant sensing systems. The roadmap is explicitly modular and non-linear, integrating (i) qualitative research planning and gap analysis, (ii) computational screening via molecular docking as a hypothesis-generation tool with well-defined limitations, (iii) graphene electrode fabrication and functionalization using pulsed laser deposition (PLD) to enable tunable thickness/defect engineering and strong interface control, (iv) multiscale characterization combining laboratory methods with in situ/portable diagnostics, and (v) field-oriented performance evaluation focused on response time, stability, selectivity against industrial interferents, and false-positive/false-negative behavior. Iterative feedback loops connect all modules, enabling progressive refinement of material processing, recognition chemistry, and device architecture. By framing success in terms of technology-maturity progression and operational metrics, this roadmap provides a practical, defense-relevant framework for developing deployable graphene-based CBRN sensing platforms. Full article

Camera calibration is an essential research direction in photonics and computer vision. It achieves the standardization of camera data by using intrinsic and extrinsic parameters. Recently, RGB-D cameras have been an important device by supplementing deep information, and they are commonly divided into three kinds of mechanisms: binocular, structured light, and Time of Flight (ToF). However, the different mechanisms cause calibration methods to be complex and hardly uniform. Lens distortion, parameter loss, and sensor degradation et al. even fail calibration. To address the issues, we propose a camera calibration method based on the Expectation–Maximization (EM) algorithm. A unified model of latent variables is established for the different kinds of cameras. In the EM algorithm, the E-step estimates the hidden intrinsic parameters of cameras, while the M-step learns the distortion parameters of the lens. In addition, the depth values are calculated by the spatial geometric method, and they are calibrated using the least squares method under an optical motion capture system. Experimental results demonstrate that our method can be directly employed in the calibration of monocular and binocular RGB-D cameras, reducing image calibration errors between 0.6 and 1.2% less than least squares, Levenberg–Marquardt, Direct Linear Transform, and Trust Region Reflection. The deep error is reduced by 16 to 19.3 mm. Therefore, our method can effectively improve the performance of different RGB-D cameras. Full article

The margin of stability (MoS) is a metric used to assess dynamic postural stability during walking. Although MoS is typically computed from optical motion capture data, previous studies have shown that MoS can be approximated from six-axis kinematic signals—linear acceleration and angular velocity—measured by inertial measurement units (IMUs). With IMU-equipped devices such as smartphones and smartwatches becoming widespread, it is increasingly common for individuals to carry two or more such devices in daily life. This study aimed to identify combinations of two body locations that most effectively predict MoS. IMU sensors were attached to ten body locations while participants walked on a treadmill. Principal motion analysis, a reductive regression method for multidimensional time-series data, was employed for MoS prediction, and cross-validation was used for reliable model evaluation. Appropriate combinations of two IMU sensors achieved mean errors of approximately 30 mm and 11 mm in anterior and mediolateral MoS, respectively, compared with reference values derived from optical motion capture. These errors were comparable to the intrinsic standard deviations of MoS, suggesting that IMU-based MoS estimation is sufficiently accurate for the classification of individuals at high fall risk. Full article

The monitoring and conservation of built heritage is a major challenge for the scientific community, given the continuous degradation caused by natural, anthropogenic and climatic factors. The generation of high-resolution 3D documentation is important in the diagnosis of deterioration in historic buildings and the planning of conservation and restoration efforts. The present study proposes an integrated, multi-source workflow combining terrestrial laser scanning (TLS), unmanned aerial vehicle (UAV) photogrammetry, and 3D camera interior scanning. This workflow was employed to document and evaluate the Casa Rusănescu monument in Craiova, Romania. The following processes were incorporated: coordinated acquisition, processing, alignment, evaluation of geometric consistency and deviation-based diagnosis. The diagnosis process include measuring the distance between data clouds and analyzing surface roughness, curvature, planarity and linearity. The workflow was designed to be applicable in real urban conditions, ensuring the coverage of façades, interiors and roof structures. The final, combined dataset contained over 235 million points and includes both interior and exterior geometries. This process helped identify various types of damage, such as cracks, exfoliation, plaster detachment, moisture-related changes, and geometric deformations. An additional AI-assisted validation step (Twinspect) was used to cross-check the degradation indicators derived from point-cloud analyses. The findings suggest that using multiple sensors improves spatial completeness, enhances anomaly detection, and establishes a reliable baseline prior to restoration interventions and long-term monitoring. This methodology facilitates the development of digital twins and GIS-based risk assessments, thereby providing a scalable solution for heritage preservation. Full article

Lycium barbarum L. is a widely used medicinal and edible Chinese medicinal material. However, with consumers’ heightened concern for health and food safety, pesticide residues have become one of the major challenges affecting its quality and safety. Cyhalothrin is a pyrethroid insecticide and a typical type of pesticide with excessive pesticide residues in Lycium barbarum L. Rapid detection of pesticide residues is an effective way to ensure the quality and safety of traditional Chinese medicinal materials. In this work, a molecularly imprinted polymer electrochemiluminescence (ECL) sensor based on gold nanoparticles (AuNPs)@Ru-ZIF-8 was constructed for rapid detection of cyhalothrin residues. The prepared cyhalothrin molecularly imprinted polymers (MIPs) were used as a recognition element and modified on the surface of a glassy carbon electrode (GCE) by an electrochemical polymerization method. AuNPs were utilized to promote the excitation of Ru(bpy)₃²⁺ and TPrA in the ECL system, which improved the observability of the light signal. The GCE modified with the metal–organic frameworks (MOFs) ZIF-8 was employed to increase the specific surface area and enhance the electron transfer capacity on the electrode, thereby improving the sensing sensitivity of the sensor. In addition, the luminescent reagent of Ru(bpy)₃²⁺ was introduced into the synthesis process of ZIF-8, which caused Ru(bpy)₃²⁺ to be tightly bound around it and enhanced the stability of the sensor. Under optimal conditions, the linear detection range of the sensor is 1 × 10⁻¹~1 × 10⁴ nM, with a limit of detection (LOD) of 10 pM. The accuracy of the ECL-MIP sensor has been verified through spiked recovery experiments and actual sample detection. This study has opened up a new approach to rapid detection of pesticide residues in traditional Chinese medicinal materials used for both food and medicine. Full article