Search Results (220,289)

We report the study of Cur@HKUST-1 composites, obtained through one-pot infiltration of HKUST-1 with curcumin (Cur) as a guest-sensitizing molecule. Cur features a HOMO energy above the valence band (VB) of HKUST-1, enabling modulation of the electronic structure of the host framework by introducing additional energy states within the bandgap. Structural characterization, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA), confirmed successful guest incorporation and preservation of HKUST-1 crystallinity. An initial Cur amount of 50% (relative to the BTC linker) was added to the synthetic mixture, and differential UV-vis analysis has shown an infiltration efficiency of 28.0%, corresponding to an infiltration degree of 14% in the Cur@HKUST-1 composite, highlighting a challenging loading process, primarily due to the size and conformations of the Cur structure. Textural analysis revealed a reduction in surface area and pore volume, consistent with a high degree of guest infiltration. Optical properties evaluated by diffuse reflectance UV-vis spectroscopy revealed new absorption bands and a notable decrease of 1.83 eV in the bandgap energy from 3.68 eV (HKUST-1) to 1.85 eV (Cur@HKUST-1) due to guest molecule infiltration. Density functional theory (DFT) calculations supported the experimental findings, showing that guest HOMOs promoted the formation of a new valence band (VB), while the original VB remains lower in energy. Density-of-states analysis confirmed that the new VB originates from 2p orbitals belonging to the guest, while the conduction band remains predominantly Cu-based from the HKUST-1 framework. Photoelectrochemical characterization revealed that the guest-modified material exhibits an enhanced photocurrent response compared to HKUST-1. Cur@HKUST-1 displayed higher stability and stronger photocurrent density, attributed to its narrower bandgap and increased charge carrier density. These results demonstrate the potential of rational guest selection to engineer band structure and improve the light-harvesting performance of MOFs in solar-driven applications. Full article

Background: Micromanagement is an extensively prevalent yet relatively under-theorized management process in healthcare organizations. This narrative review synthesizes the literature on micromanagement and related leadership practices in healthcare, focusing on its antecedents, manifestations, consequences, and mitigation strategies. Methods: A structured literature search was conducted on 10 May 2024 across eight electronic databases. Eligible studies included qualitative, quantitative, mixed-methods, and applied studies published between 2003 and 2024. The main outcomes were the underlying causes and behavioral measures of micromanagement, examined directly, or closely related constructs such as excessive supervision, reduced autonomy, authoritarian leadership, toxic leadership, and controlling managerial behavior. The secondary outcomes involved organizational and patient-related effects and their respective interventions. Results: A total of twelve studies were selected. The identified antecedents of micromanagement were authoritarian leadership styles, autocratic and toxic leadership personality traits, overly intrusive supervisory practices, poor employee empowerment, complicated regulation, unclear definition of professional roles, and inherent structural challenges. Micromanagement behavior was seen in authoritative decision-making, transactional supervision, systematic reduction in employee autonomy, and institutionalized distrust. The consequences recorded include high levels of occupational stress, poor organizational productivity, poor quality of healthcare services, high employee turnover rates, and psychological problems. Conclusions: This review represents a preliminary conceptual synthesis of the literature that addresses micromanagement in healthcare. The evidence base is inconsistent, with many studies focusing on constructs that relate to micromanagement while not studying it directly. In future research, validated tools to assess micromanagement should be designed, as well as leadership interventions that benefit both workplace and patient outcomes. Full article

In the context of industrial digitalization and the widespread adoption of process automation systems, Knowledge Management Systems (KMS) play a key role in providing operational personnel with up-to-date instructions and regulations. However, the inherent ambiguity of natural language in technical documentation remains a serious obstacle, leading to incorrect operator actions, process deviations, and increased safety risks. This article investigates the integration of Large Language Models (LLMs) into KMS and its impact on user experience and human–machine interaction in industrial automation environments. A method called Semantic Latent Choice Detection is presented, designed to systematically identify interpretation ambiguities in process instructions and operator commands. Unlike existing approaches that require access to the internal model architecture (“white box”) or token-level logits, the proposed method is logit-free and operates with closed commercial LLMs (“black box”) via standard API interfaces. The method analyzes the semantic similarity of binary text blocks and polysemous terms within the context of a specific technological process. Using a metallurgical production case study, we demonstrate how the system detects hidden semantic collisions (e.g., the difference between “adding ferroalloys into the ladle” and “feeding ferroalloys onto the conveyor”) that are missed by traditional rule-based validation methods. Instead of arbitrarily selecting an interpretation, the system initiates a clarification request to the human operator, thereby reducing cognitive load, preventing erroneous automated decisions, and increasing trust in the KMS. An empirical evaluation conducted in a real-world industrial setting (unit control rooms and dispatch centers) shows a statistically significant reduction in errors related to misinterpretation of process regulations. The article contributes to the fields of automation engineering, knowledge management, and human-centered automation by proposing a novel method for validating operational instructions in high-risk industrial environments. Full article

This study investigates the relationship between economic growth, health expenditure, institutional quality, gross fixed capital formation, and foreign direct investment in EU countries outside the euro area over the period 2000–2024. The analysis is grounded in neoclassical and endogenous growth theory, with particular emphasis on the role of institutional quality as a conditioning factor in the growth process. Methodologically, this study employs an integrated empirical time-series framework focusing on selected health, institutional and investment-related determinants of growth, including linear and nonlinear unit root tests, structural break analysis, and an Autoregressive Distributed Lag/Error Correction Model (ARDL/ECM) approach to capture both long-run equilibrium relationships and short-run dynamics. ECM-based Granger causality tests are further applied to examine the direction of causal interactions. The results confirm the existence of a long-run cointegration relationship across all countries, although the magnitude and direction of the effects vary considerably. Gross fixed capital formation exerts a robust positive influence on economic growth, while foreign direct investment mainly affects growth in the short run and is highly sensitive to external shocks. Health expenditure contributes to growth through human capital formation, with predominantly lagged effects. Institutional quality is associated with growth dynamics, although the direction and strength of this relationship vary across countries and should be interpreted in light of feedback effects identified in the causality analysis. Overall, the findings highlight significant cross-country heterogeneity and underscore the importance of institutional quality in enhancing the effectiveness of investment and public spending for sustainable economic growth. Full article

Apartment floor plans have traditionally been interpreted through qualitative typological readings, but coded floor-plan datasets now enable reproducible quantitative analysis. This article examines architectural metadata from apartment units in Aurinkolahti, Helsinki, Finland, to explore typological repetition, spatial compactness, and selected indicators of domestic spatial quality. Rather than reconstructing full apartment geometries, the study treats each mapped layout as an architectural metadata record and distinguishes it from the number of built apartments represented by that layout. This stock-sensitive distinction allows repeated floor plans to be analyzed as components of housing production, not merely as individual cases. The workflow includes data cleaning, classification-coverage assessment, weighted and unweighted summaries, temporal grouping, compactness metrics, repetition indicators, kitchen-related quality markers, exploratory clustering, and statistical modeling. Results show typological concentration around a limited number of layout families and identify the 2021–2023 period as combining smaller weighted mean floor areas, higher repetition intensity, and lower kitchen natural-light shares. Coded floor-plan metadata are therefore positioned as a limited but useful intermediate form of architectural evidence: more structured than visual typological description, but not a substitute for direct plan analysis or comprehensive housing-quality assessment. Full article

Atrial fibrillation (AF) and heart failure (HF) frequently coexist and mutually worsen prognosis, creating a complex clinical scenario in which treatment decisions are increasingly imaging driven. Catheter ablation has emerged as a pivotal rhythm control strategy in selected patients with HF, but careful phenotyping of the atrial and ventricular substrate is essential to balance potential benefits against procedural risk and the likelihood of durable sinus rhythm. In this narrative review, we summarize the role of multimodality imaging across the entire AF care pathway in patients with HF, from candidate selection to intraprocedural guidance and post-ablation follow-up. Ultrasound imaging remains the cornerstone of pre-procedural assessment. Cardiac computed tomography (CCT) refines anatomical characterization of the left atrium, pulmonary veins, and left atrial appendage. Cardiovascular magnetic resonance (CMR) offers comprehensive tissue characterization of atrial and ventricular fibrosis, allowing distinction between atrial primary and atrial secondary AF phenotypes and informing expectations of reverse remodelling. During ablation, intracardiac echocardiography and transesophageal echocardiography optimize transseptal access, catheter navigation, and complication monitoring, and they are particularly relevant with contemporary Pulsed Field Ablation systems. In follow-up, echocardiography, CCT, and CMR are pivotal for quantifying structural reverse remodelling and detecting rare but life-threatening complications such as atrio esophageal fistula and pulmonary vein stenosis. An integrated, multimodality, substrate-based imaging strategy is therefore crucial to personalize rhythm versus rate control decisions and to guide safe, effective ablation in patients with AF and HF. Full article

Complex sex determination and a large genome hinder conventional spinach breeding. To address this challenge, a biotechnological approach could be used to establish a reliable protocol for somatic embryogenesis and apply genetic tools such as CRISPR. However, spinach is recalcitrant to somatic embryogenesis, with substantial inter- and intrapopulation variability in embryogenic capacity. In this study, we assessed the impact of environmental conditions during donor plant growth on the embryogenic capacity of the resulting seedlings. Seed populations, selected for differing embryogenic capacities, were sown in greenhouses at two distinct locations, and cross-pollination was only permitted between plants of the same origin. The resulting seeds were aseptically sown, and the embryogenic capacity of the seedlings’ root apices was determined. Root explants from seedlings originating from Ukraine and Poland showed low regenerative capacity regardless of cultivation locality, with a maximum of 22.71% regenerating explants and 1.3 somatic embryos per explant. Conversely, seedlings originating from Slovenia exhibited high regeneration potential, with significant differences between cultivation localities: 89.36% vs. 59.72% regenerating explants and 12.04 vs. 3.77 somatic embryos per explant. Therefore, the embryogenic capacity in spinach is strongly influenced by environmental conditions during donor plant growth and could be further increased by manipulating these factors. Full article

The Sustainable Development Goals (SDGs) are widely presented as an integrated framework for social, economic, and environmental progress, yet recent assessments indicate substantial implementation shortfalls. This scoping review maps post-2015 scholarship on one of the framework’s most contested fault lines: the relationship between Goal 8 (economic growth) and the ecologically oriented goals, especially Goals 6, 12, 13, 14, and 15. Following established scoping review guidance, 32 sources published between 2015 and 2026 were identified from Scopus, Web of Science, Google Scholar, citation searching, and selected grey literature. The synthesis indicates four main patterns in the included corpus. First, a substantial share of the reviewed literature characterizes continued growth-centred development and ecological sustainability as difficult to reconcile under current technological and institutional conditions, particularly given evidence on material throughput, emissions, and planetary boundaries. Second, the corpus recurrently describes three mechanisms through which this tension is muted within the SDG architecture: the rhetorical absorption of ecological limits into “green growth” discourse, strategic vagueness in targets and indicators, and the marginalization of alternative development ontologies. Third, the review synthesizes these mechanisms under the interpretive concept of paradigmatic stacking. Fourth, the corpus identifies alternative resources for a successor framework, including relational and plural conceptions of well-being associated in the reviewed literature with Ubuntu, Buen Vivir, and Gross National Happiness. Taken together, the findings suggest that debates about SDG underperformance cannot be reduced to implementation alone but also involve questions of conceptual design. The article concludes by outlining ontological pluralism as a possible direction for post-2030 framework design. Full article

Lipomyelomeningocele (LMMC) is one of the most common forms of occult spinal dysraphism, with an estimated incidence of 3–6 per 100,000 live births, and microsurgical untethering remains the cornerstone of management for symptomatic and selected at-risk children. The operation is technically demanding: reported rates of long-term symptomatic re-tethering after partial resection still reach 15–25%, and the surgeon must balance adequate untethering against preservation of the placode and lumbosacral nerve roots. In this technical note, we present a stepwise, illustrated description of our institutional 14-step microsurgical technique for pediatric LMMC. Each step is anchored to a defined anatomical landmark, beginning with a midline skin incision planned away from the anal verge and proceeding through subtotal subcutaneous lipoma resection, identification of the dural penetration site, a limited rostral laminectomy over normal anatomy, dural opening with circumferential dissection of lipoma–dura–cord adhesions, exploitation of the arachnoid–dura plane, electrophysiologically guided debulking of the intradural lipoma, stimulation-controlled division of the fatty filum, pia-to-pia reconstruction of the placode with 8-0 monofilament suture, expansile duraplasty with an artificial dural substitute, and reinforced multilayered watertight closure. Technical pearls aimed at minimizing the risks of cord injury, cerebrospinal fluid leak, and postoperative re-tethering are highlighted at each stage, and the role of multimodal intraoperative neurophysiological monitoring is emphasized. This note is intended as a practical, image-anchored operative reference for pediatric neurosurgeons and trainees managing this challenging closed neural tube defect. Full article

Background: The incremental value of iodine-125 (I-125) seed implantation in advanced refractory lung squamous cell carcinoma (LUSC) with hemoptysis treated with bronchial artery chemoembolization (BACE) and immunotherapy remains unclear. Methods: This retrospective cohort study included 90 patients treated between June 2023 and June 2025. Patients receiving BACE plus immunotherapy were classified according to whether I-125 seed implantation was performed within 7 days after BACE: G1, BACE plus immunotherapy (n = 42), and G2, BACE, I-125 seed implantation, and immunotherapy (n = 48). Inverse probability of treatment weighting (IPTW) served as the primary adjustment method. Results: After IPTW, baseline covariates were well balanced; propensity score matching yielded 26 patients per group. Compared with G1, G2 was associated with longer hemoptysis-free survival (not reached vs. 11 months; HR = 0.34, 95% CI 0.18–0.64, p < 0.05), overall survival (19 vs. 14 months; HR = 0.26, 95% CI 0.15–0.44, p < 0.05), and progression-free survival (12 vs. 9 months; HR = 0.34, 95% CI 0.21–0.56, p < 0.05). The 6-month objective response rate (ORR) and disease control rate (DCR) were higher in G2, whereas no significant difference in 24-h hemostasis or recorded grade 3 or higher adverse events was observed. Conclusions: Adding I-125 seed implantation to BACE plus immunotherapy was associated with improved outcomes in selected patients, and prospective validation is warranted. Full article

In this study, an exploratory transcriptomic investigation was conducted to evaluate the feasibility of using feather transcriptomics to detect sex differences and gene responses to physiological changes in chickens. Feathers represent a promising non-invasive biological source of RNA, as the feather pulp of growing feathers contains living cells capable of active transcription. Growing feathers were collected from 150-day-old male and female chickens (Bionda Piemontese, a slow-growing breed) raised under a free-range system and fed two finisher diets differing in lipid content: low-lipid (LL, ether extract 3.6%) and high-lipid (HL, ether extract 9.3%) diets. RNA was extracted from feather pulp, and 12 pools were subjected to whole RNA-Seq analysis. The study was designed as 2 × 2 factorial experiments investigating the effects of diet and sex on gene expression. A total of 17,360 transcripts were detected and used for downstream analyses. Differential gene expression and functional enrichment analyses were performed. The main effects of diet and sex were estimated with an additive design using the DEseq2 package, while for the sex-specific diet analyses, subgroup comparisons were conducted on the RaNA-Seq platform. The analysis of the main effect of diet reveals that three genes associated with ether lipid metabolism (PLA2G10, PLA2G4F, and ENPP6) were upregulated in chickens fed the HL diet. In roosters, HL feeding significantly altered the expression of APOA1 and SLC27A4, suggesting an effect on lipid transport and metabolic regulation within the PPAR signaling pathway. In contrast, hens showed differential expression primarily in pathways related to apelin signaling, extracellular matrix remodeling, and cardiovascular function, rather than classical lipid metabolism pathways; additionally, gene set enrichment analysis indicated a limited enrichment of linoleic acid metabolism, suggesting secondary involvement of lipid metabolic processes. These findings are consistent with those in the literature reporting sex-related differences between males and females. The results further suggest that transcriptomic responses to dietary lipid supplementation can be investigated through the expression of selected candidate genes in feather pulp. Among the genes identified, PLA2G10, PLA2G4F, ENPP6, APOA1, and SLC27A4 emerged as potential molecular markers associated with dietary treatment, and the importance of sex-dependent transcriptional responses was highlighted. In conclusion, this study demonstrates the potential of feather pulp as a viable source of RNA for transcriptomic analyses in live chickens, providing a minimally invasive alternative to conventional tissue sampling. These preliminary results also support the hypothesis that feathers represent a practical and ethically favorable tissue for future nutrigenomic and genetic improvement studies, ultimately supporting more sustainable poultry production. Full article

Cytoreductive surgery remains one of the key treatment modalities in advanced ovarian cancer. Complete cytoreduction is the main surgical goal. PARP inhibitors are currently established mainly as maintenance therapy after response to platinum-based chemotherapy, particularly in patients with BRCA-mutated or homologous recombination-deficient tumors. Their use before cytoreductive surgery remains investigational. This review evaluates preoperative PARP inhibition from a surgical perspective. This narrative review summarizes current evidence, ongoing clinical trials, and perioperative considerations related to preoperative or neoadjuvant PARP inhibitor strategies in advanced ovarian cancer. Particular attention was given to the review of current clinical trials’ strategies, resectability, complete cytoreduction, patient selection, perioperative safety, treatment timing, and surgery-specific endpoints. Current studies explore several preoperative approaches, including short window-of-opportunity treatment before primary debulking surgery, PARP inhibitor monotherapy as potential conversion therapy in homologous recombination-deficient disease, PARP inhibitor-based strategies before interval debulking surgery, combination regimens with immunotherapy or antiangiogenic therapy, and preoperative PARP inhibitor use before secondary cytoreduction in recurrent disease. These studies suggest that preoperative PARP inhibition may provide biological and surgical insights, but available evidence remains preliminary. Key concerns include hematologic toxicity, surgical postponement, perioperative complications, wound healing, postoperative recovery, and the risk of delaying standard chemotherapy or surgery. Preoperative PARP inhibitor therapy is theoretically promising but an unproven strategy in ovarian cancer. Its future value will depend on prospective trials showing that it can safely improve resectability and complete cytoreduction without compromising treatment timing. Future studies should include surgery-specific endpoints in addition to conventional oncologic outcomes. Full article

Electrochemical impedance spectroscopy (EIS) is a powerful, non-destructive tool for evaluating ion-selective electrode (ISE) membrane condition. This work investigated EIS for identifying degradation mechanisms in all-solid-state Pb²⁺-selective electrodes. Graphene-containing PVC membranes deposited on glassy carbon electrodes were exposed to synthetic urine, river water, and seawater (24 h and 1 week) and to mechanical damage (cutting, needle puncture, or both). Degradation was assessed using EIS, potentiometric measurements, contact-angle analysis, profilometry, and SEM. River water and urine exposure decreased hydrophobicity, increased roughness, and produced fouling deposits. Seawater caused only minor morphological and wettability changes, though impedance data showed increased membrane hydration due to high ionic strength. Mechanical damage substantially disrupted membrane integrity, causing pronounced impedance changes, increased potential drift, and reduced analytical performance. Fouling and mechanical damage produced distinct electrochemical signatures: fouling mainly affected surface properties, while mechanical damage altered the membrane–transducer interface, increasing capacitance and reducing resistance. Notably, needle-punctured electrodes retained a near-Nernstian response despite clear impedance changes and reduced long-term stability, showing that EIS detects defects invisible to conventional calibration. These results confirm EIS as a sensitive method for distinguishing fouling from physical damage, useful for early degradation detection and lifetime monitoring of all-solid-state ISEs. Full article

Background/Objectives: Cervical spinal cord injury (SCI) carries a significant burden in Saudi Arabia, frequently resulting in permanent ventilator dependence and high morbidity. While laparoscopic diaphragmatic pacing (DP) has emerged as an alternative to long-term mechanical ventilation (MV) globally, regional evidence regarding its application within the Middle East remains limited. This study evaluates a single-center cohort of ventilator-dependent cervical SCI patients undergoing laparoscopic DP. Methods: We conducted a retrospective analysis of all ventilator-dependent patients with cervical SCI admitted to a tertiary hospital in Riyadh between 2012 and 2024 who underwent laparoscopic DP after failing traditional weaning attempts. Inclusion criteria required at least 3 months of MV dependence, intraoperative diaphragmatic stimulability and a minimum one-year follow-up post-implantation. Across the entire cohort, the long-term follow-up duration reached a median of 60.0 months (interquartile range [IQR]: 36.0–84.0 months; range: 12.0–120.0 months). Results: Out of 30 initial candidates with cervical SCI, 28 patients (22 males, 6 females; median age 24.0 years (interquartile range [IQR]: 15.0–33.0 years)) were included. Patients had been on MV for a median of 13.0 months (IQR: 10.5–16.0 months) prior to the procedure. Utilizing a combined weaning success rate (complete or partial weaning), 26 patients (92.86%; 95% CI: 77.42–98.01%) were successfully transitioned to the pacing protocol, while 2 patients (7.14%) experienced DP failure. Complete (24 h) daily MV independence was achieved by 18 patients (64.29%), and partial weaning (≥4 h/day of MV-free time) was achieved by 8 patients (28.57%). Age at the time of injury ranged from 5 to 62 years. No major intraoperative or postoperative complications occurred. Minor exit-site skin irritation was observed in 3 patients (10.71%), all of which resolved completely with conservative local care alone without requiring antibiotic therapy. Conclusions: In this selected single-center Saudi cohort of ventilator-dependent cervical SCI patients, laparoscopic DP was feasible and was associated with high rates of partial or complete ventilator-free breathing. Larger prospective multicenter studies with standardized selection criteria, safety reporting, respiratory outcomes, quality-of-life measures, and longer follow-up are needed. Full article

Introduction: Nicotine dependence is a chronic disorder with both psychological and somatic components which, in the intensive care unit (ICU) setting, may affect the course of treatment through mechanisms related both to long-term nicotine exposure and to the consequences of its abrupt cessation. The aim was to collect and map the current knowledge on smoking-related complications, the prevalence of nicotine withdrawal symptoms in this group, and to identify and describe interventions used to prevent or alleviate nicotine withdrawal symptoms in patients hospitalised in the ICU. Methods: The review included sources retrieved from databases such as PubMed, CINAHL, Scopus, Web of Science, and the Cochrane Library, published in English, that met the PCC criteria, with no time restrictions. Results: Forty-four sources were included. Twenty-nine contributed evidence on smoking-related status as an exposure or associated factor, five explicitly focused on abrupt nicotine cessation or nicotine withdrawal syndrome, and fifteen addressed interventions; categories overlapped. Delirium was the most frequently investigated outcome in smoking-related exposure studies. Withdrawal-focused sources reported or discussed nonspecific manifestations, including agitation, restlessness, anxiety, craving, and delirium-like presentations, but no validated ICU-specific diagnostic approach or robust prevalence estimate was identified. NRT was the only intervention evaluated. Conclusions: Smoking-related status was associated with agitation and delirium in several observational studies; however, heterogeneous exposure definitions and inconsistent evidence syntheses preclude causal or general prognostic conclusions. Evidence specific to nicotine withdrawal syndrome was limited, and the effectiveness and safety of NRT remain uncertain. Implications for clinical practice included routine identification of nicotine dependence at ICU admission, early monitoring of withdrawal symptoms, individualisation of sedation management, careful and selective consideration of nicotine replacement therapy (NRT), education of the therapeutic team, planning of further care, and smoking cessation interventions. Full article