Search Results (5,654)

A universal approach to managing a person’s digital identity may be the single most important advancement to the Internet since its inception, promising the seamless flow of information, averting cybercrime, eliminating login credentials, and restoring privacy and trust through greater control of one’s identity online. However, this advancement brings significant risks, especially regarding personal privacy. It demands the meticulous development of digital identity infrastructure that balances robust data security measures with ethical handling of sensitive information, thereby safeguarding against misuse and unauthorised access. Currently, a consolidated vision for digital identity implementation remains unresolved, and aligning the different stakeholders’ motives and expectations is a challenging task. This article reviews and analyses the perspectives and expectations of four key stakeholder groups—government, business, academia, and consumers—regarding a digital identity ecosystem, aiming to increase trust in an eventual design framework. Using an online survey stratified across government, business, academia, and consumers, we identify areas of alignment and divergence regarding privacy, trust, usability, and governance expectations. We then encode these stakeholder expectations into a layered conceptual structure and illustrate its use as metadata for context-layered retrieval-augmented generation (RAG) in digital identity scenarios. Full article

Financialisation has an increasing influence on the functioning of non-financial enterprises. It is therefore important to examine whether and to what extent food sector enterprises are subject to the process of financialisation. The research objective was to determine the level of financialisation of food industry enterprises in Poland in relation to the whole industry sector. To achieve this objective, the following research hypothesis was formulated: the process of financialisation of food industry enterprises proceeds similarly to the analogous process undergoing in industrial enterprises but varies across different sectors of the food industry. The research was conducted on the basis of statistical data from Statistics Poland (SP) published in various statistical studies. Financial data from 2010 to 2023 were analysed. For this purpose, research tools used in the paper are referred to in the literature as measures of the level of financialisation, so-called balance sheet indicators. The main limitation of the research is that the results can only be applied to countries with similar economic conditions, especially post-communist countries, and that balance sheet indicators are used to measure financialisation, which, although widely used, are limited in their effectiveness because they focus only on balance sheet data. The results support the research hypothesis. The companies in the analysed industries are characterised by a low level of financialisation. The process of financialisation of food industry companies is similar to the one in industrial companies and is more intense in beverage production than in other food industry sectors. There is room for a sustainable financing policy. The results indicate that there is room for higher financing of food industry enterprises in Poland, but excessive financing may lead to excessive concentration and monopolisation of enterprises and even to speculation on agricultural markets. To maintain financial stability, it will be important to pursue a stable monetary policy, limit the risk of food price volatility, improve communication and coordination in international monetary policy, and increase national food self-sufficiency. This study fills a research gap in understanding the process of financialisation, assessing its degree of advancement and diversity in the main sectors of food processing enterprises. Full article

Fund similarity is important for investors when constructing diversified portfolios. Because mutual funds do not always adhere closely to their stated investment policies, investors may unintentionally hold funds with overlapping exposures, leading to reduced diversification and instead causing “diworsification”, which is an investment term for when too much complexity leads to worse results. As a result, various quantitative methods have been proposed in the literature to investigate fund similarity, primarily using portfolio holdings. Recently, machine learning tools such as clustering and graph theory have been introduced to capture fund similarity. This paper builds on this literature by applying bipartite graphs and node2vec embeddings to a comprehensive dataset that covers 3874 funds over a nearly 6-year period. Our empirical evidence suggests that, bipartiteness is not preserved for non-index (active) funds. Furthermore, while graph embeddings yield higher similarity scores than holding-based measures, they do not necessarily outperform holding-based similarity in explaining returns. These findings suggest that graph-based embeddings capture structural relationships among funds that are distinct from direct portfolio overlap but are not sufficient substitutes when similarity is evaluated solely through returns. As a result, we recommend a more comprehensive similarity measure that includes important risk metrics such as volatility risk, liquidity risk, and systemic risk. Full article

The complement system is a key component of innate immunity, responsible for mediating the rapid clearance of pathogens and coordinating adaptive immune responses. Although complement activation is essential for effective infection control and prevention, its excessive or dysregulated function contributes to the pathogenesis of various immune-mediated disorders. Therefore, therapeutic inhibition of the overactive complement cascade, in which specific components are selectively blocked to suppress pathological activation, plays an important role in the treatment of various complement (immune)-mediated diseases. This article provides an overview of complement inhibition as a therapeutic strategy, highlighting the infectious risks associated with its use. Disruption of complement-dependent host defence mechanisms increases the risk of invasive infections (caused by encapsulated pathogens, e.g., Neisseria spp., Streptococcus pneumoniae and Haemophilus influenzae type B), which represent a significant clinical challenge. Therefore, the use of complement inhibition should not only be effective but also safe in combination with the application of all possible tools to prevent infections. Strategies, such as vaccination and antibiotic prophylaxis, are crucial to minimise these complications, despite the persistence of the risk of breakthrough infections. Furthermore, this review examines advancements in patient risk stratification, evaluates alternative preventive measures, and identifies key gaps in current clinical practice. Future directions include improving monitoring protocols, creating more selective or locally acting complement inhibitors, and implementing biomarker-driven personalised therapies that maximise benefits while reducing side effects. Full article

Regenerative hardfacing of steel substrates is an important technology for restoring the surface layer of components operating under wear conditions, supporting the goals of the circular economy (CE) by extending the service life of components, reducing material and energy consumption throughout their life cycle, and shortening downtime during machine repairs. The article provides a synthetic analysis of the literature on the production of functional layers exclusively on steels and systematizes process → structure → properties (PSP) relationships in the context of technological quality and the prediction of the functional properties of welds. The review covers methods used and developed in steel hardfacing (including arc processes and variants with increased energy concentration), analyzed on the basis of measurable process indicators: energy parameters (arc energy/heat input/volume energy), dilution, bead geometry, heat-affected zone characteristics, and the risk of welding defects. It has been shown that these factors determine the structural effects in the weld and the area at the fusion boundary (including phase composition and morphology, hardness gradient, and susceptibility to cracking), which translates into functional properties (hardness, wear resistance, adhesion, and fatigue life) and durability after regeneration. The main result of the work is the development of a PSP table dedicated to hardfacing on steel substrates, mapping the key “levers” of the process to structural consequences and trends in functional properties. This facilitates the identification of optimization directions (minimization of energy input and dilution while ensuring fusion continuity), which translates into longer durability after regeneration and a lower risk of defects—key, measurable effects of CE. Research gaps have also been identified regarding the comparability of results (standardization of energy metrics) and the need to determine and verify “technology windows” within the WPS/WPQR (welding procedure specification/welding procedure qualification record) for layers deposited on steels. Full article

Background/Objectives: Healthcare workers at the frontline of managing pandemics are at increased risk for adverse physical and mental health outcomes, which has been shown to result in burnout. The relationship between personal resilience and burnout among clinical and non-clinical healthcare staff working in an acute care setting was assessed at the start of the COVID-19 pandemic. Methods: A prospective cross-sectional survey design with electronic questionnaires was used to measure resilience (Connor-Davidson Resilience Scale,) and burnout (Maslach Burnout Inventory—Human Services Survey). Linear regression analyses were conducted to examine the relationship between resilience and emotional exhaustion, depersonalization, and personal accomplishment. Results: A significant inverse relationship between resilience and both emotional exhaustion and depersonalization, and a positive relationship between resilience and personal accomplishment were identified. Higher resilience scores were significantly associated with lower emotional exhaustion and depersonalization and higher personal accomplishment under pandemic conditions. Conclusions: Strategies to boost resilience organization-wide amongst healthcare staff providing patient care are critical for providing skills to reduce the onset of burnout and support employee mental health. From a pandemic preparedness lens, organizational-level emergency management should consider the importance of resilience-building among staff to proactively prevent burnout and its subsequent effects on patient-care and general hospital functioning. Full article

Background: Cigarette smoking remains one of the most important preventable causes of respiratory morbidity, exerting detrimental effects even in young adults. Medical students represent a particularly relevant population, as the lifestyle habits they adopt during their training years may influence both their personal health and professional credibility. Methods: We conducted a cross-sectional analysis of 264 medical students from the University of Medicine, Pharmacology, Science and Technology of Târgu-Mures, aged 18–30 years, stratified according to smoking status, type of tobacco product used, and lifestyle characteristics (athletic vs. sedentary). Standardized spirometry was performed to assess FVC, FEV₁, FEV₁/FVC ratio, PEF, and small airway flow parameters (MEF₂₅, MEF₅₀, MEF₇₅). Statistical comparisons between groups were performed using t-tests, Mann–Whitney U tests, chi-square tests, and correlation analyses, with p < 0.05 considered statistically significant. Results: Smokers demonstrated significantly lower values for FEV₁, PEF, and MEF parameters compared with non-smokers, confirming early functional impairment of both large and small airways. Within the smoking group, users of e-cigarettes or heated tobacco products exhibited more favorable FEV₁ and small airway flow values than conventional cigarette smokers. However, differences in FVC were less pronounced. Significantly, athletes consistently outperformed their sedentary peers across all respiratory parameters, regardless of smoking status, with markedly higher FEV₁, FVC, and MEF values and a lower prevalence of obstructive patterns. Cumulative smoking exposure (pack-years) was inversely associated with small airway function, whereas higher levels of physical activity were independently linked to a pronounced protective effect. Conclusions: Even in early adulthood, smoking is related to measurable declines in lung function, particularly affecting small airway dynamics. Although alternative products may appear less harmful than conventional cigarettes, they cannot be considered risk-free. Conversely, regular physical activity demonstrated a protective association in the case–control analysis, attenuating functional decline and supporting the preservation of long-term respiratory health. These findings underscore the importance of integrated prevention strategies in medical universities, combining smoking cessation initiatives with the systematic promotion of physical activity to safeguard the health of future physicians and reinforce their role as credible health advocates. Full article

Galba truncatula acts as an intermediate host for several parasitic flukes of veterinary importance, but a targeted study on its spatial presence as well as the impact of environmental factors in Southeastern Europe has not been conducted. During the summer months of 2017 and 2018, a survey of 191 water bodies in 14 districts in Central, Southern and Western Bulgaria was conducted, with a focus on animal drinking fountains. Each site was assessed for snail presence and characterized by altitude, temperature, precipitation, shade and type of water body. Logistic regression modeling was used to identify the important factors related to the occurrence of snail species. The frequency of habitats found was 29.3%, with no differences observed between the studied districts (p > 0.05). Snails were present across a wide range of altitudes (78–1926 m), annual mean temperature (7.8–14.0 °C) and annual mean precipitation (523–796 mm). The high habitat frequencies were recorded in streams (60.0%) and on the banks on small rivers (50.0%). The presence of snails in the two studied types of fountains (without or with a concrete platform) was 24.1% and 17.2%, respectively, with no significant difference between them (p > 0.05). Regression analysis revealed temperature, shade, and type of water body as factors that could significantly influence the spatial presence of G. truncatula. The findings demonstrate the ecological adaptability of G. truncatula and highlight its presence in habitats with high potential for contact with domestic and wild ruminants. This information fills a regional knowledge gap and can support risk assessment and control measures for fluke-borne diseases in livestock and wildlife. Full article

Transanal Irrigation (TAI) and Colon Hydrotherapy (CHT) represent emerging therapeutic options that may complement first-line interventions or serve as rescue treatments for chronic constipation and fecal incontinence. Their clinical utility depends on patient characteristics, specific therapeutic goals, device features, and probe type, as well as the procedural setting. This review presents the various pathophysiological contexts in which these techniques can be applied, analyzing their specific characteristics and potential pros and cons. Moreover, these interventions are also considered within a Psycho-Neuro-Endocrino-Immunological (PNEI) framework, given the potential influence of intestinal function and microbiota modulation on the bidirectional communication pathways linking the enteric nervous system, neuroendocrine regulation, immune activity, and global patient well-being. Since there is not yet enough scientific data on this topic, future research should prioritize randomized controlled trials comparing these techniques with other standard treatments (e.g., laxatives or dietary fiber) in defined patient populations. Longitudinal studies will also be essential to clarify long-term safety, potential effects on microbiota, and both risks and benefits. Standardization of technical procedures also remains a critical need, especially regarding professional competencies, operating parameters (e.g., instilled volumes and pressure ranges), and reproducible protocols. Moreover, future investigations should incorporate objective outcome measures, as colonic transit time, stool form and frequency, indices of inflammation or intestinal wall integrity, and changes to microbiome composition. In conclusion, TAI and CHT have the potential to serve as important interventions for the treatment and prevention of chronic constipation and intestinal dysbiosis, as well as their broader systemic correlates, in the setting of bio-integrated medicine. Full article

Active music and movement engagement has been widely integrated in human socialization across history and cultures, and is particularly prevalent in early childhood play and learning. For clinical populations, music therapy is known to support social skills and wellbeing for young children. However, there is less evidence for the value of active music engagement for non-clinical populations in terms of supporting social and behavioral wellbeing in the early years. This study reports results from the Rhythm and Movement for Self-Regulation (RAMSR) program delivered by generalist kindergarten teachers in low socioeconomic communities. This randomized control trial involved 213 children across eight preschools in disadvantaged communities in Queensland, Australia. The intervention group received 16 to 20 sessions of RAMSR over eight weeks, while the control group undertook usual preschool programs. Data was collected through teacher report at pre and post intervention, and again six months later once children had transitioned into their first year of school. Robust mixed models accounting for repeated measures and clustering of children within kindergartens (random effects), evidenced significant intervention effects across the three time points for improved prosocial skills (p = 0.04, n_p² = 0.02), and reduced externalizing (p < 0.01, n_p² = 0.03) and internalizing behavior problems (p = 0.04; n_p² = 0.02), with small to moderate effect sizes. These findings highlight the valuable role that intentional active music engagement in universal settings such as preschool can play in terms of social and behavioral wellbeing. The importance of these results lies in the fact that children from lower socioeconomic backgrounds are more likely to experience risks to social and behavioral development, requiring additional supports, yet experience inequities in access to high-quality music and movement programs. Full article

In fixed orthodontic treatment, brackets are orthodontic attachments bonded to the tooth enamel, and their placement and removal may affect the underlying enamel surface. Enamel degradation is a critical factor for oral health, as it reduces the mechanical strength of teeth and increases susceptibility to caries and erosion. Accurate diagnosis of enamel changes is therefore essential for the evaluation of preventive and restorative treatments. In this study, enamel degradation was investigated via two integrated methods: energy-dispersive X-ray spectroscopy (EDS) and surface roughness measurement. The experimental protocol was performed in three stages: before bracket bonding, after bracket removal, and after applying a remineralization treatment. The experimental design included a repeated-measures structure, with stage (baseline, post-debonding, post-remineralization) as the within-tooth factor and bracket type (sapphire vs. metallic) as the between-tooth factor. Given the violation of the variance homogeneity assumption, group comparisons were ultimately performed using Welch ANOVA followed by Games–Howell post hoc tests, with Bonferroni-adjusted values used for pairwise comparisons. The presence of orthodontic brackets can influence enamel mineralization because the bonding and debonding procedures modify the enamel surface microtopography. These procedures can generate microcracks and surface irregularities, which may affect mineral exchange between enamel and the surrounding environment. In our study, bracket removal led to a significant decrease in the mean atomic percentages of Ca (from 32.65% to 16.37% for sapphire) and P (from 16.35% to 8.60% for sapphire), accompanied by a sharp increase in surface roughness. After remineralization, Ca and P levels increased, while roughness decreased. However, neither the mineral content nor the surface topography fully returned to the initial values, indicating that remineralization achieved only a partial recovery of enamel integrity. These findings highlight that the integrated EDS approach and roughness analysis offer a promising descriptive framework for assessing enamel degradation and monitoring the effectiveness of remineralization therapies. The generated mathematical model provides a powerful descriptive framework for the in vitro data obtained, correlating roughness with mineral composition and treatment stage. However, such a high goodness-of-fit (R² > 0.98) should be interpreted cautiously due to the risk of overfitting. Therefore, rigorous external validation is mandatory before this model can be considered a reliable predictive tool. It also highlights the importance of enamel remineralization therapies after orthodontic treatment, but also the importance of choosing personalized treatment strategies adapted to the enamel type. Full article

Objectives: Ex vivo confocal laser scanning microscopy (EVCM) is a pioneering diagnostic method that enables fresh tissue samples to be analyzed directly during surgery. For the assessment of non-melanocytic skin cancer (NMSC), including cutaneous squamous cell carcinoma (cSCC), it provides a rapid addition to conventional histology. While previous studies have shown that EVCM reliably identifies the morphological features of cSCCs, quantitative criteria such as tumor thickness have not yet been systematically evaluated. This study investigated whether EVCM can be used to accurately and reproducibly measure the thickness of cSCCs, an important parameter for predicting metastatic risk. Methods: Eighty-two histologically verified cSCCs from different anatomical sites were assessed by the current gold standard of histopathology and EVCM. A statistical comparison of the confocal tumor thickness (CTT) and the histopathological tumor thickness (HTT) was then performed. In addition, it was analyzed how reliable EVCM was in the assignment of cSCCs to the correct tumor thickness category. Results: There was a very high agreement between both methods, evidenced by a Spearman correlation coefficient of 0.94 and a coefficient of determination of 0.859. Overall, 95.1% of the samples were correctly classified into the appropriate tumor thickness category using EVCM. Cohen’s Kappa of 0.90 indicated almost perfect agreement between EVCM and histology. Conclusions: These findings demonstrate that EVCM is a precise and reliable method for determining tumor thickness and the corresponding category in cSCCs. It enables immediate intraoperative assessment of the metastatic risk and preliminary classification of low-risk tumors. Additional studies with larger patient cohorts are required to further validate these results and support clinical implementation. Full article

This study addresses the challenge of evaluating artificial intelligence (AI) systems across heterogeneous regulatory frameworks. Although the NIST AI RMF, EU AI Act, and ISO/IEC 23894/42001 define important governance requirements, they do not provide a unified quantitative method. To bridge this gap, we propose the Cross-Assessment & Verification for Evaluation (CAVe) Framework, which maps shared regulatory requirements to four measurable indicators—accuracy, robustness, privacy, and fairness— and aggregates them into a Cross-Compliance Index (CCI) using normalization, thresholding, evidence penalties, and cross-framework weighting. Two validation scenarios demonstrate the applicability of the approach. The first scenario evaluates a Naïve Bayes-based spam classifier trained on the public UCI SMS Spam Collection dataset, representing a low-risk text-classification setting. The model achieved accuracy 0.9850, robustness 0.9945, fairness 0.9908, and privacy 0.9922, resulting in a CCI of 0.9741 (Pass). The second scenario examines a high-risk healthcare AI system using a CheXNet-style convolutional model evaluated on the MIMIC-CXR dataset. Diagnostic accuracy, distribution-shift robustness, group fairness (finding-specific group comparison), and privacy risk (membership-inference susceptibility) yielded 0.7680, 0.7974, 0.9070, and 0.7500 respectively. Under healthcare-oriented weighting and safety thresholds, the CCI was 0.5046 (Fail). These results show how identical evaluation principles produce different compliance outcomes depending on domain risk and regulatory priorities. Overall, CAVe provides a transparent, reproducible mechanism for aligning technical performance with regulatory expectations across diverse domains. Additional metric definitions and parameter settings are provided in the manuscript to support reproducibility, and future extensions will incorporate higher-level indicators such as transparency and human oversight. Full article

Ready-to-eat (RTE) sandwiches are consumed globally due to their convenience, availability, and affordability. Sandwich processing practices and their ingredients expose the sandwiches to various sources of contamination, which can enhance their microbial diversity and introduce certain pathogenic and spoilage bacteria, thereby affecting their safety and quality. Sandwiches may not receive safe cooking temperatures sufficient to destroy food poisoning bacteria, as they are often cooked and served quickly to meet high consumer demand. Improper storage temperatures can enhance microbial growth, and frequent improper handling makes this food a good vehicle for various pathogens such as Escherichia coli, Listeria monocytogenes, Salmonella spp., Staphylococcus aureus, and norovirus. Many pathogenic sandwich-associated bacteria, such as L. monocytogenes, showed resistance to clinically important antibiotics. Sandwich microbiota have been investigated; however, their diversity, antimicrobial resistance, and importance to sandwich safety and quality have been rarely reviewed. Therefore, this review elucidates the diversity of sandwich microbiota as an impact of ingredients, handling practices, and storage, with emphasis on the importance of this diversity on sandwich safety and quality. It also discusses strategies, control measures, and recommendations to reduce the risk of contamination of sandwiches with pathogenic bacteria or their antibiotic resistance genes, thereby safeguarding public health. Full article

Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus (DM), leading to sensory loss, balance disturbances, and an increased risk of ulcers and amputations. Early screening is crucial, and devices for measuring vibration perception threshold (VPT) play an important role in the timely detection and management of this condition. Objective: The aim of this systematic review was to evaluate the diagnostic accuracy and reliability of VPT measurement devices in individuals with DM. Methods: A systematic search was conducted in four databases, including studies that assessed the diagnostic accuracy and reliability of VPT measurement devices in patients with type 1 or type 2 DM, with VPT compared against reference standards for DPN, including nerve conduction studies (NCS) and clinical diagnosis. Cross-sectional and case–control studies were included. Risk of bias was assessed using the Quality Appraisal of Reliability (QAREL) tool and the JBI Critical Appraisal Checklist for Diagnostic Test Accuracy Studies. Results: Eighteen studies were analyzed. Most studies demonstrated moderate sensitivity and specificity and an acceptable level of reliability, with results varying according to technical and methodological factors. Conclusions: VPT measurement devices appear to be useful screening tools for detecting DPN; however, their diagnostic accuracy and reliability are not uniform and largely depend on technical and methodological factors. Standardized threshold values and measurement procedures, along with further research comparing the effectiveness of different protocols, are needed to improve clinical utility. Full article