Search Results (143)

Background/Objectives: Huntington’s disease (HD) is a neurodegenerative disorder involving the basal ganglia and is characterized by psychiatric, cognitive, and movement dysfunction, including gait and balance impairment. Given the limited efficacy of pharmacological treatments for HD motor symptoms, nonpharmacological approaches like rhythmic auditory stimulation are being explored. This study aims to describe walking performance in people with HD during rhythmic auditory stimulation using external musical cues and internal singing cues. Methods: Individuals in the manifest stage of HD performed walking in four conditions: (1) comfortable pace, (2) cognitive dual task, (3) musical cue (music was played aloud), and (4) singing cue (participants sang aloud). Sensors measured cadence, velocity, stride length, and variability. Relationships between change in cadence and motor and cognitive measures were explored. Results: While no direct measurements of synchronization were performed, limiting our interpretation, neither the external musical cue nor the singing cue significantly improved walking performance. Both cues increased variability, similar to what was observed during the dual task. Greater subjective balance confidence and better cognitive performance were associated with positive cadence change during cueing. Conclusions: Musical cues may be too cognitively demanding for individuals with Huntington’s disease as they worsen gait variability without increasing gait speed, cadence, or stride length. Although global cognition and perceived balance confidence were related to the ability to increase cadence, very few people were able to increase their cadence during either cue. Therefore, the results do not support the use of musical cues to improve gait for individuals with Huntington’s disease. Full article

Freezing of gait (FoG) impairs mobility and daily functioning and increases the risk of falls, leading to a reduced quality of life (QoL) in people with Parkinson’s disease (PD). The Cue2walk, a wearable smart cueing device, can detect FoG and hereupon provides rhythmic cues to help people with PD manage FoG in daily life. This study investigated the user experiences and device usage of the Cue2walk, and its impact on health-related QoL, FoG and daily activities. Twenty-five users of the Cue2walk were invited to fill out an online survey, which included a modified version of the EQ-5D-5L, tailored to the use of the Cue2walk, and its scale for health-related QoL, three FoG-related questions, and a question about customer satisfaction. Sixteen users of the Cue2walk completed the survey. Average device usage per day was 9 h (SD 4). Health-related QoL significantly increased from 5.2/10 (SD 1.3) to 6.2/10 (SD 1.3) (p = 0.005), with a large effect size (Cohen’s d = 0.83). A total of 13/16 respondents reported a positive effect on FoG duration, 12/16 on falls, and 10/16 on daily activities and self-confidence. Customer satisfaction was 7.8/10 (SD 1.7). This pilot study showed that Cue2walk usage per day is high and that 15/16 respondents experienced a variety of positive effects since using the device. To validate these findings, future studies should include a larger sample size and a more extensive set of questionnaires and physical measurements monitored over time. Full article

Objective: Retained primitive reflexes are associated with delayed motor and behavioral development in children with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). This study examined the effects of a 12-week structured exercise intervention on reflex integration, motor coordination, and socio-behavioral outcomes in these populations. Method: Fifteen children with ASD (13 boys, 2 girls) and twelve with ADHD (8 boys, 4 girls), aged 6–12 years, participated in rhythmic, balance, and coordination-based exercises. Primitive reflexes, including the asymmetrical tonic neck reflex (ATNR), were assessed using standardized protocols, and fine motor coordination was evaluated using the Finger and Thumb Opposition Test (FOT). Behavioral outcomes were measured using the Social Responsiveness Scale-2 (SRS-2) for the ASD group and the Conners 3 for the ADHD group. Results: The ASD group showed significant reductions in left-standing ATNR retention scores (p = 0.012) and improvements in right-hand FOT scores (p = 0.023). In the ADHD group, significant improvements were also observed in right-hand FOT scores (p = 0.007). Furthermore, Conners 3 Total and Global Index scores significantly decreased in the ADHD group (p = 0.016 and 0.020, respectively). Reflex retention patterns appeared broader and more bilateral in ASD than in ADHD, suggesting distinct motor developmental profiles. Conclusions: Short-term rhythmic, balance, and whole-body coordination exercise interventions may support behavioral and motor development in children with ASD and ADHD. Tailored programs emphasizing reflex integration hold promise for clinical and educational applications. Full article

Introduction: Previous neuroimaging studies have reported structural brain alterations and local network hyperexcitability in terms of increased slow-wave electroencephalography (EEG) activity in patients with borderline personality disorder (BPD). In particular, intermittent rhythmic delta and theta activity (IRDA/IRTA) has drawn attention in mental health contexts due to its links with metabolic imbalances, neuronal stress, and emotional dysregulation—processes that are highly pertinent to BPD. These functional disturbances may be reflected in corresponding structural brain changes. The current study investigated cortical thickness and subcortical volumes in BPD and examined their associations with IRDA/IRTA events per minute, symptom severity, and neuropsychological measures. Methods: Seventy female BPD patients and 36 age-matched female healthy controls (HC) were included (for clinical EEG comparisons even 72 patients were available). IRDA/IRTA rates were assessed using an automatic independent component analyses (ICA) approach. T1-weighted MRI data were obtained using a MAGNETOM Prisma 3T system and analyzed with FreeSurfer (version 7.2) for subcortical structures and CAT12 for cortical thickness and global volume measurements. Psychometric assessments included questionnaires such as Borderline Symptom List (BSL-23) and Inventory of Personality Organization (IPO). Neuropsychological performance was evaluated with the Test for Attentional Performance (TAP), Culture Fair Intelligence Test (CFT-20-R), and Verbal Learning and Memory Test (VLMT). Results: Between-group comparisons exhibited no significant increase in IRDA/IRTA rates or structural abnormalities between the BPD and HC group. However, within the BPD group, cortical thickness of the right isthmus of the cingulate gyrus negatively correlated with the IRDA/IRTA difference (after minus before hyperventilation, HV; p < 0.001). Furthermore, BPD symptom severity (BSL-23) and IPO scores positively correlated with the thickness of the right rostral anterior cingulate cortex (p < 0.001), and IPO scores were associated with the thickness of the right temporal pole (p < 0.001). Intrinsic alertness (TAP) significantly correlated with relative cerebellar volume (p = 0.01). Discussion: While no group-level structural abnormalities were observed, correlations between EEG slowing, BPD symptom severity, and alertness with cortical thickness and/or subcortical volumes suggest a potential role of the anterior cingulate cortex, temporal pole, and cerebellum in emotion regulation and cognitive functioning in BPD. Future research employing multimodal EEG-MRI approaches may provide deeper insights into the neural mechanisms underlying BPD and guide personalized therapeutic strategies. Full article

Rhythmic and artistic gymnastics expose athletes to a high risk of musculoskeletal disorders such as low back pain (LBP), often caused by repetitive and intensive training demands. This study aimed to evaluate the effects of a 12-week postural treatment using the Mézières method, focused on posture correction and vertebral movement assessed with the Spinal Mouse system, in elite rhythmic gymnasts with LBP. A randomized controlled trial with two parallel groups was conducted, comparing the Mézières method to an equivalent isostretching intervention under similar conditions. Seventeen elite gymnasts with LBP participated, receiving two weekly sessions for 12 weeks. Frontal stand posture (upright, left, and right) was measured at baseline, post-treatment, and at 2, 6, and 12 weeks using the Spinal Mouse system. The experimental group (n = 8) received Mézières therapy; the control group (n = 9) received isostretching. Significant differences in pain reduction were found between the groups (p = 0.000). In the frontal upright position, lumbar and sacral segmental angles (p = 0.021) and regional inclination (p = 0.000) also showed significant group differences. Similarly, in the frontal left position, all vertebral variables except LSpTH12 also demonstrated significant differences between the groups, with p-values ranging from 0.001 to 0.017. Both treatments reduced pain and improved flexibility, but the Mézières group showed significantly greater improvements than the isostretching group. Full article

The circadian rhythm of an animal’s body color change is crucial for its survival and adaptation to the environment, with photoperiod serving as a primary “zeitgeber” that significantly affects the circadian rhythm of color change. To explore the circadian body color change in juvenile Chinese giant salamanders (Andrias davidianus), four distinct photoperiod regimens were established, including the DD group (constant darkness), the LD12:12 group (12 h photophase, 12 h scotophase), the LD16:8 group (16 h photophase, 8 h scotophase), and the LD8:16 group (8 h photophase, 16 h scotophase). Reflectance spectra of dorsal skin were measured every 4 h over a 24 h cycle, with data collected every other day for three consecutive days, totaling 72 h. Reflectance spectra were converted into colorimetric variables to analyze circadian patterns. The results demonstrated that juvenile A. davidianus exhibited highly significant circadian rhythmicity under different photoperiods, with their body color becoming darker during the photophase (mean brightness: 14.650 ± 0.629 to 16.385 ± 1.301) and lighter during the scotophase (mean brightness: 16.473 ± 0.875 to 34.422 ± 2.692). Photoperiod alterations significantly affected the rhythm parameters (mesor, amplitude, and acrophase) of mean brightness variation. Compared with the LD12:12 group, the LD16:8 group (extended photophase) reduced rhythm mesor by 1.415, decreased amplitude by 0.988, and induced a 1.510 h acrophase delay. Conversely, the LD8:16 group (extended scotophase) increased rhythm mesor by 2.141 and amplitude by 2.919. These findings indicate that the circadian rhythm of body color change in juvenile A. davidianus is coordinately regulated by endogenous circadian rhythms and exogenous photoperiodic signals. The findings of this study provide a theoretical foundation for the conservation and management of A. davidianus. Full article

This study examines the surf and swash zone dynamics of a microtidal, low-energy, dissipative beach in Kos Island, Greece, using high-frequency optical monitoring with a Beach Optical Monitoring System (BOMS) and in situ wave measurements during the winter period. Increased wave heights induced the offshore migration of the wave-breaking zone with significant alongshore variability; however, no triggering of NOM (Net Offshore Movement) behavior was verified, while occasional rhythmic patterns were observed in the breaking location under moderate wave conditions. Shoreline dynamics showed transient erosional episodes coupled with elevated run-up excursions, yet the shoreline showed signs of recovery, suggesting a quasi-equilibrium state. Run-up energy spectra were consistently dominated by lower frequencies than those of incoming waves under both low- and high-energy conditions. This behavior is attributed to the nearshore sandbars acting as low-pass filters, dissipating high-frequency wave energy and allowing for lower-frequency motions to dominate run-up processes. A widely used empirical wave run-up predictor corresponded well with the video observations, confirming its applicability to low-energy dissipative beaches. These results underscore the role of submerged sandbars in regulating wave energy dissipation and stabilizing beach morphology under low-to-moderate wave conditions. Full article

Background/Objectives: Postural therapies have emerged as effective non-invasive approaches to managing and preventing LBP in athletes. These therapies focus on correcting muscular imbalances, enhancing body awareness, and promoting proper alignment. Therefore, the objective of this study was to evaluate the effectiveness of implementing the Mézières method and isostretching postures in Spanish high-level national rhythmic gymnasts with low back pain (LBP). Specifically, the study aims to assess the impact of these postural therapies on functional limitations associated with LBP. Methods: This study was a parallel group, randomized controlled trial implemented in 17 rhythmic gymnastics athletes with low back pain conducted at baseline, at 2, 4, and 6 weeks, and upon completion of the 12-week intervention period. The outcome measures included pain measurement, the Borg effort scale, and trunk movement as flexion, extension, inclination, and rotation assessed using a wearable device sensor. Results: The trial included eight participants in the Mézières group and nine in the isostretching group, with no significant age difference between the groups (p = 0.589). Significant differences were found for time (p = 0.000) and group (p = 0.001), indicating variations in left trunk inclination performance over time and between the groups. Both groups showed increased trunk flexion, with the Mézières group demonstrating higher values at all time points. Right trunk rotation fluctuated, with a notable increase in the Mézières group at 6 weeks. The Mézières group also showed higher left trunk rotation values, peaking at 6 weeks. Conclusions: Although the Mézières method showed certain advantages in right trunk rotation and left tilt, the results overall suggest that both approaches are effective in the specific context of this population. Full article

Rhythm is fundamental in many physical and biological systems. Rhythm is relevant to a broad range of phenomena across different fields, including animal bioacoustics, speech sciences, and music cognition. As a result, the interest in developing consistent quantitative measures for cross-disciplinary rhythmic analysis is growing. Two quantitative measures that can be directly applied to any temporal structure are the normalized pairwise variability index (nPVI) and rhythm ratios (r_k). The nPVI summarizes the overall isochrony of a sequence, i.e., how regularly spaced a sequence’s events are, as a single value. Meanwhile, r_k quantifies ratios between a sequence’s adjacent intervals and is often used for identifying rhythmic categories. Here, we show that these two rhythmic measures are fundamentally connected: the nPVI is a summary static of the r_k values of a temporal sequence. This result offers a deeper understanding of how these measures are applied. It also opens the door for creating novel, custom measures to quantify rhythmic patterns based on a sequence’s r_k distribution and compare rhythmic patterns across different domains. The explicit connection between nPVI and r_k is one further step towards a common quantitative toolkit for rhythm research across disciplines. Full article

This study aims to investigate the influence of the Mézières method and Isostretching postures on countermovement jump (CMJ) performance in rhythmic gymnasts with low back pain (LBP) by examining changes in jump height, movement efficiency, and pain perception. A randomized controlled trial (RCT) with a parallel-group design was conducted. Participants were randomly allocated into one of two intervention groups: the Mézières or the Isostretching group. Both groups underwent a total of 24 sessions. The Baiobit sensor was used as the primary assessment tool for measuring CMJ performance in elite rhythmic gymnasts with low back pain. A total of 17 rhythmic gymnastics athletes with LBP participated in the study. No differences were observed between groups in age, weight, or height; nevertheless, the Isostretching group had greater variability in age (SD = 4.82 vs. 0.91), while the Mézières group showed higher variability in height. As per maximal speed and height, the overall treatment effect was significant (p = 0.006, η² = 0.431), indicating long-term benefits for Mezieres training, which also had a significant impact on CMJ Maximal Force, particularly at four sessions (p = 0.036), with improvements continuing over time (p = 0.003, η² = 0.672). The Mezieres group showed higher force values compared to the Isostretching group at all time points. The results indicate that Mezieres training significantly improved CMJ Flight Time over time (p = 0.005, η² = 0.440), with notable increases at all time points compared to the Isostretching group. Improvements were particularly evident in the 12th and 24th sessions, confirming its sustained effectiveness. CMJ Contact Time also showed a significant overall effect (p = 0.027, η² = 0.521), with Mezieres training leading to greater reductions in contact time, particularly at 24 sessions (p = 0.003), highlighting improved efficiency in jump execution. Lastly, CMJ VAS (perceived exertion or discomfort) showed a significant overall effect (p < 0.001, η² = 0.896), with Mezieres training leading to a progressive reduction in perceived exertion, particularly from eight sessions onwards, and the most pronounced effect at 24 sessions. The Mézières method and Isostretching postures offer substantial benefits for gymnasts with low back pain, though their mechanisms of improvement differ. Full article

Objectives: The purpose of this study was to investigate the relationship of any error (delta; ∆) between the image of one’s own walking rhythm and the actual walking rhythm and physical activity, as a new motor imagery assessment. Methods: The subjects were classified into two groups: a high activity group (HA-Group) having high physical activity with less than four hours of sitting time per day, and a low activity group (LA-Group) having low physical activity with more than four hours of daily sitting time. Visual rhythm, auditory rhythm, mental comfortable walking rhythm, and mental maximum walking rhythm were used to assess new motor imagery. Their beats per minute were measured and any error (delta; ∆) from the actual rhythm was calculated: ∆ visual rhythm, ∆ auditory rhythm, ∆ mental normal gait rhythm, and ∆ mental maximal gait rhythm. Results: When comparing the two groups, the HA-Group had significantly higher ∆ visual rhythm, lower ∆ auditory rhythm, higher ∆ mental comfortable walking rhythm, and lower ∆ mental maximum walking rhythm ability than the LA-Group. Furthermore, in an ANCOVA with age, ∆visual rhythm, and ∆auditory rhythm as adjustment factors, the HA-Group had significantly lower ∆mental maximum walking rhythm than the LA-Group. Conclusions: These results showed that the rhythmic assessment of the imagery of maximum walking was associated with stationery time. It is possible that the more inaccurate the imagery of maximum walking, the longer the sitting or lying time. Full article

The regularity of sleep–wake cycles is a defining characteristic of normative sleep patterns that are typically associated with proper circadian rhythmicity. The previous literature indicates that consistent patterns of sleep and wake are associated with improved sleep quality and cognitive functioning. Conversely, sleep irregularity has been associated with reduced well-being and inefficiency in resting-state neural networks. This study investigated the relationship between specific sleep regularity measures and outcomes, including emotional affect, sleep quality, and resting-state functional connectivity. We found that variability in wake onset predicted poorer sleep quality and reduced positive affect. Furthermore, sleep regularity measures were associated with altered functional connectivity between the posterior cingulate cortex and regions involved in emotional processing. We propose that alterations in default mode network (DMN) connectivity linked to sleep irregularity reflect disruptions in emotional processing and sleep quality. Full article

Introduction: Implanted spinal cord epidural stimulation (SCES) is an emerging neuromodulation approach that increases the excitability of the central pattern generator [CPG] and enhances tonic and rhythmic motor patterns after spinal cord injury (SCI). We determine the effects of exoskeleton-assisted walking [EAW] + epidural stimulation [ES] + resistance training [RT] on volitional motor control as a primary outcome, as well as autonomic cardiovascular profile, body composition, and bladder function compared to EAW + delayed ES + noRT in persons with motor-complete SCI AIS A and B. Methods and Analysis: Twenty male and female participants [age 18–60 years] with traumatic motor-complete SCI [2 years or more post injury], and level of injury below C5 were randomized into either EAW + ES + RT or EAW + delayed-ES + no-RT groups for more than 12 months. Baseline, post-interventions 1 and 2 were conducted six months apart. Measurements included body composition assessment using anthropometry, dual x-ray absorptiometry, and magnetic resonance imaging prior to implantation to evaluate the extent of spinal cord damage, neurophysiologic assessments to record H-reflexes, overground ambulation and peak torque for both groups, and the Walking Index for Spinal Cord Injury Scale [WISCI 2]. Metabolic profile measurements included the resting metabolic rate, fasting biomarkers of HbA1c, lipid panels, total testosterone CRP, IL-6, TNF-α, plasma IGF-I, IGFBP-3, and then a glucose tolerance test. Finally, urodynamic testing was conducted to assess functional bladder improvement due to ES. Results: The restoration of locomotion with ES and EAW may result in a reduction in psychosocial, cardiovascular, and metabolic bladder parameters and socioeconomic burden. The addition of the resistance training paradigm may further augment the outcomes of ES on motor function in persons with SCI. Conclusions: Percutaneous SCES appears to be a feasible and safe rehabilitation approach for the restoration of motor function in persons with SCI. The procedure may be successfully implemented with other task-specific training similar to EAW and resistance training. Full article

The paramount objectives of this study were to analyze the beneficial role of the circadian clock in alleviating drought stress in an essential green leafy horticultural crop, spinach (Spinacia oleracea), and to attain knowledge on drought-stress adaptation for crop productivity. From dawn to dusk, a circadian core oscillator-based defense mechanism was noticed in relation to the strength of the chloroplast proteome and transcriptome, and the defense hormone fused it along with the molecular physiology using genotypes “Malav Jyoti” and “Delhi Green”. A photo-periodic rhythmicity containing a 4 h time interval (morning–evening loop) for 12 h in spinach was exhibited under drought-stressed (day-5) and drought re-irrigated (day-10) conditions. The circadian oscillator controlled 70% of the major part of growth and physiological measures such as the biomass, plant height, leaf-relative water content, and the shoot–root ratio under drought stress. Contrarily, drought stress resulted in the upregulation of antioxidative activities and stress markers, whereas it was diversified and maintained in the case of the re-irrigated state at certain rhythmic time intervals of the circadian clock. The physiological parameters we examined, such as net photosynthesis, transpiration, stomatal conductance, and antioxidative enzymes, exhibited the role of the circadian clock in drought stress by showing 80–90% improvements found in plants when they were re-watered after drought stress based on their circadian oscillations. Based on the physiological results, 10 a.m. and 2 p.m. were disclosed to be the rhythmic times for controlling drought stress. Moreover, an extensive study on a gene expression analysis of circadian clock-based genes (CCA1, LHY, TOC1, PRR3, PRR5, PRR7, PRR9, and RVE8) and drought-responsive genes (DREB1, DREB2, and PIP1) depicted the necessity of a circadian oscillator in alleviating drought stress. Hence, the findings of our study allowed for an intense understanding of photo-periodic rhythms in terms of the morning–evening loop, which is in line with the survival rate of spinach plants and occurs by altering cellular ROS-scavenging mechanisms, chloroplast protein profiles, gene regulation, and metabolite concentrations. Full article

Background/Objectives: The purpose of this study has been to evaluate the effects of a dance-based aerobic training program on frailty, cognitive impairment, executive functions, and verbal fluency in older adults with mild cognitive impairment. Methods: Randomized clinical trial, whose sample was made up of 92 older adults, of which 47 performed rhythmic physical activity for 12 weeks. Data on frailty were collected through FRAIL, cognitive function through the Mini-Mental State Examination (MMSE), cognitive impairment through The Montreal Cognitive Assessment (MoCA), verbal fluency using the Isaac test, and executive functions with the Trail Making Test (TMT). All variables were measured before and after the intervention by an independent researcher blinded to the treatment. Results: Participants in the experimental group showed statistically significant improvements in frailty (Cohen’s d = 0.60), cognitive function (Cohen’s d = 0.98), cognitive impairment (Cohen’s d = 1.22), verbal fluency (Cohen’s d = 0.61) and executive functions (Cohen’s d = 0.64). Conclusions: This study demonstrated that a 12-week dance-based aerobic training program can significantly reduce frailty and improve cognitive abilities in older adults with mild cognitive impairment. These improvements suggest that the intervention is not only effective in terms of physical health, but also in promoting mental health and general well-being. Full article