Search Results (467)

Background and Clinical Significance: Antisynthetase syndrome (ASyS) is a rare autoimmune entity defined by the presence of anti-aminoacyl-t ribonucleic acid (RNA) synthetase autoantibodies and classically associated with a triad of interstitial lung disease (ILD), inflammatory myopathy, and arthritis. Additional clinical features may include Raynaud’s phenomenon and “mechanic’s hands”. Among antisynthetase antibodies, anti-PL-12 is notably associated with predominant or isolated ILD and may occur in the absence of clinically evident myositis, thereby complicating timely diagnosis. Case Presentation: We are presenting a 45-year-old non-smoking female patient with a prior diagnosis of seronegative rheumatoid arthritis (RA) who developed progressive dyspnea, dry cough, and sicca symptoms. High-resolution computed tomography revealed a nonspecific interstitial pneumonia (NSIP) pattern. Despite normal creatine kinase and lactate dehydrogenase levels, serological work-up revealed positive anti-PL-12 and anti-Ro52 antibodies, supporting a diagnosis of antisynthetase syndrome without myositis, fulfilling the diagnostic criteria for ASyS per Connors and Solomon. Treatment with corticosteroids and cyclophosphamide induced clinical and functional respiratory improvement, while azathioprine was initiated for maintenance. Conclusions: This case underscores the clinical heterogeneity of antisynthetase syndrome and highlights the diagnostic challenge posed by anti-PL-12–associated ILD in the absence of myositis. Importantly, it demonstrates that in patients with pre-existing rheumatologic diagnoses, the emergence of atypical pulmonary manifestations warrants repeat serologic evaluation to assess ASyS and other autoimmune conditions. Early diagnosis and immunosuppressive treatment are essential to optimize outcomes. Full article

Structural Health Monitoring (SHM) techniques are crucial for evaluating the condition of structures, enabling early maintenance interventions, and monitoring factors that could compromise structural integrity. Modal analysis studies the dynamic response of structures when subjected to vibrations, evaluating natural frequencies and vibration modes. This study focuses on detecting and comparing the natural frequencies of a 3-DoF structure under various excitation scenarios, including ambient vibration (in healthy and damaged conditions), two types of transient excitation, and three harmonic excitation variations. Signal processing techniques, specifically Power Spectral Density (PSD) and Continuous Wavelet Transform (CWT), were employed. Each method provides valuable insights into frequency and time-frequency domain analysis. Under ambient vibration excitation, the damaged condition exhibits spectral differences in amplitude and frequency compared to the undamaged state. For the transient excitations, the scalogram images reveal localized energetic differences in frequency components over time, whereas PSD alone cannot observe these behaviors. For the harmonic excitations, PSD provides higher spectral resolution, while CWT adds insight into temporal energy evolution near resonance bands. This study discusses how these analyses provide sensitive features for damage detection applications, as well as the influence of different excitation types on the natural frequencies of the structure. Full article

Salinity intrusion is a growing threat to freshwater resources, particularly in low-lying coastal and estuarine regions, necessitating the development of effective early warning systems (EWS) to support timely mitigation. Although various water quality monitoring technologies exist, many face challenges related to long-term sustainability, ongoing maintenance, and accessibility for local users. This study introduces a novel hybrid real-time salinity intrusion early warning system that uniquely integrates fixed and portable monitoring technologies with strong community participation—an approach not yet widely applied in comparable urban-adjacent delta regions. Unlike traditional systems, this model emphasizes local ownership, flexible data collection, and system scalability in resource-constrained environments. This study presents a real-time salinity intrusion early warning system for Bang Kachao, Thailand, combining eight fixed monitoring stations and 20 portable salinity measurement devices. The system was developed in response to community needs, with local input guiding both station placement and the design of mobile measurement tools. By integrating fixed stations for continuous, high-resolution data collection with portable devices for flexible, on-demand monitoring, the system achieves comprehensive spatial coverage and adaptability. A core innovation lies in its emphasis on community participation, enabling villagers to actively engage in monitoring and decision-making. The use of IoT-based sensors, Remote Telemetry Units (RTUs), and cloud-based data platforms further enhances system reliability, efficiency, and accessibility. Automated alerts are issued when salinity thresholds are exceeded, supporting timely interventions. Field deployment and testing over a seven-month period confirmed the system’s effectiveness, with fixed stations achieving 90.5% accuracy and portable devices 88.7% accuracy in detecting salinity intrusions. These results underscore the feasibility and value of a hybrid, community-driven monitoring approach for protecting freshwater resources and building local resilience in vulnerable regions. Full article

Precision irrigation plays a crucial role in managing crop production in a sustainable and environmentally friendly manner. This study builds on the results of the GreenWaterDrone project, aiming to estimate, in real time, the actual water requirements of crop fields using the crop water stress index, integrating infrared canopy temperature, air temperature, relative humidity, and thermal and near-infrared imagery. To achieve this, a state-of-the-art aerial micrometeorological station (AMMS), equipped with an infrared thermal sensor, temperature–humidity sensor, and advanced multispectral and thermal cameras is mounted on an unmanned aerial system (UAS), thus minimizing crop field intervention and permanently installed equipment maintenance. Additionally, data from satellite systems and ground micrometeorological stations (GMMS) are integrated to enhance and upscale system results from the local field to the regional level. The research was conducted over two years of pilot testing in the municipality of Trifilia (Peloponnese, Greece) on pilot potato and watermelon crops, which are primary cultivations in the region. Results revealed that empirical irrigation applied to the rhizosphere significantly exceeded crop water needs, with over-irrigation exceeding by 390% the maximum requirement in the case of potato. Furthermore, correlations between high-resolution remote and proximal sensors were strong, while associations with coarser Landsat 8 satellite data, to upscale the local pilot field experimental results, were moderate. By applying a comprehensive model for upscaling pilot field results, to the overall Trifilia region, project findings proved adequate for supporting sustainable irrigation planning through simulation scenarios. The results of this study, in the context of the overall services introduced by the project, provide valuable insights for farmers, agricultural scientists, and local/regional authorities and stakeholders, facilitating improved regional water management and sustainable agricultural policies. Full article

REG3A, a prominent member of the human regenerating islet-derived (REG) lectin family, plays a pivotal and multifaceted role in immune defense, inflammation, and cancer biology. Primarily expressed in gastrointestinal epithelial cells, REG3A reinforces barrier integrity, orchestrates mucosal immune responses, and regulates host–microbiota interactions. It also functions as a potent non-enzymatic antioxidant, protecting tissues from oxidative stress. REG3A expression is tightly regulated by inflammatory stimuli and is robustly induced during immune activation, where it limits microbial invasion, dampens tissue injury, and promotes epithelial repair. Beyond its antimicrobial and immunomodulatory properties, REG3A contributes to the resolution of inflammation and the maintenance of tissue homeostasis. However, its role in cancer is highly context-dependent. In some tumor types, REG3A fosters malignant progression by enhancing cell survival, proliferation, and invasiveness. In others, it acts as a tumor suppressor, inhibiting growth and metastatic potential. These opposing effects are likely dictated by a combination of factors, including the tissue of origin, the composition and dynamics of the tumor microenvironment, and the stage of disease progression. Additionally, the secreted nature of REG3A implies both local and systemic effects, further modulated by organ-specific physiology. Experimental variability may also reflect differences in methodologies, analytical tools, and model systems used. This review synthesizes current knowledge on the pleiotropic functions of REG3A, emphasizing its roles in epithelial defense, immune regulation, redox homeostasis, and oncogenesis. A deeper understanding of REG3A’s pleiotropic effects could open up new therapeutic avenues in both inflammatory disorders and cancer. Full article

The address is a key element in the construction of smart cities. When receiving reports from citizens, public security officers need to quickly and accurately locate a crime scene based on the address provided by the reporter. The address from the reporter may be a standard address or it may be a point of interest, abbreviation, or common name. The difficulty in converting the address into a standard address can be solved through the analysis of address elements and address matching. We developed a bidirectional encoder representations from transformers (BERT)-based address feature resolution method and an address-matching algorithm. On this basis, a police force address-matching system for City A was designed and implemented. A Web application system was also developed based on the address database of City A. The developed address resolution and matching method with the database maintenance module successfully matched the reported address to the standard one. Full article

An underground utility tunnel (UUT) is essential for the efficient use of urban underground space. However, current maintenance systems rely on patrol personnel and professional equipment. This study explores industrial detection methods for identifying and monitoring natural gas leaks in UUTs. Via infrared thermal imaging gas experiments, data were acquired and a dataset established. To address the low-resolution problem of existing imaging devices, video super-resolution (VSR) was used to improve the data quality. Based on a convolutional recurrent neural network (CRNN), the image features at each moment were extracted, and the time series data were modeled to realize the risk-level classification mechanism based on the automatic classification of the leakage rate. The experimental results show that when the sliding window size was set to 10 frames, the classification accuracy of the CRNN was the highest, which could reach 0.98. This method improves early warning precision and response efficiency, offering practical technical support for UUT maintenance management. Full article

Steel wire ropes used in transport and aerospace applications are critical components whose failure can lead to significant safety, operational, and environmental consequences. Current diagnostic practices based on magnetic rope testing (MRT) often suffer from signal misalignment and subjective interpretation, particularly under varying operational conditions or in polymer-impregnated ropes with delayed damage indicators. This study explores the application of the Dynamic Time Warping (DTW) algorithm to enhance the reliability of MRT diagnostics. The research involved analyzing long-term MRT recordings of wire ropes used in mining operations, including different scanning resolutions and signal acquisition methods. A mathematical formulation of DTW is provided along with its implementation code in R and Python. The DTW algorithm was applied to synchronize diagnostic signals with their baseline recordings, as recommended by ISO 4309:2017 and EN 12927:2019 standards. Results show that DTW enables robust alignment of time series with slowly varying spectra, thereby improving the comparability and interpretation of MRT data. This approach reduces the risk of unnecessary rope discard and increases the effectiveness of degradation monitoring. The findings suggest that integrating DTW into existing diagnostic protocols can contribute to safer operation, lower maintenance costs, and reduced environmental impact. Full article

Object detection technology enables the automatic identification of photovoltaic (PV) panel locations and conditions, significantly enhancing operational efficiency for maintenance teams while reducing the time and cost associated with manual inspections. Challenges arise due to the low resolution of remote sensing images combined with small-sized targets—PV panels intertwined with complex urban or natural backgrounds. To address this, a parallel architecture model based on YOLOv5 was designed, substituting traditional residual connections with parallel convolution structures to enhance feature extraction capabilities and information transmission efficiency. Drawing inspiration from the bottleneck design concept, a primary feature extraction module framework was constructed to optimize the model’s deep learning capacity. The improved model achieved a 4.3% increase in mAP, a 0.07 rise in F1 score, a 6.55% enhancement in recall rate, and a 6.2% improvement in precision. Additionally, the study validated the model’s performance and examined the impact of different loss functions on it, explored learning rate adjustment strategies under various scenarios, and analyzed how individual factors affect learning rate decay during its initial stages. This research notably optimizes detection accuracy and efficiency, holding promise for application in large-scale intelligent PV power station maintenance systems and providing reliable technical support for clean energy infrastructure management. Full article

Crack detection in complex pavement scenarios remains challenging due to the sparse small-target features and computational inefficiency of existing methods. To address these limitations, this study proposes an enhanced architecture based on Mask2Former. The framework integrates two key innovations. A Local Perception Module (LPM) reconstructs geometric topological relationships through a Sequence-Space Dynamic Transformation Mechanism (DS2M), enhancing neighborhood feature extraction via depthwise separable convolutions. Simultaneously, an Auxiliary Convolutional Layer (ACL) combines lightweight residual convolutions with shallow high-resolution features, preserving critical edge details through channel attention weighting. Experimental evaluations demonstrate the model’s superior performance, achieving improvements of 3.2% in mIoU and 2.7% in mAcc compared to baseline methods, while maintaining computational efficiency with only 12.8 GFLOPs. These results validate the effectiveness of geometric relationship modeling and hierarchical feature fusion for pavement crack detection, suggesting practical potential for infrastructure maintenance systems. The proposed approach balances precision and efficiency, offering a viable solution for real-world applications with complex crack patterns and hardware constraints. Full article

Aging port infrastructure demands frequent and reliable inspections, yet the existing automated systems often require expensive industrial drones, posing significant adoption barriers for local governments with limited resources. To address this challenge, this study develops a low-cost, automated crack detection system for port quay walls utilizing orthophotos generated from a small general-purpose drone. The system employs the YOLOR (You Only Learn One Representation) object detection algorithm, enhanced by two novel image processing techniques—overlapping tiling and pseudo-altitude slicing—to overcome the resolution limitations of low-cost cameras. While official guidelines for port facilities designate 3 mm as an inspection threshold, our system is specifically designed to achieve a higher-resolution detection capability for cracks as narrow as 1 mm. This approach ensures reliable detection with a sufficient safety margin and enables the proactive monitoring of crack progression for preventive maintenance. The effectiveness of the proposed image processing techniques was validated, with an F₁ score-based analysis revealing key trade-offs between maximizing detection recall and achieving a balanced performance depending on the chosen simulated altitude. Furthermore, evaluation using real-world inspection data demonstrated that the proposed system achieves a detection performance comparable to that of a well-established commercial system, confirming its practical applicability. Crucially, by mapping the detected cracks to real-world coordinates on georeferenced orthophotos, the system provides a foundation for advanced, data-driven asset management, allowing for the quantitative tracking of deterioration over time. These results confirm that the proposed workflow is a practical and sustainable solution for infrastructure monitoring. Full article

With the large-scale application and high-quality development demands of optical fiber cables, higher requirements have been placed on the corresponding measurement technologies. In recent years, optical fiber testing has played a crucial role in evaluating cable performance, as well as in the deployment, operation, maintenance, fault repair, and upgrade of optical networks. The Optical Time-Domain Reflectometer (OTDR) is a fiber fault diagnostic tool recommended by standards such as the International Telecommunication Union and the International Electrotechnical Commission. It is used to certify the performance of new fiber links and monitor the status of existing ones, detecting and locating fault events with advantages including simple operation, rapid response, and cost-effectiveness. First, this paper introduces the working principle and system architecture of OTDR, along with a brief discussion of its performance evaluation metrics. Next, a comprehensive review of improved OTDR technologies and systems is provided, categorizing different performance enhancement methods, including the enhanced measurement distance with simple structure and low cost in 2024, and the high spatial resolution measurement of optical fiber reflection events and non-reflection events in 2025. Finally, the development trends and future research directions of OTDR are outlined, aiming to achieve the development of low-cost, high-performance OTDR systems. Full article

Structural health monitoring (SHM) plays a pivotal role in ensuring the integrity and safety of critical infrastructure and mechanical components. While traditional non-destructive testing (NDT) methods offer high-resolution data, they typically require periodic access and disassembly of equipment to conduct inspections. In contrast, SHM employs permanently installed, cost-effective sensors to enable continuous monitoring, though often with reduced detail. This study presents an integrated hybrid SHM-NDT methodology enhanced by deep learning to enable the real-time monitoring and classification of mechanical stresses in structural components. As a case study, a 6-foot-long parallel flange I-beam, representing bridge truss elements, was subjected to variable bending loads to simulate operational conditions. The hybrid system utilized an ultrasonic transducer (NDT) for excitation and piezoelectric sensors (SHM) for signal acquisition. Signal data were analyzed using 1D and 2D convolutional neural networks (CNNs), long short-term memory (LSTM) models, and random forest classifiers to detect and classify load magnitudes. The AI-enhanced approach achieved 100% accuracy in 47 out of 48 tests and 94% in the remaining tests. These results demonstrate that the hybrid SHM-NDT framework, combined with machine learning, offers a powerful and adaptable solution for continuous monitoring and precise damage assessment of structural systems, significantly advancing maintenance practices and safety assurance. Full article

As the demand for expansive back-end systems in online applications continues to grow, novel frameworks are necessitated to address the escalating operational demands, energy consumption, and associated costs. Traditional Client–Server models, while offering centralized security and reliability, are characterized by their high deployment and maintenance expenses. Conversely, Peer-to-Peer (P2P) models, despite being cost-effective and scalable, are hindered by inherent security and data integrity challenges. Moreover, the lack of a central authority in P2P systems complicates a definitive resolution of scenarios involving stakes, where users cannot withdraw without incurring a tangible loss. In this research work, a hybrid back-end framework is introduced, combining the advantages of both models through the utilization of cryptographic algorithms and Secure Multi-Party Computation (MPC) protocols. The baseline solution is lightweight and fully composable, making it capable of utilizing different more complex slot-in MPC techniques. The proposed framework’s effectiveness is demonstrated through a simplified two-player Spades game, although it is fully generalizable to any application. Evaluations across multiple case studies reveal substantial performance enhancements compared to conventional approaches, particularly post-initialization, highlighting the scheme’s potential as a cost-effective, energy-efficient, and secure solution for modern online applications. Full article

Background/Objectives: Abnormal brain glycerolipid metabolism has been reported for Alzheimer’s disease (AD). This includes both diacylglycerols (DGs) and monogalactosyl-DGs (MGDGs), which are elevated in AD subjects. While DGs are also elevated in subjects with mild cognitive impairment (MCI), MGDGs have not yet been examined at this early stage of cognitive impairment. Methods: MGDG, triacylglycerol (TG), and ether glycerolipid levels in the cerebral cortex gray matter of controls, MCI, and non-demented Alzheimer’s neuropathology (NDAN) subjects were monitored by high-resolution mass spectrometry (<2 ppm mass error). Results: MGDG, MGDG ether, DG ether, and TG levels were elevated in the cerebral cortex of MCI but not NDAN subjects. Conclusions: A diverse array of glycerolipids was elevated in MCI subjects, suggesting a role in cognitive dysfunction. This suggestion is further supported by the maintenance of normal glycerolipid levels in NDAN subjects with amyloid accumulation but not cognitive deficits. Our data clearly indicate that while complex lipid alterations occur in MCI subjects, relative to controls 20 years younger, no such lipid alterations occur in NDAN subjects. While amyloid deposition in MCI is not involved in the observed lipid alterations, other ongoing neuropathologies may contribute to changes in lipid dynamics and vice versa. Full article